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David Vallenet

@vallenet.bsky.social
79 followers 138 following 23 posts

Researcher at LABGeM, Genoscope @genolabgem.bsky.social in bioinformatics, genomics, metabolic networks

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Reposted by David Vallenet
Biochemical Society @biochemsoc.bsky.social · 08/09/2026
Check out our newest Essays in Biochemistry review by Fiona J Whelan if you’re curious about how bacterial niches and interactions can alter their genetic diversity and how we can detect this doi.org/10.1042/EBC20250039
A cartoon depiction of a microbial pangenome
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Jim Shaw @jimshaw.bsky.social · 02/09/2026
Cool preprint about strain-level metagenome association studies using k-mer containment. Mallawaarachchi et al. from @gerrythill.bsky.social's group. I tried tackling this in our original paper for sylph (sylph-docs.github.io), but this seems to be much more sophisticated. Excited to read!
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Cameron Thrash @jcamthrash.bsky.social · 02/09/2026
The importance of interbacterial relationships in shaping cyanobacterial ecology www.cell.com/trends/micro... #jcampubs 🌊
cell.com
The importance of interbacterial relationships in shaping cyanobacterial ecology
Cyanobacteria are a globally abundant bacterial phylum that make key contributions to primary production and nutrient cycling in aquatic ecosystems. However, some cyanobacteria also cause substantial ...
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AI x Bio Discovery @aixbiobot.bsky.social · 02/09/2026
Designing antimicrobials with programmable mechanism and safety [new] ...conditional diffusion framework controls physicochemical properties & motifs, enabling de novo, analog, and motif-guided design for desired activity and safety.
Designing antimicrobials with programmable mechanism and safetyFigure 1Figure 2Figure 3
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AI x Bio Discovery @aixbiobot.bsky.social · 01/09/2026
A genomic catalog of Earth’s bacterial and archaeal symbionts [new] ...is predicted & cataloged by a machine learning tool identifying their symbiotic relationships.
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PLOS Biology @plosbiology.org · 01/09/2026
Bacterial genomes are remarkably dynamic, shaped by horizontal transfer of plasmids that follow evolutionary trajectories of their own. This study uses eco-evolutionary perspectives to reveal how #plasmid communities are shaped and contribute to bacterial #evolution. 🧪 #AcademicSky plos.io/4gAJGlB
Plasmid eco-evolutionary sorting in action. Each dot represents a plasmid species in trait space (horizontal transfer rate on the x-axis, resistance level on the y-axis). Dot size reflects abundance; color indicates the community identity. After 1,000 generations, three distinct clusters of plasmid species have emerged: (i) high resistance level with low horizontal transfer rate, (ii) high horizontal transfer rate with low resistance level, and (iii) high horizontal transfer rate with high resistance level. This reflects an eco-evolutionary sorting driven by local stress regimes and connectivity across communities. Image credit: Rémi Tuffet.
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Cameron Thrash @jcamthrash.bsky.social · 01/09/2026
MetaCAT enables reconstruction of high-quality microbial genomes and their association with host traits from metagenomic data www.nature.com/articles/s41... #jcampubs
nature.com
MetaCAT enables reconstruction of high-quality microbial genomes and their association with host traits from metagenomic data - Nature Microbiology
MetaCAT is a computational framework to assess host–microbiome interaction via a combination of high-accuracy and efficient microbial genome reconstruction and metagenome-wide association studies with...
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David Vallenet @vallenet.bsky.social · 10/08/2026
🧬 PanGBank is now available! • 4,600+ prokaryotic #pangenomes, 393,000+ genomes • #PPanGGOLiN graph partitioning, RGPs & Modules • User-friendly web interface, API & CLI 🌐 pangbank.genoscope.cns.fr 🎓 Try it in on #AMR in A. baumannii : shorturl.at/Vw3zc #ABRomics @ifb-elixir-fr.bsky.social
PanGBank web interface
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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 10/08/2026
PanGBank: a large-scale resource of precomputed microbial pangenomes built with PPanGGOLiN www.biorxiv.org/content/10.64898/20…
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arXiv q-bio.QM Quantitative Methods @qbioqm-bot.bsky.social · 28/07/2026
Arnoux, Mainguy, Bazin, Gautreau, Lemane, Vallenet, Calteau: PPanGGOLiN V2: technical enhancement and extended functionalities for prokaryotic pangenome analysis arxiv.org/abs/2607.24111 arxiv.org/pdf/2607.24111 arxiv.org/html/2607.24111
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Jérôme Arnoux @jpjarnoux.bsky.social · 20/07/2026
8/ Co-author Jean Mainguy, Laura Bry, Quentin Fernandez De Grado, Yazid Hoblos, @vallenet.bsky.social, Alexandra Calteau @genolabgem.bsky.social
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LABGeM @genolabgem.bsky.social · 15/07/2026
🧬 We're thrilled that PANORAMA has been published! An open-source method to predict & compare biological systems across bacterial pangenomes. Built on PPanGGOLiN, it runs at #pangenome scale in minutes vs. hours for genome-by-genome tools. 📄 doi.org/10.1371/jour... @jpjarnoux.bsky.social
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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 09/07/2026
Lossless compression of k-mer matrices enabling random row access www.biorxiv.org/content/10.64898/20…
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bioRxivpreprint @biorxivpreprint.bsky.social · 07/06/2026
Using protein language models for pangenome construction www.biorxiv.org/content/10.64898/20…
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Bacterial Genomics @bactgenrss.bsky.social · 21/06/2026
A syntenic pangenome of Gardnerella reveals novel plasmids and phage, taxonomic boundaries, and species-level stratification of metabolic and virulence potential www.nature.com/articles/s41...
nature.com
A syntenic pangenome of Gardnerella reveals novel plasmids and phage, taxonomic boundaries, and species-level stratification of metabolic and virulence potential - Nature Communications
Bacteria of the genus Gardnerella are associated with bacterial vaginosis. Here, the authors compile and analyse a reference set of high-quality Gardnerella genomes, revealing previously hidden specie...
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Reposted by David Vallenet
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 04/07/2026
Synteny-aware microbial pangenome graphs reveal blueprints of genomic variation www.biorxiv.org/content/10.64898/20…
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LABGeM @genolabgem.bsky.social · 02/07/2026
7/ From landfills to beaches to insect guts 🐛 the Bioplastomics project explores Brazilian environments to find microbes and enzymes capable of breaking down plastics 🔬♻️ #JOBIM2026 Meet Julia Cantuti-Gendre at poster 47 👋
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LABGeM @genolabgem.bsky.social · 02/07/2026
6/ MetaPanG 🧬 a new tool for strain-level profiling of metagenomic samples, powered by pangenome graphs from PanGBank. Going beyond species ID to reveal which strains — and which genes — are really there 🔬 #pangenomics #JOBIM2026 Meet @tlemane.bsky.social at poster 43 👋
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LABGeM @genolabgem.bsky.social · 02/07/2026
5/ Curious about pangenomes? Check out PangBank, our database built to explore gene content variation across bacterial species and support comparative genomics research 🔬 #pangenomics #JOBIM2026 Meet @j-main-guy.bsky.social at poster 49
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Janina Rinke @jannelrinke.bsky.social · 02/07/2026
Excited to share that our paper on Horizontal Gene Transfer is now out in its final form in @gigascience.bsky.social! 🥳 By analysing 163 high-quality ant genomes, we show that HGT from bacteria is widespread across the ants and likely has adaptive functions! doi.org/10.1093/giga... 🐜📸: Alex Wild
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EMBL-EBI @ebi.embl.org · 13/05/2026
There's also an associated policy briefing, which looks at untangling the international legal frameworks that govern microbial resources. academic.oup.com/sumbio/artic...
academic.oup.com
Policy Briefing: from access to use—untangling the international legal frameworks that govern microbial resources
Abstract. The wide geographic distribution of microorganisms, combined with their vast taxonomic and functional diversity, make them indispensable reservoi
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AI x Bio Discovery @aixbiobot.bsky.social · 13/05/2026
Deep Learning for Protein Complex Prediction and Design [new] ...investigates domain-specific architectures and search algorithms to model hierarchical protein structures, identify interacting homologs, and design protein sequences.
Figure 1.1Figure 1.2Figure 2.1Figure 2.2
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AI x Bio Discovery @aixbiobot.bsky.social · 13/05/2026
Learning the Interaction Prior for Protein-Protein Interaction Prediction: A Model-Agnostic Approach [new] by designing a bio-informed classifier based on L3 rule, using graph prompt learning to reformulate embed pair classification into a graph task.
Abstract AbstractFigure 1Figure 2Figure 3
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AI x Bio Discovery @aixbiobot.bsky.social · 13/05/2026
SCOPE: Siamese Contrastive Operon Pair Embeddings for Functional Sequence Representation and Classification [new] employs PLM embeddings & Siamese MLP for scalable operon pair class. across diverse microbial genomes, aiding annot. & network reconstruction.
Figure 1Figure 2Table 1
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AI x Bio Discovery @aixbiobot.bsky.social · 13/05/2026
Set-Aggregated Genome Embeddings for Microbiome Abundance Prediction [new] Predicts microbiome abundance by aggregating genomic language model embeddings from raw DNA sequences, enabling few-shot learning.
Abstract AbstractFigure 2Figure 3Figure 4
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James McInerney @jomcinerney.bsky.social · 08/05/2026
A short piece about what "the pangenome" is and is not. open.substack.com/pub/profmcin...
open.substack.com
The Pangenome Is Not a Parts List
The pangenome is the total genetic repertoire of a group of organisms. It is a property of populations, maintained by evolutionary processes.
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Alexander Rakitko @alexrakitko.bsky.social · 09/05/2026
🧬CroCoDeEL is a new tool for detecting cross-sample contamination in metagenomic data.🐊🦠 The idea behind CroCoDeEL is simple and elegant. Imagine different cocktails poured into a row of glasses...🧵 www.nature.com/articles/s41... #Microbiome #Metagenomics #Contamination
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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 07/05/2026
ProtSpace: Protein Universe in Your Browser www.biorxiv.org/content/10.64898/20…
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Nature Microbiology @natmicrobiol.nature.com · 24/04/2026
Out Now! Cayman enables large-scale analysis of gut microbiome carbohydrate-active enzyme repertoires #MicroSky
go.nature.com
Cayman enables large-scale analysis of gut microbiome carbohydrate-active enzyme repertoires
Nature Microbiology, Published online: 24 April 2026; doi:10.1038/s41564-026-02318-2Cayman enables computational analysis of carbohydrate-active enzymes (CAZymes) in microbial community data. It revealed novel mucus-foraging gut microorganisms and differences in gut microbial CAZyme repertoires associated with lifestyle and disease.
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AI x Bio Discovery @aixbiobot.bsky.social · 06/05/2026
Graph Neural Network based Hierarchy-Aware Embeddings of Knowledge Graphs: Applications to Yeast Phenotype Prediction [new] ...leveraging ontology-derived semantic loss to create embeddings that better reflect domain know. and facilitate biological discovery.
Graph Neural Network based Hierarchy-Aware Embeddings of Knowledge Graphs: Applications to Yeast Phenotype PredictionFigure 1Figure 2Figure 3
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Mizrahi Lab @mizrahilab.bsky.social · 26/04/2026
"Tell me who your friends are, and I’ll tell you who you are." It turns out, microbes follow the same rule! Very proud to share our lab's new paper in @natmicrobiol.nature.com showing that bacteria don't just respond to their environment, they respond to each other. www.nature.com/articles/s41...
nature.com
Community context reshapes microbial proteomes and reduces functional overlap - Nature Microbiology
Biotic interactions modulate protein abundance, reducing functional redundancy and increasing productivity in complex bacterial communities.
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Harry Low’s Lab @lowlab.bsky.social · 20/04/2026
Most bacteria remain uncultured with vast microbial ‘dark matter’ awaiting discovery.. to address this am excited to share EDEN - an enhanced domestication method to grow uncultured bacteria & new diversity. Using EDEN we isolate a new species active against MDR pathogens.. doi.org/10.1093/isme...
doi.org
An enhanced domestication method for uncultured bacteria
Abstract. When environmental bacteria transition to laboratory conditions, a process termed domestication, the shift from the native habitat to a culture m
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Stephen Turner @stephenturner.us · 20/04/2026
What am I looking at here opensource.posit.co/blog/2026-04...
opensource.posit.co
ggsql: A grammar of graphics for SQL
Introducing ggsql, a grammar of graphics for SQL that lets you describe visualizations directly inside SQL queries.
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José Cediel-Becerra @jcedielbecerra.bsky.social · 20/04/2026
Happy to share our latest work, 'Integrating targeted genome mining and structure-guided modeling reveals unexplored 7-deazapurine-containing pathways.' 1/n www.biorxiv.org/content/10.6...
biorxiv.org
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Bioinformatics Advances @bioinfoadv.bsky.social · 13/04/2026
🧬 New in Bioinformatics Advances: "The pangenome: A statistical model, not a fixed biological property"  Read it at doi.org/10.1093/bioadv/vbag069
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Frédérique Le Roux @fredoleroux.bsky.social · 11/04/2026
>1000 lytic vibriophages sequenced. 4 years later… still there. Same genomes. Same vibes. Different story. When nothing changes—but everything does. Congrats to Jeff & Karine et al. and @epcrocha.bsky.social for the intellectual turbulence ;-) www.nature.com/articles/s41...
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Cameron Thrash @jcamthrash.bsky.social · 13/04/2026
Intracellular Amorphous Calcium Carbonate Biomineralization in Methanotrophic Gammaproteobacteria Was Acquired by Horizontal Gene Transfer From Cyanobacteria enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/... #jcampubs
enviromicro-journals.onlinelibrary.wiley.com
Intracellular Amorphous Calcium Carbonate Biomineralization in Methanotrophic Gammaproteobacteria Was Acquired by Horizontal Gene Transfer From Cyanobacteria
Horizontal gene transfer from Microcystis-like cyanobacteria to members of the Methylococcaceae has enabled the latter to become capable of biomineralizing intracellular amorphous calcium carbonate i...
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Sebastian Schmidt @tsbschm.bsky.social · 03/04/2026
Our work on 'hidden diversity' in unbinned contigs is now published in @natmicrobiol.nature.com : www.nature.com/articles/s41... See the linked threads for more details!
nature.com
Unbinned contigs expand known diversity in the global microbiome - Nature Microbiology
Re-analysis of over 92,000 metagenomes reveals hundreds of thousands of previously undescribed Bacterial and Archaeal clades hidden in plain sight.
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AI x Bio Discovery @aixbiobot.bsky.social · 30/03/2026
MAAMOUL: Metabolic network-based discovery of microbiome-metabolome shifts in disease [new] ...integrates multi-omic data via a global metabolic network, identifying custom microbial metabolic modules for disease-associated shifts.
MAAMOUL: Metabolic network-based discovery of microbiome-metabolome shifts in diseaseFigure 1Figure 2Figure 3
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AI x Bio Discovery @aixbiobot.bsky.social · 31/03/2026
Protein sequence domain annotation using a language model [updated] ...integrates a pretrained protein language model with a per-residue classifier and a probabilistic decoder for explicit, non-overlapping domain calls.
Figure 1Figure 2Figure 3Figure 4
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AI x Bio Discovery @aixbiobot.bsky.social · 30/03/2026
Compressing the collective knowledge of ESM into a single protein language model [new] ...that self-improves through co-distillation of confident predictions for variant effect prediction from sequence data.
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Jim Shaw @jimshaw.bsky.social · 27/03/2026
Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback. rdcu.be/famFj
rdcu.be
High-resolution metagenome assembly for modern long reads with myloasm
Nature Biotechnology - A long-read metagenome assembly method recovers circular and complete genomes better than existing tools.
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Cameron Thrash @jcamthrash.bsky.social · 24/03/2026
Contrasting population structures coexist in a strain-resolved estuarine microbiome www.biorxiv.org/content/10.6... #jcampubs 🌊
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Cameron Thrash @jcamthrash.bsky.social · 24/03/2026
Growth dynamics of 3,909 Escherichia coli single-gene knockouts in rich and minimal media www.nature.com/articles/s41... #jcampubs
nature.com
Growth dynamics of 3,909 Escherichia coli single-gene knockouts in rich and minimal media - Scientific Data
Scientific Data - Growth dynamics of 3,909 Escherichia coli single-gene knockouts in rich and minimal media
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Ben J Woodcroft @benjwoodcroft.bsky.social · 23/03/2026
New paper in mSystems! 🧵 - how much of your metagenome is actually bacterial/archaeal DNA? For many samples, nobody knows. We built SingleM prokaryotic_fraction (SPF) to answer this, then ran it on >100,000 public metagenomes. 🧬🖥️🦠 Here's what we found 👇 doi.org/10.1128/msystems.01062-25
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Tominaga K. (tomiken) @pacyc184.bsky.social · 14/03/2026
gplasCC: classification and recovery of plasmids from short-read sequencing data for any bacterial species | NAR Genomics and Bioinformatics | Oxford Academic academic.oup.com/nargab/article/8/1…
dx.doi.org
gplasCC: classification and recovery of plasmids from short-read sequencing data for any bacterial species
Abstract. Plasmids play a pivotal role in the spread of antibiotic resistance genes. Accurately reconstructing plasmids often requires long-read sequencing
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AI x Bio Discovery @aixbiobot.bsky.social · 11/03/2026
AF2BIND: predicting small-molecule binding sites using the pair representation of AlphaFold2 [new] Predicts protein small molecule binding site residues via AlphaFold2 pair features, uncovers 1000s new ligandable sites in the human proteome.
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AI x Bio Discovery @aixbiobot.bsky.social · 11/03/2026
Reaction-Conditioned Enzyme Discovery with Multimodal Deep Learning [new] Unifies reaction encoding w/ protein language models to enable zero-shot discovery of enzymes for previously unseen chemical reactions, moving beyond homology.
Reaction-Conditioned Enzyme Discovery with Multimodal Deep LearningFigure 1Figure 2Figure 3
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 11/03/2026
Bacterial proteome foundation model enhances functional prediction from enzymes to ecological interactions www.biorxiv.org/content/10.64898/20…
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