Cells preserve genome stability while occasionally generating genetic diversity through mutations and chromosomal rearrangements, but how these opposing outcomes are balanced remains unclear. Because ...

Investigator Scientist (Roving Researcher) (LMS 2369) Salary £42,159 – 44,801 plus London Allowance (£5,560) per annum | 2 years fixed term | Full time | Closing Date: 21 June

Mammalian cells can pass damaged pieces of their genome directly to neighboring cells via contact-dependent, nanotube-like connections. These transferred DNA fragments persist and function, revealing ...

The adult heart grows by the addition of sarcomeres along the length or width of individual cardiomyocytes, yet how directional growth is spatially coordinated remains unclear. We found that microtubu...

Cas12a2 enables RNA-triggered, sequence-specific killing of eukaryotic cells via widespread DNA shredding, allowing selective elimination of cells on the basis of gene expression, including virus-infe...

The role of lumen acidification during endosome maturation has been unclear. Here, the authors show that proton efflux via a Na+/H+ exchanger is detected by a pH-sensitive Rab GAP, which promotes endo...

Because all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational d...

Tang, Dai, Qing, Zhang and colleagues describe a role for N-glycosylation in the nucleus: N-glycans modify inner nuclear membrane proteins, and the modification is implicated in the maintenance of H3K...

The heart rarely develops cancer, and, at the same time, it lacks regenerative capacity, as cardiomyocytes stop proliferating after birth. This suggests that mechanisms limiting cardiac regeneration m...

During myogenesis, inner nuclear membrane buds export extremely long sarcomeric transcripts. UIF controls RNA cargo targeting into these buds, and ESCRT-III remodeling is required to internalize UIF a...

Phase 1/2 data from 2 separate studies have shown signals of improved survival and safety with the agent, supporting its evaluation in a phase 3 trial.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

CRISPR screening shows that claudin-4 is a receptor for the pro-carcinogenic B. fragilis toxin on colonic epithelial cells, and that this interaction promotes cleavage of E-cadherin, le...

Introducing correlative light and electron microscopic lipid imaging.See Lennartz et al. and the related N&Vs by Weigel

Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...

Marescal et al. show that quiescent cells disassemble their centromeres through the transcriptional downregulation of most centromere proteins while preser

A single base pair insertion in the Sox9 enhancer, Enh13, mediates XX female-to-male sex reversal. This subtle non-coding mutation reconfigures transcriptional regulation, enhances Sox9 expression, re...

Bixonimania doesn’t exist except in a clutch of obviously bogus academic papers. So why did AI chatbots warn people about this fictional illness?

Zhu et al. report an approach to reversibly control protein S-palmitoylation by fusing the depalmitoylase APT1 to target proteins. Using RAS proteins, they show that this approach enables the dynamic modulation of RAS palmitoylation and membrane localization by an APT1 inhibitor, and offers a platform for screening RAS palmitoyltransferase inhibitors.

Drugs that inhibit KRAS signaling delay the development of pancreatic cancer in mice

Zhang et al. use deep learning-based protein design to create isoform-specific Ras binders that selectively target the disordered C termini. These tools enable precise dissection of Ras isoform functions and uncover distinct Ras dependencies that emerge during RasG12C inhibitor resistance.

Lung cancer cells rely on protein homeostasis regulators, particularly the ubiquitin-proteasome system (UPS), to sustain malignancy. Genetic alterations in UPS components, such as E3 ubiquitin ligases...

Endomembrane damage of intracellular vesicles triggers signals that activate membrane repair in mammalian cells to restore homeostasis. However, the signals that drive diverse membrane repair recruitm...

Nature Communications - SLCO2A1 (also known as OATP2A1) is responsible for the transport of eicosanoids, including prostaglandins (PGs), as well as of a subset of nonsteroidal anti-inflammatory...

Prolonged mitosis results in the destruction of MDM2, initiating a p53-dependent G1 cell-cycle arrest in the absence of DNA damage. Here, we investigate how DNA damage earlier in the cell cycle affect...

A safety engineer feels abandoned by their principal investigator. How should they find support?

Wee1 phosphorylates and inhibits CDK activity to inhibit mitotic entry and establish a G2 DNA damage checkpoint. Consequently, Wee1 inhibitors are in clinical trials, developed to be synthetically let...

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

Fulcher et al. show that MDM2 times mitosis through self-catalysed ubiquitination and proteasomal destruction, triggering G1 arrest following delays in mitosis associated with chromosome instability and aneuploidy.

Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...

Dual cyclin A/B RxL inhibitors selectively kill small cell lung cancer cells and other cancer cells with high E2F activity.

Very excited to share our latest paper on the effect of DNA damage in the preceding G2 phase on the mitotic timer pathway! Cells that experience delays in mitosis, indicative of problems in aligning...

Cell cycle checkpoints preventing the replication and inheritance of damaged DNA are crucial for maintaining genome stability and stopping the growth of damaged cells. Canonical checkpoints do this by preventing passage between cell cycle phases until damage has been repaired, or by promoting cell cycle exit. Herein we review checkpoint integration between cell cycle phases, specifically findings showing that extended spindle assembly checkpoint surveillance in mitosis is a danger signal triggering G1 cell cycle arrest. Evidence linking mitotic delays induced by activation of the spindle assembly checkpoint with positive and negative regulators of the G1 DNA damage checkpoint target p53 is discussed, with a focus on time-dependent changes to a p53-binding deubiquitinating complex USP28–53BP1 and the p53 ubiquitin-ligase mouse double minute homologue 2 (MDM2), respectively.

Cell cycle checkpoints preventing the replication and inheritance of damaged DNA are crucial for maintaining genome stability and stopping the growth of damaged cells. Canonical checkpoints do this by...

imageimageProlonged delays in mitosis and G2 DNA-damage stress both lead to cell-cycle arrest in G1. This work shows how these pathways normally lead to G1 arrest by different routes, and how cancer-a...

Nature Cell Biology - Fulcher et al. show that MDM2 times mitosis through self-catalysed ubiquitination and proteasomal destruction, triggering G1 arrest following delays in mitosis associated with...