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Luc-Alban Vuillemenot

@lavuillemenot.bsky.social
45 followers 111 following 0 posts

Postdoc @ Alexis Barr Lab (@imperialcollegeldn.bsky.social, @mrc-lms.bsky.social). Cell cycle control, Systems Biology, Cancer, Aging, Metabolism, Computer vision.

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Reposted by Luc-Alban Vuillemenot
MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 30/07/2026
A new study maps where dormant cancer cells hide in breast tumours: tucked into neighbourhoods of immune + support cells that may shield them from treatment. Understanding these hideouts could lead to new drug targets🧬 @mrc-lms.bsky.social @imperialmed.bsky.social @ucl.ac.uk
lms.mrc.ac.uk
Scientists map dormant cancer cells' hideouts, opening new targets for treatment
Researchers at the MRC Laboratory of Medical Sciences (LMS), Imperial College London and UCL Genetics Institute have created a detailed map of cells within breast tumours and identified distinct neigh...
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Reposted by Luc-Alban Vuillemenot
Alexis Barr @alexisbarr.bsky.social · 03/12/2025
New lab preprint! We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook www.biorxiv.org/cgi/content/...
biorxiv.org
Wee1 opposes APC/C(Cdh1) activity to promote S-phase entry
Wee1 phosphorylates and inhibits CDK activity to inhibit mitotic entry and establish a G2 DNA damage checkpoint. Consequently, Wee1 inhibitors are in clinical trials, developed to be synthetically let...
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Reposted by Luc-Alban Vuillemenot
Alexis Barr @alexisbarr.bsky.social · 02/01/2025
New Year, new paper! (Ok, it actually came out just before Christmas but who was working then?!) Here we show that p21 promotes the survival of non-small cell lung cancer cells, under normal growth & after chemotherapy: rdcu.be/d4kvU
rdcu.be
Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer
British Journal of Cancer - Pro-survival roles for p21(Cip1/Waf1) in non-small cell lung cancer
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