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Tom Lau

@tomlau.bsky.social
305 followers 321 following 29 posts

Science, Drug Discovery, Public Infrastructure, Soccer Analytics & Miscellany. Boston via Dublin.

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Tom Lau @tomlau.bsky.social · 16/06/2026
Didn't think my chembio cup could get much fuller after the GRC Bioorganic chem last week but going to the pub event tonight too. Few tickets left www.eventbrite.com/e/chembio-in...
eventbrite.com
ChemBio in the PUB 2026
Chemical Biology in the PUB
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Tom Lau @tomlau.bsky.social · 19/11/2025
I love lamp
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Sarah Taber @sarahtaber.bsky.social · 18/11/2025
People had questions, like "Are there apples that taste & crunch like Honeycrisp? But without the existential rage about being alive?" Yep! Let's talk about them!
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Tom Lau @tomlau.bsky.social · 07/10/2025
Job alert! Looking for a mass spectrometry expert to come join our team. Please share and let me know if you have any personal recommendations. #teammassspec www.linkedin.com/jobs/view/43...
linkedin.com
Vertex Pharmaceuticals hiring Mass Spectrometry Sr. Research Scientist in Boston, MA | LinkedIn
Posted 12:01:53 AM. Job DescriptionGeneral Summary:We are seeking a Mass Spectrometrist to join the Chemical Biology…See this and similar jobs on LinkedIn.
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Tom Lau @tomlau.bsky.social · 20/05/2025
Chembio in the Pub! The tastier, chattier version of the popular Boston conference. Jun 12th is pretty close to the GRC too so whether you're a local or visiting it would be great to hang out www.eventbrite.com/e/chembio-in... #chembio #chemicalbiology #bostonbiotech
eventbrite.com
ChemBio in the PUB 2025
Chemical Biology in the PUB
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John Hatchard @johnhatchard.bsky.social · 26/03/2025
#NeilPostman #Trump #MAGA #Musk #ElonMusk #Project2025 #TheFourthReich #BadFaith #Fascism archive.is/6TBfY Still Amusing Ourselves Why does this 40-year-old book by a career academic still hit so hard? ⏬ Bluesky 'bite-sized' article thread (12 min) with added links 📖🍿🔊
slate.com
The One Book That Explains Our Current Era Was Written 40 Years Ago
NYT pundits and NBA coaches alike can't stop recommending this four-decade-old book.
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Samuel A. Myers' lab @samyers-lab.bsky.social · 06/02/2025
Truncated gRNA sequences to target Cas9 fusions to hundreds of sites with similar sequences: www.nature.com/articles/s41... This should address a question I commonly get for GLoPro (PMID: 29735997), about targeting TF binding sites throughout the genome, rather than a single locus. Cool work.
nature.com
Multi-locus CRISPRi targeting with a single truncated guide RNA - Nature Communications
A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Here the authors present a CRISPRi-based method using trun...
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Virtual ChemBioTalks @chembiotalks.bsky.social · 31/01/2025
Whom would you like to hear at our next event? The planning for the 5th Virtual ChemBioTalks is starting. We are excited for talks by @oconnorlab.bsky.social, @craigmcrews.bsky.social and Kelly Chibale. Let us know in reply to this post, whom you would additionally like to hear!
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Ingo Hartung @hartungingo.bsky.social · 25/11/2024
There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD). www.nature.com/articles/s41...
nature.com
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications
Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...
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Nature Chemical Biology @natchembio.nature.com · 09/01/2025
We asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?” You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw
rdcu.be
Thoughts for the future
Nature Chemical Biology - As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most...
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Possu Huang Lab @possuhuanglab.bsky.social · 17/12/2024
1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens TRACeR for MHC-I: go.nature.com/4gcLzn5 TRACeR for MHC-II: go.nature.com/4gj5OQk
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Sebastian S. Cocioba @atinygreencell.bsky.social · 11/12/2024
Come with me as I troubleshoot this very high GC PCR toward clonable homology arms in an actinobacteria. Testing DMSO, Betaine 1M, and Propylene Glycol to see if we get amplification. Arms are 1000bp. Full length with arms and gene is 2800bp. Let's go! 🧵 1/n
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Tom Lau @tomlau.bsky.social · 05/12/2024
Very neat system from Alice's team. I love the name too!
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Fyodor Urnov @urnov.bsky.social · 29/11/2024
Fellow Genetics professors - rejoice! This is pedagogy heaven: the paradigmatic epiallele in calico cats … is built on a cis-regulatory deletion, not a coding mutation! We can teach it all off 1 paper! 1. Woo 2. Hoooo!!! H/t @lianafaye.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Molecular and genetic characterization of sex-linked orange coat color in the domestic cat
The Sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X-inactivation in female tortoiseshell and calico cats. Unlike th...
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Tom Lau @tomlau.bsky.social · 24/11/2024
Delighted these fun explainers have made it to bluesky
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Ben Bellenie @chemb.bsky.social · 21/11/2024
Assume all small molecules are unselective for their protein target until proven otherwise. Even if the vendor tells you it’s a selective inhibitor for X, there’s a decent chance it isn’t selective! So how do we find quality molecules for scientific experiments? academic.oup.com/nar/advance-...
academic.oup.com
The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research
Abstract. The Chemical Probes Portal (www.chemicalprobes.org) is a free, public resource, based on expert-reviews, that supports the assessment, selection
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Steven Cheng @scheng23.bsky.social · 22/11/2024
Nice new large proteomics dataset on drug MoA applying proteome integral solubility alteration (PISA) from @dschweppe.bsky.social and Gygi lab #TeamMassSpec Article: doi.org/10.7554/eLif... Blog post by @dereklowe.bsky.social: www.science.org/content/blog...
doi.org
Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays
An approachable framework for the scalable implementation of proteome-wide thermal shift assays to assess drug mechanisms of action.
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Tom Lau @tomlau.bsky.social · 20/11/2024
Is ProteomicsDb dead? Even a single protein search just infinitely loads for me
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Tom Lau @tomlau.bsky.social · 18/11/2024
In a wonderful intersection of my science and local policy bluesky worlds, Somerville City Councilor @benforward3.bsky.social created a better split-Gal4 system
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Stephan Hacker @stephanhacker2.bsky.social · 15/11/2024
Interesting @biorxivpreprint.bsky.social preprint by a team around Jason Thomas and Andrea Byrnes of Novartis. They developed a photoaffinity probe based on the RNA-splicing modulator branaplam for the transcriptome-wide identification of RNA binding events in native cells. doi.org/10.1101/2024...
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Tom Lau @tomlau.bsky.social · 14/11/2024
Been a while since I checked this app and glad to see it's on the up again. Welcome new and old friends!
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Tom Lau @tomlau.bsky.social · 18/01/2024
Thinking about how a research lab could learn from the discipline, teamwork and efficiency from a commercial kitchen as I watch Syd from The Bear think about how you could learn similar from college basketball. Minus the shouting preferably
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Ben Neely @benneely.com · 08/11/2023
Then we talked about on-tip processing of sorted cells. Started with @proteomicsnews.bsky.social writing about EvoSep-based method. But fortunately @schejbaljlab.bsky.social was here to talk about his on-tip method too. 5/n
proteomicsnews.blogspot.com
ONE-TIP Preprint! Do your entire sample digestion protocol on your EvoTip!
You've probably seen talks that this was coming. Here it is! Wait. What month is it? I've been busy. Not the newest news, but still worth ta...
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Tom Lau @tomlau.bsky.social · 06/11/2023
For some reason bluesky is suggesting a ton of ornithology to me and I'm not mad at all. Significant improvement over the suggested posts on the other bird site.
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Mark Rubin @markrubin.bsky.social · 19/10/2023
🧪 Scientist? 🟦 New to BlueSky? 👀 Wanna find posts by other people in your area and use the right hashtags in your own posts? 📃 Here’s a list of around 160 science-related feeds and their hashtags. #AcademicSky #PhDSky
docs.google.com
BlueSky Science-Related Feeds
Sheet1 Likes,Name (Click to visit feed),Tags,Contact to ask to be added to contributor list 11,<a href="https://bsky.app/profile/did:plc:ftnzzw4cnon2pzpw7i5m2xu7/feed/aaaiqnkwsgsz6">#AI&HCI</a>,#HCI,...
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Tom Lau @tomlau.bsky.social · 24/10/2023
Instead of just trying to find the people I followed on Twitter here anyone got suggestions for scientists I should be following on blue sky?
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Tom Lau @tomlau.bsky.social · 21/10/2023
Hello world? Nice to see so many friends from "that other site" over here. Hopefully this will be a better alternative to that slow embering dumpster fire
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