Here, the authors show that chromatin modifiers are required for transcription factors to bind new enhancers, revealing that enhancer landscapes are built through cooperation rather than a strict step...

Kim, Geiger et al. report that early-life stress increases the chromatin modification H3K4me1 and its enzymatic writer, SETD7, in the ventral tegmental area. They show that this form of epigenetic pri...

The C-terminal domain (CTD) of RNA polymerase II acts as a regulatory platform during the transcription cycle. Here, the authors use a simple tail CTD and reveal how repeating sequence patterns and ch...

X‑linked dystonia‑parkinsonism involves disrupted transcription and mRNA processing. Here, the authors show that altering 3′ mRNA processing rescues the disease molecular signature, linking XDP pathol...

Thinking about a PhD in life sciences? Learn what to expect, get advice from experts, and find the right program in Austria or across Europe.

An MSK study reveals new details about how pancreatic cells carrying oncogenic mutations transition from benign to malignant — shining new light on the ecosystems that supports emerging tumors.

Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

Cellular responses to stimuli can involve learned behaviors through memory formation. Here, the authors show that cancer cells encode gene expression into cellular memories during therapy resistance v...

Multiple copies of intact MSR nucleate de novo heterochromatin and reveal that the establishment of mouse pericentric heterochromatin is associated with bidirectional repeat RNA, Integrator complex en...

The Mouse Cancer Cell line Atlas (MCCA) provides major advances towards a mechanistic understanding of cancer genomes.

To investigate organism-wide cellular alterations and epigenomic dynamics during aging, we constructed a single-cell chromatin accessibility atlas spanning 21 mouse tissues across three age groups and...

The memory of gene expression states, active or repressive, is a fundamental biological concept as it controls cell fate in development, immunity and abiotic stress responses. Such memory is maintaine...

A discovery in mice reveals why fasting enhances a type of breast cancer treatment — a hormone-signalling pathway and gene-expression changes have key roles.

Abstract. Post-translational modifications of histone tails constitute a key epigenetic mechanism controlling chromatin environment and gene transcription.

Scientific Reports - Contrasting roles of KMT2C and KMT2D in breast cancer

Tatarakis et al. study how H3K9me3 heterochromatin is formed and inherited in mammalian cells. Using a synthetic heterochromatin assembly system and genetic screens, they uncover requirements for init...

Taghbalout et al. apply collections of advanced multi-omics analyses to substantiate ecDNA’s mobile enhancer model in diverse types of cancer models, reveal the MED1-ecDNA condensates and establish their causal links to the modulation of oncogenic expression and cell proliferation. This study offers a chromatin-based mechanism of ecDNA function in cancer.

Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that is critical for their regenerative function. Treatment with exogenous PGE2 reverses age-related defects in muscle stem cells and imparts an epigenetic response that enhances their capacity for repair after injury and transplantation.

Defining viral proteomes is crucial to understanding viral life cycles and immune recognition but the landscape of translated regions remains unknown for most viruses. We have developed massively para...

Indigenous Orang Asli of Peninsular Malaysia raised concerns about the etiology, treatment, and transmission routes of the skin disorder tinea imbricata. Analyses of the associated Trichophyton concen...

Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell antitumor immunity and synergize with anti-PD-1, highlighting SSRIs as potential cancer immunotherapeutics.

Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.

We are delighted to invite you to to the second symposium, “Epigenetics of Early Mouse Development”, taking place on April 24, 2025, at the Max Planck Institute of Immunobiology and Epigenetics in Fre...

Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.

A study identifies public neoantigens generated by tumor-wide aberrant mRNA splicing activity across distinct cancer types.

The child, who is now almost three years old, shows no signs of the often fatal motor neuron disease.

Cancer cells display distinct, recurrent phenotypic cell states. Metastatic spreading correlates with tumor cell state evolution. However, the molecular mechanisms underlying metastasis remain elusive...

Join this info session to learn more about the open Call for Application from Daiichi Sankyo and BioMed X! Available position is Group Leader on "New Strategies for Proximity Induction between Novel T...

In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...

X-chromosome inactivation affects age-related decline in spatial memory.

Abstract. To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based o