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Tim Kendall

@timkendall.bsky.social
499 followers 1.8K following 51 posts

Liver pathologist in Edinburgh, looking for patterns on glass. Luton Town fan, hoping for beauty on grass. 🔬

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Reposted by Tim Kendall
Ed Zitron @edzitron.com · 23/01/2026
Premium: The AI Bubble is a time bomb, burdening hyperscalers with billions of new depreciation a quarter that will soon eat away profits, VCs with dead equity in fallen AI startups, and Oracle with hundreds of billions of unpayable leases. www.wheresyoured.at/premium-timebomb/
wheresyoured.at
Premium: The AI Bubble Is A Time Bomb
The Words of Ed Zitron, a PR person and writer.
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Joe Bak-Coleman @jbakcoleman.bsky.social · 30/12/2025
It's strange how rarely journalists covering this space can ask "Hey, but is it bullshit?". CEO's whose companies are over-leveraged, bubbly, and unprofitable promise a major breakthrough that will justify their fragile position and no one seems to *consider* they may be lying. It's Theranos 2.0.
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Ed Zitron @edzitron.com · 12/11/2025
Exclusive: Based on documents viewed by this newsletter, OpenAI spent over $12.4 billion on inference from 2024 to September 2025. As part of its Microsoft revenue share, it sent $493.8m in 2024/$865.8m Jan-Sep 2025, implying lower revenues than previously reported. www.wheresyoured.at/oai_docs/
wheresyoured.at
Exclusive: Here's How Much OpenAI Spends On Inference and Its Revenue Share With Microsoft
As with my Anthropic exclusive from a few weeks ago, though this feels like a natural premium piece, I decided it was better to publish on my free one so that you could all enjoy it. If you liked or f...
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Mark A. Hanson @hansonmark.bsky.social · 11/11/2025
We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing: a 🧵 1/n Drain: arxiv.org/abs/2511.04820 Strain: direct.mit.edu/qss/article/... Oligopoly: direct.mit.edu/qss/article/...
A table showing profit margins of major publishers. A snippet of text related to this table is below.

1. The four-fold drain
1.1 Money
Currently, academic publishing is dominated by profit-oriented, multinational companies for
whom scientific knowledge is a commodity to be sold back to the academic community who
created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis,
which collectively generated over US$7.1 billion in revenue from journal publishing in 2024
alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit
margins have always been over 30% in the last five years, and for the largest publisher
(Elsevier) always over 37%.
Against many comparators, across many sectors, scientific publishing is one of the most
consistently profitable industries (Table S1). These financial arrangements make a substantial
difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor &
Francis revenues were generated in North America, meaning that North American
researchers were charged over US$2.27 billion by just two for-profit publishers. The
Canadian research councils and the US National Science Foundation were allocated US$9.3
billion in that year.A figure detailing the drain on researcher time.

1. The four-fold drain

1.2 Time
The number of papers published each year is growing faster than the scientific workforce,
with the number of papers per researcher almost doubling between 1996 and 2022 (Figure
1A). This reflects the fact that publishers’ commercial desire to publish (sell) more material
has aligned well with the competitive prestige culture in which publications help secure jobs,
grants, promotions, and awards. To the extent that this growth is driven by a pressure for
profit, rather than scholarly imperatives, it distorts the way researchers spend their time.
The publishing system depends on unpaid reviewer labour, estimated to be over 130 million
unpaid hours annually in 2020 alone (9). Researchers have complained about the demands of
peer-review for decades, but the scale of the problem is now worse, with editors reporting
widespread difficulties recruiting reviewers. The growth in publications involves not only the
authors’ time, but that of academic editors and reviewers who are dealing with so many
review demands.
Even more seriously, the imperative to produce ever more articles reshapes the nature of
scientific inquiry. Evidence across multiple fields shows that more papers result in
‘ossification’, not new ideas (10). It may seem paradoxical that more papers can slow
progress until one considers how it affects researchers’ time. While rewards remain tied to
volume, prestige, and impact of publications, researchers will be nudged away from riskier,
local, interdisciplinary, and long-term work. The result is a treadmill of constant activity with
limited progress whereas core scholarly practices – such as reading, reflecting and engaging
with others’ contributions – is de-prioritized. What looks like productivity often masks
intellectual exhaustion built on a demoralizing, narrowing scientific vision.A table of profit margins across industries. The section of text related to this table is below:

1. The four-fold drain
1.1 Money
Currently, academic publishing is dominated by profit-oriented, multinational companies for
whom scientific knowledge is a commodity to be sold back to the academic community who
created it. The dominant four are Elsevier, Springer Nature, Wiley and Taylor & Francis,
which collectively generated over US$7.1 billion in revenue from journal publishing in 2024
alone, and over US$12 billion in profits between 2019 and 2024 (Table 1A). Their profit
margins have always been over 30% in the last five years, and for the largest publisher
(Elsevier) always over 37%.
Against many comparators, across many sectors, scientific publishing is one of the most
consistently profitable industries (Table S1). These financial arrangements make a substantial
difference to science budgets. In 2024, 46% of Elsevier revenues and 53% of Taylor &
Francis revenues were generated in North America, meaning that North American
researchers were charged over US$2.27 billion by just two for-profit publishers. The
Canadian research councils and the US National Science Foundation were allocated US$9.3
billion in that year.The costs of inaction are plain: wasted public funds, lost researcher time, compromised
scientific integrity and eroded public trust. Today, the system rewards commercial publishers
first, and science second. Without bold action from the funders we risk continuing to pour
resources into a system that prioritizes profit over the advancement of scientific knowledge.
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Tomer Ullman @tomerullman.bsky.social · 03/11/2025
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
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David Henig @davidheniguk.bsky.social · 25/10/2025
Yay. Priceless. The right column at the right time. And a gleefully English two fingers to the haters.
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Patrick McCray @patrickmccray.bsky.social · 17/09/2024
If you're having a rough day, remember that in 1991 Tim Berners-Lee's paper for the World Wide Web was rejected and he was relegated to the poster session.
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Hannibal TaBOO! | writer/VO actor (he/him/his) @hannibaltabu.bsky.social · 11/10/2025
I saw the dot coms crash from a front row seat. AI is running out of money way faster. The evangelism is insecurity from people who made the wrong bet. I’ve seen it before. futurism.com/future-socie...
futurism.com
AI Data Centers Are an Even Bigger Disaster Than Previously Thought
An investment manager realized he made a crucial mistake — and that his grim prediction about AI investments may not have been cynical enough.
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Dr van Tilburg @drvantilburg.bsky.social · 02/10/2025
The Trump administration has stopped funding of PubMed, not considering a vital service. Your doctor will not know the newest information that affects your health. This will cost lives.
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Andrea Murillo @andreamurillo.bsky.social · 05/10/2025
"Science communication isn't about dumbing it down, it's about meeting people where they are with curiosity, care and clarity." Great read in Development, and I will definitely try some of these challenges to practice science communication. doi.org/10.1242/dev....
doi.org
Speaking science in a fractured world: making truth land when facts alone cannot
ABSTRACT. Scientific misinformation is a defining challenge of our time. As public trust in science declines and falsehoods spread faster than facts, the scientific community must rethink its role in ...
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Jay Van Bavel, PhD @jayvanbavel.bsky.social · 25/09/2025
Reminder: It's always good to stay humble!
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Neil Lewis, Jr. @neillewisjr.bsky.social · 27/12/2024
I've shared this quote before but I'll share it again, as it's one I've been thinking about a lot as I've watched how our oligarchs have been behaving over the past few months.
At a party given by a billionaire on Shelter Island, Kurt Vonnegut informs his pal, Joseph Heller, that their host, a hedge fund manager, had made more money in a single day than Heller had earned from his wildly popular novel Catch-22 over its whole history. Heller responds, “Yes, but I have something he will never have … enough.” Enough. I was stunned by the simple eloquence of that word—stunned for two reasons: first, because I have been given so much in my own life and, second, because Joseph Heller couldn’t have been more accurate. For a critical element of our society, including many of the wealthiest and most powerful among us, there seems to be no limit today on what enough entails.
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Tim Kendall @timkendall.bsky.social · 20/09/2025
League One football always offers surprises. Not Luton playing badly and losing away at Lincoln this afternoon. That's expected. But direct-to-consumer marketing of asbestos is not something I've seen before.
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Olivia Guest · Ολίβια Γκεστ @olivia.science · 06/09/2025
Finally! 🤩 Our position piece: Against the Uncritical Adoption of 'AI' Technologies in Academia: doi.org/10.5281/zeno... We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical thinking, expertise, academic freedom, & scientific integrity. 1/n
Abstract: Under the banner of progress, products have been uncritically adopted or
even imposed on users — in past centuries with tobacco and combustion engines, and in
the 21st with social media. For these collective blunders, we now regret our involvement or
apathy as scientists, and society struggles to put the genie back in the bottle. Currently, we
are similarly entangled with artificial intelligence (AI) technology. For example, software updates are rolled out seamlessly and non-consensually, Microsoft Office is bundled with chatbots, and we, our students, and our employers have had no say, as it is not
considered a valid position to reject AI technologies in our teaching and research. This
is why in June 2025, we co-authored an Open Letter calling on our employers to reverse
and rethink their stance on uncritically adopting AI technologies. In this position piece,
we expound on why universities must take their role seriously toa) counter the technology
industry’s marketing, hype, and harm; and to b) safeguard higher education, critical
thinking, expertise, academic freedom, and scientific integrity. We include pointers to
relevant work to further inform our colleagues.Figure 1. A cartoon set theoretic view on various terms (see Table 1) used when discussing the superset AI
(black outline, hatched background): LLMs are in orange; ANNs are in magenta; generative models are
in blue; and finally, chatbots are in green. Where these intersect, the colours reflect that, e.g. generative adversarial network (GAN) and Boltzmann machine (BM) models are in the purple subset because they are
both generative and ANNs. In the case of proprietary closed source models, e.g. OpenAI’s ChatGPT and
Apple’s Siri, we cannot verify their implementation and so academics can only make educated guesses (cf.
Dingemanse 2025). Undefined terms used above: BERT (Devlin et al. 2019); AlexNet (Krizhevsky et al.
2017); A.L.I.C.E. (Wallace 2009); ELIZA (Weizenbaum 1966); Jabberwacky (Twist 2003); linear discriminant analysis (LDA); quadratic discriminant analysis (QDA).Table 1. Below some of the typical terminological disarray is untangled. Importantly, none of these terms
are orthogonal nor do they exclusively pick out the types of products we may wish to critique or proscribe.Protecting the Ecosystem of Human Knowledge: Five Principles
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Tim Kendall @timkendall.bsky.social · 25/08/2025
www.theregister.com/2025/08/25/o...
theregister.com
The air is hissing out of the overinflated AI balloon
Opinion: Are tech giants getting nervous? They should be
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Alexander Luckmann @aluckmann.bsky.social · 20/08/2025
Academia may not give you job security, flexibility, or wealth, but it will let you unexpectedly connect to eduroam in foreign cities
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Carol Atack @carolatack.bsky.social · 16/08/2025
This is both funny and acute…might assign it to my incoming students as an introductory exercise…
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Dr. Sabrina Mittermeier @smittermeier.bsky.social · 09/07/2025
I did this before in German but I guess today is a good day to compile English resources on why AI isn‘t actually intelligent and also a real danger: 🧵
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Albert Vilella, PhD. @albertvilella.bsky.social · 21/06/2025
@andywatson on the NGS Sequencing market and the prisoner's dilemma
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Tim Kendall @timkendall.bsky.social · 12/06/2025
It was good to make the case for the molecular testing we need to help patients with cholangiocarcinoma in Scotland to @jennimintomsp.bsky.social and the Scottish Government. Hopefully this will stimulate a solution. Thanks to @benmacpherson.bsky.social for hosting.
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Ben Ansell @benansell.bsky.social · 17/05/2025
As Jon says this is absolutely fascinating and a stark warning to science journalists that if a result looks too good to be true it probably is.
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Ed Zitron @edzitron.com · 28/04/2025
Newsletter: I am sick and god damn tired of everybody pretending that generative AI is the next big thing. The media is complicit in accepting fantastical nonsense - both in the numbers put out by OpenAI and the silly jobs created by Anthropic - and it has to stop. www.wheresyoured.at/reality-check/
wheresyoured.at
Reality Check
I'm sick and god-damn tired of this! I have written tens of thousands of words about this and still, to this day, people are babbling about the "AI revolution" as the sky rains blood and crevices open...
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Matthias C. Rillig @mrillig.bsky.social · 25/04/2025
Interesting opinion in Science suggesting to replace 'scientific consensus' with convergent evidence. Because it is less easily derailed by quoting one dissenting opinion. Seems like a good idea! www.science.org/doi/10.1126/...
science.org
Convergence and consensus
In these days of political instability, geopolitical tensions, and social discontent around the world, there are continued threats to the principles, conduct, and findings of science. This assault on ...
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Janelle Shane @janelleshane.com · 13/04/2025
1. LLM-generated code tries to run code from online software packages. Which is normal but 2. The packages don’t exist. Which would normally cause an error but 3. Nefarious people have made malware under the package names that LLMs make up most often. So 4. Now the LLM code points to malware.
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Masud Husain @masudhusain.bsky.social · 06/03/2025
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness academic.oup.com/brain/articl...
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Tim Kendall @timkendall.bsky.social · 02/03/2025
If LiverTox has gone, my reporting of ?DILI will be far less nuanced.
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Dorian Lynskey @dorianlynskey.bsky.social · 26/02/2025
Love the energy of young Shostakovich. He looks like a Harry Potter who will fuck you up
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Annie Waldman @anniewaldman.bsky.social · 22/02/2025
Amy Paris was hired to help modernize the nation's donor organ network, which ensures critically-ill people get the organs they need. She was also let go. "We had alignment from Democrats and Republicans on the Hill, we had funding, and they were hiring more of us.”
For more than a decade, Amy Paris worked for federal agencies as a problem solver: retooling overly bureaucratic and cumbersome processes to make them easier for the public to navigate.

Last year, she was hired to help reform the nation’s organ procurement and transplantation network, a public-private partnership that connects organ donors to patients in vital need of a transplant.

The program had recently come under fire. As thousands of patients were dying on waitlists, some donor organs weren’t even being used. Multiple kidneys had to be thrown out because of transport delays — couriers not picking them up in time or airlines misplacing them. One was accidentally left on an airport luggage trolley.
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Andy Williams @llantwit.bsky.social · 21/02/2025
Two Weeks In The Death Spiral Of Cardiff University, by an anonymous academic. This is truly shocking read. The Cardiff executive board should hang their heads in shame. voice.cymru/two-weeks-in...
voice.cymru
Two Weeks In The Death Spiral Of Cardiff University -
Reading Time: 4 minutesBy an anonymous academic. Cover image by Adwitiya Pal On the second day of classes…
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Stephen Curry @scurry.bsky.social · 15/02/2025
More than 500 signatures added in the past 24 hrs. Please keep signing and sharing.
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Tim Kendall @timkendall.bsky.social · 05/02/2025
The new AMMF campaign to raise awareness of cholangiocarcinoma is fantastic and has already been picked up widely by the Scottish and UK media. The pictures of the wonderful stars are amazing (ammf.org.uk/faces-of-cho...) and everyone should watch the behind the scenes video, too! #CCAAwarenessMonth
ammf.org.uk
The Faces of Cholangiocarcinoma 2025 - AMMF
AMMF was delighted to work with the celebrity photographer, Rankin, and eight people who have been diagnosed with cholangiocarcinoma, to produce a stunning portfolio of images, “The Faces of Cholangio...
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NEJM AI @ai.nejm.org · 01/02/2025
The authors of an editorial recommend clearer guidelines and ethical standards for the use of #AI in research, to enhance research quality while preserving human oversight and integrating “data-chaining” transparency mechanisms more broadly. nejm.ai/4a6LwHo #MedSky #ScienceSky
“Rather than crafting new theories, AI’s true potential may lie in its ability to reproduce and verify scientific findings from raw data, bridging the reproducibility gap that challenges modern research.”

Editorial
“The Promise and Perils of Autonomous AI in Science” by Junyi Gao, M.S., and Ewen M. Harrison, FMedSci.
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Open Culture @openculture.bsky.social · 21/01/2025
Discover the CIA’s Simple Sabotage Field Manual: A Timeless Guide to Subverting Any Organization with “Purposeful Stupidity” (1944)
openculture.com
Discover the CIA’s Simple Sabotage Field Manual: A Timeless Guide to Subverting Any Organization with “Purposeful Stupidity” (1944)
I’ve always admired people who can successfully navigate what I refer to as “Kafka’s Castle,” a term of dread for the many government and corporate agencies that have an inordinate amount of power ove...
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Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 23/01/2025
📚🧪 A recent human #omics + in vitro study revealed important findings in Metabolic-Associated Steatotic Liver Disease (MASLD) research. By Andrew S. Perry, Niran Hadad, Emeli Chatterjee, et al. In @cellpress.bsky.social: www.cell.com/cell-reports...
cell.com
A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver
Perry et al. use a translational approach across phenotypes, outcomes, circulating proteomics, and tissue transcriptomics to identify functional biomarkers of hepatic steatosis. These markers are asso...
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Ben Williamson @benpatrickwill.bsky.social · 11/01/2025
"I would like universities to commit to matching every dollar they spend on AI with a dollar spent asking critical questions about AI."
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Ed Zitron @edzitron.com · 06/01/2025
I was told point blank multiple times in the last year that I was "missing something" about OpenAI and was "dead wrong" but not one of these people could say why. Not a single person has an argument as to how OpenAI will become a real business. They're all pie in the sky
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Arjun Raj @arjunraj.bsky.social · 05/01/2025
💯. Most aspects of the system subtly (or not-so-subtly) push you back in your lane, making interdisciplinary work very hard.
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Ian Dunt @iandunt.bsky.social · 04/01/2025
The comments under this week's newsletter, particularly from people who changed their career in their 40s, are extremely lovely. In short: it's not too late. You can still do it iandunt.substack.com/p/happy-new-...
iandunt.substack.com
Happy New Year: Now sort your fucking life out
It'll keep on pissing itself away until you set goals.
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Raphael Viscarra Rossel @ravr19.bsky.social · 26/12/2024
Good piece by @natureportfolio.bsky.social. The erosion of thinking time—driven by admin, bureaucracy, industry agendas, and unrealistic output targets—stifles curiosity-led science. These pressures undermine innovation and the intellectual freedom vital for real progress. 🧪🌱🌍 #ScienceIsNotBusiness
Scientists need more time to think
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Earl K. Miller @earlkmiller.bsky.social · 19/12/2024
The Dimensions of dimensionality www.cell.com/trends/cogni... #neuroscience
cell.com
The Dimensions of dimensionality
Cognitive scientists often infer multidimensional representations from data. Whether the data involve text, neuroimaging, neural networks, or human judgments, researchers frequently infer and analyze latent representational spaces (i.e., embeddings). However, the properties of a latent representation (e.g., prediction performance, interpretability, compactness) depend on the inference procedure, which can vary widely across endeavors. For example, dimensions are not always globally interpretable and the dimensionality of different embeddings may not be readily comparable. Moreover, the dichotomy between multidimensional spaces and purportedly richer representational formats, such as graph representations, is misleading. We review what the different notions of dimension in cognitive science imply for how these latent representations should be used and interpreted.
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Tim Kendall @timkendall.bsky.social · 20/12/2024
This is a most wonderful story to warm the coldest of hearts. Demons (probably goblins, too), AI, and memories can't be trusted but librarians definitely can.
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Kit de Waal @kitdewaal.com · 14/12/2024
Have a hobby, not a side hustle and other great pearls of wisdom. Words to Live By Number 157
irishtimes.com
Patrick Freyne: I am becoming a demotivational speaker – let’s all have an averagely productive December
I keep meeting people who are extremely burned out. I meet them so often that I’m beginning to think burnout is something that exists by design
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Miriam Posner @miriamposner.com · 06/12/2024
Maybe one of the reasons there are so many unhinged academics is that in order to keep your job, you’re constantly required to tout yourself as a Scholar of World-Historical Significance, even as your office’s ceiling tiles slowly dislodge themselves to fall on your head.
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Tim Kendall @timkendall.bsky.social · 05/12/2024
The Mesopotamians saw the liver as the source of happiness within the body. I've always thought they were wise! #LiverSky www.cell.com/iscience/ful...
cell.com
Embodied emotions in ancient Neo-Assyrian texts revealed by bodily mapping of emotional semantics
Neuroscience; Linguistics; History
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Tim Kendall @timkendall.bsky.social · 04/12/2024
This paper is important. It provides a really strong case for working as hard as possible to include samples from those centres that serve the traditionally underrepresented patient groups in research. If we want treatments to work on everyone, we need to ensure research includes everyone.
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Megan Ranney MD MPH @meganranney.bsky.social · 01/12/2024
A friend sent this article to me today. It feels like a good moment to remind us: the LLM outperformed physicians on STRUCTURED cases. Someday the AIs may perform better than us in the unstructured, messy, real-world patient encounter...but that day is not today.🩺🛟 jamanetwork.com/journals/jam...
jamanetwork.com
Large Language Model Influence on Diagnostic Reasoning
This randomized clinical trial evaluates the diagnostic performance of physicians with use of a large language model compared with conventional resources.
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Thorn-Seshold Lab @thornsesholdlab.bsky.social · 22/11/2024
Wishing the Elsevier editors who desk-accepted this all the best for their next career moves. doi.org/10.1016/j.ij...
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Tim Kendall @timkendall.bsky.social · 23/11/2024
Could you add me too, please? Liver pathologist.
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Maarten van Smeden @maartenvsmeden.bsky.social · 23/11/2024
Academic publishing really is a billion dollar business largely based on public money
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