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Jun Allard

@allardlab.bsky.social
21 followers 24 following 11 posts

Allard Lab at UC Irvine

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Jun Allard @allardlab.bsky.social · 19/05/2026
Out now in Biophysical Journal! @biophysj.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Impact of N-terminal dimerization on formin homology 1 domain polymer dynamics and actin assembly
Many proteins contain intrinsically disordered regions (IDRs) that lack stable three-dimensional structure. IDR behavior is poorly understood, leading…
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Jun Allard @allardlab.bsky.social · 19/04/2026
Brady's work is published this week in Biophysical Journal! Mathematical link between cell mechanics and percolation theory www.cell.com/biophysj/ful...
cell.com
Astral architecture can enhance mechanical strength of cytoskeletal networks by modulating percolation thresholds
A repeated pattern in cytoskeletal architecture is the aster, in which a number of F-actin filaments emerge star shaped from a central node. Aster-based structures occur in cytoplasmic actin, the earl...
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Jun Allard @allardlab.bsky.social · 21/01/2026
Review article with Omer Dushek @tcell.bsky.social on tethered signaling proteins, out now! Tethered bio-molecular reactions can do at least 7 cool things that freely-diffusing reactions do not. Read more here! #IDR #TCells #cytoskeleton www.annualreviews.org/content/jour...
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Jun Allard @allardlab.bsky.social · 03/12/2025
Katie Bogue's new preprint with Margot Quinlan and Bryan Christian, out now! www.biorxiv.org/content/10.1...
biorxiv.org
Impact of N-terminal dimerization on formin homology 1 domain polymer dynamics and actin assembly
Many proteins contain intrinsically disordered regions (IDRs) that lack stable 3-dimensional structure. IDR behavior is poorly understood, leading to challenges for biochemical and computational analy...
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Jun Allard @allardlab.bsky.social · 02/12/2025
Very excited to be involved in this new work led by Junhao Gu and Elizabeth Read, out this week in Bioinformatics. Collaboration with Timothy Downing, Chris Miles and others! academic.oup.com/bioinformati...
academic.oup.com
Scalable inference and identifiability of kinetic parameters for transcriptional bursting from single cell data
AbstractMotivation. Stochastic gene expression and cell-to-cell heterogeneity have attracted increased interest in recent years, enabled by advances in sin
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Jun Allard @allardlab.bsky.social · 08/09/2025
We can make the flexibility of a model match the hypothesis being tested -- more flexibility is not always better, if it prohibits rejection of the hypothesis. Here is one simple case involving T cells where it made a difference! www.biorxiv.org/content/10.1...
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Jun Allard @allardlab.bsky.social · 08/09/2025
Brady Berg's new work is out on biorxiv! Shows a surprising connection between astral architecture and percolation in the cytoskeleton. www.biorxiv.org/content/10.1...
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Jun Allard @allardlab.bsky.social · 08/09/2025
Our paper, lead by Jack Corrette, with Timothy Downing and Andrew Spakowitz is out in Nucleic Acids Research! academic.oup.com/nar/article/...
academic.oup.com
Nucleosome placement and polymer mechanics explain genomic contacts on 100 kb scales
Abstract. The 3D organization of the genome—in particular, which two regions of DNA are in contact with each other—plays a role in regulating gene expressi
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