iiinova — where your digital self keeps evolving

Reposted by Justin Eyquem

Gladstone Institutes @gladstoneinst.bsky.social · 13/04/2026

Scientists have found a way to create cancer killing CAR-T cells inside the body. This eliminates the costly, time-consuming manufacturing process that has kept these therapies out of reach of cancer patients around the world. @j-eyquem.bsky.social

youtube.com

Scientists Find a Better Way to Make CAR-T Cells

YouTube video by UC San Francisco (UCSF)

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Reposted by Justin Eyquem

Gladstone Institutes @gladstoneinst.bsky.social · 31/03/2026

A new study—led by Justin Eyquem from The Gladstone-UCSF Institute of Genomic Immunology —uses a dual-vector system to engineer cancer-fighting T cells in vivo, potentially simplifying and expanding access to these life-saving therapies. @j-eyquem.bsky.social

bit.ly

Dual-Vector System Generates CAR T Cells In Vivo

The researchers say that, to their knowledge, this is the first demonstration of programmable, site-specific integration of a large DNA payload into T cells in vivo.

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Reposted by Justin Eyquem

UCSF Helen Diller Family Comprehensive Cancer Center @ucsfcancer.bsky.social · 24/03/2026

“I think this is just the beginning of a big wave of new therapies that will be truly transformational and save a lot of lives” Justin Eyquem, PhD @j-eyquem.bsky.social @ucsanfrancisco.bsky.social on recent @nature.com pub with breakthrough research on CAR T therapy www.ucsf.edu/news/2026/03...

ucsf.edu

Scientists Create Cancer-Fighting Immune Cells Right in the Body

UCSF scientists found a precise way to turn on cancer-fighting immune cells inside the body. This more potent form of CAR-T has the potential to treat many more cancers.

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Justin Eyquem @j-eyquem.bsky.social · 04/11/2025

Genomic medicine has transformed lives through ex vivo cell therapies, now it’s time to make it scalable. Today we unveil Azalea Therapeutics, making in vivo genomic medicine a reality without compromising precision or specificity, starting with T cells!

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Justin Eyquem @j-eyquem.bsky.social · 21/10/2025

Exciting collaboration combining multiplex epigenetic reprogramming and site-specific payload integration!

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Justin Eyquem @j-eyquem.bsky.social · 25/07/2025

The Weill Cancer Hub is fostering groundbreaking @ucsanfrancisco.bsky.social - @stanford-cancer.bsky.social collaborations to develop transformative cancer therapies. I’m grateful to co-lead one of the selected teams with @mfgrp.bsky.social to advance next-generation in vivo CAR T cell therapy!

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Justin Eyquem @j-eyquem.bsky.social · 05/02/2025

Excited to share our latest work, now out in @NatureBiotech ! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇 www.nature.com/articles/s41...

nature.com

SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci - Nature Biotechnology

Primary T cells with multiple genetic modifications are rapidly isolated by negative selection.

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Reposted by Justin Eyquem

Rod Rahimi @rodrahimi.bsky.social · 15/11/2024

Wonderful to see the #immunology community growing here. The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added go.bsky.app/PY5tCas go.bsky.app/FmERUoD

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