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Malcolm Sim

@mjwsim.bsky.social
532 followers 388 following 24 posts

Immunologist and group leader at University of Oxford. www.immonc.ox.ac.uk/team/malcolm-si…

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Malcolm Sim @mjwsim.bsky.social · 10/01/2026
Congrats to 2nd year PhD student Emery for her brilliant write up of this important preprint on Neoantigen vaccination www.nature.com/articles/s41...
nature.com
Client Challenge
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Centre for Immuno-Oncology @oxcio.bsky.social · 12/12/2025
🎓 Best of luck to Max Quastel, who’s defending his DPhil thesis today! He’ll be giving a pre-viva talk open to everyone, come along and cheer him on. Break a leg, Max! ✨ #CIODphil
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Centre for Immuno-Oncology @oxcio.bsky.social · 15/12/2025
Our #CIO DPhil student Lisha Jeena is about to give her pre-viva talk on the effects of HIV-associated inflammation on musculoskeletal health🦴. Come support Lisha in the NDMRB seminar room! Best of luck, Lisha 🍀 you’ve got this! 💪🎓
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Tumour-Immune Cell Dynamics Lab @witherslab.bsky.social · 03/12/2025
We’re happy to be in Liverpool for this years @britsocimm.bsky.social congress: In today’s “What’s hot in cancer immunology?” session, Prof David Withers presented our new data on an orthotopic colorectal cancer model for the first time! 🐭💪
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Centre for Immuno-Oncology @oxcio.bsky.social · 02/12/2025
CIO is at @britsocimm.bsky.social BSI congress in Liverpool. Look out for presentations, posters and session chairs from CIO members @witherslab.bsky.social @galvez-cancino.bsky.social @timmunologist.bsky.social @mjwsim.bsky.social
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Malcolm Sim @mjwsim.bsky.social · 02/12/2025
The Sim lab is at BSI Congress with two posters @britsocimm.bsky.social Come see what we’ve been up to! Numbers 400 and 403.
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Centre for Immuno-Oncology @oxcio.bsky.social · 26/11/2025
Tomorrow we welcome Jonathon Worboys from the University of Manchester to our CIO seminar series. Jon is a Wellcome research fellow and will give a talk titled ‘The nanoscale governance of TIGIT signalling and blockade’
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Malcolm Sim @mjwsim.bsky.social · 31/10/2025
More details on the Oxford KIR Workshop 2026 sites.google.com/view/oxfordkir… I even made a logo
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Centre for Immuno-Oncology @oxcio.bsky.social · 23/10/2025
Welcome DPhil class of 2025! Great to have you in CIO.
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Malcolm Sim @mjwsim.bsky.social · 23/10/2025
UK NK 2026 in Cardiff. January 9th. Be there. eventbrite.co.uk/e/uk-nk-confer… Hosted by Rich Stanton, Ceri Fielding & Eddie Wang
eventbrite.co.uk
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Malcolm Sim @mjwsim.bsky.social · 22/10/2025
Delighted to be hosting the Oxford KIR Workshop 2026 April next year. Please register here and contact me regarding accommodation. www.oxforduniversitystores.co.uk/conferences-...
oxforduniversitystores.co.uk
Oxford KIR Workshop 2026 | University of Oxford
An international gathering of scientists studying the killer-cell immunoglobulin-like receptors (KIR). It will cover topics such  evolution, immunogen
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Malcolm Sim @mjwsim.bsky.social · 16/10/2025
Any labs in Europe / US using Loderan products? Never heard of them but could save my lab a pretty penny www.lorderan.com/en-gb/produc...
t.co
https://www.lorderan.com/en-gb/products/benchtop-80l-incubated-refrigerated-shaker
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The Journal of Immunology @jimmunol.bsky.social · 06/10/2025
Congratulations to new Nobel Laureate and AAI Distinguished Fellow Shimon Sakaguchi, co-winner of the 2025 Nobel Prize in Physiology or Medicine for his foundational discoveries on regulatory T cells and peripheral immune tolerance! Published in The JI in 1995: ow.ly/LGk150X7984.
academic.oup.com
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
Abstract. Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor α-chain (CD2
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Centre for Immuno-Oncology @oxcio.bsky.social · 03/10/2025
Today we welcome Associate Prof. Amir Horowitz from the Tish Cancer Institute at Mt Sinai to the CIO Seminar Series. Amir will present work from his group with the title 'Targeting HLA-E and NKG2A in solid tumors to overcome resistance to cancer immunotherapies'
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Malcolm Sim @mjwsim.bsky.social · 01/10/2025
We're hiring! Come join our lab in Oxford as a research assistant and study peptide recognition of MHC molecules - please reach our for more details! www.jobs.ac.uk/job/DOW691/r...
jobs.ac.uk
Research Assistant at University of Oxford
An opportunity for an academic position as a Research Assistant is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.
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Centre for Immuno-Oncology @oxcio.bsky.social · 09/07/2025
🎨 After lunch we had some team-building fun with a sciency embossing workshop 🧑‍🎨 so many creative scientists in the room! Huge thanks to Asma for teaching us a new skill!! #CIOawayday #embossing
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Centre for Immuno-Oncology @oxcio.bsky.social · 09/07/2025
🧪 We continued with an engaging afternoon poster session featuring more of our talented PhD students 🐣 Fantastic science, thoughtful questions, and great discussions all around. The future is bright! #CIOawayday
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Centre for Immuno-Oncology @oxcio.bsky.social · 09/07/2025
🐣 We followed with our Junior PIs telling us about their questions for the next 5 years 💡 Lots of exciting, cutting-edge new ideas that will hopefully materialise soon and bring even more new questions to #CIO 🤓 🥳 #CIOawayday @galvez-cancino.bsky.social @mjwsim.bsky.social
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Centre for Immuno-Oncology @oxcio.bsky.social · 09/07/2025
🌟 Fantastic morning poster session from our DPhil students 📚🧫 so much talent and fresh thinking on display! More to come this afternoon. #CIOawayday
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Centre for Immuno-Oncology @oxcio.bsky.social · 09/07/2025
✨ Kicking off #CIOawayday with our senior PIs sharing the experiments that changed their careers 🧑‍🔬👩‍🔬🧫 A reminder that serendipity, curiosity, and pub chats can spark groundbreaking ideas 🤓 Clearly science thrives on kindness and collaboration and we got a lot of that in #CIO 😉🙃 #ScienceLife
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bioRxiv Immunology @biorxiv-immuno.bsky.social · 25/06/2025
Atom-level mechanism of tapasin-independent peptide editing by Major Histocompatibility Complex class I molecules www.biorxiv.org/content/10.1101/202…
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Chris Thorpe @drchristhorpe.bsky.social · 26/06/2025
Fascinating preprint from @timmunologist.bsky.social @mjwsim.bsky.social and co-authors
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Centre for Immuno-Oncology @oxcio.bsky.social · 20/06/2025
Feeling proud and looking sharp! Repping the Centre for Immuno-Oncology in style 😎 🔥Our top models, @anthonyhsieh.bsky.social and @mjwsim.bsky.social, rocking the CIO polos, in black and navy, which seems to be the unofficial Friday uniform around here! Team spirit (and outfits) on point 💛🖤💙
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Centre for Immuno-Oncology @oxcio.bsky.social · 19/06/2025
Lucy, FHS student at @mjwsim.bsky.social’s lab, has outdone herself! Not only is this the prettiest cake we’ve seen 😍, but it’s also seriously delicious 🤤🍰 #LabLife #BakingScience
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Oxford Cancer @oxfordcancer.bsky.social · 13/06/2025
And we're off!! @timmunologist.bsky.social opens our third annual OCION Symposium ‪@oxfordmathematics.bsky.social today! Don't forget to visit our sponsors posters/exhibition stands. @imtadvances.bsky.social (STAND) @nanoporetech.com (STAND) @Immunocore (POSTER) @10xgenomics.bsky.social (STAND)
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Malcolm Sim @mjwsim.bsky.social · 11/06/2025
NK2026 in Italy!
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Malcolm Sim @mjwsim.bsky.social · 08/06/2025
Jet lagged and ready to rock #NK2025 in Tasmania
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Malcolm Sim @mjwsim.bsky.social · 21/05/2025
It’s Wednesday morning. There’s no more new Andor and I’m just supposed to carry on with my life.
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Malcolm Sim @mjwsim.bsky.social · 20/05/2025
chng.it/ZYvmHTMZnJ
chng.it
Sign the Petition
#StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK
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Roychoudhuri Lab @roychoudhurilab.bsky.social · 20/05/2025
Please sign this urgent petition to Parliament: #StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK chng.it/tsH8ZSJfRH via @ukchange.bsky.social
chng.it
Sign the Petition
#StopIsraelNow: Urgent Call for Economic Sanctions and Arms Embargo on Israel by the UK
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Eileen Parkes @eileenparkes.bsky.social · 20/05/2025
Delighted to share our review, published in Matrix Biology, led by Subashan Vadibeler, Shannique Clarke & Su Phyu - understanding matrix biology in oesophagogastric cancer is essential to improve therapeutic options, we highlight existing knowledge & gaps here - www.sciencedirect.com/science/arti...
sciencedirect.com
Interactions between cancer-associated fibroblasts and the extracellular matrix in oesophageal cancer
Stromal components of the tumour microenvironment, such as cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM), are actively invol…
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Malcolm Sim @mjwsim.bsky.social · 16/05/2025
Why axes labels are so important. More supervision = more risk. Maybe this is what my students think when I’m in lab? -As part of (another) health & safety training-
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Eileen Parkes @eileenparkes.bsky.social · 12/05/2025
Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...
Model figure - in EAC cancers, as chromosomal instability (CIN) increases, we found that a CIN-driven cGAS-dependent axis drives myeloid directed chemokine expression and recruitment of tumor-favoring myeloid populations
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DGFI Young Immunologists @dgfi-yi.bsky.social · 10/05/2025
🎯 Wanna know how NK cells recognise viruses? Sign-up for this month's @dgfi-yi.bsky.social virtual seminar as we host @quirinhammer.bsky.social, who'll enlighten us on the molecular mechanisms underlying recognition of virus-infected cells by NK cells. Registration👇🏼 docs.google.com/forms/d/e/1F...
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Malcolm Sim @mjwsim.bsky.social · 09/05/2025
Delighted to be hosting the next KIR workshop in Oxford next year. Please save these dates if you're interested. More details to follow.
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Eileen Parkes @eileenparkes.bsky.social · 17/04/2025
This year I'll be running 10k, 10 miles and a half marathon to raise awareness (with a just giving page too) for the ME Association - #millionsmissing can't run so I'll do it for them
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Malcolm Sim @mjwsim.bsky.social · 18/04/2025
Delighted that this review is now accepted and online. We review evidence from us and others that germline-encoded receptors of the innate immune system can detect peptides presented by MHC molecules, some with high peptide-specificity. t.co/9EKH2SpGEy
t.co
https://academic.oup.com/ooim/advance-article/doi/10.1093/oxfimm/iqaf003/8115587
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Malcolm Sim @mjwsim.bsky.social · 26/03/2025
academic.oup.com/jimmunol/adv...
academic.oup.com
Peptide selectivity of killer cell immunoglobulin-like receptors differs with allotypic variation in HLA class I
Abstract. Natural killer (NK) cell activation is regulated by killer cell immunoglobulin-like receptors (KIRs) that recognize human leukocyte antigen (HLA)
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Centre for Immuno-Oncology @oxcio.bsky.social · 24/03/2025
🔬CIO is at #BSIOxford today! 🎯 Beinig Li gave a fantastic talk this morning on peptide-specificity of KIR during the Innate Immunity session. 🤓You still have the chance to check out all the CIO insightful posters—lots of cutting-edge science on display! #Immunology #BSI2025 @britsocimm.bsky.social
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Oxford Immunology Network @immunologyoxford.bsky.social · 24/03/2025
....and thanks to Beining Li for a brilliant talk on the peptide specificity of KIR with yeast display of HLA-C #OIS25 @oxcio.bsky.social
Beining Li giving a talk
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Society for Natural Immunity @sni-nkmeeting.bsky.social · 12/03/2025
🌟 Early Bird Extension 🌟 We’ve extended the Early Bird registration for NK2025! This is your chance to lock in your spot at a discounted rate! 📅 Don't miss out – Register by Friday 28 March 2025! ! #EarlyBirdExtension #NK2025
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Malcolm Sim @mjwsim.bsky.social · 27/01/2025
The Trp Flip! Great paper from Brian, Chris & co
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Malcolm Sim @mjwsim.bsky.social · 11/01/2025
Had the best time hosting @malmberglab.bsky.social this week. Two great talks, two great tennis sessions and not enough margaritas.
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Matt Higgins @parasitematt.bsky.social · 07/01/2025
A really fun day out at the UK NK cell meeting. Thanks to @mjwsim.bsky.social for organising a great day and for inviting @sam-chamberlain.bsky.social to talk about his work on how RIFINs bind to the KIR immune receptors to modulate NK function in malaria.
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Malmberg Lab @malmberglab.bsky.social · 10/01/2025
Heading back home after a full week at the University of Oxford, hosted by brilliant @mjwsim.bsky.social. Very inspired by all the amazing science in the UK NK community and at the Center for Immuno-Oncology.
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Malcolm Sim @mjwsim.bsky.social · 13/12/2024
Eric O'Neill and I are excited to welcome over 120 NK cell enthusiasts to the UK NK meeting, to be held in Oxford in January. Details can be found here sites.google.com/view/uknk202...
sites.google.com
Event
One day meeting of NK cell immunologists 3 sessions NK cells and cancer NK cells and pathogens NK cells in tissues
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Malcolm Sim @mjwsim.bsky.social · 12/12/2024
Sim lab 2024.
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Paul Norman @pn0rmski.bsky.social · 27/11/2024
Found @labwaggoner.bsky.social --Now things are looking up!
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Eileen Parkes @eileenparkes.bsky.social · 25/11/2024
Happy to promote our recent preprint watch piece led by Matthew Jackson - intriguing story on PD1 biology #preprintClub www.nature.com/articles/s41...
nature.com
Redefining PD1 as a guardian of stem-like T cells - Nature Reviews Immunology
A preprint by Hor et al. shows that PD1 signalling regulates the maintenance of a high-affinity, stem-like T cell subset in tumour-draining lymph nodes.
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Paul Norman @pn0rmski.bsky.social · 22/11/2024
Here Malcolm Sim and Eric Long discuss peptide sensitivity of the HLA/KIR interaction. For anyone interested in this evolving subject (i.e. immune mediated disease), this review explains the difficult concepts really nicely and introduces a couple of models. #immunology www.cell.com/trends/immun...
cell.com
The peptide selectivity model: Interpreting NK cell KIR-HLA-I binding interactions and their associations to human diseases
Combinations of the highly polymorphic KIR and HLA-I genes are associated with numerous human diseases. Interpreting these associations requires a molecular understanding of the multiple killer-cell i...
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