A ketogenic diet promotes tumour growth in the small intestine in susceptible mice. In people, diet advice might need to be tailored to individual cancer risks.

The use of antivirals has transformed viral infection management and reduced mortality. However, the effect of antivirals on the commensal virome, a crucial player in microbiome homeostasis and mammal...

The use of antivirals has transformed viral infection management and reduced mortality. However, the effect of antivirals on the commensal virome, a crucial player in microbiome homeostasis and mammal...

Wen et al. identify two gut mucosal virome enterotypes that influence intestinal inflammation susceptibility. They reveal that a bacteriophage alters sphingosine production in B. thetaiotaomicron and ...

Read this exciting story from Scientific American November 2025 issue. Your digestive tract is crawling with viruses— and that's a good thing

Nature Metabolism, Published online: 26 March 2026; doi:10.1038/s42255-026-01489-wThe authors provide an interactive resource of folate one-carbon metabolism in 37 tissues in germ-free and conventional mice.

Clostridium perfringens lacking perfringolysin O toxin isolated from preterm infants metabolizes human milk oligosaccharide disialyllacto-N-tetraose to produce metabolites that promote the growth of commensal bifidobacteria, inhibit pathogens and suppress inflammation in an organoid model.

Wen et al. identify two gut mucosal virome enterotypes that influence intestinal inflammation susceptibility. They reveal that a bacteriophage alters sphingosine production in B. thetaiotaomicron and ...

Multi-omics profiling of the mucosal mycobiome in individuals with Crohn’s disease identifies C. sphaerospermum as a protective fungal species that counteracts intestinal inflammation and reinforces t...

It's disappointing, but try to not take it personally.

Nature Reviews Gastroenterology & Hepatology, Published online: 02 January 2026; doi:10.1038/s41575-025-01164-7Glycans are essential components of the gut mucosa that modulate epithelial barrier integrity, host–microbiota interactions and gut immune response. This Review discusses the role of mucosal glycans in gut homeostasis, in intestinal inflammation and their therapeutic potential for inflammatory bowel disease.

A tiny population of cells that are passed across the placenta between mother and baby challenge basic tenets of human immunology.

Transposable elements can insert into genes, disrupting protein-coding potential. Researchers discover a mode of RNA processing, ‘SOS splicing’, that provides a quick fix.

The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.

Engineered T cells that have been used to treat ulcerative colitis, rheumatoid arthritis and lupus show promising results.

Nature Reviews Gastroenterology & Hepatology, Published online: 03 November 2025; doi:10.1038/s41575-025-01140-1The gut microbiome presents in a multi-kingdom form and tunes host health in various ways. Studies published in 2025 have further pushed this frontier by unveiling the enigmatic roles of the gut fungi and bacteria in cross-organ regulations of host homeostasis through metabolite and immune cell-mediated pathways.

Insects colonized with Metarhizium fungi emit longifolene to lure new hosts for infection to disperse spores. A fungal strain was engineered to emit longifolene to attract and eliminate mosquitoes.

Combining fossil-based and molecular calibrations with data on horizontal gene transfer events, the authors develop a time-calibrated phylogeny of Fungi. This timescale, which integrates analytic uncertainties, suggests an older age of crown Fungi (1,401–896 million years ago), as well as a minimum age for ancient interactions involving fungi and the algal ancestors of embryophytes in terrestrial ecosystems (1,253–797 Ma).

Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.

Molecular Psychiatry - Glucagon-like Peptide-1 receptor agonists as emerging therapeutics in bipolar disorder: a narrative review of preclinical and clinical evidence

Genetic-sequencing techniques have uncovered the oldest host-associated microbial DNA ever recorded — inside samples of teeth and bones from woolly and steppe mammoths.

Now that the US has stopped funding Gavi, the vaccine alliance will likely become more dependent on philanthropy than ever before.

Nature Reviews Gastroenterology & Hepatology, Published online: 11 June 2025; doi:10.1038/s41575-025-01090-8Post-antibiotics microbiome restoration driven by diet

Nature - Geographic and age variations in mutational processes in colorectal cancer

Background The gut microbiome and diet are important factors in the pathogenesis and management of Crohn’s disease (CD). However, the role of the gut phageome under dietary influences is unknown. Obj...

Nature Reviews Gastroenterology & Hepatology, Published online: 17 February 2025; doi:10.1038/s41575-025-01038-yBiological sex has a vital role in the pathogenesis of inflammatory bowel disease (IBD). This Review examines sex in IBD pathophysiology and…