Clostridium perfringens lacking perfringolysin O toxin isolated from preterm infants metabolizes human milk oligosaccharide disialyllacto-N-tetraose to produce metabolites that promote the growth of c...

This postdoctoral research position is part of a Cystic Fibrosis Canada Early Career Investigator Award funded for 3-years led by Dr. Fabrice Jean-Pierre and Dr. Fiona Whelan. The aim of this project is to identify the genetic changes that arise in the Pseudomonas aeruginosa genome following perturbations – such as antibiotic treatment – in an in vitro system. The PDRA will use a large dataset of P. aeruginosa genomes and experimental metadata to predict key mutationsto the organism.

Clostridium perfringens lacking perfringolysin O toxin isolated from preterm infants metabolizes human milk oligosaccharide disialyllacto-N-tetraose to produce metabolites that promote the growth of commensal bifidobacteria, inhibit pathogens and suppress inflammation in an organoid model.

Microbial-based and microorganism-targeting therapies are emerging to prevent or treat preterm infant complications, but more preclinical research and clinical evidence is needed.

A leading young scientist is the first at Newcastle University to win an esteemed Blavatnik award.

Applied Microbiology International member Dr Christopher Stewart of Newcastle University has been named as a finalist for the eighth Blavatnik Awards for Young Scientists in the UK. He is the 2023 win...

YouTube video by CanadaGairdnerAwards

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This exciting BBSRC-funded project aims to mechanistically characterise the fitness costs associated with vancomycin resistance in the Gram-positive opportunistic pathogens Enterococcus faecalis and E...

PhD Project - MRC DiMeN Doctoral Training Partnership: Unravelling how human milk bioactive components modulate the infant gut microbiome at Newcastle University, listed on FindAPhD.com

Pediatric Research - Impact of probiotics on gut microbiome of extremely preterm or extremely low birthweight infants

Masi et al. show that mother’s own milk bacterial composition and load are not altered in preterm infants diagnosed with necrotizing enterocolitis. Milk microbiome, human milk oligosaccharide, and pre...