Sign in

STY

@syip.bsky.social
56 followers 147 following 51 posts

UBC/MGH, 2/3 NSx, glass+genomics. VGH NP & Director of Clinical Genomics at BC Cancer. No to AK47 #Neuropathology #Molecularpathology #Genomics #AIpathology

PostsRepliesMedia
Reposted by STY
Kai Kupferschmidt @kakape.bsky.social · 13/08/2026
“The investigation suggests the group embraced a dubious approach to identifying protective mutations, improperly changed patient data to tease provocative findings from Christchurch carriers, and published multiple papers containing suspect or copied images.” More trouble in Alzheimer research…🧪
science.org
Science investigation casts doubt on genes hailed for warding off Alzheimer’s disease
Mutations found in Colombian families raised hopes for treatments. Altered patient data and suspect images call their benefits into question
29133
Reposted by STY
The New York Times @nytimes.com · 07/07/2026
From @theathleticfc.bsky.social: Belgium knocked out the Americans in the World Cup round of 16, leaving no co-hosts left in the tournament.
nyti.ms
USA eliminated from World Cup after timid defeat by Belgium: Live updates
The USA’s World Cup dream is over after it was thoroughly outplayed by Belgium.
7718316
Reposted by STY
Larry the Cat @number10cat.bsky.social · 06/07/2026
HIGH ALTI-JUDE! 🏴󠁧󠁢󠁥󠁮󠁧󠁿
1699375
Reposted by STY
Financial Times @financialtimes.com · 24/06/2026
Experts know less than they like to think ft.trib.al/vz9vLfp | opinion
ft.trib.al
Experts know less than they like to think
In a world of untested treatments, disputed policies and untried inventions, it can’t be hard to remember why evidence is so important
10155
Reposted by STY
Doudna Lab @doudna-lab.bsky.social · 09/06/2026
We now present our latest work, now out in @nature.com! A creative new CRISPR-based approach can selectively destroy cells carrying undruggable mutations in cancer. Work led by @jingkunzeng.bsky.social In collaboration with Alan Ashworth, Yang Liu and Ryan Jackson. www.nature.com/articles/s41...
nature.com
Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding - Nature
Nature - Targeting Cancer-Specific Mutations with RNA-Triggered Chromatin Shredding
05914
Reposted by STY
Oded Rechavi @odedrechavi.bsky.social · 02/06/2026
PhD committee trying to help a struggling student
711514
Reposted by STY
David Ho @davidho.bsky.social · 25/04/2026
No one could have predicted that electing a convicted criminal to be President of the United States would lead to so much chaos.
1339750
Reposted by STY
Eric Topol @erictopol.bsky.social · 25/04/2026
You will be surprised about the extent and impact of our acquired DNA mutations for health & disease. Including 3 new publications this past week. This is a Ground Truths not to miss. erictopol.substack.com/p/we-are-all...
erictopol.substack.com
We Are All Genetic Mosaics
Roxanne Khamsi's phenomenal book BEYOND INHERITANCE on the critical impact of our acquired, somatic mutations for health and disease
315633
Reposted by STY
Mark Jacob @markjacob.bsky.social · 01/04/2026
It’s actually possible to write headlines that don’t obscure who did what. Thanks, AP.
Trump criticizes European allies for not helping fix the damage his war against Iran has caused
6174381679
STY @syip.bsky.social · 11/03/2026
Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2026/03/10/h...
nytimes.com
Cancer Haunts Neighbors of Canada’s Oil Sands Wastelands
010
STY @syip.bsky.social · 06/03/2026
Can a wealthy family change the course of a deadly brain disease? | Science | AAAS www.science.org/content/arti...
science.org
Can a wealthy family change the course of a deadly brain disease?
Inspired by the loss of their mother, they have poured millions into studying a key protein behind frontotemporal dementia. But all has not gone according to plan
000
Reposted by STY
Financial Times @financialtimes.com · 03/03/2026
Howard Lutnick and top Goldman lawyer to testify to Congress over Epstein links ft.trib.al/vyf18mN
ft.trib.al
Howard Lutnick and top Goldman lawyer to testify to Congress over Epstein links
US commerce secretary will be first Trump cabinet member to face questions from House panel about late child sex offender
37617
Reposted by STY
Darth Putin @darthputinkgb.bsky.social · 30/01/2026
Fomenting separatist movements in your neighbors is another play Donald is stealing from Prez.
435975
Reposted by STY
Financial Times @financialtimes.com · 05/01/2026
Good morning, Asia. While you were sleeping, this editorial about Donald Trump’s reckless intervention in Venezuela was one of our most-read articles. ft.trib.al/FLxoMI8
65713
Reposted by STY
Darth Putin @darthputinkgb.bsky.social · 04/01/2026
Comparison of tweets from comrade @jeremycorbyn.bsky.social on Ukraine & Venezuela. -Russia "enters", USA makes "illegal attack" -Russia actions excused cos of NATO. USA accused of wanting oil -Russia created a "crisis" & offered diplomacy. USA "should be condemned by everyone"
21698161
Reposted by STY
Matt Zoller Seitz @mattzollerseitz.bsky.social · 27/12/2025
This is a metaphor for the tech industry overall circa 2025
2538201205
Reposted by STY
Mark D. Levine @marklevinenyc.bsky.social · 23/12/2025
Year 1 data on congestion pricing in Manhattan… * Vehicle traffic: -11% * Foot traffic: +3.4% * Storefront vacancy: -0.9% * Pollution: -22% * Revenue for mass transit: $548M So YES this has been a huge success.
9187812341
Reposted by STY
Rob DenBleyker @robdenbleyker.com · 20/12/2025
why did they redact this
272993488
Reposted by STY
Darth Putin @darthputinkgb.bsky.social · 16/12/2025
This morning. Again.
381440230
Reposted by STY
Hong Kong Free Press HKFP @hongkongfp.com · 28/11/2025
A grassroots relief effort has sprung to life across Tai Po, and online, as Hongkongers rally to volunteer, offer food, shelter and clothing to the victims of the Tai Po fire tragedy. In full: buff.ly/nzDkM3C
buff.ly
Hong Kong fire: How thousands mobilised to support victims
A grassroots relief effort has sprung to life across Tai Po, and online, as Hongkongers rally to volunteer, offer food, shelter and clothing to the victims of the Tai Po fire tragedy.
01414
Reposted by STY
Darth Putin @darthputinkgb.bsky.social · 20/11/2025
How many more kids must I accidentally murder before you realise it's deliberate?
121110276
Reposted by STY
Eric Topol @erictopol.bsky.social · 10/11/2025
No clear evidence to support any link between maternal acetaminophen (Tylenol) intake and autism or ADHD in offspring, a new umbrella, systematic review @bmj.com
10467164
Reposted by STY
Hong Kong Free Press HKFP @hongkongfp.com · 08/11/2025
Legislative election hopeful Vivian Kong sees a rocky start to her political career as public sentiment towards the ex-Olympic champion changed drastically. Meanwhile, broadcaster TVB may face legal action from Japanese chain Sushiro. In full: buff.ly/s2wSm85
buff.ly
Backlash of 'smiling fencing queen' Vivian Kong, TVB's sushi row
Legislative election hopeful Vivian Kong sees a rocky start to her political career as public sentiment towards the ex-Olympic champion changed drastically. Meanwhile, broadcaster TVB may face legal action...
012
Reposted by STY
Larry the Cat @number10cat.bsky.social · 30/10/2025
The pariah formerly known as Prince
632042282
Reposted by STY
Jonathan Howard @joho.bsky.social · 03/10/2025
The sequel to We Want Them Infected is done! COVID killed 1.2 million Americans while vaccines saved millions. Yet, disinformation superspreaders were empowered, where they are taking a wrecking ball to science & medicine. How did that happen?🧵 sciencebasedmedicine.org/everyone-els...
sciencebasedmedicine.org
Everyone Else is Lying to You: My Book is Done!
The pandemic’s biggest disinformation superspreaders are now in charge. How did this happen?
15763295
Reposted by STY
International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 03/09/2025
#ICOM & some of our members just published an article investigating the prevalence & prognostic association of #TERT expression in #meningiomas, with implications for diagnosis & treatment: bit.ly/4g8L0LZ @gelarehzadeh.bsky.social @justinzwang.bsky.social @felixehretmd.bsky.social @syip.bsky.social
011
Reposted by STY
American Physiological Society @apsphysiology.bsky.social · 20/08/2025
Science is at the breaking point. With funding up in the air, labs are freezing hires and canceling plans. Innovation can’t wait. Read more in #TPhysMag: ow.ly/MZaL50WBucw @darachadwick.bsky.social 🧪
Image of a glass beaker breaking
154
STY @syip.bsky.social · 01/07/2025
www.nytimes.com/2025/06/30/w...
nytimes.com
What Makes Someone Cool? A New Study Offers Clues.
010
Reposted by STY
Bruce Stallsmith @laimosemion.bsky.social · 27/06/2025
I think everyone needs this reminder. 🧪
434843
Reposted by STY
EANO @eanoassociation.bsky.social · 13/06/2025
🧠 A recent article on glioblastoma-instructed astrocytes suppressing tumour-specific T cell immunity is now available in @nature.com. 📖 Full article: www.nature.com/articles/s41... #EANOessentials #NeuroOncology #Glioma #ImmunoOncology
nature.com
Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity - Nature
A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve o...
0103
Reposted by STY
Denis Wirtz @deniswirtz.bsky.social · 07/06/2025
InterpolaAI, based on deep learning-based optical flow, restores and interpolates sparse image stacks. This first example is a stack of histological images of a human pancreatic duct. 6 out of 7 images were missing or defective, all now generated. Download here: www.nature.com/articles/s41...
0233
Reposted by STY
Eric Topol @erictopol.bsky.social · 31/05/2025
"Gold standard science"
1834282
STY @syip.bsky.social · 24/05/2025
010
STY @syip.bsky.social · 20/05/2025
omicsomics.blogspot.com/2025/05/cliv...
omicsomics.blogspot.com
Clive Brown At ONT: A Belated Retrospective
on Calling is imminent, and this is a notable one: the first held without Clive Brown in an official capacity at Oxford Nanopore. I started ...
000
Reposted by STY
Avantika Gupta @avantikagupta.bsky.social · 16/05/2025
So excited to share our latest work with @saratchandarlapaty.bsky.social, Antonio Marra, Andrea Gazzo @mskcancercenter.bsky.social out today in @natgenet.nature.com! We uncover the function and mechanism of APOBEC3-driven therapy resistance in breast cancer. 🧵 1/ www.nature.com/articles/s41...
nature.com
APOBEC3 mutagenesis drives therapy resistance in breast cancer - Nature Genetics
Analysis of a large cohort of metastatic breast cancer samples shows that APOBEC mutational signatures are enriched in post-treatment samples. APOBEC activity was also associated with mutations known ...
164
Reposted by STY
Deacon Blues @kaibutsu.bsky.social · 13/05/2025
Earth, Wind & Friar
321428153
STY @syip.bsky.social · 03/05/2025
on.ft.com/4jD3Ag2
on.ft.com
Wanted: a mean liberal
Mark Carney shows how to be moderate in substance and populist in style
010
Reposted by STY
Nature Portfolio @natureportfolio.nature.com · 03/05/2025
A study in Scientific Reports shows that the dog-human relationship exhibits characteristics of both child and best friend relationships, combining the positive aspects of the parent-child bond with the minimal negative interactions of close friendships. go.nature.com/4cJtdcs 🧪
Two dogs peek over a barrier. Stock image.
09920
Reposted by STY
NEJM.org @nejm.org · 27/04/2025
Both clonal hematopoiesis of indeterminate potential (CHIP) and cancer are more common with age. When they coexist in the same patient, CHIP cells may migrate to the tumor and have an adverse effect on overall survival. Full study results: nej.md/3EnzMVu #MedSky #Hematology
A schematic representation of clonal hematopoiesis of indeterminate potential (CHIP) and tumor-infiltrating clonal hematopoiesis (TI-CH) in a patient with lung cancer.
1239
Reposted by STY
Kevin M. Kruse @kevinmkruse.bsky.social · 25/04/2025
Oh my God, this really is Hegseth.
421308117
Reposted by STY
Eric Topol @erictopol.bsky.social · 23/04/2025
New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....
nejm.org
Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM
Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...
314134
Reposted by STY
Oded Rechavi @odedrechavi.bsky.social · 19/04/2025
When you scan the email from the editor and spot the words "accepted in principle"
1935
Reposted by STY
International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 18/04/2025
This new report by several ICOM authors in JAMA Oncology highlights the importance of a role for #CytogeneticProfiling in the next iteration of #CNS WHO grading. Read the full report now: bit.ly/3EmWNb2 @gelarehzadeh.bsky.social @justinzwang.bsky.social
042
STY @syip.bsky.social · 10/04/2025
110
STY @syip.bsky.social · 08/04/2025
010
Reposted by STY
Darth Putin @darthputinkgb.bsky.social · 07/04/2025
It is becoming apparent to me that having a moron achieve my goal of wrecking US economy will have unwanted side effects for Russia too..
402342373
Reposted by STY
Fritz Sedlazeck @sedlazeck.bsky.social · 03/04/2025
Long reads such as @nanoporetech.com or @pacbio.bsky.social can provide insights into epigenetic. We @yileifu.bsky.social & @timp0.bsky.social )summarize the latest #Bioinformatics approaches & why this matters! Out now @natrevgenet.bsky.social at: bit.ly/4cjxUtl @bcmhouston.bsky.social @jhu.edu
04216
STY @syip.bsky.social · 29/03/2025
000
Reposted by STY
Eric Topol @erictopol.bsky.social · 27/03/2025
DOGE
1126260
Reposted by STY
David Ho @davidho.bsky.social · 25/03/2025
The NatSec group chat shitshow illustrates why DEI is necessary. Otherwise, completely unqualified people will be hired just because they're white dudes.
411760404