Felix Ehret, David R Raleigh; All roads lead to ROAM: A look at the results of the ROAM/EORTC-1308 clinical trial, Neuro-Oncology, , noag234, https://doi.o

A subset of breast cancer patients will eventually develop leptomeningeal disease (LMD). There is a lack of large, in-depth analyses of the pattern of care and outcomes, with a particular focus on rad...

tives. The aim of this study was to compare the prognostic performance of SG vs MRI-based EOR paradigms for predicting recurrence and survival across histomolecular subgroups. METHODS: International multicenter, retrospective cohort study included 475 meningiomas, resected between 1983 and 2024, which were classified by World Health Organization grade and molecular subgroups (DNA methylation, gene expression, and integrated grade). Area under the curve (AUC) was calculated for LFFR and overall survival (OS) from Cox models with a histomolecular subgroup and an EOR paradigm. Delta AUC (ΔAUC) compared EOR predictive performance within each subgroup, and log-rank comparisons of LFFR and OS were performed. RESULTS: MRI-defined gross total resection was associated with significantly longer LFFR and OS when compared with subtotal resection across most histomolecular subgroups. SG1-3 vs 4 distinguished differences in LFFR across several subgroups, but there were no consistent differences in outcomes when comparing degrees of dural treatment. Multivariable Cox including gene expression groups revealed that volumetric EOR (%) had a significantly higher AUC than SG (ΔAUC 0.07, P = .036) for 5-year OS; otherwise, there were no other differences between MRI-based or SG EOR paradigms for 5-year LFFR or OS. Additional significant differences for predicting 10-year LFFR all favored MRI-based EOR paradigms. CONCLUSION: Although SG and MRI-based EOR paradigms provide similar prognostic performance for predicting LFFR and OS in the era of molecular classification, MRI-based definitions may be preferred for future clinical trial inclusion criteria....

Abstract. Background: Outcomes for grade 2 and 3 meningiomas are poor. A few studies suggest a benefit from radiation therapy dose escalation. This trial evaluates the safety and efficacy of dose esca...

Meningiomas are the most common primary brain tumors in adults. Surgery and radiation therapy are the main treatment options and often achieve initial tumor control. However, tumor progression and loc...

Oligometastatic cancer is characterised by a low volume of metastases to a small number of anatomical sites. However, evaluating the impact of metastases-directed therapies (MDTs) on overall survival ...

Brain arteriovenous malformations (AVMs) are high-risk vascular anomalies associated with hemorrhage, neurological morbidity, and mortality. Stereotactic radiosurgery (SRS) is a well-established, non-...

Background Since the inception of spinal radiosurgery decades ago, the factors influencing spinal cord recovery have remained unclear. Elucidating these factors would aid in reirradiation planning a.....

Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most common malignancy worldwide, with an estimated 900,000 new cases diagnosed annually.1 While the majority of treatment failures occ...

Radiation therapy has a central role in the treatment of various malignant central nervous system tumors, including gliomas, high-grade meningiomas, a…

Grade 2 meningiomas often recur after surgery and radiation therapy. However, large, in-depth failure analyses are lacking, limiting the potential to refine radiation therapy. We report a pattern of f...

The proposed RANO classification for extent of resection could serve as a tool for prognostic stratification. Although associations between survival and extensive surgery are evident sooner in patient...

Radiotherapy (RT) remains a cornerstone in the management of primary brain tumours. However, recurrences within previously irradiated volumes present a complex clinical challenge. In the absence of an...

AbstractBackground. DNA methylation profiling can be used to robustly predict postsurgical outcomes and response to radiotherapy (RT) for meningioma patien

Brain radionecrosis (RN) is a significant late toxicity of radiation therapy, yet its progression remains challenging to predict due to patient-specific factors. This study develops a mechanistic mode...

The indolent behaviour of certain TERTp-mutant meningiomas suggests that TERTp mutation is not sufficient to assign the most aggressive meningioma grade. Instead, TERT sequencing might offer prognosti...

Adrenal metastases are frequently diagnosed in patients with common solid tumors. Surgical adrenalectomy has historically been used for their management. However, stereotactic body radiotherapy (SBRT)...

group. METHODS: We included patients who underwent BM resection and had postoperative MRI <72 hours. Presence of any residual on MRI was defined as subtotal resection (STR) as opposed to gross tota...

Stereotactic radiosurgery (SRS) is an established treatment modality for a variety of benign and malignant central nervous system (CNS) lesions in adults [1,2]. However, data for its use in the pediat...

Vestibular schwannomas (VS), also known under the historical misnomer “acoustic neuroma”, are benign nerve sheath tumors that develop from the Schwann cells of the vestibular branch of the vestibuloco...

Background Leptomeningeal disease (LMD) is a fatal complication of cancer linked to poor survival rates and limited treatment options. While photon involved-field radiotherapy is the standard of care ...

This cohort study examines chromosomal copy number alterations that could be used to improve the current World Health Organization grading of meningioma

Radiotherapy (RT) is a central pillar of a multimodal cancer treatment approach. The ongoing advances in the fields of RT, imaging technologies, cancer biology, and others yield the potential to refin...

Vestibular schwannomas (VS) are the most common benign intracranial nerve sheath tumors. Surgery and radiotherapy – particularly stereotactic radiosurgery (SRS) – are the primary treatment options. SR...

The value of stereotactic body radiotherapy (SBRT) in patients with oligometastatic head-and-neck squamous cell carcinoma (HNSCC) remains unclear, as existing evidence is primarily derived from retros...