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Kim et al. uncover a role for U1 snRNP in regulating internal promoter activity. Beyond its canonical role in splicing, U1 snRNP suppresses premature polyadenylation, enabling upstream transcription t...

mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...

Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

A microbe from the Dead Sea switches to a tissue-like form when compressed

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Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Current HHMI Employees, click here to apply via your Workday account. The Howard Hughes Medical Institute (HHMI) advances the discovery and sharing of scientific knowledge to benefit us all. As a biom...

Schedule, talks and talk submissions for SciPy 2025

RNA-binding proteins (RBPs) are important contributors to post-transcriptional regulatory processes. The combinatorial action of expressed RBPs and non-coding factors bound to the same transcript dete...

It is currently unknown to what degree parents’ life history can affect the next generation and how such information might be transmitted. A new study finds that nematodes transmit amyloid proteins to...

Join us for an exciting and insightful session with **Yanina Bellini Saibene**, as she explores the integration of **GitHub Copilot** (and other **Large Language Models**,

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The exclusion of Blacks/African-Americans, Latinx/Hispanics, and Indigenous people from science has resulted in their underrepresentation in the biomedical workforce, especially in academia. Faculty d...