Stephan Wilmes @stephanwilmes.bsky.social · 26/08/2026sounds a bit like a microscope consisting of cells or cells doing cryo-EM, doesn't it? 220
Reposted by Stephan WilmesPavel Barahtjan @pavelbarahtjan.bsky.social · 23/01/2026We have several Master’s thesis projects available in the D’Angelo lab, spanning different areas of lipid biology/biochemistry. If you know someone who might be interested, we’d really appreciate you sharing this. #lipidtime www.epfl.ch/labs/dangelo...epfl.chMaster ProjectsDANGELOLAB 078
Stephan Wilmes @stephanwilmes.bsky.social · 13/11/2025That's what i wanted to suggest. ChatGPT also worked on occasion... 010
Stephan Wilmes @stephanwilmes.bsky.social · 13/11/2025Have you tried feeding what you remember into an llm to help search for it. Worked for me recently and better than I would have thought 100
Reposted by Stephan WilmesMaria Bohnert Lab @bohnertlab.bsky.social · 07/11/2025Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...cell.comThe Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motilityZhao et al. identify the molecular machinery for lipid droplet motility, consisting of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor Ldo16. They uncover a molecular l... 43412
Reposted by Stephan WilmesHolthuis Lab @holthuislab.bsky.social · 17/10/2025🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa... 01212
Stephan Wilmes @stephanwilmes.bsky.social · 02/09/2025Huge thanks to all involved, including but not limited to @jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @nartimsoole.bsky.social @arnemoeller.bsky.social 020
Stephan Wilmes @stephanwilmes.bsky.social · 02/09/2025With a combination of #cryo-EM, biochemical, biophysical and in vivo data we show what contributes to substrate and target membrane specificity and reveal a function of the third subunit of the metazoan MC1 GEF, RMC1/Bulli. 110
Stephan Wilmes @stephanwilmes.bsky.social · 02/09/2025Thrilled to share our newest publication in Science Advances! We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core. www.science.org/doi/full/10....science.orgMechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-InturnedThe molecular comparison of related RabGEFs reveals adaptation mechanisms of a functional module for specific cellular tasks. 284
Stephan Wilmes @stephanwilmes.bsky.social · 09/08/2025Always found it odd we were never thaught how to assess publications. Of course your experiences, discussion and reading loads are key, but I think a reminder on Master's level that not everything you come across in literature can be taken for granted and what to look for would help lots of students 110
Reposted by Stephan WilmesJan-Hannes Schaefer @jhschaef.bsky.social · 01/08/2025Check out our new preprint from the @landerlab.bsky.social, Stagg-Lab and Cianfrocco-Lab: CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection www.biorxiv.org/content/10.1... Happy testing: cryosift.org #cryoEM #CNN 1177
Stephan Wilmes @stephanwilmes.bsky.social · 06/04/2025Happy our preprint on the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned is out! doi.org/10.1101/2025... Thanks to everyone involved! @jessetoenjes.bsky.social @jhschaef.bsky.social @djanuliene.bsky.social @arnemoeller.bsky.social @nartimsoole.bsky.socialdoi.orgMechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-InturnedRab GTPases organize intracellular trafficking and provide identity to organelles. Their spatiotemporal activation by guanine nucleotide exchange factors (GEFs) is tightly controlled to ensure fidelit... 040
Reposted by Stephan WilmesbioRxivpreprint @biorxivpreprint.bsky.social · 29/03/2025Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned www.biorxiv.org/content/10.1101/202… 053
Reposted by Stephan WilmesbioRxiv Biochemistry @biorxiv-biochem.bsky.social · 26/11/2024Structure and mechanism of the RalGAP tumor suppressor complex www.biorxiv.org/content/10.1101/202… biorxiv.orgStructure and mechanism of the RalGAP tumor suppressor complex https://www.biorxiv.org/content/10.1101/2024.11.25.625123v1 The RalGAP (GTPase activating protein) complexes are negative regulators of the Ral GTPases and thus 031