Reposted by JessebioRxiv Biochemistry @biorxiv-biochem.bsky.social · 15/07/2026Molecular basis of TSC complex GAP activity www.biorxiv.org/content/10.64898/20… 044
Reposted by JesseGBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 27/03/2026The 2026 Otto Warburg Medal winner Maya Schuldiner received the medal from @volkerhaucke-lab.bsky.social after a moving laudatio by Christian Ungermann Thanks to @elsevierconnect.bsky.social for the continuous support! 0449
Reposted by JesseStephan Wilmes @stephanwilmes.bsky.social · 02/09/2025Thrilled to share our newest publication in Science Advances! We uncovered how two RabGEF complexes — Mon1-Ccz1 and Fuzzy-Inturned — adapt to regulate distinct Rab GTPases despite their structurally conserved catalytic core. www.science.org/doi/full/10....science.orgMechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-InturnedThe molecular comparison of related RabGEFs reveals adaptation mechanisms of a functional module for specific cellular tasks. 284
Reposted by JessebioRxivpreprint @biorxivpreprint.bsky.social · 29/03/2025Mechanistic Plasticity of the RabGEFs Mon1-Ccz1 and Fuzzy-Inturned www.biorxiv.org/content/10.1101/202… 053
