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Sourik Dey

@sourikdey.bsky.social
460 followers 391 following 21 posts

Microbiome Engineer | Cleveland Clinic Lerner Research Institute | PhD in Synthetic Biology | Leibniz-INM, Germany | IIT Roorkee | St. Xavier's College, Kolkata

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Reposted by Sourik Dey
Sebastian S. Cocioba @atinygreencell.bsky.social · 04/06/2026
Lux operon so pretty
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Vivek Mutalik @vivekmutalik.bsky.social · 19/04/2026
www.nature.com/articles/s41... #microsky
nature.com
Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments - Nature Biotechnology
Modular integration of bacterial strains expands the application range of whole-cell bioelectric sensors.
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Reposted by Sourik Dey
Innovative Genomics Institute @innovativegenomics.bsky.social · 13/01/2026
A new review from the Doudna Lab lab on tissue-targeted in vivo delivery of gene editors: www.nature.com/articles/s41587-025-… #CRISPR #delivery
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The Rockefeller University @rockefeller.edu · 27/12/2025
Treatments for autoimmune diseases have big shortcomings, including high cost and supply shortages. A alternative developed this year from the #RavetchLab achieves the same effectiveness at a fraction of the dose. #RockefellerScience #YearInReview 🔗: bit.ly/3HFdsbs
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Sourik Dey @sourikdey.bsky.social · 22/11/2025
Intracellular competition shapes plasmid population dynamics | Science www.science.org/doi/10.1126/...
science.org
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
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Reposted by Sourik Dey
Sternberg Lab @sternberglab.bsky.social · 14/11/2025
1/9 Metagenomics lets us read microbiomes in nature without cultivation, but writing (editing) them in their native context is still a major challenge. Meet MetaEdit: a platform for pathway-scale metagenomic editing inside the gut microbiome. science.org/doi/10.1126/...
science.org
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
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Sourik Dey @sourikdey.bsky.social · 19/09/2025
www.sciencedaily.com/releases/202...
sciencedaily.com
Goodbye colonoscopy? Simple stool test detects 90% of colorectal cancers
Scientists at the University of Geneva have created the first detailed catalogue of gut bacteria at the subspecies level, unlocking powerful new ways to detect colorectal cancer. By applying machine l...
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Sourik Dey @sourikdey.bsky.social · 10/09/2025
Very interesting read! #synbio www.tandfonline.com/doi/full/10....
tandfonline.com
Being a better version of yourself: genetically engineered probiotic bacteria as host defense enhancers in the control of intestinal pathogens
Intestinal pathogens pose a significant global health burden, and traditional antibiotic treatments often disrupt the beneficial gut microbiota that plays a crucial role in maintaining host health ...
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Sourik Dey @sourikdey.bsky.social · 01/07/2025
Excited to launch my postdoc at the Cleveland Clinic Lerner Research Institute! 🧪 In Prof. Dwidar’s lab, I’m harnessing bacterial synthetic biology 🦠to pioneer new therapeutics and shape the future of precision medicine. Let’s do this! 🚀#synbio #PostdocJourney #ClevelandClinic
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 23/06/2025
Wow: Plastic → Tylenol? 🧪♻️💊 A biocompatible Lossen rearrangement—a reaction never seen in nature—occurring INSIDE E. coli Bacteria engineered to convert PET plastic → Tylenol in <24h, with 92% yield + low emissions Stunning blend of chemistry and synthetic biology www.nature.com/articles/s41...
nature.com
A biocompatible Lossen rearrangement in Escherichia coli - Nature Chemistry
Biocompatible chemistry merges chemo-catalytic reactions with cellular metabolism for sustainable small-molecule synthesis. Now a biocompatible Lossen rearrangement has been demonstrated to control ba...
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Sourik Dey @sourikdey.bsky.social · 15/05/2025
When academics say industries were running after them for recruitment, but they chose a path of passion instead!
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Elisabeth Bik @elisabethbik.bsky.social · 15/05/2025
The 'Oscar' of food prizes goes to a Brazilian who harnessed the power of bacteria Mariangela Hungria found microbes that were good at capturing nitrogen from the air and turning it into fertilizer for crops. www.npr.org/2025/05/14/n...
npr.org
The 'Oscar' of food prizes goes to a Brazilian who harnessed the power of bacteria
This year's $500,000 World Food Prize, for advances in agriculture and nutrition, goes to a Brazilian who boosted the country's farming revolution, turning it into a soybean superpower.
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Varun Tadimarri @varunsays.bsky.social · 14/05/2025
Excited to share our latest work, published in a peer-reviewed journal. We studied how Gram +/- probiotic bacteria would adapt in mechanical confinements - key part in understanding the fundamentals of Engineered living materials. Read it here: pubs.acs.org/doi/10.1021/...
pubs.acs.org
Adaptations of Gram-Negative and Gram-Positive Probiotic Bacteria in Engineered Living Materials
Encapsulation of microbes in natural or synthetic matrices is a key aspect of engineered living materials, although the influence of such confinement on microbial behavior is poorly understood. A few ...
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Sebastian S. Cocioba @atinygreencell.bsky.social · 14/04/2025
Finally, access to a pichia pastoris strain. Time to adapt it enough to become a truly open strain, without the $5000 buy in of the current "open" version. Worst case $20/stab and zero MTA. Evolved with love. Big thanks to @koeng101 off Twitter for sourcing! 💚
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Sourik Dey @sourikdey.bsky.social · 06/04/2025
#harvard #budgetcut
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Cheshire @thatsregrettab1.bsky.social · 03/04/2025
Article (paywalled) about our pre-print discussing Bioengineered journal’s paper mill problem: www.nature.com/articles/d41... arxiv.org/abs/2503.21267 Thanks to @deadneanderthals.bsky.social @mortenoxe.bsky.social @elisabethbik.bsky.social @smutclyde.bsky.social for letting me tag along!
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Sebastian S. Cocioba @atinygreencell.bsky.social · 26/03/2025
Lol I have A LOT of work to do before I get even remotely close to the level of protein expression a well designed plasmid can generate. This is pCambia2300 expressing the same RFP circuit (albeit in Agrobacterium; left) and my single copy transposon integration in BL21 Ecoli (right).
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Olivier Borkowski @oborkowski.bsky.social · 26/03/2025
From the hasty lab: Evolved microbial diversity enables combinatoric biosensing in complex environments doi.org/10.1101/2025...
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Sourik Dey @sourikdey.bsky.social · 26/03/2025
"In other words, traditional probiotics don’t really work, but you should give these new ones a try and keep an eye out for more evidence-based probiotics in the future!" #synbio #probiotics
synbiobeta.com
There’s a New Generation of Probiotics Coming to a Store Near You - SynBioBeta
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American Chemical Society @acs.org · 23/03/2025
Researchers at @mitchemistry.bsky.social have developed a new system for delivering peptide-based drugs, like GLP-1, by “painting” them on antibodies to improve and prolong their therapeutic effects. They report their results today at #ACSSpring2025: buff.ly/f6oHqxb
buff.ly
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Maxence Lejars @mlejars.bsky.social · 21/03/2025
Happy to share our genetic toolkit designed to make your gene editing (life) easier, faster and very efficient! Also suitable to build saturated chromosomal variant libraries using oligo-recombineering with extra short homology arms! www.biorxiv.org/content/10.1...
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Jake Wintermute @synbio1.bsky.social · 21/03/2025
When you grow yeast on yeast extract medium
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Shirish @shrikrishnans.bsky.social · 18/03/2025
Synthetic Biology runs on plasmids and we've got some for engineering lactobacilli that are in high demand! So, we finally did the sensible thing and deposited them with Addgene to make them easily accessible - www.addgene.org/Shrikrishnan... Thanks @sourikdey.bsky.social & @marcblanch.bsky.social
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Trends in Biotechnology @cp-trendsbiotech.bsky.social · 08/03/2025
Online now: Protein-based molecular imprinting: gelatin nanotraps for interleukin-6 sequestration in inflammation cell models
dlvr.it
Protein-based molecular imprinting: gelatin nanotraps for interleukin-6 sequestration in inflammation cell models
Gelatin methacryloyl (GelMA) was harnessed to create nanotraps via molecular imprinting that were specifically designed to scavenge interleukin-6 (IL-6) in inflammation models. This innovative approach leverages safe and biocompatible protein-based…
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Reposted by Sourik Dey
Sebastian S. Cocioba @atinygreencell.bsky.social · 09/03/2025
Good branding
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Shirish @shrikrishnans.bsky.social · 08/03/2025
It's hard to express how lucky I feel to have a team that self-organizes a vibrant lunch together on a Saturday and are happy to have their boss there 🤓 We even got to celebrate our wonderful women in science on Women's Day! 👩‍🔬 #womensday
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Christie Wilcox @nerdychristie.bsky.social · 04/03/2025
Genetically altered 'woolly mice' express several mammoth-like traits, including the animal's iconic coat. The cuteness, meanwhile, is a complete coincidence. That and more of the best in @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪
A woolly mouse (left) next to an ordinary one. CREDIT: Colossal Biosciences
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Olivier Borkowski @oborkowski.bsky.social · 27/02/2025
Exploring the principles behind antibiotics with limited resistance www.nature.com/articles/s41...
nature.com
Exploring the principles behind antibiotics with limited resistance - Nature Communications
This study shows that only those dual-targeting antibiotics limit resistance in Gram-negative pathogens that also target the membrane of the bacteria. This mechanism provides a basis for designing fut...
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Reposted by Sourik Dey
Sebastian S. Cocioba @atinygreencell.bsky.social · 26/02/2025
The first night ended in a burial ritual on the beach, symbolically burying our presumptions and assumptions that we brought with us from all over the world, to start the first day of work with an open mind.
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Sourik Dey @sourikdey.bsky.social · 26/02/2025
These kind of research are one of the reasons why people lose their trust in science! #cancer #ridiculous forbetterscience.com/2025/02/26/t...
forbetterscience.com
The Men Who Stare At Mice
“Do Cohen’s colleagues and superiors know or care that he hosts wizards in his lab? Or perhaps this is simply common place, wizards roam throughout MD Anderson free range, blasting the …
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Elisabeth Bik @elisabethbik.bsky.social · 26/02/2025
A former Stanford employee was convicted of altering data used in a breast cancer study after she was fired, according to the United States Department of Justice. www.kron4.com/news/bay-are...
kron4.com
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Shirish @shrikrishnans.bsky.social · 26/02/2025
In the bubbling world of bioreactors, lonely Lactobacilli are searching for a perfect partner. Will it be strong and stable Cyanobacteria or resourceful Microalgae? We're seeking a PhD candidate to turn microbial matchmaking into productive co-cultures! - tinyurl.com/Alacto @leibnizinm.bsky.social
tinyurl.com
DOCTORAL RESEARCHER POSITION IN MICROBIAL CO-CULTURES (F/M/D) at INM - Leibniz-Institut für Neue Materialien gGmbH
We're looking for: DOCTORAL RESEARCHER POSITION IN MICROBIAL CO-CULTURES (F/M/D) (Full Time) • Campus, 66123 Saarbrücken, Deutschland
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 25/02/2025
First time I try an edible GMO 🤩! The purple tomato has two genes added from snapdragons (Antirrhinum) that so the resulting fruit has high levels of antioxidants (purple pigments) made in the whole tomato. And they are flavorful and delicious 😋!
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EngBio CDT @engbiocdt.bsky.social · 24/02/2025
Application deadline approaching! 📣 A quick reminder that the deadline to submit your application for the EngBio CDT is fast approaching! Don't miss your chance to be a part of this incredible opportunity ⚛️ Deadline: midday on Tuesday 4th March How to apply: bit.ly/EngBioCDTOx
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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 25/02/2025
Molecular mechanisms at the heart of modern Synthetic Biology inspire stunning choreographies at Asilomar—an unforgettable after-dinner social event! 👏
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Trends in Biotechnology @cp-trendsbiotech.bsky.social · 23/02/2025
Online now: Navigating B2B and B2C business models in biotechnology
dlvr.it
Navigating B2B and B2C business models in biotechnology
Commercialising biotechnology innovations relies on selecting an appropriate business model. This article explores the nuances of the business-to-business and business-to-consumer pathways, highlighting key considerations for selecting the best model. It…
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 22/02/2025
New in Nat Comm PROBIOTIC 🦠 DRUG 💊 DELIVERY 🚚 Type zero secretion system (T0SS) enables E. coli Nissle to package and deliver enzymes into the bloodstream via OMVs Demonstrated in hyperuricemic mice, this approach outperforms direct secretion for uricase therapy www.nature.com/articles/s41...
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Vaughn Cooper @vscooper.micropopbio.org · 21/02/2025
Fascinating paper about the potential of phage for local drug delivery by Brian Hsu (Va Tech) and colleagues. (also nice acknowledgment for SeqCoast Genomics @seqcoast.bsky.social!) www.nature.com/articles/s41...
nature.com
Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage - Nature Biotechnology
Biologics are delivered to the gut using phage that infects resident commensal bacteria.
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Akos Nyerges @akosnyerges.bsky.social · 18/02/2025
Excited to share this @nature.com interview about the current state of synthetic genomics. Our work on the 57-codon E.coli genome shows that while biological complexity continues to surprise us, advanced omics & massively parallel assays now enable genome engineering & design at unprecedented scale
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EMBL @embl.org · 11/02/2025
We celebrate International Day of Women and Girls in Science with our EIROforum partners. 🧪 The eight organisations, including EMBL, teamed up to highlight #WomenInScience across different disciplines. For more inspiration by #EMBLWomenInScience: www.embl.org/news/tag/wom... #SciComm
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Leibniz INM @leibnizinm.bsky.social · 11/02/2025
Science knows no gender—only curiosity, talent, and passion! Yet, women in research still face challenges. Today, we honor their achievements and encourage girls to pursue careers in science. 👩‍🔬 Let’s break down barriers and work together for a future where everyone has equal opportunities!
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Rahul K @theresearch.bsky.social · 10/02/2025
If the article below (from @shrikrishnans.bsky.social lab) interests you, you may want to follow the weekly curated list of Engineered Living Materials (ELMs) research articles here: biomed.news/bims-enlima/... #engineeredlivingmaterials #ELMs
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Leibniz INM @leibnizinm.bsky.social · 11/02/2025
Today, we've assembled experts in automation and data science to learn and discuss how to accelerate research in materials science 🚀- www.leibniz-inm.de/en/events/ac... 🧵
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Leibniz INM @leibnizinm.bsky.social · 10/02/2025
Engineered living materials (ELMs) have shown considerable promise for therapeutic applications. Find more information in V.S. Tadimarri et. al. #INM publication. Early view version is available: doi.org/10.1002/smll...
doi.org
PEARL: Protein Eluting Alginate with Recombinant Lactobacilli
Probiotic lactobacilli meet engineered living materials: This study introduces PEARL (protein eluting alginate with recombinant lactobacilli), an innovative engineered living material combining Lacti...
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Elisabeth Bik @elisabethbik.bsky.social · 11/02/2025
Congratulations @jabyrnesci.bsky.social on winning the well-deserved David Vaux Research Integrity Fellowship Award. bit.ly/4aVDilW
bit.ly
Professor renowned for expunging fake research receives David Vaux
Professor Jennifer Byrne’s career has diverted from cancer research to research integrity. Image: supplied The Academy is delighted to announce Professor Jennifer Byrne from the University of Sydney
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Leibniz INM @leibnizinm.bsky.social · 09/02/2025
We're looking for a post-doctoral candidate to engineer fungi for creating sustainable Engineered Living Materials within the EIC LoopOfFun project. So, if you're looking for a place with exciting research and stable funding, apply here - leibniz-inm.softgarden.io/job/53304534...
leibniz-inm.softgarden.io
Postdoc in Engineered Living Materials, Synthetic Biology, and Microbiology (f/m/d) at INM - Leibniz-Institut für Neue Materialien gGmbH
We're looking for: Postdoc in Engineered Living Materials, Synthetic Biology, and Microbiology (f/m/d) (Full Time) • Campus, 66123 Saarbrücken, Deutschland
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Elisabeth Bik @elisabethbik.bsky.social · 08/02/2025
Playing now: Tariffs, Future of Cancer and Alzheimer's, Global Debt Cycles | Wall Street Week with Matthew Schrag, Charles Piller, and myself. #Alzheimers #ImageForensics www.bloomberg.com/news/videos/...
bloomberg.com
Tariffs, Future of Cancer and Alzheimer's, Global Debt Cycles | Wall Street Week
This week, Former US Treasury Secretary Lawrence H. Summers and Council on Foreign Relations Director of Studies Shannon O'Neil tell us why tariffs may not protect US jobs. Pfizer chairman and CEO Alb...
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Shirish @shrikrishnans.bsky.social · 07/02/2025
Who knew stuffing engineered lactobacilli in a gel would make them better at secreting our engineered proteins? A pleasant surprise for us and a great outcome for engineered living materials - doi.org/10.1002/smll... @marcblanch.bsky.social @varunsays.bsky.social @leibnizinm.bsky.social
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Guillermo Nevot @nevoti.bsky.social · 07/02/2025
C. acnes is the most abundant bacterium on human skin. But what if we could make it the smarterst? 🦠✨ In our new @cellpress.bsky.social #CellSystems study, we programmed C. acnes to actively protect the skin for therapeutic applications! 🛡️ authors.elsevier.com/sd/article/S...
authors.elsevier.com
ScienceDirect.com | Science, health and medical journals, full text articles and books.
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Sebastian S. Cocioba @atinygreencell.bsky.social · 07/02/2025
Oh this is so cool! Culture glows despite only in LB; no abx. I really think the Himar1 transposase did its thing. Fully homebrewed chromosomal integration vector, made from scratch and fully open source. Gonna add sacB and integrate my whole library lol. *happy bionerd noises*
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