Author summary Plague is caused by the bacterium Yersinia pestis and transmitted between mammals by fleas. To spread, the bacteria must survive in the flea gut after a blood meal. This environment is ...

Bacterial pathogens must withstand metal-induced stress during infection, yet the mechanisms by which they sense and respond to toxic metal ions remain incompletely understood. Here, we uncover a prev...

YouTube video by Pasteur Lille

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

In this Review, Kocher, Krause and Spyrou explore how ancient pathogen genomics is providing new perspectives on the history and evolution of infectious agents. They show how ancient DNA has revealed ...

Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…

Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

Transmise par les tiques, la maladie de Lyme est causée par des bactéries capables de se camoufler, de s’adapter et de résister à nos défenses immunitaires grâce à d’ingénieux stratagèmes.

[Ouest-France] Un cas de peste a été détecté en Californie, aux États-Unis, mardi 19 août. Pourrait-on voir réapparaître la bactérie responsable de la maladie en France, où la dernière infection connu...

Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adaptation and infection processes. Here, we present a protocol for the semi-quantitative assessment of the phosphorylation level of the transcriptional regulator CpxR during the infection process using Phos-tag gel. We describe steps for Dickeya dadantii infection of chicory leaves, followed by bacterial extraction, rapid acidic cell lysis, and subseque...

Analysis of synteny blocks and genomic rearrangement patterns of 178 newly sequenced and 64 publicly available complete genomes of Yersinia pestis highlights the impact of key variations on genes invo...

Quantifying the phosphorylation levels of proteins involved in bacterial signaling pathways is essential for understanding their role in stress adapta…

Outer membrane attachment to peptidoglycan enables periplasmic pressure to build up and counter cytoplasmic turgor pressure, preventing lysis during osmotic challenges in Escherichia coli.

Climate parameters show negative correlations with B. burgdorferi infection prevalence but low impact on uninfected tick density.

This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows the discovery of two superfa...

Today, Dr. Brian Stevenson of the University of Kentucky College of Medicine joins the #QualityQuorum to discuss a twisty twirling form of life, spirochetes,...

Background The Oriental rat flea, Xenopsylla cheopis, is a main vector of plague caused by the bacterium Yersinia pestis. Transcriptomic analysis of this insect and the interaction between Yersinia an...

Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch through enzymatic conversion. Over the past decades, CDs and their derivatives (dC…

This study documents the evolution of antibiotic resistance and major growth defects in Yersinia enterocolitica in a patient over 14 years, revealing genetic changes that shed light on bacterial adapt...

Scientific Reports - Exploring temperature-dependent transcriptomic adaptations in Yersinia pestis using direct cDNA sequencing by Oxford Nanopore Technologies

Scientists at the Institut Pasteur and McMaster University have discovered that the evolution of a gene in the bacterium that causes bubonic plague, Yersinia pestis, may have prolonged the duration of...

STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all are...

Yersinia pestis has spilled over from wild rodent reservoirs to commensal rodents and humans, causing three historically recorded pandemics. Depletion in the copy number of the plasmid-encoded virulen...

Several bacterial pathogens have transitioned from tick-borne to louse-borne transmission, which often involves genome reduction and increasing virulence. However, the timing of such transitions remai...

Comprendre comment les bactéries modulent leur croissance face à des changements environnementaux est essentiel pour développer de nouvelles stratégies de lutte contre les infections. Dans notre labo...

YouTube video by Pasteur Lille

YouTube video by Pasteur Lille