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Arnaud Machelart

@arnaudmachelart.bsky.social
910 followers 658 following 13 posts

Tries to understand the cellular response against Mtb and improve antiTB drugs delivery. @inserm @InstitutPasteurLille France

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Arnaud Machelart @arnaudmachelart.bsky.social · 22/08/2026
Can tuberculosis ever be beneficial to the host? Our new review explores this complex interplay between TB and coinfections. Congratulations to Joan Fine for her tremendous work! @ciilofficiel.bsky.social Unraveling the multifaceted impact of tuberculosis on coinfections www.cell.com/iscience/ful...
cell.com
Unraveling the multifaceted impact of tuberculosis on coinfections
Health sciences; Medicine; Medical specialty; Medical microbiology
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 26/05/2026
📢 New publication in Scientific Reports by @natureportfolio.nature.com A new study led by Dr @arnaudmachelart.bsky.social reveals that the route of BCG vaccination critically shapes protection against bacterial pneumonia. @inserm.fr @pasteurlille.bsky.social @cnrs.fr @univlille.bsky.social
doi.org
BCG immunisation through intranasal instillation protects mice against Streptococcus pneumoniae infection by enhancing alveolar macrophage activity - Scientific Reports
Scientific Reports - BCG immunisation through intranasal instillation protects mice against Streptococcus pneumoniae infection by enhancing alveolar macrophage activity
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Arnaud Machelart @arnaudmachelart.bsky.social · 14/05/2026
Very happy to have participated in the “Health Effects of Vaccines: From Genomics to Policy” conference at Wellcome Connecting Science. Inspiring discussions on vaccines, host responses, genomics & public health. Congrats to Carine and Valentin for presenting their work!@ciilofficiel.bsky.social
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Arnaud Machelart @arnaudmachelart.bsky.social · 09/12/2025
Very happy to share our group’s second publication this month! In this work, we investigate the intrinsic anti-tuberculosis activity of polymeric β-cyclodextrin nanoparticles. Proud of the team’s efforts!
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Arnaud Machelart @arnaudmachelart.bsky.social · 26/11/2025
🚀Thrilled to announce our latest publication in Journal of Controlled Release! Our team reveals a key property of antimicrobial nanovectors in the fight against infectious diseases. 🎉🔬 www.sciencedirect.com/science/arti...
sciencedirect.com
Selective accumulation of nanoparticles in infected cells for targeted drug delivery
In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 22/11/2025
📢 A new pub in Journal of Controlled Release by Dr @arnaudmachelart.bsky.social group and Dr Ruxandra Gref team “Selective accumulation of nanoparticles in infected cells for targeted drug delivery” @inserm.fr @cnrs-hautsdefrance.bsky.social @rechercheulille.bsky.social @pasteurlille.bsky.social
sciencedirect.com
Selective accumulation of nanoparticles in infected cells for targeted drug delivery
In response to the escalating threat of infectious diseases and antimicrobial resistance, novel therapeutic strategies are under active development. A…
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Arnaud Machelart @arnaudmachelart.bsky.social · 22/09/2025
Ravis d’accueillir le public pour les Journées Européennes du Patrimoine à l’Institut Pasteur de Lille ! 🧬 Notre équipe passionnée a présenté nos travaux sur la tuberculose. Merci à tous pour cette belle journée ! 👏
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 20/08/2025
The @ciilofficiel.bsky.social team is at #IUIS2025 in Vienna! N. Mielcarek on BPZE1 pertussis vaccine, E. Hoffmann on ERA4TB drug testing, while @joanfine.bsky.social , I. Leleu, @vsencio.bsky.social & @arnaudmachelart.bsky.social are showcasing their work in poster sessions. #Immunology
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Arnaud Machelart @arnaudmachelart.bsky.social · 19/08/2025
🦠✨ Exciting science at #IUIS2025 in Vienna! Don’t miss posters on host–pathogen interactions by: 🔹 #338 Joan Fine 🔹 #342 Valentin Sencio 🔹 #347 Ines Leleu
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 29/07/2025
Institut @pasteurlille.bsky.social teams joined the GRC #TB Drug Discovery and Dev. to present their latest work. With rising resistance and 1.5M deaths/year, better TB treatments are urgent. A week of fruitful talks & new collaborations! @hartkoorn-lab.bsky.social @arnaudmachelart.bsky.social
Amine Pochet, Yoel Dagan, Ernesto Anoz Carbonell, Vien Quang Tri Ho, Arnaud Machelart, Zainab Edoo, Ruben C. Hartkoorn, Nicolas Willand, Oriane Rivière, Axelle Grandé, Alain Baulard
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Arnaud Machelart @arnaudmachelart.bsky.social · 02/07/2025
🚨 New review from our group! PhD student Amine Pochet dives into the use of cyclodextrins beyond drug delivery — as active agents against infectious diseases. @ciilofficiel.bsky.social @pasteurlille.bsky.social @inserm.fr @univlille.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Beta-cyclodextrins in infectious disease therapy: A review of their function beyond simple drug carriers
Cyclodextrins (CDs) are cyclic oligosaccharides derived from starch through enzymatic conversion. Over the past decades, CDs and their derivatives (dC…
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Institut Pasteur de Lille @pasteurlille.bsky.social · 17/06/2025
À l’Institut Pasteur de Lille, le Dr F. Real et son équipe (@ciilofficiel.bsky.social) montrent que le #VIH infecte les mégacaryocytes en réduisant IFITM3, une protéine antivirale. Ces cellules pourraient former un réservoir viral caché, empêchant de parvenir à une guérison du VIH ➡️ bit.ly/3FSMc8C
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Arnaud Machelart @arnaudmachelart.bsky.social · 12/05/2025
Excited to share our latest work on incorporating an antiviral molecule into delivery vectors to target pulmonary infections. 🍃🦠 www.sciencedirect.com/science/arti...
sciencedirect.com
Pulmonary delivery of clofoctol-loaded nanoparticles inhibits SARS-CoV-2 replication and reduces pneumonia
Despite the progress made through vaccination campaigns and the use of antivirals, the need for more effective therapeutics to combat respiratory vira…
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Institut Pasteur de Lille @pasteurlille.bsky.social · 06/05/2025
🎤 Laurye Van Maele, chercheuse @inserm.fr au @ciilofficiel.bsky.social à l'Institut Pasteur de Lille, a joué le jeu de l’interview menée par une élève de 3e pour “Ta voix », le media jeune de @lavoixdunord.fr. Une belle rencontre intergénérationnelle autour de la #recherche 👉 bit.ly/4k3D2o1
bit.ly
Rencontre avec Laurye Van Maele, chercheuse à l’Institut Pasteur de Lille
Laurye Van Maele est chercheuse à l’Institut Pasteur de Lille. Melye, en stage che...
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Institut Pasteur de Lille @pasteurlille.bsky.social · 03/05/2025
À l’Institut Pasteur de Lille, l’équipe du Dr François Trottein au @ciilofficiel.bsky.social montre qu’un microbiote intestinal déséquilibré chez les aînés aggrave le #COVID19. Probiotiques et prébiotiques pourraient améliorer la récupération 👉 pasteur-lille.fr/2025/04/16/m...
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 30/04/2025
🚨New Pub🚨 #PulmonaryDelivery of clofoctol-loaded #Nanoparticles inhibits #SARSCoV2 replication and reduces pneumonia 💥 Study co-led by Drs Brodin, Trottein, Machelart ( @arnaudmachelart.bsky.social ) & Dr. R. Gref ( @ismolab.bsky.social ) | Institut des Sciences Moléculaires d'Orsay
sciencedirect.com
Pulmonary delivery of clofoctol-loaded nanoparticles inhibits SARS-CoV-2 replication and reduces pneumonia
Despite the progress made through vaccination campaigns and the use of antivirals, the need for more effective therapeutics to combat respiratory vira…
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 23/04/2025
@arnaudmachelart.bsky.social , chercheur @inserm.fr Comment le #réchauffement #climatique favorise-t-il l’ #émergence des maladies tropicales ?
youtu.be
Réchauffement climatique et maladies tropicales : quels sont les liens ? - Arnaud Machelart - 10' #3
YouTube video by Pasteur Lille
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 23/04/2025
@arnaudmachelart.bsky.social , chercheur @inserm.fr avec les doctorants Axelle Grandé et Amine Pauchet @univlille.bsky.social L’ #antibiorésistance, une bombe à retardement ?
youtu.be
L’antibiorésistance : quel danger pour l’environnement et notre santé ? - 10' de Prév'
YouTube video by Pasteur Lille
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 28/04/2025
Réchauffement climatique et maladies infectieuses émergentes : (re)découvrez la conférence de nos chercheurs @inserm.fr @cnrs-hautsdefrance.bsky.social Dr A. Machelart @arnaudmachelart.bsky.social Dr M. Gissot. @gissotlab.bsky.social Dr S. Pied Dr S. Bontemps-Gallo @sebbontempsgallo.bsky.social
youtube.com
Conférences Envie de Savoir(s) dans le cadre des Printemps de la Prev' 2025
YouTube video by Pasteur Lille
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Arnaud Machelart @arnaudmachelart.bsky.social · 15/04/2025
Excited to introduce our (expanded) research group for 2025!
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Arnaud Machelart @arnaudmachelart.bsky.social · 01/04/2025
I am happy to have participated in the @anrs-mie.bsky.social Start Day. Young researchers have talent too!
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Institut Pasteur de Lille @pasteurlille.bsky.social · 24/03/2025
24 mars, journée mondiale de lutte contre la #tuberculose ! À l’Institut Pasteur de Lille, Albert Calmette et Camille Guérin ont créé le BCG en 1921. Plus de 130 ans plus tard, nos chercheurs poursuivent cet héritage et continuent de lutter contre cette maladie mondiale 👉 bit.ly/4iFrsiS #EndTB.
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Arnaud Machelart @arnaudmachelart.bsky.social · 21/03/2025
Colloque I3M at Strasbourg! @joanfine.bsky.social @vsencio.bsky.social
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 07/03/2025
#StandUpforScience 2025 – Because science is a common good. The @ciilofficiel.bsky.social was present alongside all colleagues on the @pasteurlille.bsky.social campus. #ScienceForAll @cnrs-hautsdefrance.bsky.social @inserm.fr @chulille.bsky.social @univlille.bsky.social
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 08/03/2025
🔴 Women scientists at @ciilofficiel.bsky.social were joined by their colleagues from @pasteurlille.bsky.social, all dressed in red for the #Coquelicots initiative on #InternationalWomensDay Women in science exist! Let’s be visible: wear red & form a vast poppy field from the sky! 🌍🔬
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Institut Pasteur de Lille @pasteurlille.bsky.social · 07/03/2025
📣 Stand Up for Science 2025 à l'Institut Pasteur de Lille parce que la science est un bien commun. 📣 Plus d'infos sur le mouvement 👉 standupforscience.fr #pasteurlille
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Arnaud Machelart @arnaudmachelart.bsky.social · 06/03/2025
Bravo Joan! @joanfine.bsky.social
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 28/02/2025
#FluorescenceFriday The macrophage (nucleus in blue) protein Tirap (in red) is recruited to the Mycobacterium tuberculosis (in green)-containing vacuole. This recruitment is essential to enable bacterial replication. Belhaouane et al. PLoS Pathogens 2023
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Centre d'Infection et d'Immunité de Lille @ciilofficiel.bsky.social · 08/02/2025
The Center for Infection and Immunity of Lille (CIIL) is now on Bluesky ! 📢 Follow us for updates on our latest research, collaborations, and breakthroughs in #infectious #diseases, #immunology, and #microbiology. 📍 Follow us here: @ciilofficiel.bsky.social
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Arnaud Machelart @arnaudmachelart.bsky.social · 07/02/2025
Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice: Cell Reports www.cell.com/cell-reports...
cell.com
Rev-erb-α antagonism in alveolar macrophages protects against pneumococcal infection in elderly mice
Silva Angulo et al. provide insights into mechanisms underlying respiratory bacterial susceptibility in the elderly. The authors demonstrate that the altered circadian expression of the nuclear recept...
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Olivier Neyrolles @oneyrolles.bsky.social · 31/01/2025
🦠 How does #Tuberculosis survive the journey through the air? New research from C. Nathan’s lab shows that Mtb actively resists desiccation, remodeling its transcriptome and using anti-desiccant proteins to endure aerosolization! #InfectiousDisease #MycroSky #TBSky www.biorxiv.org/content/10.1...
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The New Republic @newrepublic.com · 28/01/2025
The state of Kansas is experiencing a massive tuberculosis outbreak, just as the Trump administration has ordered the Centers for Disease Control and Prevention and the National Institutes of Health to cease communications with the public. newrepublic.com/post/190797/tubercu……
newrepublic.com
Tuberculosis Is Back—Just in Time for Trump to Make Things Even Worse
State officials say the U.S. is suffering its largest documented TB outbreak in history. Meanwhile, Trump is busy gutting health programs.
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Liz (or Lizzie) Kim 김혜성 💫 @lizzielizliz.bsky.social · 28/01/2025
A tuberculosis (TB) outbreak in Kansas City has become the largest documented TB outbreak on record in the United States. www.cidrap.umn.edu/tuberculosis...
cidrap.umn.edu
Kansas tuberculosis outbreak now largest in US
Sixty-seven active TB cases and 79 latent TB cases have been reported in 2 Kansas counties since the beginning of 2024.
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Nigel Curtis @nigelcurtis.bsky.social · 05/01/2025
#TBSky #IDSky
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Gabriele Pollara @gpollara.bsky.social · 05/01/2025
⚠️ Bit of an alarm bell to MDR-TB regimen BPaL/M - resistance to constituent antibiotics developing and transmission of such strains already occurring #TBSky #IDSky @nejm.org www.nejm.org/doi/10.1056/...
nejm.org
Transmission as a Key Driver of Resistance to the New Tuberculosis Drugs | NEJM
Whole-genome sequencing was used to show that resistance to newer antituberculosis drugs is present in at least 27 countries and that up to a quarter of this resistance may be due to person-to-...
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Nature Microbiology @natmicrobiol.nature.com · 10/01/2025
OUT NOW - A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity www.nature.com/articles/s41...
nature.com
A BCG kill switch strain protects against Mycobacterium tuberculosis in mice and non-human primates with improved safety and immunogenicity - Nature Microbiology
Engineered Mycobacterium bovis BCG encoding tetracycline-controlled phage lysin kill switches elicits protective immunity against subsequent M. tuberculosis infection in mice and non-human primates.
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Kate LeGrand @lekate.bsky.social · 23/01/2025
Reducing #TB burden requires understanding local contexts. Our new preprint emphasizes the importance of considering social contact patterns for interventions like active case finding, infection prevention & control, & cluster trial design #TBsky #IDsky #GlobalHealth www.medrxiv.org/content/10.1...
medrxiv.org
Within-country heterogeneity in patterns of social contact relevant for tuberculosis infection transmission, prevention, and care
Mycobacterium tuberculosis (Mtb) transmission is driven by variable social, environmental, and biological factors, including the number and duration of indoor contacts. Social contact data can provide...
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Jonathan Ryder, MD @jonathanrydermd.bsky.social · 22/01/2025
New from @cidjournal.bsky.social Linezolid TDM for TB from UF ID PK Lab If dose reducing from 600mg, 3x/week more likely to achieve appropriate trough (<2) and peak (12-26) compared to 300mg daily (inadequate peaks) Really interesting/useful data #IDSky #TBSky academic.oup.com/cid/advance-...
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Josh Mattila @joshmattila.bsky.social · 17/01/2025
I'm very happy to have contributed to this recently-released review on macrophage heterogeneity in TB granulomas. #TBSky www.nature.com/articles/s41...
nature.com
How macrophage heterogeneity affects tuberculosis disease and therapy - Nature Reviews Immunology
This Perspective discusses current knowledge of the diverse roles played by different macrophage populations within the Mycobacterium tuberculosis-infected lung. The underlying hypothesis is that dise...
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J.-F. Cavalier @jefcavalier.bsky.social · 04/12/2024
After a BioRxiv preprint, here is the final published version of our article dealing with the ph-driven mode of action of salicylic acid derivatives @pierresantucci.bsky.social @canaanlab.bsky.social and more febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com
FEBS Press
Salicylic acid (SA), its two iodinated analogues 5ISA and 3,5diISA, as well as the anti-inflammatory drug aspirin (ASP), are anti-TB drugs that disrupt the intrabacterial pH homeostasis of Mycobacter...
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