iiinova — where your digital self keeps evolving

Schiracha (Schirra) @schiracha.bsky.social · 6h

The guilty feeling of taking a non-conference #vacation defeated thanks to this little #adventurer who climbed rabbit ears and fish creek falls in Steamboat #Colorado

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Arnaud Vanden Broeck @avbroeck.bsky.social · 23/09/2026

Very happy to share the first paper from our lab, out now in Nature Communications!🎉🥳 Structural basis of step II Spliced Leader RNA trans-splicing in trypanosomatid parasites 🧬🔬 🔗 www.nature.com/articles/s41... @natcomms.nature.com @universitedeliege.bsky.social @rockefeller.edu #cryoEM #cryo-EM

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Vasilii Mikirtumov @vasiliimikirtumov.bsky.social · 24/09/2026

to keep the channels fully intact, we have purified sarcoplasmic reticulum (SR) vesicles directly from the native muscle tissue (completely detergent-free). and then we did tomography ofc, look at these beautiful RyR1 arrays sitting on the vesicle surfaces!

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David Solecki @so-lets-kilab70.bsky.social · 24/09/2026

Georgios Skiniotis and I are announce a unique St. Jude faculty search: a joint effort between the CoE for Structural Cell Biology an intellectual community advancing structural imaging & the Division of Neuronal Cell Biology. CryoET/vEM + neuron cell biology = 🚀 talent.stjude.org/careers/JobD...

talent.stjude.org

Faculty position, Neuronal Cell Biology and Cryo-ET/vEM

Department of Developmental NeurobiologyCenter of Excellence for Structural Cell Biology and Neuronal Cell Biology DivisionSt. Jude Children’s Research HospitalThe Center of Excellence for...

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cryoEM papers @cryoempapers.bsky.social · 25/09/2026

On-grid enrichment strategies in cryo-EM: affinity-functionalized supports for low-abundance and challenging targets pubmed.ncbi.nlm.nih.gov/42781870/ #cryoEM

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Cedric Feschotte @cedricfeschotte.bsky.social · 24/09/2026

Thrilled to see this published today! Truly special because we made the initial discovery >15 yrs ago! We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic! www.science.org/doi/10.1126/... 🧵1/n

science.org

Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates

Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...

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Sjors Scheres @sjorsscheres.bsky.social · 24/09/2026

Over the last week I have had separate discussions with three people being disillusioned by how bad their colleagues are at their job. Large organizations seem worse. I wonder whether having line managers work together with their people, instead of just leading from above, is a good solution.

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Schiracha (Schirra) @schiracha.bsky.social · 23/09/2026

...in order to form a more perfect union, establish justice, ensure domestic tranquility, provide a common defense and promote the general welfare.. Its in the preamble not the constitution, so it doesnt matter...

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Schiracha (Schirra) @schiracha.bsky.social · 23/09/2026

I feel like the onion has had to get increasingly ridiculous and less political as politics has become so unbelievable

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Korak Ray @korakray.bsky.social · 23/09/2026

🚨Preprint news!!🚨 Using specifically purified mitotic chromosomes, we show that chromosome mechanics vary based on identity and cell type. Chromosomes from differentiated cells are more compact and stiffer, likely due to increased non-covalent crosslinks within them www.biorxiv.org/content/10.6...

biorxiv.org

Individual mouse mitotic chromosomes exhibit cell type-specific differences in biomechanical properties

Cyclic episodes of chromosome compaction and de-condensation are features of eukaryotic cell division that aid mitotic segregation and help prevent aneuploidy. While biophysical data on mitotic chromo...

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Jenna Norton @jenna-m-norton.bsky.social · 23/09/2026

As you call members of Congress to raise concern about a Vought-led grant review panel, encourage them to sign onto proposed legislation that could help: 1) Follow the Science Act by @degette.house.gov would remove political appointees from the grant-making process: www.congress.gov/bill/119th-c...

congress.gov

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Schiracha (Schirra) @schiracha.bsky.social · 23/09/2026

Ask both what your country can do for your and what you can do for your country. If you can lead a lab, you can lead a community. Vote blue in November to rescue democracy and consider running for local offices. The best way to change the system is to be the system. - Veteran and scientist.

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ACLU @aclu.org · 22/09/2026

Taxpayers are footing the bill for President Trump's radical anti-immigrant agenda. Our government must prioritize investing in working families over ICE raids and more militarization of our communities.

Brown graphic reading "Instead of spending $268,999,966,016 or $2,358 per taxpayer, the U.S. could fund:..." with a list of things that could be funded instead, including school teachers, firefighters, and people on medicaid

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Schiracha (Schirra) @schiracha.bsky.social · 23/09/2026

After my postdoc I will likely go back to teach high school. As someone who thoroughly enjoys teaching at that level, I feel like its becoming more and more necessary. The education system is being dismantled. Good science teachers are hard to come by in rural America. Rebuild the foundation

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Schiracha (Schirra) @schiracha.bsky.social · 22/09/2026

Oh no! Don't tell Florida man that science can save the plants from disease! The radical left fake news is trying to trick them into gain of function research, it couldn't possibly be that a higher level of understanding of underlying biology leads to solutions that benefit mankind! 😨

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Schiracha (Schirra) @schiracha.bsky.social · 22/09/2026

A good case study for peak evolutionary niche filling? Can this species adapt to environmental challenges over reasonable time scales?

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Harmit Singh Malik @harmitmalik.bsky.social · 22/09/2026

Amazing work

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Schiracha (Schirra) @schiracha.bsky.social · 22/09/2026

Exactly. If is malfunctioning, and "going against its instructions", that's bad programming. Code can only do what code what built to do.

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The Onion @theonion.com · 21/09/2026

Congress Sends Unemployed Americans 40 Million Boxes Of Saltwater Taffy From Vacation theonion.com/congress-sends-unemplo…

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Schiracha (Schirra) @schiracha.bsky.social · 22/09/2026

If on section of fox news can boycott trump, than the GOP can impeach him.

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Sue Biggins @suebiggins.bsky.social · 21/09/2026

Here it is! @basicsci.fredhutch.org is searching for an associate or senior faculty member!

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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026

ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...

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Schiracha (Schirra) @schiracha.bsky.social · 21/09/2026

Oh, well at least now we can get the play book on what not to do and then go right ahead and do it.

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The Onion @theonion.com · 19/09/2026

Parents Gently Explain To Child That Their Money In Heaven Now theonion.com/parents-gently-explain…

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Schiracha (Schirra) @schiracha.bsky.social · 20/09/2026

Lowes and Amazon on Christmas is just way too early and for those of us with young children it is just the worst.

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Schiracha (Schirra) @schiracha.bsky.social · 20/09/2026

This is a horror story I did not need before Halloween.

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The New York Times @nytimes.com · 20/09/2026

As incidents involving rogue artificial intelligence become more common, so too have calls for a mechanism that would easily power down A.I. systems that go dangerously off the rails — a so-called kill switch. But creating such a switch is much more difficult than many policymakers assume.

nyti.ms

Creating a Kill Switch to Shut Down a Rogue A.I. Is Harder Than It Sounds

A bipartisan group in Congress and Gov. Gavin Newsom of California have floated ideas for building a mechanism that would instantly power down an A.I. system. Only no one really knows how.

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Chise @sailorrooscout.bsky.social · 18/09/2026

Oh to be a little Tardigrade walking around a microscopic volvox algae colony. 🫧🐻🧪

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Schiracha (Schirra) @schiracha.bsky.social · 19/09/2026

Discussiom have been moved indoors as bigfoot will attack bigots discussing their existance within earshot.

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Schiracha (Schirra) @schiracha.bsky.social · 18/09/2026

One of the things I like about the network view is i can process multiple data collections in a single project and keep track of each pipeline. Then when I merge star files later, and combine data sets, it's all under one roof, no guessing and no jumping. #Relion #cryoEM #cryoET ❄️🔬

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Schiracha (Schirra) @schiracha.bsky.social · 18/09/2026

Cool science, made the NYTimes, but honestly Science Journal should've done better to tell Jennifer to not salami slice this study into 2 papers. But when you have the Nobel...

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Carl Quintanilla @carlquintanilla.bsky.social · 18/09/2026

Cost of diesel for a typical Los Angeles-to-Dallas truckload: $1,430 — up about $600, or 72%, from the day before the Feb. 28 strikes on Iran.” @bloomberg.com ⛽️

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Robert Reich @rbreich.bsky.social · 17/09/2026

Elizabeth Warren, AOC, and other members of Congress have introduced a bill to ban private equity funds from owning or controlling medical practices. This is a big deal. Here’s what you need to know about the shady private equity industry and how it operates.

youtube.com

This One Thing Is Making Your Life More Expensive | Robert Reich

Private equity is shutting out millions of people from buying their own homes.In 2021, private equity investors bought n

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Schiracha (Schirra) @schiracha.bsky.social · 18/09/2026

Shortly after buying from another store, her credit information was stolen...

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Patrick van der Wel @pcavanderwel.bsky.social · 18/09/2026

A new preprint from my lab - this time on chemRxiv: Xingang Liu et al "Unmasking the Non-Covalent Nature of HA–Dopamine Assemblies: Insights from 1H NMR Degradation Tracking and Multidimensional NMR” Notably, my lab’s first solution #NMR paper !! #nmrchat #glycotime doi.org/10.26434/che...

doi.org

Unmasking the Non-Covalent Nature of HA–Dopamine Assemblies: Insights from 1H NMR Degradation Tracking and Multidimensional NMR | ChemRxiv

Hyaluronic acid (HA) is a polysaccharide with diverse clinical and industrial applications. One of the key challenges is its sensitivity to enzymatic degradation. Chemical modifications offer a potent...

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Schiracha (Schirra) @schiracha.bsky.social · 18/09/2026

This is insane. There is so much 3d flu data it took me second to understand the images but they are aamazing

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Schiracha (Schirra) @schiracha.bsky.social · 17/09/2026

If you are preaching against #vaccinehesitancy but then also preaching for #AIhesitancy, you are preaching healthy #skepticism in one domain and advocating unhealthy skepticism in another. Embrace the #technology with healthy skepticism in the name of #science. #KeepCalmAndCarryOn.

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Schiracha (Schirra) @schiracha.bsky.social · 17/09/2026

I thought terrible legacies was the goal of this administration? Is it not the goal?!

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PLOS Biology @plosbiology.org · 17/09/2026

#Flaviviruses reshape cell membranes to build replication sites, but how are these organized? This study shows that homotypic #membrane tethering driven by host ER protein atlastin-2 is essential for organizing these sites & supporting #viral replication @plosbiology.org 🧪 buff.ly/9MBKCbR

Left: A549 cells expressing HA-tagged ATL2 were infected with ZIKV. After 48 h, cells were fixed with paraformaldehyde and glutaraldehyde, followed by staining for dsRNA and HA using specific antibodies and reversible saponin permeabilization. Cells were imaged by confocal microscopy, then immediately embedded and processed for EM imaging. Right: Model. ATL2 membrane tethering is critical for the spatial organization of flavivirus genome replication. ATL2 tethering dimers bring ER membranes into close contact, facilitating the trafficking of newly synthesized viral genomes from existing vROs into vROs forming on juxtaposed membranes (top). This close connection forms a microdomain which brings together the necessary factors for nascent vRO formation and shields the cytosol-exposed viral RNA from innate immune sensors. Because membrane tethering is reversible, this also permits the expansion of viral genome replication away from sites of existing vRO biogenesis. In the absence of ATL2 membrane tethering (bottom), viral genomes extruded from the vRO are exposed to the cytosol and more likely to form new vROs on the same membrane, leading to the concentration of sites of vRO biogenesis and increased recognition by RIG-I-like receptors (RLRs) in the cytosol.

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jenna newman phd @jennanewman.bsky.social · 17/09/2026

“To navigate the shock waves of A.I., we must restore social science research as an enterprise that starts from the public interest.”🧪 @himself.bsky.social @alisongopnik.bsky.social

“The fear that machines were wrecking society created political demand for reliable information on what was happening on the ground and how people were living. In Britain, where the Industrial Revolution began, the journalist Henry Mayhew calculated that hundreds of Londoners made their living gathering bones, rags and cigar ends from the street, as well as dog excrement for tanneries.
Commissions of inquiry and censuses followed and gathered information on working conditions and education.
Politicians, lawyers and bureaucrats debated whether allowing poor people to vote would lead to disaster.

Social science research arose to study these issues in a more rigorous fashion.
Economists studied markets, political scientists studied politics and the state, sociologists studied changing society, and psychologists studied minds. Though these investigations had flaws and were sometimes biased, together they rebuilt our public understanding of what was necessary and possible.”

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Schiracha (Schirra) @schiracha.bsky.social · 17/09/2026

Unsurprising result but verification is the only way to know and now action can be taken to help and support the haters until they are no longer haters. Also start changing the way we educate people early on.

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Shicheng Guo @shihcheng.bsky.social · 17/09/2026

Breakthrough: Cryo-EM reveals structures of human LWS-, MWS-, and SWS-opsins with G protein, decades after rhodopsin. Stunning insights! PMID:42348690, Science 2026, @ScienceMagazine doi.org/10.1126/science.adz8141 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

doi.org

https://doi.org/10.1126/science.adz8141

No description available

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Schiracha (Schirra) @schiracha.bsky.social · 17/09/2026

Finally! More of this. Where are the Ivies?

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