Schiracha (Schirra) @schiracha.bsky.social · 6hWhen you say "the function of this protein is... ONE THING" I'm sorry, you're just wrong. Instead "We know the protein does this ONE THING, so there is still much to be discovered because every protein interacts with other things in its environment and has many different potential interactions" 052
Schiracha (Schirra) @schiracha.bsky.social · 7hYes! More #protocol papers. Because, you know damn well, a 2 paragraph "method" with 8 citations starting from 1995 and going to 2025 is not only impossible to reproduce, it still manages to forget that BME works but DTT doesn't. This (right here) is how you #DoBetter in #Science 000
Reposted by Schiracha (Schirra)Max Planck Institute for Plant Breeding Research @mpipz.bsky.social · 11h📣Paper Alert! 🥳 A new study @cp-cell.bsky.social from the Schulze-Lefert group @mpipz.bsky.social reveals how Arabidopsis adapts its iron acquisition strategy to soil pH, using coumarins & bacterial pathways to access this essential nutrient. 👏 👉 bit.ly/4yEU9Em #plantsci www.cell.com/cell/fulltex...cell.comArabidopsis uses distinct coumarins and bacterial pathways for pH-adaptive iron acquisitionArabidopsis coordinates Fe acquisition with its root microbiota by releasing distinct coumarin chemotypes in response to environmental pH. These root-exuded specialized metabolites interact with root-... 03015
Reposted by Schiracha (Schirra)Jennifer Ouellette @jenlucpiquant.bsky.social · 7hAn experimental tour-de-force: Entanglement between glass bead and light arstechnica.com/science/2026...arstechnica.comAn experimental tour-de-force: Entanglement between glass bead and lightGetting a glass bead to act like a quantum object by entangling it with light. 0122
Reposted by Schiracha (Schirra)Marco Mauri @marcomauri.bsky.social · 7h🚨 In 1h, at 15:30 EU, Marco Cosentino Lagomarsino (University of Milano and IFOM) will present the talk Ribosomal growth laws, beyond bacteria at the Population Dynamics Seminars. Subscription sites.google.com/view/popdyn/ 033
Schiracha (Schirra) @schiracha.bsky.social · 7hSo right fucking now is the time to write a couple #grants that support this claim by real #scientists and when the #evidence comes back that the #virus is much worse, #publish proactively before the pseudo scientists get ahead of this. And go! 000
Schiracha (Schirra) @schiracha.bsky.social · 17h**puts typo in the word language ** Posting without glasses is like driving while intoxicated, kids... only on your own property when no one else is around otherwise it's frowned upon and very dangerous 000
Schiracha (Schirra) @schiracha.bsky.social · 18hRealizing I am much better at the theory, principles and technical languagehl than the bench. I am just going to introduce myself as a Philosopher of Biophysics from now on. Then when I break more glassware, I can claim I had a stroke of genius and run away.static.klipy.comMichael Scott Declares Bankruptcy in The OfficeALT: Michael Scott Declares Bankruptcy in The Office 100
Reposted by Schiracha (Schirra)Vytaute Boreikaite @vytaute.bsky.social · 08/10/2026I’m very excited to share my postdoc work in the @plaschkalab.bsky.social, where we investigated the very final act of splicing – spliceosome termination, revealing the stepwise dismantling of the spent spliceosome www.nature.com/articles/s41... (1/11)nature.comMechanism of spliceosome termination - NatureA coordinated sequence of RNA helicases and associated factors dismantles normal and defective spliceosome complexes to enable intron degradation and ensure accurate gene expression. 27525
Schiracha (Schirra) @schiracha.bsky.social · 07/10/2026www.facebook.com/share/v/1BjL...facebook.com 000
Schiracha (Schirra) @schiracha.bsky.social · 07/10/2026Exactly what I was looking for for my structure lecture next month. Now to see if it actually works 030
Reposted by Schiracha (Schirra)Institute of Science and Technology Austria (ISTA) @istaresearch.bsky.social · 01/10/2026Do bacteria have sex? ISTA scientists @pavelpayne.bsky.social and Călin Guet have uncovered a process resembling sexual reproduction that occurs when the gut bacterium E. coli is close to starvation. Read more: ista.ac.at/en/news/bact...ista.ac.atBacterial Immunity—or a Form of Sex?How do bacteria adapt when resources run low? ISTA researchers have found that, under starvation stress, E. coli can use bacteriophages and CRISPR-Cas immunity to transfer and incorporate DNA, acceler... 193
Reposted by Schiracha (Schirra)Javier del Campo @fonamental.bsky.social · 07/10/2026An atlas of eukaryotic centromere architecture reveals recurrent evolutionary dynamics #protists www.biorxiv.org/content/10.6... 14114
Schiracha (Schirra) @schiracha.bsky.social · 06/10/2026static.klipy.comOppenheimer: J. Robert Oppenheimer WalkingALT: Oppenheimer: J. Robert Oppenheimer Walking 020
Schiracha (Schirra) @schiracha.bsky.social · 06/10/2026Oh yes. My favorite greeting is "Hello Random, " because my name is Randall. I turn off autocorrect in settigns and just have to right click all the words underlined with little red squiggles because I dont want to call people by some random word after getting called "Random" myself several times. 010
Schiracha (Schirra) @schiracha.bsky.social · 06/10/2026There seems to be a spreading misconception that systems are intentional or almost 'designed' and this is not the case. Its extremely important to be careful with our #language when speaking to students as they internalize these concepts rapidly and lean into them. #scientists and #educators 000
Schiracha (Schirra) @schiracha.bsky.social · 06/10/2026Speaking about #biochemical reactions with intention is common and I would argue its fine as long as you understand that there really is no intention of a #subcellular process. A #virus has no intention, neither does a cell. They react together under given conditions because of underlyimg #physics. 120
Reposted by Schiracha (Schirra)Banned Books Week @bannedbooksweek.bsky.social · 05/10/2026TODAY! Don't miss the spotlight on Buffalo Fluffalo writer and honorary chair Bess Kalb, led by youth honorary chairs Marshall Romero and Azeemah Sadiq. 2pm ET ala-events.zoom.us/webinar/regi... #BannedBooksWeek #LetBooksBe 326651
Reposted by Schiracha (Schirra)The New York Times @nytimes.com · 03/10/2026In @nytopinion.nytimes.com As the UN General Assembly embraced “blustering speeches and endless unread communiqués,” our columnist Lydia Polgreen says, Zohran Mamdani seems to be “offering an antidote to globe-spanning distemper. To restore faith in institutions, you must begin from the bottom up.”nyti.msOpinion | Zohran Mamdani Is Showing the World How It’s DoneThe New York City mayor has an antidote to globe-spanning distemper. 1729463
Reposted by Schiracha (Schirra)Alondra Nelson @alondra.bsky.social · 03/10/2026In the Biden administration, l led the team that developed what was arguably the first White House “AI safety” framework, the AI Bill of Rights. David Robinson, author of this forthright and sobering essay about risk culture at OpenAI and in Silicon Valley was on that team. 10443188
Reposted by Schiracha (Schirra)Jennifer Ouellette @jenlucpiquant.bsky.social · 04/10/2026Milt Windler, NASA flight director who helped save Apollo 13, dies at 94 arstechnica.com/space/2026/1...arstechnica.comMilt Windler, NASA flight director who helped save Apollo 13, dies at 94Milt Windler, one of the leaders of Mission Control who directed the effort to bring the Apollo 13 astronauts back to Earth safely, has died. 29023
Reposted by Schiracha (Schirra)Addgene @addgene.bsky.social · 04/10/2026On this day 75 years ago, Henrietta Lacks died of aggressive cervical cancer. She left behind a husband, five children, and a sample of her cancer cells — taken without her knowledge — that had already begun to replicate independently in a lab. Thread 🧵👇 (1/8) #HenriettaLacks #HeLa #Bioethics 12314
Reposted by Schiracha (Schirra)RCSB Protein Data Bank @rcsbpdb.bsky.social · 04/10/2026How X-rays and crystals revealed the true nature of things The story behind the 100-year-old discovery that continues to render Nobel Prizes.nobelprize.orgHow X-rays and crystals revealed the true nature of things - NobelPrize.orgThe story behind the 100-year-old discovery that continues to render Nobel Prizes. 0122
Reposted by Schiracha (Schirra)Sean Carroll @seanmcarroll.bsky.social · 03/10/2026I do think philosophy as a discipline has dramatically underperformed at answering the question “When would an artificial system qualify as conscious?” Should have nailed that one long before it became a practical issue. 4217916
Schiracha (Schirra) @schiracha.bsky.social · 04/10/2026I thunk Vegas is part of mega Denver. I do support the dome idea . The Truman show will kill 000
Schiracha (Schirra) @schiracha.bsky.social · 01/10/2026The guilty feeling of taking a non-conference #vacation defeated thanks to this little #adventurer who climbed rabbit ears and fish creek falls in Steamboat #Colorado 010
Reposted by Schiracha (Schirra)Arnaud Vanden Broeck @avbroeck.bsky.social · 23/09/2026Very happy to share the first paper from our lab, out now in Nature Communications!🎉🥳 Structural basis of step II Spliced Leader RNA trans-splicing in trypanosomatid parasites 🧬🔬 🔗 www.nature.com/articles/s41... @natcomms.nature.com @universitedeliege.bsky.social @rockefeller.edu #cryoEM #cryo-EM 33410
Reposted by Schiracha (Schirra)Vasilii Mikirtumov @vasiliimikirtumov.bsky.social · 24/09/2026to keep the channels fully intact, we have purified sarcoplasmic reticulum (SR) vesicles directly from the native muscle tissue (completely detergent-free). and then we did tomography ofc, look at these beautiful RyR1 arrays sitting on the vesicle surfaces! 131
Reposted by Schiracha (Schirra)David Solecki @so-lets-kilab70.bsky.social · 24/09/2026Georgios Skiniotis and I are announce a unique St. Jude faculty search: a joint effort between the CoE for Structural Cell Biology an intellectual community advancing structural imaging & the Division of Neuronal Cell Biology. CryoET/vEM + neuron cell biology = 🚀 talent.stjude.org/careers/JobD...talent.stjude.orgFaculty position, Neuronal Cell Biology and Cryo-ET/vEMDepartment of Developmental NeurobiologyCenter of Excellence for Structural Cell Biology and Neuronal Cell Biology DivisionSt. Jude Children’s Research HospitalThe Center of Excellence for... 01818
Reposted by Schiracha (Schirra)cryoEM papers @cryoempapers.bsky.social · 25/09/2026On-grid enrichment strategies in cryo-EM: affinity-functionalized supports for low-abundance and challenging targets pubmed.ncbi.nlm.nih.gov/42781870/ #cryoEM 063
Reposted by Schiracha (Schirra)Cedric Feschotte @cedricfeschotte.bsky.social · 24/09/2026Thrilled to see this published today! Truly special because we made the initial discovery >15 yrs ago! We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic! www.science.org/doi/10.1126/... 🧵1/nscience.orgEscape of the BC200 gene to a human poxvirus reveals its persistent transposition in primatesTransposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta... 216986
Reposted by Schiracha (Schirra)Sjors Scheres @sjorsscheres.bsky.social · 24/09/2026Over the last week I have had separate discussions with three people being disillusioned by how bad their colleagues are at their job. Large organizations seem worse. I wonder whether having line managers work together with their people, instead of just leading from above, is a good solution. 282
Schiracha (Schirra) @schiracha.bsky.social · 24/09/2026Repost with your favorite version of James Bond. Wrong answers only.static.klipy.comChristian Bale as BatmanALT: Christian Bale as Batman 011
Schiracha (Schirra) @schiracha.bsky.social · 23/09/2026...in order to form a more perfect union, establish justice, ensure domestic tranquility, provide a common defense and promote the general welfare.. Its in the preamble not the constitution, so it doesnt matter... 000
Schiracha (Schirra) @schiracha.bsky.social · 23/09/2026Total external reflectance microscopy Its sort of like "vegetative electron microscopy" 000
Schiracha (Schirra) @schiracha.bsky.social · 23/09/2026I feel like the onion has had to get increasingly ridiculous and less political as politics has become so unbelievable 000
Reposted by Schiracha (Schirra)Korak Ray @korakray.bsky.social · 23/09/2026🚨Preprint news!!🚨 Using specifically purified mitotic chromosomes, we show that chromosome mechanics vary based on identity and cell type. Chromosomes from differentiated cells are more compact and stiffer, likely due to increased non-covalent crosslinks within them www.biorxiv.org/content/10.6...biorxiv.orgIndividual mouse mitotic chromosomes exhibit cell type-specific differences in biomechanical propertiesCyclic episodes of chromosome compaction and de-condensation are features of eukaryotic cell division that aid mitotic segregation and help prevent aneuploidy. While biophysical data on mitotic chromo... 053
Reposted by Schiracha (Schirra)Jenna Norton @jenna-m-norton.bsky.social · 23/09/2026As you call members of Congress to raise concern about a Vought-led grant review panel, encourage them to sign onto proposed legislation that could help: 1) Follow the Science Act by @degette.house.gov would remove political appointees from the grant-making process: www.congress.gov/bill/119th-c...congress.gov 27646
Schiracha (Schirra) @schiracha.bsky.social · 23/09/2026Ask both what your country can do for your and what you can do for your country. If you can lead a lab, you can lead a community. Vote blue in November to rescue democracy and consider running for local offices. The best way to change the system is to be the system. - Veteran and scientist. 021
Reposted by Schiracha (Schirra)ACLU @aclu.org · 22/09/2026Taxpayers are footing the bill for President Trump's radical anti-immigrant agenda. Our government must prioritize investing in working families over ICE raids and more militarization of our communities. 7269110
Reposted by Schiracha (Schirra)Nature @nature.com · 22/09/2026The device can image materials as low as about -266 degrees Celsius for 30 hours or more go.nature.com/4yfed06go.nature.comThis super-cold microscope could spur a quantum revolutionThe instrument, which operates near absolute zero for hours, will soon ship to a few labs. Researchers are thrilled. 1262
Reposted by Schiracha (Schirra)Mark Peifer (He, him) @peiferlabunc.bsky.social · 23/09/2026@ascbiology.bsky.social Have you spoken up? 1114
Schiracha (Schirra) @schiracha.bsky.social · 23/09/2026After my postdoc I will likely go back to teach high school. As someone who thoroughly enjoys teaching at that level, I feel like its becoming more and more necessary. The education system is being dismantled. Good science teachers are hard to come by in rural America. Rebuild the foundation 0122
Schiracha (Schirra) @schiracha.bsky.social · 22/09/2026Oh no! Don't tell Florida man that science can save the plants from disease! The radical left fake news is trying to trick them into gain of function research, it couldn't possibly be that a higher level of understanding of underlying biology leads to solutions that benefit mankind! 😨 010
Schiracha (Schirra) @schiracha.bsky.social · 22/09/2026A good case study for peak evolutionary niche filling? Can this species adapt to environmental challenges over reasonable time scales? 110
Reposted by Schiracha (Schirra)Harmit Singh Malik @harmitmalik.bsky.social · 22/09/2026Amazing work 0182
Schiracha (Schirra) @schiracha.bsky.social · 22/09/2026Exactly. If is malfunctioning, and "going against its instructions", that's bad programming. Code can only do what code what built to do. 030
Reposted by Schiracha (Schirra)The Onion @theonion.com · 21/09/2026Congress Sends Unemployed Americans 40 Million Boxes Of Saltwater Taffy From Vacation theonion.com/congress-sends-unemplo… 171537165