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Patrick van der Wel

@pcavanderwel.bsky.social
1.7K followers 1.7K following 505 posts

Solid-state NMR, Zernike Institute, university of Groningen. Posts = personal. Spectroscopy, biochemistry, structural biology, amyloid & condensates, Huntington disease, membrane biophysics, biomaterials etc

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Patrick van der Wel @pcavanderwel.bsky.social · 3h
Interesting podcast featuring @jasonsynaptic.bsky.social talking about tau, arc and extracellular vesicles… in This Week in Neuroscience : overcast.fm/+AAVD6PZHkhs
overcast.fm
TWiN 75: Arc, tau, and Alzheimer’s — This Week in Neuroscience
Jason Shepherd joins TWiN to discuss the work in his laboratory showing that Arc protein plays a role in intercellular transmission of tau protein, which becomes hyperphosphorylated and misfolded, a m...
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Kai Yi @kaiyi94.bsky.social · 23h
1/7 Excited to share GuideFlip! We use guided discrete flow matching to co-design protein sequences and structures for flexible interactions, with experimental validation across three systems: α-synuclein, RBX1 and active-state GPCR nanobodies.
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Virtual ChemBioTalks @chembiotalks.bsky.social · 29/09/2026
The Virtual ChemBioTalks get on the way with a great keynote lecture by @dirktrauner.bsky.social. He gave an insightful talk on "Designing Molecules to Restore Human Vision and Alleviate Pain" #ChemBioTalks #ChemBio #ChemSky #AnywhereChem #Science
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Prof Frank McDonough @fxmc1957.bsky.social · 29/09/2026
29 September 1571. Leading artist Michelangelo Caravaggio was born in Milan. He used an innovative use of light and dark called tenebrism which placed subjects in bright beams of light against dark shadows. He depicted saints and biblical figures using ordinary people as models.
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Tom Flood @tomflood.bsky.social · 28/09/2026
strange how your family has no interest in your work when travel is in North America yet as soon as you’re scheduling Aus/NZ dates everyone is like “hey dad would be great to see you do your thing?”
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Patrick van der Wel @pcavanderwel.bsky.social · 28/09/2026
Webinar: "Proteostasis Consortium Seminar: Amyloid Polymorphism: More than just the Fibril Core”. by Sheena Radford @radford-lab.bsky.social (presumably about the cruciial ‘fuzzy coat’ of #amyloid fibrils ) Sep 30, 2026; #Proteostasis consortium seminar www.proteostasisconsortium.com/seminars/
urldefense.com
Proteostasis Consortium Seminars | Proteostasis Consortium
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Virtual ChemBioTalks @chembiotalks.bsky.social · 22/09/2026
Due to force majeure we have a change in our speaker program. We are very thankful that @dirktrauner.bsky.social agreed to give a keynote lecture on "Designing Molecules to Restore Human Vision and Alleviate Pain". If you have not registered yet, do so for free: events.zoom.us/ev/Ag1AUcW3n...
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Chelsea Brown @chelseabrown.bsky.social · 01/09/2026
We used CG simulations to investigate this at a large scale, and saw that these dimers could also generate membrane curvature. An incredibly high level of cardiolipin occupancy was measured, with residues known to be vital for cardiolipin recruitment found at this binding site
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Jannis Anstatt @jannisanstatt.bsky.social · 22/09/2026
A cool new pathway that could explain how lysosomal BMP synthesis is decoupled from mitochondrial cardiolipin synthesis although both are structurally derived from PG!
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Dagblad van het Noorden @dvhn.nl · 26/09/2026
Minister Karremans: beloftes over aanpak spoorknooppunt Meppel en Nedersaksenlijn niet langer heilig
dlvr.it
Minister Karremans: beloftes over aanpak spoorknooppunt Meppel en Nedersaksenlijn niet langer heilig
De beloofde aanleg van de Nedersaksenlijn en de aanpak van het spoorknooppunt Meppel zijn volgens VVD-minister Vincent Karremans van Infrastructuur niet langer heilig.
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David Eerdmans @davideerdmans.bsky.social · 16/09/2026
Hebben jullie toevallig nog tips voor fijne non-fictie-boeken om mee te nemen op reis binnenkort? Bijvoorbeeld over geschiedenis (vooral vanaf industriële revolutie), wetenschap (bijv. toegankelijk uitgelegde dingen over het heelal etc), politiek, maatschappij...
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Gawen Jenkin @gawenjenkin.bsky.social · 25/09/2026
They then publish their method - and everyone uses AI to game their application so it says the right things and gets a high score. What then? No prizes for doing something different and imaginative.
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Ed Hollox @edhollox.bsky.social · 24/09/2026
Dreadful, I'm sorry. The obvious next step is to sell those LLMs to universities who can then churn out grant applications perfectly tailored to these models without any academic input at all. A triumph of efficiency...
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Dutchscientist (the real one) @dutchscientist.bsky.social · 25/09/2026
What food will you bring to a job interview?
static.klipy.com
Man Eats Huge Ice Cream Cornet
ALT: Man Eats Huge Ice Cream Cornet
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Patrick van der Wel @pcavanderwel.bsky.social · 18/09/2026
A new preprint from my lab - this time on chemRxiv: Xingang Liu et al "Unmasking the Non-Covalent Nature of HA–Dopamine Assemblies: Insights from 1H NMR Degradation Tracking and Multidimensional NMR” Notably, my lab’s first solution #NMR paper !! #nmrchat #glycotime doi.org/10.26434/che...
doi.org
Unmasking the Non-Covalent Nature of HA–Dopamine Assemblies: Insights from 1H NMR Degradation Tracking and Multidimensional NMR | ChemRxiv
Hyaluronic acid (HA) is a polysaccharide with diverse clinical and industrial applications. One of the key challenges is its sensitivity to enzymatic degradation. Chemical modifications offer a potent...
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Giovanni D’Angelo @giodang.bsky.social · 23/09/2026
#lipidtime: It's a lipid universe. Today in Nature we publish the Lipid Brain Atlas, the first map of membrane lipid composition across the entire mouse brain, a layer of organisation that cell-type and transcript maps had left out. #lipidomics #neuroscience #BrainAtlas
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Biophysical Journal @biophysj.bsky.social · 23/09/2026
Special issue call for papers: Fifty Years of Protein Dynamics: Celebrating Andy McCammon and the Evolution of Computational Biophysics. buff.ly/JcBPrrO
biophysics.org
https://www.biophysics.org/Portals/0/BPSAssets/Publications/Documents/BJ_CallForPapers_ProteinDynamics.pdf#Page=1
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Roel Kramer @roelkramer.bsky.social · 23/09/2026
Het uitzicht vanaf het Groninger Forum verveelt nooit.
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Yale MB&B @yalembb.bsky.social · 23/09/2026
We are excited to announce a tenure-track position in Computational Biophysics and Biochemistry, exploring the intricate molecular and cellular processes and the complex interactions of their macromolecular components! apply.interfolio.com/193444
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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David Ho @davidho.bsky.social · 23/09/2026
Wtaf is this question my university just asked me about my project?
Does the project involve any work that could be interpreted as promoting DEIA, climate change research, or non-compliant to any Presidential Executive Orders?
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UKrant @ukrant.bsky.social · 22/09/2026
Dankzij de computersimulaties van moleculen die Siewert-Jan Marrink maakt, leren we meer over hoe cellen functioneren. ‘Je hebt altijd het gevoel dat je een soort ontdekkingsreiziger bent.’ ukrant.nl/magazine/een...
ukrant.nl
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What a week, huh? all Wednesdays @whataweekhuh.bsky.social · 23/09/2026
Captain Haddock looking very frazzled, saying, “What a week, huh?”
Tintin leans into the frame and says, “Captain, it’s Wednesday.”
Snowy aka Milou is very excited about the drink he has found.

Viñeta de Tintin
El capitán Haddock, sentado a una mesa y con aspecto de estar agotado, dice: "¡Menuda semana, ¿eh?".
Tintín, a su derecha, le dice: "Capitán, es miércoles".
A la izquierda, Milú mira muy contento la bebida que está en la mesa.
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Patrick van der Wel @pcavanderwel.bsky.social · 23/09/2026
Article in the @rug.nl university newspaper with our colleague Siewert-Jan Marrink: ukrant.nl/magazine/een... #Martini #moleculardynamics
ukrant.nl
Een perfecte digitale cel: de baanbrekende simulaties van Siewert-Jan Marrink
Dankzij de computersimulaties van moleculen die Siewert-Jan Marrink maakt, leren we meer over hoe cellen functioneren. ‘Je hebt altijd het gevoel dat je een soort ontdekkingsreiziger bent.'
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ENC @enc-conference.org · 21/09/2026
Abstract submissions are open for #ENC2027! Share your work with the magnetic resonance community at Asilomar, April 4–8, 2027. - Jan. 8: Oral + Early Decision Poster deadline - Feb. 19: Late-Breaking Poster deadline www.enc-conference.org/enc-2027 #ENC2027 #NMRchat #NMR
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Rahul K @theresearch.bsky.social · 20/09/2026
A call to action report from @mit.edu on AI and Education
aiandeducation.mit.edu
Report – AI and Education
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The Daily Show @thedailyshow.com · 16/09/2026
Make Sunsets founder Luke Iseman explains how he plans to solve the climate crisis with... balloons?
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Patrick van der Wel @pcavanderwel.bsky.social · 19/09/2026
Some rainy #running today. Recovery mode 🏃‍♀️
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Wilma M @wilmeij.bsky.social · 19/09/2026
Drukke dag gehad maar nu even tijd voor bluesky!😁 Gisteren zagen @wnmonique.bsky.social en ik ook nog de #paardenbijter en de #bloedrode-heidelibel in de Engbertsdijksvenen. 🧚‍♂️❤️😃 Fijne middag en avond! 🙋‍♀️ #natuur #libellen #dragonfly
Linksboven de paardenbijter.
Rechtsboven en onder de bloedrode heidelibel 🧚‍♂️❤️😃
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BioF:GREAT @biof-great.bsky.social · 17/09/2026
📅 Mark your calendars for the 2027 Gordon Research Conference on Glycobiology! 🗓️ March 14–19, 2027 📍 Ventura, California 🧬 BioF:GREAT is a proud sponsor & Dr. Lance Wells@docgatordawg1.bsky.social is co-chairing the conference! www.grc.org/glycobiology... #NSF #biofgreat #glycotime
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Patrick van der Wel @pcavanderwel.bsky.social · 18/09/2026
A new preprint from my lab - this time on chemRxiv: Xingang Liu et al "Unmasking the Non-Covalent Nature of HA–Dopamine Assemblies: Insights from 1H NMR Degradation Tracking and Multidimensional NMR” Notably, my lab’s first solution #NMR paper !! #nmrchat #glycotime doi.org/10.26434/che...
doi.org
Unmasking the Non-Covalent Nature of HA–Dopamine Assemblies: Insights from 1H NMR Degradation Tracking and Multidimensional NMR | ChemRxiv
Hyaluronic acid (HA) is a polysaccharide with diverse clinical and industrial applications. One of the key challenges is its sensitivity to enzymatic degradation. Chemical modifications offer a potent...
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#NeuroDegeneration preprints @prepub-neurodegen.bsky.social · 18/09/2026
Cryo-EM Structures of Infectious Low-Twist α-Synuclein Filaments in Lewy Bodies #NeuroDegeneration 🧪🧠 www.biorxiv.org/content/10.64898/20…
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Dagblad van het Noorden @dvhn.nl · 17/09/2026
Studenten RUG krijgen mail over weggestuurde docent. Rechter: universiteit zat fout
dlvr.it
Studenten RUG krijgen mail over weggestuurde docent. Rechter: universiteit zat fout
De Rijksuniversiteit Groningen (RUG) moet een mail rectificeren die is verstuurd aan studenten. Hierin wordt gesuggereerd dat een docent zich heeft misdragen richting zijn studenten.
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Chemjobber @chemjobber.bsky.social · 17/09/2026
This is the coolest #facultychemjobs positions I've seen in a long, long time: "Canada Impact+ Emerging Leader in the Chemistry of Wildfires", UBC-Okanagan, Kelowna, BC research.ubc.ca/media/file/i... Best wishes to those interested #chemjobscanada #chemsky
research.ubc.ca
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Geoff Hutchison @geoffhutchison.net · 16/09/2026
I was shocked after moving to Pittsburgh and learning there were 130 municipalities in Allegheny County, for like 1.2M people.
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ENC @enc-conference.org · 16/09/2026
Nominations are open for two prestigious awards! Oct. 31 → Laukien Prize Nov. 30 → Varian Young Investigator Award Learn more and submit your nominations through the ENC website. www.enc-conference.org/Awards #ENC2027 #NMRchat #NMR
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Dagblad van het Noorden @dvhn.nl · 16/09/2026
Scharissa (18) uit Bovensmilde vliegt naar Shanghai voor vakwedstrijd bloembinden. ’Rustig blijven is mijn sterkste punt’
dlvr.it
Scharissa (18) uit Bovensmilde vliegt naar Shanghai voor vakwedstrijd bloembinden. ’Rustig blijven is mijn sterkste punt’
Van Bovensmilde naar Shanghai om Nederland te vertegenwoordigen tijdens de finale van WorldSkills. Bloemiste Scharissa Blomsma (18) gaat het doen. Gespannen is ze niet, want ze heeft er het volste vertrouwen in.
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HDBuzz @hdbuzzfeed.bsky.social · 16/09/2026
Skyhawk Therapeutics shared data for SKY-0515, an experimental once-daily pill that targets both huntingtin and somatic instability, making it a possible “two-for-one” drug to treat HD. Read more about this exciting news on HDBuzz → en.hdbuzz.net/encouraging-...
Graphic of a megaphone with the words, "Encouraging news from Skyhawk Therapeutics!" above.Picture of pills from a pill bottle with words on text boxes: "A potential 2-for-1 approach to treat HD is safe and shows potential! SKY-0515 is an experimental once-daily pill that aims to lower huntingtin AND target somatic instability."Close up photo of a doctor checking lab results. Words in text boxes read, "In the Phase 1/2 study, SKY0515 did just that, and showed positive changes in tests of movement & thinking." But will that add up to a treatment that slows HD?"Text box: "Skyhawk's Phase 2/3 study, FALCON-HD, will tell us whether the Phase 1/2 study's promising signs hold up in a larger, placebo-controlled trial."
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Patrick van der Wel @pcavanderwel.bsky.social · 16/09/2026
For NMR/MR researchers in the Netherlands: the 61st NMR-DG meeting will be on Oct 16 in Wageningen. Keynotes by Rustem Valiullin (Leipzig) and Melanie Britton (Birmingham). Program and free registration: sac.kncv.nl/nmr/annual-m... #nmrchat #nmrdg
sac.kncv.nl
Annual Meeting - SAC
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Patrick van der Wel @pcavanderwel.bsky.social · 16/09/2026
Interesting new paper by Daniel Huster and colleagues, looking at #cardiolipin lipids, how they affect enzymes and membranes, and the role of (NMR-detected) dynamics: doi.org/10.1021/jacs... #nmrchat #ssNMR
doi.org
Cardiolipin Modulates the Activity of the Intramembrane Protease GlpG Inducing Membrane Restructuring
Abstract. Cardiolipin (CL) is a very important lipid in bacteria and the mitochondria of higher cells. CL is characterized by a unique structure, featuring
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What a week, huh? all Wednesdays @whataweekhuh.bsky.social · 16/09/2026
Captain Haddock looking very frazzled, saying, “What a week, huh?”
Tintin leans into the frame and says, “Captain, it’s Wednesday.”
Snowy aka Milou is very excited about the drink he has found.

Viñeta de Tintin
El capitán Haddock, sentado a una mesa y con aspecto de estar agotado, dice: "¡Menuda semana, ¿eh?".
Tintín, a su derecha, le dice: "Capitán, es miércoles".
A la izquierda, Milú mira muy contento la bebida que está en la mesa.
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Patrick van der Wel @pcavanderwel.bsky.social · 16/09/2026
“Dear Dr. van der Wel, Thank you for sending your manuscript …” Now we wait!
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Ben Auxier @benauxier.bsky.social · 15/09/2026
It's like PNAS Contributed papers, but for grants!
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Kumaran Ramamurthi @ramamurthilab.bsky.social · 15/09/2026
How do proteins localize in bacteria? Usually by binding to a prelocalized protein-but how does that protein localize? @vanipande.bsky.social found a #Bacillus subtilis protein that localizes via a lipid cue,undecaprenyl phosphate,that guides it to sites of PG synthesis www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Nikolay Tumanov @ntumanovxray.bsky.social · 27/08/2026
Night and thunderstorm - perfect time to present "The Cursed Glycine"! Let's start from light L-glycine: #chemchat 1/x
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Markus Deserno @markusdeserno.bsky.social · 31/08/2026
📣 I am super thrilled to announce that during “Emerging Science Week” the MSAF subgroup of the Biophysical Society will run a webinar with three awesome speakers on “Lipids Feeling the World.” More info, including how you sign up, is contained in the ALT text of the image! Please share widely! 🧪
Lipids form the compartments that organize life. While doing so, they interact with an incredible variety of other molecules and supramolecular structures—things that touch the membrane on either side, are embedded inside, or simply want to get through. What are the chemical and biophysical principles that shape such interactions? How have biomembranes evolved to become such versatile interfaces to the world? In this webinar we will hear from three scientists who have examined questions of this kind from different directions, focusing on different molecules, and using different tools.

Speakers:

(1) Janice Robertson, Dept. of Biochemistry and Molecular Biophysics, Washington University St. Louis, USA 
(2) Luca Monticelli, Molecular Microbiology and Structural Biochemistry, INSERM, Lyon, France 
(3) Rumiana Dimova, Biophysics Lab, Max-Planck-Institute for Colloids and Interfaces, Potsdam, Germany 

Here’s the link to register:

https://my.biophysics.org/Events/Calendar-Of-Events/Meeting-Home-Page?meetingid=4ea7bbbf-b695-f111-8075-6045bdff16f4

Attention: you’ll be asked to sign in or create an account. That’s just to keep track and send you an access link. YOU WILL NOT HAVE TO BE OR BECOME A BPS MEMBER!
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Markus Deserno @markusdeserno.bsky.social · 14/09/2026
Reminder! THIS IS TOMORROW, September 15, 11am EST. Please join us! Details for how are in the ALT text of the original post's image! Also, due to some logistic-snafu a wrong Zoom link was sent, but you all received the correct one later by email, and will again receive it prior to the webinar!
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Patrick van der Wel @pcavanderwel.bsky.social · 15/09/2026
Ooof… grant submitted. Just in time… :) fingers crossed
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Frédéric A. Perras @fredaperras.bsky.social · 14/09/2026
To me, the result we found in this work was truly shocking. @carlfleischer.bsky.social was able to improve the performance of dipolar recoupling used in S-REDOR/S-RESPDOR by a factor of 5 over the status quo SR4 sequence!!! This means a near doubling of the distance scale! doi.org/10.1039/D6CP...
doi.org
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UofT Department of Chemistry @chemuoft.bsky.social · 14/09/2026
Join our faculty! The Department of Chemistry at U of T invites applications for a full-time tenure stream position in Theoretical Chemistry. To learn more or apply, visit: jobs.utoronto.ca/job/Toronto-...
Poster for a job ad for a Theoretical Chemistry Professor.
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Justin Taraska @taraska.bsky.social · 14/09/2026
Join us this Wednesday! "Biophysics of Clathrin Coat Assembly, Curvature, and Mechanics" Wednesday, September 16, 2026 1:00–3:00 PM Eastern Time Registration and meeting access my.biophysics.org/Events/Calen... Talks by Marko Kaksonen, Jeanne Stachowiak, Julien Berro, and Padmini Rangamani.
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