Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza A virus (IAV) transcription/replication process. Herein,...

Trois de nos plus grands scientifiques, Yasmine Belkaid, Bana Jabri et Alain Puisieux, prennent la parole pour appeler à des réponses courageuses des pouvoirs publics face aux attaques contre la recherche, aux Etats-Unis, mais aussi de ce côté de l’Atlantique.

Tenthorey et al. compare the effects of missense and indel mutations on the acquisition of functional novelty by the rapidly evolving antiviral protein TRIM5α. They find that single indel mutations al...

Here, using ribosomal profiling, the authors characterize the translatome of HIV-1 revealing tens of alternative open reading frames (ARF) that encode conserved viral antigens and show that ARF-derive...

In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

Functional systematic pseudotype virus-based analysis of the ability of diverse animal viruses to enter into a panel of well-characterized human cell lines shows a broad compatibility between animal v...

Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.

Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein co...

A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access

l'ANRS MIE lance son appel à projets « Emergences PRFI », destiné à soutenir des projets de recherche entre des équipes françaises et des équipes de recherche basées dans des pays à revenus faibles et...

Like all viruses, SARS-CoV-2, the causative agent of COVID-19, relies on host cell resources to replicate. Our study reveals that, among these resources, SARS-CoV-2 hijacks the oxysterol-binding prote...

Cell Discovery - The comprehensive SARS-CoV-2 ‘hijackome’ knowledge base

Kamel et al. apply complementary approaches to elucidate the composition of Sindbis virus ribonucleoproteins. They identified a subset of nuclear proteins that selectively translocate to the cytoplasm, interact with viral RNA, and suppress virus infection. Among them, U2 snRNP emerges as a ribonucleoprotein complex with moonlighting antiviral activity.

Zhou et al. discovered a specific role of adenosine modifications in the coding region of mRNAs. These chemical alterations slow down the movement of the ribosome during translation and trigger degradation of the corresponding mRNAs.

Parker et al. demonstrate that some proteins responsible for organizing ribonucleoprotein granules can chaperone intermolecular RNA-RNA interactions in addition to their role in scaffolding. These findings cement RNA-RNA interaction networks as a key component of granules, highlighting the need to further explore the regulation of RNA dynamics within granules.

Database confirms that overlooked segments of the genome code for a multitude of tiny proteins

Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultras...

Le premier jour du mois de décembre est synonyme de Journée mondiale de lutte contre le sida. La Coordination Régionale de Lutte contre le VIH (Corevih) des Hauts-de-France a publié des chiffres pour ...

The genomic RNAs of influenza A viruses (IAVs) are replicated in the nucleus of infected cells in th

ChIP-DIP (ChIP done in parallel) is a highly multiplex assay for protein–DNA binding, scalable to hundreds of proteins including modified histones, chromatin regulators and transcription factors, offe...

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KSHV modifies paraspeckles during its lytic replication cycle. They enhance virus replication by functioning as hubs for viral RNA processing and their modification is implicated in virus-mediated gen...