This Article demonstrates that direct preference optimization (DPO) can be used to effectively align an unsupervised structure-conditioned language model with biophysical information. The aligned mode...

introduction and membership Boston Protein Design and Modeling Club (BPDMC) is a community of computational protein engineers and modelers from both academia and industry. While we are based in Boston...

Artificial intelligence (AI) has reshaped protein design by enabling models trained on large-scale sequence and structure data to generate proteins wi…

AI adoption stalls not because of weak tools or insufficient training, but because learning remains invisible. Generative AI requires employees to redesign their own workflows, and in uncertain enviro...

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

Proteins and other macromolecules exist not in a single state but as dynamic ensembles of interconverting conformations, which are essential for catalysis, allosteric regulation, and molecular recogni...

Trump’s most brazen attack on free speech yet.

A simple, whitespace theme for academics. Based on [*folio](https://github.com/bogoli/-folio) design.

Led by US senator Jon Ossoff, the investigation cites hundreds of reports since January, including accounts of miscarriages, child neglect, and sexual abuse at ICE detention centers in dozens of state...

Deep learning methods trained on protein structure databases have revolutionized biomolecular structure prediction, but developing and training new models remains a considerable challenge. To facilita...

Recent efforts in protein language modeling have focused on scaling single-sequence models and their training data, requiring vast compute resources that limit accessibility. Although models that use ...

Protests against President Donald Trump and his administration are planned nationwide Saturday, but in Boston, organizers say the “No Kings” demonstration will look a little different, since the day o...

Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.

A massively parallel assay developed to map the essential photosynthetic enzyme rubisco showed that non-trivial biochemical changes and improvements in CO2 affinity are possible, signposting further e...

As Microsoft approaches its 50th anniversary, the landscape of work continues to evolve at an unprecedented pace. The past year has marked a pivotal shift, moving from predictions and controlled lab s...

The current “consensus” order in which amino acids were added to the genetic code is based on potentially biased criteria, such as the absence of s...