Bioactive microbial natural products remain the preeminent source of new lead compounds for drug development. Due to the increasingly high levels of strain and compound rediscovery from terrestrial en...

Bacteria of the genus Chlamydia cause millions of infections each year and have an obligate intracellular lifestyle that makes finding specific treatments particularly difficult. This study developed ...

Abstract. The Bakta command line application is widely used and one of the most established tools for bacterial genome annotation. It balances comprehensiv

Abstract. Microorganisms synthesize small bioactive compounds through their secondary or specialized metabolism. Those compounds play an important role in

Abstract. Microorganisms synthesize small bioactive compounds through their secondary or specialized metabolism. Those compounds play an important role in

How Real-Time Climate Data from Climate TRACE is transforming emissions tracking—bringing transparency, speed, and accountability to global climate action.

Making concerned people aware their views are far from alone could unlock the change so urgently needed

The Genome Taxonomy Database (GTDB) is an initiative to establish a standardised microbial taxonomy based on genome phylogeny.

Scientists, with expertise in fields that include mental health, cancer and infectious disease, typically serve five-year terms and were not given a reason for their dismissal.

The ability to capture images of results or processes is an important tool in the biologist’s tool kit. In microbiology, capturing high-quality images of mic...

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Abstract . Comparing and searching protein structures independent of primary sequence has proved useful for remote homology detection, function annotation,

Covering: 2019 to 2024 Secondary metabolites (SMs) are naturally occurring defense or signaling molecules that are also utilized as human and animal drugs, crop protection agents, and fine chemicals.…

AbstractSummary. Genome-centric analysis of metagenomic samples is a powerful method for understanding the function of microbial communities. Calculating r

Gene editing and many other useful biotechnology tools came from studies of bacteria fighting off viral invaders. But scientists have only begun to unlock the secrets of this ancient arms race.

The Chemistry and Biology of Natural Products Symposium XVIII

Biosynthetic gene clusters (BGCs) are usually tightly controlled to avoid production of costly goods at inappropriate time points or unfavorable conditions. However, in most cases, the regulatory sign...

The genus Streptomyces are valuable producers of antibiotics and other pharmaceutically important bioactive compounds. Advances in molecular engineeri…

Nature Biotechnology - An open letter to graduate students and other procrastinators: it’s time to write

Nature - A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common...

The mycobacterial cell envelope plays both infectious and protective roles. Understanding its structure is crucial for unlocking the molecular basis underlying these functions. Studying glycans, the p...

Covering: 2019 to 2024Secondary metabolites (SMs) are naturally occurring defense or signaling molecules that are also utilized as human and animal drugs, crop protection agents, and fine chemicals. C...

Nature Reviews Microbiology, Published online: 27 March 2025; doi:10.1038/s41579-025-01167-wPiddock and colleagues explore new antibacterial compounds in active late discovery phase and preclinical development focusing on innovative strategies, with a global health perspective.