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Andy Truman

@andytruman4.bsky.social
518 followers 593 following 32 posts

Group Leader at the John Innes Centre. Biosynthesis and discovery of specialised metabolites. Norwich. He/Him. www.jic.ac.uk/people/andrew-truman

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Reposted by Andy Truman
Max Jordan @maxljordan.bsky.social · 04/09/2026
Really excited to share our new manuscript on how the #NLR protein #AfsR regulates #Streptomyces antibiotic production - and how we can use its similarity to plant NLR immune receptors to enhance this production! 📄🧵 (1/17) @johninnescentre.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
A conserved NLR activation switch governs global transcriptional control of antibiotic biosynthesis in Streptomyces
Nucleotide-binding and oligomerization domain-like receptors (NLRs) are conserved molecular switches that regulate innate immunity across diverse domains of life. While best known for their roles in i...
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Reposted by Andy Truman
Otto English @ottoenglish.bsky.social · 13/12/2025
Meanwhile Robin Ince genuinely has been cancelled for daring to voice his opinions and for defending trans people. Where's the outrage from the "cancel culture" lot? What are the Free Speech Union doing to help him?
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Reposted by Andy Truman
John Innes Centre @johninnescentre.bsky.social · 11/12/2025
NEWS - Professor Mark Buttner receives Marjory Stephenson Prize 2026 Professor Buttner, one of our Emeritus Fellows, has received the @microbiologysociety.org Marjory Stephenson Prize for 2026. Congratulations Mark! 👏 Read about his exceptional research and career: www.jic.ac.uk/news/profess...
Professor Mark Buttner
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Reposted by Andy Truman
Greg Jenner (Historian) @gregjenner.bsky.social · 22/07/2025
People are starving to death, or being gunned down while desperately trying to access food at aid sites — even journalists are in grave danger. This abhorrent situation cannot be allowed to continue www.bbc.co.uk/news/live/cv...
bbc.co.uk
Gaza health ministry says 33 people dead from malnutrition in last 48 hours
New figures from the Hamas-run ministry include 12 children who have died, as the UN says Israel must allow aid into Gaza.
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Jennifer Raff @jenniferraff.bsky.social · 18/07/2025
Thanks for your advocacy and this excellent letter, @anthrofuentes.bsky.social !
science.org
This is not the time to step back from diversity, equity, and inclusion
Recently, I exchanged views with a prominent Ivy League scientist who was complaining about the minority students and junior faculty applying to his program. He claimed that the university, through di...
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Andy Truman @andytruman4.bsky.social · 12/07/2025
Cycling achievement unlocked: Strava “excluding” my ride as its rubbish AI can’t believe I could ride this fast 😂
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Andy Truman @andytruman4.bsky.social · 09/07/2025
It always pleases me to see how little we know. I can pick a random ~700 AA protein from a bacterial genome and it has no conserved domains and no characterised structural homologues, yet there are >1000 homologues across diverse Gram+ and Gram- bacteria.
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Reposted by Andy Truman
Dr. Lucky Tran @luckytran.com · 28/06/2025
Hungary banned Pride marches. This is the response ✊🏳️‍🌈
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Andy Truman @andytruman4.bsky.social · 20/05/2025
Super happy to see our work on lydiamycin biosynthesis, structure and function published in @pnas.org 😀 www.pnas.org/doi/10.1073/... The work is described in the thread below, where we use BGC info to guide the discovery of multiple key features of this antibiotic. @johninnescentre.bsky.social
pnas.org
Identification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target | PNAS
The natural products actinonin and matlystatin feature an N-hydroxy-2-pentyl-succinamyl (HPS) chemophore that facilitates metal chelation and confe...
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Andy Truman @andytruman4.bsky.social · 13/05/2025
Returning home after a fun couple of days in London at the RSC Chemical Biology Symposium and then the Chemical Biology Interface Council meeting. Excellent talks and always a joy to return to Burlington House @rsc.org
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Andy Truman @andytruman4.bsky.social · 13/05/2025
Happy Tuesday to everyone apart from whoever approved this awful design! Annoys me every time I use Greater Anglia.
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Andy Truman @andytruman4.bsky.social · 14/04/2025
Join us for the RSC Chemical Biology Leadership Retreat for Early Career Researchers! This is designed for researchers within 5 years of their first independent position. Bursuries are available (details in link below). Venue: Imperial College London Date: 10-12 Sep 2025 www.rsc.org/events/detai...
rsc.org
2nd CBIC Chemical Biology Leadership Retreat for Early Career Researchers
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Reposted by Andy Truman
Christine Faulkner @pdchristine.bsky.social · 11/03/2025
We're looking for a postdoc to join the lab to work on cell-to-cell communication via the apoplast. Candidate must be brave, as they will have to lead us (me) away from the plasmodesmata-lands we've inhabited for so long! www.jic.ac.uk/vacancies/po...
jic.ac.uk
Postdoctoral Researcher (Faulkner Group) | John Innes Centre
An exciting opportunity has arisen for a Postdoctoral Researcher to join the Faulkner Group at the John Innes Centre, working on cutting-edge science in the field of Cell & Developmental Biology.
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Reposted by Andy Truman
Pete Slater @peteslater.bsky.social · 20/02/2025
If you have a few minutes spare in your busy schedule today, it's well worth taking time to read this article from @lewisgoodall.com.
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Reposted by Andy Truman
John Innes Centre @johninnescentre.bsky.social · 13/02/2025
PRESS RELEASE - Professor Uauy appointed as Director of the John Innes Centre Following an international search, we are delighted to announce that Professor @cristobaluauy.bsky.social has been appointed as the next Director of the John Innes Centre. www.jic.ac.uk/press-releas... @ukri.org
jic.ac.uk
Professor Uauy appointed as Director of the John Innes Centre | John Innes Centre
Following an international search, Professor Cristóbal Uauy has been appointed as the next Director of the John Innes Centre. Professor Uauy is internationally recognised for his significant…
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Andy Truman @andytruman4.bsky.social · 11/02/2025
Utterly bonkers. I’m stating the very obvious, but it’s remarkable (yet also depressingly predictable) how quickly the proponents of “free speech” start banning everything they don’t like.
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Andy Truman @andytruman4.bsky.social · 11/02/2025
We have an exciting full-time permanent position available for a proteomics specialist for the Proteomics platform at @johninnescentre.bsky.social The platform has excellent facilities and provides essential experimental expertise research at the institute. jobs.jic.ac.uk/Details.asp?...
jobs.jic.ac.uk
John Innes Centre
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Andy Truman @andytruman4.bsky.social · 09/02/2025
#NowListening some banging tunes on.soundcloud.com/ZbMUDa61xrHo...
on.soundcloud.com
Anish Kumar - BBCR1 Essential Mix [02.11.24]
Tracklist 01 Anish Kumar - ID1 [unreleased] 02 DWIG - Luise und die Strandpiraten [Giegling] 03 Anish Kumar - ID2 [unreleased] 04 The Blessed Madonna - Exodus [Stripped & Chewed] 05 K-Lone - Cinco [Sw
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Andy Truman @andytruman4.bsky.social · 07/02/2025
Harmless Scientific Experiments for Boys (the introduction does at least acknowledge that girls can also use the book) including such “harmless” experiments as making gas from coal, and a DIY thermometer involving your own glass blowing and “a very small quantity of mercury” 🤔
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Reposted by Andy Truman
Sarah McAnulty, Ph.D. @sarahmackattack.bsky.social · 03/02/2025
Well the award for most cowardly, boot-lickingest academic society has squarely gone to the American Society of Microbiology, who has taken down features of various non-white scientists. Absolutely pathetic behavior. Those articles are now coming up as “under review”. Truly sickening cowardice here.
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Andy Truman @andytruman4.bsky.social · 28/01/2025
Is anyone having issues with NCBI at the moment? Really difficult to reliably retrieve sequence data using Entrez. Unsure if this is an impact of the absurd presidential decisions about the NIH, or just routine maintenance?
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Reposted by Andy Truman
Jeremy Noel-Tod @jntod.bsky.social · 09/01/2025
This is how Bruce Wayne became a millionaire
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Reposted by Andy Truman
Phil Carella @philcarella.bsky.social · 19/12/2024
Very happy to share the final version of our work on the evolution of broad host virulence in Pseudomonas out now @cellhostmicrobe It’s just in time for the holidays 🎄🦠 www.cell.com/cell-host-mi...
cell.com
A necrotizing toxin enables Pseudomonas syringae infection across evolutionarily divergent plants
Grenz et al. interrogate the Pseudomonas syringae species complex for its capacity to infect evolutionarily divergent host plants. Their results demonstrate that broad host isolates from phylogroup 2 rely on the lipopeptide toxin syringomycin to promote host necrosis and enhance bacterial growth in plants.
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Andy Truman @andytruman4.bsky.social · 13/12/2024
Returning to the UK after a great trip to beautiful Gent. Alway a pleasure to hear about the natural products research happening there 😊 Also got to dress up in a gown for the first time in years! Now to the JIC Mol Micro Xmas lunch to “recover” after last night’s Belgian beers 😂
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Reposted by Andy Truman
Mike Galsworthy @mikegalsworthy.bsky.social · 12/12/2024
Taking Britain out of the Erasmus+ programme was a huge mistake. Labour must rejoin and accept the EU’s offer of a youth mobility scheme
sussexbylines.co.uk
Bring back Erasmus+ and youth mobility in Europe
Taking Britain out of the Erasmus+ programme was a huge mistake. Labour must rejoin and accept the EU’s offer of a youth mobility scheme
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Reposted by Andy Truman
Mitja M. Zdouc @mmzdouc.bsky.social · 10/12/2024
Are you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...
academic.oup.com
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration
Abstract. Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in ag
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Reposted by Andy Truman
Matt Hutchings @handle.invalid · 29/11/2024
We find a lot of proteins - particularly antibiotic biosynthetic enzymes - are produced in soluble form in Streptomyces lividans but not E.coli. It’s a useful platform for the production of otherwise intractable proteins.
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Reposted by Andy Truman
Dr Katherine Duncan @kateduncan.bsky.social · 26/11/2024
The Natural Products Atlas 3.0: extending the database of microbially derived natural products - thanks to the Linington lab for letting the Duncan lab be part of the curation efforts academic.oup.com/nar/advance-... #NaturalProducts #SpecializedMetabolites #microsky #microbialchemistry
academic.oup.com
The Natural Products Atlas 3.0: extending the database of microbially derived natural products
Abstract. The Natural Products Atlas is a database of microbially derived natural products that contains structures, producing organism taxonomy, biosynthe
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Andy Truman @andytruman4.bsky.social · 20/11/2024
Congratulations to Nathan Byrne for passing his PhD viva 🍾 Thanks to @barriewilks.bsky.social and Chris Corre for agreeing to be examiners too!
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Reposted by Andy Truman
Dr Katherine Duncan @kateduncan.bsky.social · 19/11/2024
Just a reminder - I’ve made a second microbial natural products starter pack - let me know if you want added (please check you don’t already feature in the first pack to avoid duplication) go.bsky.app/4xnRN52
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Andy Truman @andytruman4.bsky.social · 19/11/2024
We have a fully funded 4-year PhD studenship available that builds on parts of this pre-print: biodtp.norwichresearchpark.ac.uk/projects/dis... 🗓️ Deadline 25 Nov 2024 Please do get in touch if you're interested!
biodtp.norwichresearchpark.ac.uk
Discovery and Function of Natural Metalloprotease Inhibitors | Doctoral Training Partnership
TRUMAN_J25DTP2
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Andy Truman @andytruman4.bsky.social · 15/11/2024
Trying to do a lot of writing at the moment, so have of course instead made a playlist of recent favourites… #nowlistening open.spotify.com/playlist/2WA...
open.spotify.com
Nov 2024
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Reposted by Andy Truman
Dr Katherine Duncan @kateduncan.bsky.social · 14/11/2024
If you’re interested in microbial specialized metabolites #naturalproducts - we’ve compiled a list of useful bioinformatics / community resources - it’s not meant to be comprehensive- just somewhere to start - let us know if you find it useful 😊 #microsky #secmet
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Andy Truman @andytruman4.bsky.social · 14/11/2024
New pre-print from the group 🥳 We use targeted genome mining to show that the plant pathogen Rhodococcus fascians makes the antibiotic lydiamycin. The BGC information then informed the discovery of multiple key features relating to the molecule 1/4 #biosynthesis www.biorxiv.org/cgi/content/...
biorxiv.org
Discovery of lydiamycin A biosynthetic gene cluster in the plant pathogen Rhodococcus fascians guides structural revision and identification of molecular target
The natural products actinonin and matlystatin feature an N-hydroxy-2-pentyl-succinamyl (HPS) chemophore that facilitates metal chelation and confers their metalloproteinase inhibitory activity. Actin...
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Reposted by Andy Truman
Henry Mance @henrymance.ft.com · 13/11/2024
For serious context, look at this: how Twitter fell off a cliff as a source of traffic for one publisher (the excellent conservation news site Mongabay) www.cell.com/trends/ecolo...
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Dr Katherine Duncan @kateduncan.bsky.social · 10/11/2024
go.bsky.app/72NeGsT
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Andy Truman @andytruman4.bsky.social · 13/11/2024
Some other recent work was this collaboration led by the Nair lab, where we showed how a nucleobase-peptide hybrid is generated from a ribosomal precursor peptide via YcaO domain protein catalysis #RiPPs #biosynthesis #Streptomyces www.nature.com/articles/s41...
nature.com
Biosynthesis of peptide–nucleobase hybrids in ribosomal peptides - Nature Chemical Biology
Naturally occurring peptide–nucleobase hybrids are rare. Here Pei et al. report the discovery and biosynthetic studies of the first peptide–nucleobase hybrid catalyzed by an RRE–YcaO–dehydrogenase com...
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Andy Truman @andytruman4.bsky.social · 13/11/2024
In an effort to populate my timeline a little, I'll post a few recent papers from the lab: First up is our work on understanding tropolone biosynthesis from the PhD of Alaster Moffat and some excellent biochemistry from the Teufel Lab #biosynthesis #Pseudomonas journals.asm.org/doi/10.1128/...
journals.asm.org
Understanding the biosynthesis, metabolic regulation, and anti-phytopathogen activity of 3,7-dihydroxytropolone in Pseudomonas spp. | mBio
Pseudomonas bacteria produce various potent chemicals that influence interactions in nature, such as metal-binding molecules, antibiotics, or plant hormones. This ability to synthesize bioactive molec...
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Andy Truman @andytruman4.bsky.social · 13/11/2024
Here to try this place as an alternative to the increasingly odd and toxic X. Looks like there's already a decent community over here 😀
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