Introduction Tuberculosis (TB) causes over 1 million deaths annually. Providing effective treatment is a key strategy for reducing TB deaths. In this study, we identified factors associated with unsuc...

Menopause is an important biological transition with up to 72 symptoms that shapes aging trajectories across organs and encompasses ~40% of the female lifespan. Although menopause awareness is increas...

The autoimmune regulator (Aire) promotes T cell tolerance through promiscuous gene expression in medullary thymic epithelial cells, but growing evidence suggests that it has functions beyond its canon...

10 priorities proposed to drive change in medicines for women’s health

Use of e-cigarettes makes it more likely that young people will experience mental-health disorders and take up smoking. Governments must act.

Many cancers associated with infection are preventable

Many treatment recommendations for invasive mould infections, particularly those caused by rare moulds, rely on non-randomised comparative effectiveness research (CER), which is vulnerable to design a...

In this study, increasing doses of antimicrobial prophylaxis did not improve SSI prevention. Antimicrobial side effect rates were much higher than expected, especially among patients receiving more do...

The CD1 system responds to lipids, not proteins, driving reactions to bee stings, bacteria, and possibly poison ivy

Background Children with idiopathic nephrotic syndrome (INS) receive prolonged glucocorticoids that can suppress the hypothalamic–pituitary–adrenal (HPA) axis and cause adrenal insufficiency (AI). We ...

Multiomic profiling provides a comprehensive physiological overview at the molecular level, but understanding of its spatiotemporal dynamics remains limited in human populations. We profiled longitudi...

Understanding what a ‘control’ is can help you decide for yourself how insightful new studies are.

A University of Melbourne survey of Australians as young as 13 found misogyny can predict extremist violence more strongly than ideology, religion or time online.

Researchers are racing to culture a menagerie of exotic organisms and finding lots of surprises along the way.

Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS r...