Reposted by Jeff Riffell
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![igure 2. Degenerate models show different responses to partial or complete deletion of one current. Model neuron A and model neuron B have the same constellation of ion channels, but with different values of their maximal conductances. Despite this, under ‘control’ conditions, the models are degenerate and show very similar bursting behavior (black voltage traces in the top line of each panel). The currentscapes [42] shown in color are a visualization of the amount each of the currents is contributing to the total outward or total inward currents in the models. Note that in model neuron A there is virtually no A current (purple), while in model neuron B the A current is quite large. Again, this is degeneracy, as the two sets of parameters used in the models are appreciably different, but the output is very similar. The right-hand panels show the results of decreasing the maximal conductance of one of the Ca 2+ currents from 100% to 75%, 50%, 25% or 0% relative to the control. Although the 75% panel is noticeably different in the two models, it is striking that at 50% deletion the models are again degenerate, and produce similar behavior. Nonetheless at 25% and 0% ,the two models behave markedly different.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:ijcgxigo2xdqgexkdvk64ivp/bafkreihe57rcchdkp64lieyrx54dznrgk4mbngggdrfxme5d2sy6hjzajm)
