iiinova — where your digital self keeps evolving

Reposted by Rajesh Mohandas

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 28/06/2026

Boom The European Medical Agency @ema.europa.eu pulls the approval for Tavneos aka Avacopan over trial shenanigans #Vasculitis cc @kidneyboy.bsky.social @brycebarr.bsky.social

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Anand Vaidya @anandvaidya17.bsky.social · 26/03/2026

"Over 80% of participants with obesity-related hypertension exhibited reproducible pathologic phenotypes of aldosteronism and/or hypercortisolism" www.jacc.org/doi/10.1016/...

jacc.org

Unmasking Hormonal Mechanisms of Hypertension in Obesity:

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Eric Topol @erictopol.bsky.social · 16/02/2026

A psychedelic quickly reduced depression (in patients with major depression disorder) in a small, double-blind placebo randomized trial www.nature.com/articles/s41... Plus a new review on the science of psychedelic medicine www.nature.com/articles/s41...

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NEJM.org @nejm.org · 16/02/2026

In an interim analysis, sibeprenlimab, a humanized IgG2 monoclonal antibody that inhibits APRIL (the cytokine A proliferation-inducing ligand, a key driver of IgA nephropathy), reduced proteinuria as compared with placebo. Full phase 3 VISIONARY trial results and Research Summary: nej.md/493Xtza

The New England Journal of Medicine
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial
A Research Summary based on Perkovic V et al. | 10.1056/NEJMoa2512133 | Published on November 8, 2025

Visual representations of the patients in the trial and the treatments they were assigned.

Read the full Research Summary at NEJM.org.

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Reposted by Rajesh Mohandas

NEJM.org @nejm.org · 06/02/2025

New in the February 6, 2025, issue of NEJM: Iptacopan in IgA Nephropathy (APPLAUSE-IgAN phase 3 trial) nej.md/3UmrOkh Atrasentan in Patients with IgA Nephropathy (ALIGN phase 3 trial) nej.md/3NzvISW Liraglutide for Children with Obesity (SCALE Kids phase 3a trial) nej.md/3MBP1uc #MedSky

Images and descriptions of what's available on NEJM.org this week

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Reposted by Rajesh Mohandas

Eric Topol @erictopol.bsky.social · 02/02/2026

The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system www.nature.com/articles/s41...

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Rajesh Mohandas @rajmohandas.bsky.social · 07/11/2025

50% risk reduction and curves separating in just a few months ? Insane!

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Reposted by Rajesh Mohandas

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 06/11/2025

Eli Lilly continuing to hit it out the park Selective amylin agonist as an alternative to GLP1RAs? #eloralintide www.thelancet.com/journals/lan... in @thelancet.com (Yeah I know it’s #KidneyWk but what do we do till Houston wakes up!) cc @rnflex.bsky.social

Figure 2. Change in bodyweight
(A) Mean percent change in bodyweight from baseline to week 48, shown as observed means and bars indicating SEs. The model-based estimates of the mean percent change in bodyweight and differences among treatment groups at week 48 with the corresponding p values (efficacy estimand only) and 95% CIs are shown in (B) (efficacy estimand) and (D) (treatment-regimen estimand); bars indicate SEs. Multiplicity adjustment was not performed, and p values should be interpreted as exploratory. (C) shows the percentage of participants with bodyweight reductions of at least 5%, 10%, 15%, 20%, 25%, and 30% from baseline to week 48. The percentage of participants is annotated above each bar, calculated with the use of Rubin's rules by combining the percentages of participants who met the thresholds in imputed datasets. *The model-based estimates and 95% CIs from a mixed model repeated measures analysis for the efficacy estimand are shown on the right, denoted by 48.

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Ben Goult @bengoult.bsky.social · 31/10/2025

Vinculin is a simple adapter protein right? Wrong! That’s been the prevailing view for the 46 years since it was discovered. Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains. www.science.org/doi/10.1126/...

science.org

The mechanical response of vinculin

Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.

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ASN Publications @asnpublications.bsky.social · 10/10/2025

This #ASNCJASN article finds physical exercise prior to hemodialysis provides cardioprotective effects in a randomized controlled trial. kidney.pub/CJASN0767

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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 19/09/2025

Orfoglipron in @nejm.org www.nejm.org/doi/full/10.... See discussion below for why this is significant! #MedSky #NephSky

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Nature Portfolio @natureportfolio.nature.com · 10/08/2025

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level, according to a paper in Nature. go.nature.com/47mxemu #medsky 🧪

This is figure 5, which shows the therapeutic efficacy of a plaque-evading lithium salt.

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Eric Topol @erictopol.bsky.social · 05/08/2025

Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org www.nejm.org/doi/pdf/10.1...

nejm.org

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM

The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...

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ASN Publications @asnpublications.bsky.social · 16/07/2025

Could gene-targeted therapy be coming for autosomal dominant polycystic kidney disease? Farabursen, a new medication acquired by Novartis offers to potentially impact cyst formation and even regression. kidney.pub/KN1707-07 #ASNKidneyNews @nephrosparks.bsky.social

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Eric Topol @erictopol.bsky.social · 30/04/2025

To restore the gut microbiome after antibiotics, the right diet (rich in carbohydrates, low in fat) was a better approach than fecal microbial transplants (in the experimental model) www.nature.com/articles/s41... www.nature.com/articles/d41...

nature.com

Diet outperforms microbial transplant to drive microbiome recovery in mice - Nature

Experiments in mouse models show that proper recovery of the intestinal microbiota following depletion, with or without faecal microbiota transplant therapy, is dependent on syntrophic interactions th...

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Arvind (Canchi) Conjeevaram @arvindcanchi.bsky.social · 27/04/2025

Lorundrostat - an aldosterone synthase inhibitor. Lorundrostat was associated with greater reductions in 24-hr average BP than placebo in pts with uncontrolled & treatment-resistant hypertension. K level >6.0 occurred in 5 pts (5%) in the stable-dose group. www.nejm.org/doi/full/10.... @nejm.org

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Hao Yin @haoyin.bsky.social · 23/02/2025

ExerGeneDB A physical exercise-regulated differential gene expression database Human/mouse/rat >6k samples microarray/bulk/scRNAseq +ncRNA +Genes related to interactions b/w Exercise & gender/age/BMI exergenedb.com #JSHS_MedHealth 2025 www.sciencedirect.com/science/arti...

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Eric Topol @erictopol.bsky.social · 03/01/2025

Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout) www.science.org/doi/10.1126/...

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Rajnish Mehrotra @rajmehrotra.bsky.social · 19/12/2024

As promised, @asnpublications.bsky.social is on the platform. Four publications, one account. Please follow for the best in scientific publishing in nephrology!

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Science Magazine @science.org · 25/12/2024

Move over mitochondria, a new organelle called the nitroplast is here. In a Science study from earlier this year, researchers report that a nitrogen-fixing organelle has been identified in a marine alga. Learn more in this #SciencePerspective:

scim.ag

The nitroplast: A nitrogen-fixing organelle

A bacterial endosymbiont of marine algae evolved to an organelle

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John Wallingford @jbwallingford.bsky.social · 27/11/2024

Looking for something fun to read? Here’s a #popsci piece I did on the crazy history of cilia and left/right patterning in embryos. Remember #devbiolwriteclub Bluesky Boot Camp starts Monday Dec. 2! Please RS (re-skeet?) nautil.us/the-anatomic...

nautil.us

The Anatomical Quirk That Saved Dr. No

A wild tale of how scientists unraveled embryology's most fascinating mystery.

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Joel Topf @kidneyboy.bsky.social · 28/11/2024

All modern inpatient hypertension research: "Whatever you do, don't treat inpatient hypertension" Current EHRs Blood pressure of 142/80 in red. With an exclamation point. 🤦🏻‍♂️

Blood pressure of 142/80 in red. with an exclamation point.

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The Washington Post @washingtonpost.com · 27/11/2024

People with HIV will be able to receive kidney or liver transplants from donors who also have HIV, federal health officials announced Tuesday. The landmark move, which takes effect Wednesday, is expected to shorten wait times for organs for all patients.

washingtonpost.com

U.S. okays organ transplants between people with HIV, expanding donor pool

The landmark move is expected to shorten wait times for organs for all patients and reduce hurdles to life-saving care for those with HIV.

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F. Perry Wilson, MD @fperrywilson.bsky.social · 26/11/2024

"Drink more water!" It's the easiest health advice around. Tired? Headache? Trying to be like Tom Brady? Just drink more water. But as a nephrologist, I get asked all the time: How much is the right amount? And the truth is... we don't really know. 🧵

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Saloni @scientificdiscovery.dev · 26/11/2024

This month, a phase 3 trial of tirzepatide (a GLP-1 drug) found that it reduced the chances of developing type 2 diabetes by around 90% (!), among people with obesity and pre-diabetes. That's a reduction if I ever saw one. www.nejm.org/doi/full/10....

Kaplan Meier curve showing the cumulative incidence of type 2 diabetes in people given tirzepatide vs placebo

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Joel Topf @kidneyboy.bsky.social · 26/11/2024

Down goes daprodustat. The HIF-PHI drugs for CKD anemia will go down as the drug class with the greatest hype that utterly failed in delivering anything of note for patients. Just an epic decades long drama for nothing.

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Verena Resch | 🧪🖥️ @verenaresch.bsky.social · 25/11/2024

I sometimes forget how flexible proteins are. It becomes really apparent when you use NMR states for an animation. That poor cofactor is getting pushed around a lot 😅 #sciart #blender3d #biocatalysis

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Florian Buchkremer @swissnephro.bsky.social · 21/11/2024

“Patients who are diagnosed with ACE inhibitor-induced angioedema should be tested for hereditary angioedema types 1/2“ So far, not something that I have been doing … #whatilearnedtoday #nephsky #skyneph onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com

The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update

Click on the article title to read more.

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Kenar Jhaveri, MD @kdjhaveri.bsky.social · 19/11/2024

www.dustri.com/nc/article-r... Fibroblast growth factor receptor inhibitor-induced hyperphosphatemia: Lessons for the nephrologist

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Rajesh Mohandas @rajmohandas.bsky.social · 16/11/2024

Myocardial infarction augments sleep to limit cardiac inflammation and damage- Great talk by first author and AHA funded early career researcher Huynh, P. yesterday! Nature 635, 168–177 (2024). doi.org/10.1038/s415...

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zack chiang @zchiang.bsky.social · 11/11/2024

7 years ago, I met a junior fellow named Jason Buenrostro who blew me away with a vision of futuristic genomic technologies Today, we (Ajay Labade, Caroline Comenho) are excited to share our first steps into that future: Expansion in situ genome sequencing 1/

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