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Florian Buchkremer

@swissnephro.bsky.social
767 followers 393 following 53 posts

Nephrologist. Views are my own. #UrinarySediment #Hyponatremia #POCUS 👉 www.swissnephro.org

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Reposted by Florian Buchkremer
Klaus Pforr @klauspforr.eurosky.social · 11h
Interesting paper by @lonnekevdberg.bsky.social and @pgonalon.bsky.social shows with longitudinal register data in the NL that proximity to grandmothers increases mothers’ post-birth employment, smaller for partnered mothers, bigger for single mothers academic.oup.com/esr/advance-...
academic.oup.com
Geographic proximity to grandparents and mothers’ paid work after childbirth
Abstract. Grandparents often provide childcare, which can help foster mothers’ labour market participation. Most studies on this topic compare mothers who
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Florian Buchkremer @swissnephro.bsky.social · 10h
“The vulnerability comes from external reviewers uploading confidential grant proposals to AI models to assess and rank them.“ www.ft.com/content/dd50...
ft.com
Snoop-and-scoop poses a real threat to science in the AI age
Establishing attribution in research has become harder in the age of AI-assisted breakthroughs
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Reposted by Florian Buchkremer
John Williams @johnhuww.bsky.social · 11h
Is AI supercharging science? “While the average surveyed scientist reported saving almost 7 hrs per week thanks to AI…a significant amount goes on manually auditing & verifying the results of work performed by AI — what the researchers termed the “verification tax” giftarticle.ft.com/giftarticle/...
giftarticle.ft.com
The AI Shift: Is AI supercharging science?
Productivity gains in analysis are getting stuck in physical-world bottlenecks
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ISNkidneycare @theisn.org · 15h
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: Target Trial of Glucagon-Like Peptide-1 Agonists versus Dipeptidyl Peptidase-4 Inhibitors and Mortality in Hemodialysis www.kireports.org/article/S2468-024…
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Florian Buchkremer @swissnephro.bsky.social · 13h
Bridging FSGS and X-Linked Alport Syndrome Through Genetic Testing - Kidney International Case Reports www.kicasereports.org/article/S311...
kicasereports.org
Bridging FSGS and X-Linked Alport Syndrome Through Genetic Testing
Alport syndrome is a genetically heterogeneous disorder of the glomerular basement membrane (GBM) caused by pathogenic variants in the COL4A3, COL4A4, and COL4A5 genes. The disease may follow X-linked...
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Florian Buchkremer @swissnephro.bsky.social · 13h
Quantitative serological detection of NELL1 autoantibodies in membranous nephropathy - Kidney International www.kidney-international.org/article/S008...
kidney-international.org
Quantitative serological detection of NELL1 autoantibodies in membranous nephropathy
Membranous nephropathy (MN) comprises distinct subtypes driven by autoantibodies targeting podocyte-associated proteins, one of which is neural EGFL-like 1 (NELL1). Currently, the diagnosis of NELL1-a...
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Reposted by Florian Buchkremer
Stéphane Burtey @sburtey.bsky.social · 09/09/2026
Très intéressant papier sur l'épidémiologie du syndrome nephrotique chez l'enfant. Avec deux régions plus touchées et la confirmation de la saisonnalité, une belle utilisation du SNDS. bravo aux autrices et auteurs. academic.oup.com/ndt/advance-...
academic.oup.com
Spatial and seasonal patterns of pediatric idiopathic nephrotic syndrome in France
ABSTRACTBackground and hypothesis. Idiopathic nephrotic syndrome (INS) is the most frequent glomerular disease in children, yet robust population-based dat
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Reposted by Florian Buchkremer
Måns Thulin @mansthulin.bsky.social · 19/11/2024
Looking for a book that covers both statistics and R programming? Check out my book Modern Statistics with R! Coding, visualisation, regression, ML & more. 📖 Read it for free: www.modernstatisticswithr.com 📚 Get printed copies: tinyurl.com/mswrbook #Rstats #statistics #datascience #machinelearning
Modern Statistics with R - the author holding the book
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Miquel Serra-Burriel @miquelserra.bsky.social · 02/09/2026
This paper is indeed impressive, but we think that paper's headline clinical claim does not follow from its own reported numbers. We have written a comment in pubpeer. pubpeer.com/publications...
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Aki Vehtari @avehtari.bsky.social · 13/08/2026
All four books I've co-authored are freely available online for non-commercial use: - Bayesian Workflow at avehtari.github.io/Bayesian-Wor... Links to other three books are in the quoted post 👇 (too many books to fit in one post!)
avehtari.github.io
Bayesian Workflow book: Website – Bayesian Workflow book
Website for the Bayesian Workflow book by Gelman, Vehtari, McElreath, et al. — case studies, code, and exercises in R and Stan.
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The Lancet Diabetes & Endocrinology @thelancetendo.bsky.social · 09/08/2026
#Semaglutide was effective in decreasing #CKD progression regardless of the administration route or indication (type 2 #diabetes or #obesity), adding to the evidence provided by FLOW in people with type 2 diabetes & CKD www.thelancet.com/journals/lan... #T2D #kidney #CVD #MedSky #RenalSky #CardioSky
Cumulative incidence plots showing time from randomisation to occurrence of first primary kidney composite event (A) and narrower secondary kidney composite event (B). Pooled data from the SELECT, FLOW, and SOUL trials, in the full analysis set. The primary kidney composite included onset of persistent ≥50% reduction in eGFR, kidney failure (persistent eGFR <15 mL/min per 1·73 m2 or initiation of kidney replacement therapy), kidney-related death, or cardiovascular-related death. Narrower secondary kidney composite included the above criteria, excluding cardiovascular-related death. eGFR=estimated glomerular filtration rate. HR=hazard ratio. IR=incidence rate (number of events per 100 years of observation).
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Reposted by Florian Buchkremer
Stéphane Burtey @sburtey.bsky.social · 01/08/2026
Échec de l'inhibition de l'il6 pour réduire le risque cardiovasculaire au cours de la MRC. Zeus tombe de l'Olympe www.novonordisk.com/content/nnco...
novonordisk.com
News Details
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Reposted by Florian Buchkremer
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 31/07/2026
Guidance on nutrition supplementation in dialysis www.kireports.org/article/S246... In @kireports.bsky.social Increasing protein intake once dialysis begins is important!
Algorithm
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Hilda Bastian @hildabast.bsky.social · 29/07/2026
PLOS' Independent Blog Network is ending this month (2010-2026). I've been so proud to be a longstanding member: Thank you for everything, @plos.org! My farewell post, with thoughts on blogging's history: absolutelymaybe.plos.org/2026/07/29/f...
absolutelymaybe.plos.org
Farewell Post - Absolutely Maybe
Experimenting with colors for the Absolutely Maybe logo feels like another lifetime. It was 2013, and this blog was launching on the…
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Reposted by Florian Buchkremer
Rolando Claure @runningkidneys.bsky.social · 29/07/2026
Urea may be a cost-effective alternative to tolvaptan for 🏥 SIADH patients. In a retrospective 📑 (n=537) both achieved similar correction of HypoNa (>130 mmol/L) while tolvaptan acted faster but caused more overcorrection & was substantially more 💵 🔗https://doi.org/10.1093/ndt/gfag165
doi.org
Urea vs. tolvaptan for hospitalized patients with SIADH
AbstractRationale. Hyponatremia is the most common electrolyte disorder found in hospitalized patients and is associated with an increased mortality. Urea
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Reposted by Florian Buchkremer
kireports.bsky.social @kireports.bsky.social · 29/07/2026
Divergent #RiskFactors and Outcomes in #HELLP and Isolated #Preeclampsia #VisualAbstract by Kajaree www.kireports.org/article/S2468-024…
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Reposted by Florian Buchkremer
Arkana Labs @arkanalabs.bsky.social · 29/07/2026
Here is today’s #eyeSCANdy! Acellular scanning EM of a glomerulus from a biopsy with membranous glomerulonephritis, stage II showing a reticular pattern of the subepithelial GBM. Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
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Arkana Labs @arkanalabs.bsky.social · 29/07/2026
2/ This material showed positive staining by Congo Red with apple green birefringence on polarization (see below) and lambda light chain restriction on immunofluorescence (not shown) that is consistent with an AL-type, lambda light chain restricted renal amyloidosis.
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Reposted by Florian Buchkremer
Arkana Labs @arkanalabs.bsky.social · 29/07/2026
1/ The photomicrograph shows a glomerulus on PAS stain with mesangial accumulation of homogenous PAS-pale material consistent with amyloid. #renalpath #kidneypath #pathology #renal #pathtwitter
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Arkana Labs @arkanalabs.bsky.social · 27/07/2026
What is your diagnosis? #DiagnoseThis #nephtwitter #pathtwitter #renal #kidneypath
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Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 27/07/2026
Save the date #WCN27 🇲🇾 #ISNWCN 🇲🇾 #NephSky
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Reposted by Florian Buchkremer
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 27/07/2026
The Thermo Fisher western blot story www.chemistryworld.com/news/thermo-... This looks very bad.
chemistryworld.com
Thermo Fisher antibody data manipulation is a breach of trust, say researchers
Science sleuths say the problem is impacting research progress and Thermo's response falls short
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Reposted by Florian Buchkremer
kireports.bsky.social @kireports.bsky.social · 24/07/2026
Systematic Review of #Kidney #Involvement in #Antisynthetase Syndrome #VisualAbstract by NephroloverPriti www.kireports.org/article/S2468-024…
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Reposted by Florian Buchkremer
Jonathan Zuckerman MD PhD @jzrenalpath.bsky.social · 23/07/2026
Not often caught on sections but example of penetrating vessels within the renal capsuled demonstrating the small amount of collateral circulation to the subcapsular cortex. #renalpath #pathsky #nephsky
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Reposted by Florian Buchkremer
Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 19/07/2026
Urea vs. tolvaptan for hospitalized patients with SIADH ca. 2026 #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/42455009/
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Florian Buchkremer @swissnephro.bsky.social · 17/07/2026
GLP1-Agonists and AION, reassuring results from a nationwide cohort from Sweden #nephrology www.acpjournals.org/doi/10.7326/...
acpjournals.org
Glucagon-like Peptide-1 Receptor Agonists and Risk for Anterior Ischemic Optic Neuropathy: A Nationwide Cohort Study: Annals of Internal Medicine: Vol 0, No 0
Background: There are concerns about a possible link between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and nonarteritic anterior ischemic optic neuropathy (NAION). Objective: To examine whe...
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Reposted by Florian Buchkremer
Darren Dahly @statsepi.bsky.social · 28/04/2026
🎯So many important points packed into this editorial. ht @maartenvsmeden.bsky.social www.nature.com/articles/s41...
nature.com
Show us the evidence for the value of medical AI - Nature Medicine
Claims that medical AI is improving care must be backed by appropriate evidence.
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Darren Dahly @statsepi.bsky.social · 15/07/2026
We are all statisticians 😜 statsepi.substack.com/p/im-not-a-r...
statsepi.substack.com
I’m not a real statistician, and you can be one too
Cara and I were hand-in-hand, slowly strolling around Cork on a bright, summer evening.
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 03/06/2026
Perfect timing for @kireports.bsky.social to publish the IgG4 review as the @nejm.org publishes this RCT of Obexelimab www.nejm.org/doi/full/10....
First Adjudicated Flare of IgG4-Related Disease for Which Rescue Therapy Was Required (Intention-to-Treat Population).
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Reposted by Florian Buchkremer
Christoph Schwarz @electro-like.bsky.social · 07/06/2026
Exome sequencing in patients with medullary sponge kidney academic.oup.com/ndt/article-... very interesting study on the genetics of MSK
academic.oup.com
Exome sequencing in patients with medullary sponge kidney
AbstractBackground. Medullary sponge kidney (MSK) is characterized by precalyceal dilatation of the renal tubules. This entity is associated with recurrent
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Reposted by Florian Buchkremer
Critical Care Reviews @criticalcarereviews.com · 14/07/2026
The expanding role of ultrasound in acute kidney injury: from B-mode to microcirculation CCR Journal Watch criticalcarereviews.com/latest-evide...
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Reposted by Florian Buchkremer
Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 14/07/2026
Cool case in @ckj-era.bsky.social Mass spec reveals NSAIDs in herbal supplement (which caused granulomatous AIN) academic.oup.com/ckj/article/...
Figure 2:Example of mass spectrometry analysis of the main compound in one of the traditional medicine products: (A) GC–MS chromatogram, with time on the x-axis and signal intensity on the y-axis. The peak centered at 23.40 min indicates that a compound elutes from the GC column at 23.40 min. (B) Top: Spectrum of the compound eluting at 23.40 min, with each vertical bar representing an ion fragment; bottom: comparison with the reference spectrum of the molecule proposed by the library (mefenamic acid). (C) LC–HRMS chromatogram. The peak centered at 13.413 min indicates that a compound elutes from the LC column at 13.413 min. (D) Top: The HRMS MS1 spectrum of the compound eluting at RT 13.413 min, providing the exact neutral molecular mass [M + H]+ of the compound; bottom: the HRMS MS2 spectrum of the compound eluting at RT 13.413 min, enabling structural identification and comparison with a collection of reference MS2 spectra associated with identified molecules (here mefenamic acid). (E) Composition of all compound identified in high-resolution mass spectrometry. GC–MS: gas chromatography–mass spectrometry; LC–HRMS: liquid chromatography–high-resolution mass spectrometry; RT: retention time.
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Frank Harrell @f2harrell.bsky.social · 14/07/2026
What an incredible resource!! I've added a link to it from hbiostat.org/data and hbiostat.org/bbr/ancova. How did you find this Darren? Having ready-to-analyze #RStats RDS files is wonderful. #rct #Statistics #StatsSky
hbiostat.org
Datasets
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Darren Dahly @statsepi.bsky.social · 14/07/2026
🤩 bingkaiwang.github.io/RCT_Bench-ma...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 10/07/2026
Another negative early AKI RCT jamanetwork.com/journals/jam... @jaykoyner.bsky.social et al in @jamanetworkopen.com
jamanetwork.com
Early Nephrology Consult and Acute Kidney Injury in Hospitalized Patients
This randomized clinical trial assesses whether a structured early nephrology consultation triggered by a machine-learning acute kidney injury (AKI) risk score in patients at high risk for AKI improve...
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Florian Buchkremer @swissnephro.bsky.social · 13/07/2026
Just stumbled upon this nice piece on JP Peters, a true giant of #medicine and #nephrology 👇👇👇👇 pmc.ncbi.nlm.nih.gov/articles/ins...
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Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 17/04/2026
Therapeutic targets 🎯and positioning of treatments in IgA nephropathy 🔬 #IgAN ca. 2026 #GlomConEurope 🇪🇺🇵🇹 #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/41895685/
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Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 09/06/2026
Mechanisms by which novel antihypertensive drug classes reduce blood pressure ca. 2025 from @natrevcardiol.nature.com #Nephpearls #NephSky 👉 pubmed.ncbi.nlm.nih.gov/39920248/
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Edgar V. Lerma 🇵🇭 @edgarvlermamd.medsky.network · 12/06/2026
Guideline for Prevention, Detection, Evaluation, & Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome ca. 2026 from @americanheart.bsky.social @accintouch.bsky.social @amdiabetesassn.bsky.social @asnkidney.bsky.social #Nephpearls #Cardiorenal #NephSky 👉 pubmed.ncbi.nlm.nih.gov/42265997/
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Nephrology Journal Club @nephjc.bsky.social · 12/07/2026
#NephJC Shorts is our new way to share quick takes on notable studies we can’t cover fully 👇👇Check the updated blog page for upcoming Shorts and those already published ✨Suggestions and feedback welcome www.nephjc.com/nephjc-shorts
nephjc.com
NephJC Shorts — NephJC
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Christos Argyropoulos MD, PhD, FASN 🇺🇸 0kale/acc @christosargyrop.bsky.social · 12/07/2026
Interesting perspective , not limited to code IMHO bbrtj.eu/blog/article... "Meanwhile, seniors are expected to be prompting as much as possible, running agents in parallel, and spending most of their time reviewing the AI's code diarrhea."
bbrtj.eu
When AI hype meets logic - bbrtj
Exploring long-term effects of AI overuse
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 10/07/2026
agree with the sentiments in this @asnpublications.bsky.social Kidney360 perspective journals.lww.com/kidney360/fu... read the whole thing
journals.lww.com
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ADTKD Vision Cure @adtkd-muc1.bsky.social · 05/06/2026
#ERA26 Jan Halbritter on the challenges in diagnosing #ADTKD #MUC1, but online tool #VNtyper 2 makes it much easier. 👏 @hassansaei.bsky.social @erknet.bsky.social
Blindspot of genetic testing: ADTKD MUC1Integrating VNtyper in clinical processVNtyper 2
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 09/07/2026
Trutakna (what a strange name) aka atacicept (pronounced attack-e-sept) approved by FDA based on ORIGIN for IgAN www.fda.gov/drugs/news-e... #NephJC coverage of the trial www.nephjc.com/news/atacice... Podcast www.nephjc.com/freelyfilter...
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Richard M. Carpiano, PhD, MPH @rmcarpiano.medsky.social · 09/07/2026
This one... explaining its significance and backstory to students in my intro. to public health class, I typically find myself choked up and need to pause a sec to catch myself.
time.com
World AIDS Day: The Photo That Changed the Face of HIV/AIDS
LIFE.com shares the story behind one of the most harrowing and controversial photographs to emerge from the global pandemic.
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kireports.bsky.social @kireports.bsky.social · 09/07/2026
Effect of #Hemodialysis With #Citrate on Vascular #Calcification #VisualAbstract by Husam Alzayer www.kireports.org/article/S2468-024…
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Rolando Claure @runningkidneys.bsky.social · 08/07/2026
TRACK: In advanced CKD (G4-G5/dialysis), rivaroxaban 2.5 mg BID did not reduce MACE vs placebo (HR 1.09), increased major bleeding (HR 1.51), and offered no net clinical benefit. Key lesson: don’t extrapolate COMPASS/VOYAGER to advanced CKD. #NephJC #CKD
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 08/07/2026
The bladder is often scarred or shrunk in ESRD here’s a first in human feasibility report of a combined kidney bladder transplant www.thelancet.com/journals/lan... in @thelancet.com
Figure 2. Back-table preparation of the vascularised composite bladder allograft, creating a single arterial inflow and a single venous outflow supplying the entire bladder
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Kidney Precision Medicine Project @kpmproject.bsky.social · 06/07/2026
🎉 The Q2 2026 KPMP Atlas is here! This release adds 1,200+ files to the Atlas Repository and 600+ images to the Spatial Viewer, plus new nephron schematics, better differential expression tables, and side-by-side image viewing in Chrome. Explore the updates: www.kpmp.org/help-docs/so...
atlas.kpmp.org
Kidney Tissue Atlas
The Kidney Tissue Atlas is a set of interactive tools built to promote retrieval, exploration, discovery, and analysis of the KPMP data by the greater research community.
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haysamrady @sodatroubles.bsky.social · 02/07/2026
Nephrin autoimmunity: signal, noise, and a path to clarity #nephsky #nephrology www.jci.org/articles/vie...
jci.org
JCI - Nephrin autoimmunity: signal, noise, and a path to clarity
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