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Cristian Prieto-Garcia

@prieto-garcia.bsky.social
1.6K followers 3.9K following 48 posts

RyC researcher at IBiS and University of Seville. #Proteostasis #RNA #Cancer Previously: Univ. of Córdoba · Univ. of Milan · KCL · Complutense Univ. of Madrid · CNIO · Univ. of Würzburg · Goethe Univ. Frankfurt

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Reposted by Cristian Prieto-Garcia
GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 27/03/2026
Lina Herhaus was awarded the Otto Meyerhof Prize from #BoehringerIngelheim and the #GBM at the 77. Mosbacher Kolloquium and presented her work on how IRGQ-mediated autophagy in MHC-I quality control drives tumor immune evasion. Congratulations, Lina! @helmholtzhzi.bsky.social
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Reposted by Cristian Prieto-Garcia
Manuel Kaulich @manuelkaulich.bsky.social · 21/03/2026
Happy to share another paper from the lab. While KEAP1 is often mutated in aggressive lung cancer, its loss can paradoxically suppress tumor growth in certain contexts by inducing Nrf2-driven reductive stress. link.springer.com/article/10.1...
link.springer.com
Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer - The EMBO Journal
Lung cancer cells rely on protein homeostasis regulators, particularly the ubiquitin-proteasome system (UPS), to sustain malignancy. Genetic alterations in UPS components, such as E3 ubiquitin ligases...
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Reposted by Cristian Prieto-Garcia
The EMBO Journal @embojournal.org · 20/03/2026
Loss of the ubiquitin ligase targeting factor KEAP1 induces NRF2-driven reductive stress, revealing KEAP1-dependent therapeutic vulnerabilities of KEAP1-mutant NSCLC, particularly under metabolic stress @idikic.bsky.social @diefenbacherlab.bsky.social and coworkers link.springer.com/article/10.1...
link.springer.com
Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer - The EMBO Journal
Lung cancer cells rely on protein homeostasis regulators, particularly the ubiquitin-proteasome system (UPS), to sustain malignancy. Genetic alterations in UPS components, such as E3 ubiquitin ligases...
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Reposted by Cristian Prieto-Garcia
SFB1361 @sfb1361.bsky.social · 16/02/2026
Publication alert!!📑 Congrats to the @dikiclab.bsky.social and Beli labs on their joint #SFB1361 publication, covering how DNA-protein cross-links promote cGAS-STING-driven premature aging and embryonic lethality. 🔎Read the paper here: www.science.org/doi/10.1126/...
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Reposted by Cristian Prieto-Garcia
Science Magazine @science.org · 04/02/2026
Unrepaired DNA-protein crosslinks cause a process that leads to premature aging and embryonic lethality in mice. The findings in Science reveal a previously unrecognized link between defective DNA repair and immune-driven inflammatory disease. scim.ag/4qdZWf9
science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
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Reposted by Cristian Prieto-Garcia
Cristian Prieto-Garcia @prieto-garcia.bsky.social · 01/02/2026
Our Science paper is out! 😃 www.science.org/doi/10.1126/...
science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
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Reposted by Cristian Prieto-Garcia
Goethe-Universität Frankfurt @goetheuni.bsky.social · 30/01/2026
🧪🧬 Wenn das DNA-Reparaturenzym SPRTN ausfällt, häufen sich DNA-Schäden, Entzündungen werden ausgelöst und Alterungsprozesse beschleunigt. Das zeigt eine #Studie unter Leitung von @idikic.bsky.social vom @ibc2-gu.bsky.social an der #GoetheUni. | 🔗 aktuelles.uni-frankfurt.de/forschung/ka...
Der Ausfall des Reparaturenzyms SPRTN in diesen kultivierten Zellen führt zu tödlichen Pannen bei der Zellteilung, indem zum Beispiel die Chromosomen (rot) auf drei statt auf zwei Tochterzellkerne verteilt werden (Pfeil). Grün: Zellteilungsapparat/Zytoskelett.
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Cristian Prieto-Garcia @prieto-garcia.bsky.social · 01/02/2026
Our Science paper is out! 😃 www.science.org/doi/10.1126/...
science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
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Reposted by Cristian Prieto-Garcia
Stella Hurtley @smhsci.bsky.social · 30/01/2026
Out now in @science.org DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
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Reposted by Cristian Prieto-Garcia
Waggoner Lab @labwaggoner.bsky.social · 29/01/2026
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality www.science.org/doi/10.1126/... @science.org @idikic.bsky.social @goetheuni.bsky.social
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Reposted by Cristian Prieto-Garcia
Cristian Prieto-Garcia @prieto-garcia.bsky.social · 24/10/2025
Honored to receive the RMU Award for Pharmaceutical Research & Innovative Medical Therapies for our discovery of proteotoxic RNA splicing! Huge thanks to RMU @goetheuni.bsky.social @ibc2-gu.bsky.social & @idikic.bsky.social ! 🧬 #RMU #Science www.rhein-main-universitaeten.de/en/news/rmu-...
rhein-main-universitaeten.de
RMU END OF YEAR GET TOGETHER WITH PRESENTATION OF RMU AWARDS - REGISTER NOW! | Rhein-Main Universitäten (RMU)
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Cristian Prieto-Garcia @prieto-garcia.bsky.social · 24/10/2025
Honored to receive the RMU Award for Pharmaceutical Research & Innovative Medical Therapies for our discovery of proteotoxic RNA splicing! Huge thanks to RMU @goetheuni.bsky.social @ibc2-gu.bsky.social & @idikic.bsky.social ! 🧬 #RMU #Science www.rhein-main-universitaeten.de/en/news/rmu-...
rhein-main-universitaeten.de
RMU END OF YEAR GET TOGETHER WITH PRESENTATION OF RMU AWARDS - REGISTER NOW! | Rhein-Main Universitäten (RMU)
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Reposted by Cristian Prieto-Garcia
Trends in Genetics @cp-trendsgenetics.bsky.social · 08/07/2025
"m6A in the coding sequence: linking deposition, translation and decay" by Kathi Zarnack (@zarnack-group.bsky.social) & colleagues "This review explores [m6A in] mRNA decay, with a focus on the newly discovered CDS–m6A decay (CMD) pathway..." Read it here: authors.elsevier.com/sd/article/S...
Figure 2. Overview of N6-methyladenosine (m6A) decay pathways. m6A acts as a destabilizing mark on mRNA.
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Cristian Prieto-Garcia @prieto-garcia.bsky.social · 20/06/2025
Very happy to share some exciting news! I have been awarded a Ramón y Cajal Fellowship 2024 #ryc2024 in the area of Biomedicine, having ranked 4th out of 262 applications with a final score of 99.4 out of 100.
media.tenor.com
a man wearing a sweater with a horse on it stands in front of a door with a wreath on it
ALT: a man wearing a sweater with a horse on it stands in front of a door with a wreath on it
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Reposted by Cristian Prieto-Garcia
IBiS - Instituto de Biomedicina de Sevilla @ibis-investigacion.bsky.social · 09/04/2025
🟠 SCIENCE | Extra Seminar: "Targeting proteotoxic RNA splicing for therapeutic intervention" 👤: Cristian Prieto-García 🗓️: 11-04-2025 | 12:00 h. 📍: IBiS Assembly Hall + INFO ➡️ www.ibis-sevilla.es/es/eventos/2... @csic.es @goetheuni.bsky.social @unisevilla.bsky.social
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Reposted by Cristian Prieto-Garcia
IBC2 @ibc2-gu.bsky.social · 26/03/2025
🤩 2nd day of #FCQC2025 conference in Frankfurt was filled with inspiring lectures, vibrant discussions, great posters and a lot of joy of meeting colleagues from all over the world! A huge thanks to all organizers & supporters! @goetheuni.bsky.social @sfb1177.bsky.social @proxidrugs.bsky.social
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Reposted by Cristian Prieto-Garcia
Kurianlab @kurianlab.bsky.social · 24/03/2025
RNA Salon in mRNA Translation We have an exciting lineup with Keynote by: Marvin Tanenbaum (Hubrecht/ Delft) Please RT @goetheuni.bsky.social @cpi-exstra.bsky.social
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Reposted by Cristian Prieto-Garcia
jalguerrero.bsky.social @jalguerrero.bsky.social · 07/03/2025
Retinosis pigmentosas en clínica e investigación! www.rtve.es/play/audios/...
rtve.es
Desde los genes hasta la Retinitis pigmentosa
El ADN genera ARN. En su viaje a los ribosomas, el ARN debe ser procesado mediante \"corte y empalme\" donde se eliminan algunas secciones del ARN y otras se e...
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Reposted by Cristian Prieto-Garcia
Cristian Prieto-Garcia @prieto-garcia.bsky.social · 15/11/2024
It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP doi.org/10.1126/scie...
doi.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
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Reposted by Cristian Prieto-Garcia
Marco A Calzado @marcoacalzado.bsky.social · 23/01/2025
Today, we had the privilege of having @prieto-garcia.bsky.social at @IMIBIC talking about splicing, USP38, and proteostasis. A magnificent talk and excellent work! 🧬🧪🧫
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Cristian Prieto-Garcia @prieto-garcia.bsky.social · 23/01/2025
It was great to share Science with people at the IMIBIC! Great place 🙂. Really thanks to Manuel D. Gahete for the invitation and thanks to @marcoacalzado.bsky.social , Raul , @betsaidaop.bsky.social and others for nice time and plenty Scientific discussions.
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Reposted by Cristian Prieto-Garcia
Martin Schwalm @martinschwalm.bsky.social · 04/01/2025
Interested in #TPD? This might be for you. What concentrations of UPS inhibitors are safe to use to prove your proteasome dependent degradation mechanism? #PROTAC #TPD #degradation #Science #drugdiscovery pubs.acs.org/doi/10.1021/...
pubs.acs.org
Functional Characterization of Pathway Inhibitors for the Ubiquitin-Proteasome System (UPS) as Tool Compounds for CRBN and VHL-Mediated Targeted Protein Degradation
Small molecule degraders such as PROteolysis TArgeting Chimeras (PROTACs) and molecular glues are new modalities for drug development and important tools for target validation. When appropriately opti...
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Cristian Prieto-Garcia @prieto-garcia.bsky.social · 08/12/2024
Muchas gracias @fdescubre.bsky.social y @canalsurradio.bsky.social / @canalsurnoticias.bsky.social por permitirme compartir un poquito de ciencia con Andalucia y poder explicar nuestro último Science paper desarrollado en @dikiclab.bsky.social www.canalsur.es/multimedia.h...
canalsur.es
Fundación Descubre con Cristian Prieto
El investigador andaluz Cristian Prieto García publica en la prestigiosa revista 'Science' un artículo sobre una investigación en torno a la retinitis pigmentosa, una afección de la vista de carácter ...
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Reposted by Cristian Prieto-Garcia
Dikic lab @dikiclab.bsky.social · 06/12/2024
🥁 We are live on BlueSky!! Stay tuned for more news and updates from our lab. We are looking forward to connecting with you here again. @ibc2-gu.bsky.social @idikic.bsky.social #GoetheUniversity #IBC2
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Reposted by Cristian Prieto-Garcia
Oded Rechavi @odedrechavi.bsky.social · 05/12/2024
Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance! www.biorxiv.org/content/10.1...
biorxiv.org
Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance
Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...
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Reposted by Cristian Prieto-Garcia
Watanabe Lab @JHU @watanabelab.bsky.social · 02/12/2024
Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41... We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties. Threads will follow!
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Reposted by Cristian Prieto-Garcia
the Node @the-node.bsky.social · 27/11/2024
"I don’t think I would’ve been better off being a biologist to begin with" Karen Liu @karenjliu.bsky.social, now a professor in #DevBio, worked in an architectural firm before deciding to pursue a scientific career in her late 20s. Read her interview here: thenode.biologists.com/i-dont-think...
thenode.biologists.com
I don't think I would’ve been better off being a biologist to begin with - the Node
No such thing as a standard career path – an interview with Karen Liu
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Reposted by Cristian Prieto-Garcia
mcasas.bsky.social @mcasas.bsky.social · 02/12/2024
#ciencia #investigación www.diariosur.es/malaga/corre... @prieto-garcia.bsky.social Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
diariosur.es
De corretear por la Casa Flores que regentaba su familia a publicar en 'Science' | Diario Sur
Su abuelo fundó ese popular restaurante en el corazón de El Perchel, él investiga en Alemania y obtiene el aval de una de las revistas científicas más prestigiosas
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Reposted by Cristian Prieto-Garcia
Guillermo López Lluch @glopllu.bsky.social · 15/11/2024
Más investigación de calidad de científicos españoles intentando entender los mecanismos de reciclado de proteínas y de autofagia y su importancia en la salud. Enhorabuena. www.science.org/doi/10.1126/...
science.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
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Reposted by Cristian Prieto-Garcia
Rune Busk Damgaard @rbdamgaard.bsky.social · 15/11/2024
Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn
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Reposted by Cristian Prieto-Garcia
Stefan Marciniak @profmarciniak.bsky.social · 24/11/2024
Arise, UPR & ISR scientists ! I will have missed many, so please tag below go.bsky.app/8VzRKLW
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Reposted by Cristian Prieto-Garcia
Cereda Lab @ceredalab.bsky.social · 17/11/2024
Among so many amazing starter packs, but none focused on RNA splicing - so we made one! Check out the accounts we’ve included so far, and let us know if you’d like to be added or have suggestions! go.bsky.app/TigRnmC #rnasplicing
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Reposted by Cristian Prieto-Garcia
Itai Yanai @itaiyanai.bsky.social · 09/11/2024
Doing good science is 90% finding a science buddy to constantly talk to about the project.
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Reposted by Cristian Prieto-Garcia
Cristian Prieto-Garcia @prieto-garcia.bsky.social · 18/11/2024
After much excitement about seeing our paper: “ Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy ” published in @ScienceMagazine, it’s time to summarize our discoveries here! 😊 1/20 www.science.org/doi/10.1126/...
science.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
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Reposted by Cristian Prieto-Garcia
Stella Hurtley @smhsci.bsky.social · 18/11/2024
www.science.org/doi/10.1126/...
science.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
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Reposted by Cristian Prieto-Garcia
Matthew Freeman @mjafreeman.bsky.social · 19/11/2024
Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras Complete with collective nouns I’ve been tracking these but now can’t keep up Hope it’s helpful 2/2 docs.google.com/spreadsheets...
docs.google.com
@mjafreeman.bsky.social's BlueSky starter packs for 'mechanistic' biologists
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Cristian Prieto-Garcia @prieto-garcia.bsky.social · 18/11/2024
After much excitement about seeing our paper: “ Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy ” published in @ScienceMagazine, it’s time to summarize our discoveries here! 😊 1/20 www.science.org/doi/10.1126/...
science.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
2394
Reposted by Cristian Prieto-Garcia
Ivan Dikic @idikic.bsky.social · 17/11/2024
An impressive display of technologies was used to discover how cryptic #splicing causes #celldeath and leads to development of human #diseases. www.science.org/doi/10.1126/... It was a real joy to work together with @prieto-garcia.bsky.social and all other collaborators. Many thx 👍😀
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Reposted by Cristian Prieto-Garcia
Zebrafish Rock! 🎃 @zebrafishrock.bsky.social · 17/11/2024
#ZebrafishMeeting, includes a zebrafish-centric webinar on February 27th, 2025. More details here: events.cancer.gov/dcb/beyond-m...
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Reposted by Cristian Prieto-Garcia
Michaela Müller-McNicoll @mixmue.bsky.social · 16/11/2024
My first post on bsky - I am proud to share the fruits of a huge collaborative effort spearheaded by the incredible @prieto-garcia.bsky.social published in Science. doi.org/10.1126/scie... Thanks to @idikic.bsky.social for the great experience and for making this happen. Here is what we found 1/3.
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Reposted by Cristian Prieto-Garcia
mcasas.bsky.social @mcasas.bsky.social · 17/11/2024
I am deeply excited and proud of this paper you have just published in #ScienceMagacine 📗 🧬🧫 It is very commendable . 🎉 I congratulations to all collaborators inside and outside of #IBC2 🤩 Bravo! 🤩 👨🏻‍🔬 @prieto-garcia.bsky.social doi.org/10.1126/scie...
doi.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
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Cristian Prieto-Garcia @prieto-garcia.bsky.social · 16/11/2024
Really nice summary of our work by @mixmue.bsky.social 😀 in her profile. It is amazing to work with you and learn a lot on RNA and splicing! Really thanks for all the help with this project and others that will come ☺️.
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Reposted by Cristian Prieto-Garcia
Christian Frezza @frezzalab.bsky.social · 16/11/2024
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy www.science.org/doi/10.1126/... Great work from @idikic.bsky.social & team! 🧪
science.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
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Reposted by Cristian Prieto-Garcia
Informationsdienst Wissenschaft - idw @idw-online.de · 15/11/2024
Langsame Bearbeitung von Protein-Bauanleitungen führt zu Zelltod. Internationales Forschungsteam unter Federführung der @goetheuni identifiziert Mechanismus, der für größere Genauigkeit bei der Bearbeitung von Proteinvorläufern sorgt. @IB... weiterlesen
USP39 stabilisiert das Spleißosom (grün), das nicht benötigte Teile (grau und violett) der mRNA herausschneidet. Fehlt USP39, wird die mRNA zum Teil schlecht verarbeitet. Die Folge sind fehlgefaltete Proteine, die zu Stress und Zelltod führen. - Copyright Goethe-Universität
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Reposted by Cristian Prieto-Garcia
Michael Ward @michael-e-ward.bsky.social · 15/11/2024
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy www.science.org/doi/10.1126/...
science.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
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Reposted by Cristian Prieto-Garcia
Matthias Soller @matthiassoller.bsky.social · 15/11/2024
Toxicity from cryptic splicing www.science.org/doi/10.1126/...
science.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
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Cristian Prieto-Garcia @prieto-garcia.bsky.social · 15/11/2024
It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP doi.org/10.1126/scie...
doi.org
Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...
526442