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IBC2

@ibc2-gu.bsky.social
144 followers 116 following 6 posts

This is the Institute of Biochemistry II at Goethe University Frankfurt, Germany. Our research focuses on cellular #signaling, #ubiquitin, #autophagy, #pexophagy, #ER-phagy, #TPD, #degraders, #molecularglues, #proteomics, #CRISPR, #cancer, #infection.

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Ivan Dikic @idikic.bsky.social · 06/01/2026
We introduce #ProxiCapture, an affinity-proteomics platform to map degrader-induced interactions in native cell & tissue lysates. We uncover a context-dependent “glueable” proteome and a scalable route to accelerate molecular glue discovery 🤗 @ibc2-gu.bsky.social @goetheuni.bsky.social
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Goethe-Universität Frankfurt @goetheuni.bsky.social · 23/10/2025
Raymond Deshaies @caltech.edu is biochemist & cell biologist, his work is highly relevant for the development of innovative pharmaceuticals. In 2025, he will assume the Friedrich Merz Visiting Fellowship. Read more about Prof. Deshaies in the #UniReport 🔗 aktuelles.uni-frankfurt.de/english/heal...
aktuelles.uni-frankfurt.de
Healing Cancer through Targeted Protein Degradation | Aktuelles aus der Goethe-Universität Frankfurt
Prof. Dr. Raymond Deshaies from the California Institute of Technology (U.S.A.) will assume the Friedrich Merz Visiting Fellowship in 2025. Raymond Deshaies is a biochemist and cell biologist known fo...
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Ivan Dikic @idikic.bsky.social · 12/06/2025
So proud of this work by #rukmini mukherjee on intersection of Cell Biology and Microbiology
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Dikic lab @dikiclab.bsky.social · 18/06/2025
Check out our latest paper: #Legionella SidE effectors phosphoribosyl-ubiquitinate SNAREs STX17 & SNAP29, stalling #autophagy and fueling bacterial growth. Dive into how pathogens hijack #ubiquitin driven autophagy @embojournal.org @ibc2-gu.bsky.social @idikic.bsky.social doi.org/10.1038/s443...
doi.org
Phosphoribosyl ubiquitination of SNARE proteins regulates autophagy during Legionella infection | The EMBO Journal
imageimageAmong the hundreds of proteins that are secreted by Legionella pneumophila (the causative agent of Legionnaires’ disease) during infection, the SidE class of effectors modify host proteins b...
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IBC2 @ibc2-gu.bsky.social · 23/04/2025
🚀 An inspiring milestone worth sharing! 🎥 Yesterday marked the official kick-off event for the 2nd phase of our BMBF-funded #Cluster4Future @proxidrugs.bsky.social. Thanks to all scientists, stakeholders, citizens & schools for actively participating and making it a very special day for us!
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IBC2 @ibc2-gu.bsky.social · 28/03/2025
Congratulations @adricovapinto.bsky.social 🎉
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SFB 1177 @sfb1177.bsky.social · 26/03/2025
Getting ready for day 3 of #FCQC2025! Excited to learn what is new in the fields of “Proteinopathies & neurodegeneration” and “Emerging therapeutics”. @enablefrankfurt.bsky.social @ibc2-gu.bsky.social @proxidrugs.bsky.social
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IBC2 @ibc2-gu.bsky.social · 26/03/2025
🤩 2nd day of #FCQC2025 conference in Frankfurt was filled with inspiring lectures, vibrant discussions, great posters and a lot of joy of meeting colleagues from all over the world! A huge thanks to all organizers & supporters! @goetheuni.bsky.social @sfb1177.bsky.social @proxidrugs.bsky.social
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SFB 1177 @sfb1177.bsky.social · 25/03/2025
After an inspiring first day, we’re excited to dive into the second day of #FCQC2025 filled with amazing talks on „Organelles in biology and disease“ and „RNA and protein quality control“. @enablefrankfurt.bsky.social @proxidrugs.bsky.social @ibc2-gu.bsky.social @dfg.de
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IBC2 @ibc2-gu.bsky.social · 24/03/2025
Great kick off of our #FCQC2025! Looking forward to the next days full of inspiring sessions, meaningful conversations, and exciting new connections 🙌 @sfb1177.bsky.social @enablefrankfurt.bsky.social @proxidrugs.bsky.social @goetheuni.bsky.social
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Dikic lab @dikiclab.bsky.social · 24/03/2025
What a timing! We just heard about this amazing story a moment ago at the #FCQC2025, and we can already dig further and read the paper! 😁 Congratulations, Leo and team! #ubiquitin #proteasome
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RTG2771 Humans and Microbes @rtg2771.bsky.social · 29/01/2025
🚨 Save the date! 🚨 We're thrilled to announce our International Symposium on Cell & Structural Biology of Host-Pathogen Interaction 📅 Sept 10-12, 2025 📍 @cssbhamburg.bsky.social Hamburg Registration starts soon For more info: humansandmicrobes2025.de
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SFB 1177 @sfb1177.bsky.social · 29/01/2025
We are pleased to introduce the 4th Frankfurt Conference on Quality Control in Life Processes organized by @idikic.bsky.social, Maike Windbergs & Volker Dötsch. The program is now available—more updates to come. fcqc.de @proxidrugs.bsky.social @enablefrankfurt.bsky.social #FCQC2025 #autophagy
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Ivan Dikic @idikic.bsky.social · 28/11/2024
‘Easy to handle’ Cereblon – a new tool for drug discovery and molecular glue screening 👍 www.sciencedirect.com/science/arti... Congrats to the Đikić lab and Merck KGaA, in collaboration with Enamine Ltd, the Nowak Lab, the Langer Lab and iBET 😀 #CRBN #TPD #PROTAC
Engineering and sculpturing a smaller easy-to-use CRBN for new drug discoveries
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Ivan Dikic @idikic.bsky.social · 17/11/2024
An impressive display of technologies was used to discover how cryptic #splicing causes #celldeath and leads to development of human #diseases. www.science.org/doi/10.1126/... It was a real joy to work together with @prieto-garcia.bsky.social and all other collaborators. Many thx 👍😀
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IBC2 @ibc2-gu.bsky.social · 28/11/2024
Happy to join Bluesky! Please connect @idikic.bsky.social @manuelkaulich.bsky.social @prieto-garcia.bsky.social @hartungingo.bsky.social@diefenbacherlab.bsky.social
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