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Thomas Pradeu

@pradeu.bsky.social
4.4K followers 723 following 18 posts

CNRS Research Director, Philosophy of Science and Theoretical Biology. Works on Immunology, cancer, and microbiome. CNRS & University of Bordeaux, France.

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Reposted by Thomas Pradeu
Nature Reviews Cancer @natrevcancer.nature.com · 24/09/2026
🎉 Our 25th Anniversary Issue is now live! 🎉🥳 Featuring #Reviews on - 3D tumour atlases - The systemic impact of EVs - Pyroptosis & antitumour immunity #Roadmap on - Early-onset CRC prevention Plus #Viepoints #Comments &#WorldView Check it out 👇 dlvr.it/TVcqwv
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Simon Fisher @profsimonfisher.bsky.social · 23/09/2026
“Bats are extraordinary among mammals, having uniquely evolved powered flight & laryngeal echolocation, along with disease resistance, extended healthspan & ability to hibernate. With genome assemblies of 103 bat species we provide new insights into evolutionary history & trait diversification.”🦇🧬🙌🧪
nature.com
Reference genomes and fossils revise bat family phylogeny and biogeography - Nature
An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all known bat families.
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Thomas Pradeu @pradeu.bsky.social · 23/09/2026
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Thomas Pradeu @pradeu.bsky.social · 23/09/2026
Tomorrow 5pm (UTC+2)! Eve Marder (Brandeis University, USA), “Cryptic (hidden) changes that result from perturbations and environmental change shape future dynamics of degenerate neurons and circuits” (A @philinbiomed.bsky.social event, Hybrid, open to all), philinbiomed.cnrs.fr/event/eve-ma...
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Iva Vukušić @vukusiciva.bsky.social · 21/09/2026
This ridiculous number of applications is, in my view, the result of 2 nightmare developments happening concurrently 1.the precariousness of the job market for young PhD graduates which then fuels further: 2.the AI tools enabling overproduction of proposals. #Research #ERC #ResearchFunding #Academia
Just a screenshot with an EU logo saying that the 2026 call has attracted considerable interest from the research community with 21,627 applications submitted.
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bioRxiv Immunology @biorxiv-immuno.bsky.social · 22/09/2026
Collateral Immune Cell Signaling Compromises the Efficacy of T-cell Engaging Therapies for Cardiac Fibrosis www.biorxiv.org/content/10.64898/20…
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Rob Noble @robjohnnoble.bsky.social · 19/06/2026
Started the day by belatedly reading the excellent essay "Critically assessing atavism, an evolution-centered and deterministic hypothesis on cancer" by Bertrand Daignan-Fornier and @pradeu.bsky.social: doi.org/10.1002/bies... The latter is recruiting a postdoc: philinbiomed.cnrs.fr/jobs/postdoc...
philinbiomed.cnrs.fr
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Sorek Lab @soreklab.bsky.social · 17/06/2026
Preprint: Plant pathogens cleave 2’cADPR to suppress TIR immune signaling Inspired by knowledge on how phages inhibit bacterial immunity, we now show that disease-causing bacteria inhibit plant immunity in a similar way. A 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
Plant pathogens cleave 2'cADPR to suppress TIR immune signaling
Small molecules produced by TIR (Toll-interleukin-1 receptor) domains are essential for plant immune signaling. A central TIR-derived signal is 2'cADPR, a cyclic ADP-ribose (ADPR) molecule that is gen...
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Nature Reviews Immunology @natrevimmunol.nature.com · 17/06/2026
ICYMI: Nuclear STING compromises replication fidelity
dlvr.it
Nuclear STING compromises replication fidelity
Nature Reviews Immunology, Published online: 15 June 2026; doi:10.1038/s41577-026-01324-zA preprint by Teodoro-Castro et al. reports a nuclear role for STING in impairing DNA replication and contributing to replication stress in ageing pathologies.
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Keila Stark (she/her) @keila-stark.bsky.social · 17/06/2026
Reminder to register for the Unifying Ecology Gordon Conference by next Monday! Lest you miss out on this incredible line up! www.grc.org/unifying-eco... @jennsunday.bsky.social @ewaldoleitao.bsky.social #GRC #ecoevo
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RogueESR @rogueesr.bsky.social · 08/06/2026
Sciences Po, Paris-I, Toulouse : les facs confrontées à des répressions « inédites ». www.mediapart.fr/journal/fran...
mediapart.fr
Sciences Po, Paris-I, Toulouse : les facs confrontées à des répressions « inédites »
Agression, distribution massive d’amendes, contrôles d’identité… Pour enrayer les mobilisations syndicales et étudiantes, les universités ont de plus en plus souvent recours à la police, aux dépôts d…
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Cédric Brun @cedricbrun.bsky.social · 08/06/2026
Many thanks to Markus Kunze, Jérôme Badaut, Muriel Darnaudery, Léa Peltier, Thomas Pradeu @pradeu.bsky.social Isabella Sarto-Jackson and Jan-Pieter Konsman for the great collaboration on this paper! END N=25
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Rob Noble @robjohnnoble.bsky.social · 09/06/2026
Fridolin Gross and @pradeu.bsky.social are advertising a two-year postdoc in conceptual, theoretical, or philosophical approaches to cancer at ImmunoConcept (CNRS & University of Bordeaux, France). Closing 30th July. Sounds amazing! philinbiomed.cnrs.fr/jobs/postdoc...
philinbiomed.cnrs.fr
Postdoctoral Position in Philosophy of Cancer (Bordeaux, France) – philinbiomed
Call for Applications: Postdoctoral Position in Philosophy of Cancer (University of Bordeaux)
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Thomas Pradeu @pradeu.bsky.social · 11/06/2026
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Thiago Carvalho @cyrilpedia.bsky.social · 08/06/2026
'Lower-ranked institutions exhibit higher rates than elite universities, young for-profit publishers show elevated rates vis-à-vis competitors, and academic fields differ widely in adoption. LLM adoption in academic writing is pervasive but socially stratified.' www.pnas.org/doi/10.1073/...
pnas.org
The diffusion of large language models in published academic articles | PNAS
Large language models (LLMs) are rapidly changing academic research, raising questions of who is adopting these tools and under what conditions. Th...
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Thomas Pradeu @pradeu.bsky.social · 08/06/2026
This is today and this is not to be missed.
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Aude Bernheim @audeber.bsky.social · 22/05/2026
Great piece and cover @science.org about how our field is uncovering the evolutionary and mechanistic connections between bacterial and eukaryotic immunity ! www.science.org/content/article/ancient-wars-between-microbes-gave-us-key-immune-defenses
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The New York Times @nytimes.com · 07/05/2026
Candidates for California governor discussed housing and insurance policy in the first half of an hourlong debate, then furiously attacked one another at the end.
nyti.ms
5 Takeaways From the Last Televised California Governor Debate
Candidates debated housing and insurance policy in the first half, then furiously attacked one another at the end.
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Thomas Pradeu @pradeu.bsky.social · 05/05/2026
Are all #living things capable of #cognition? Today at 5pm, Mazviita Chirimuuta, an oustanding philosopher of #neuroscience who recently received the #Lakatos Award, will give a hybrid talk that identifies the key features of non-cognitive processes. #philsci #cognitive @philinbiomed.bsky.social
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Prof Danny Altmann @daltmann.bsky.social · 30/04/2026
CDC communication undermines trust in vaccines | Science www.science.org/doi/10.1126/...
science.org
CDC communication undermines trust in vaccines
Uncertainty-based framing raises doubt, lowers vaccination intentions, and boosts science denial
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ASM @asm.org · 27/04/2026
Dismissing all members of the National Science Board will only continue the destabilization of American fundamental research and scientific workforce development. Read our statement: brnw.ch/21x1Z8n
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Cédric Brun @cedricbrun.bsky.social · 27/04/2026
Quelques échanges récents ici m’ont donné envie de proposer un panorama de la philosophie des sciences contemporaine. Non pour défendre une corporation, mais pour corriger une image assez datée de la discipline. Je resterai volontairement assez schématique pour ne pas alourdir un thread long. 1/n
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Kenneth Loi @kenjmloi.bsky.social · 27/04/2026
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR. We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets. Thread + link below.
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Bacteriophage Lab of Institut Pasteur @phagepasteur.bsky.social · 25/04/2026
#OTD in #Phage history: In 1873, the phage therapy pioneer Félix d’Hérelle was born!!! His amazing work at @pasteur.fr and other institutions laid the foundation in which groups like the BBH were founded You can read more about his fascinating life story here www.pasteur.fr/en/institut-...
F´elix d’H´erelle, 1873–1949. Contributor: HistoricImages / Alamy Stock Photo
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Nicolas Berrod @nicolasberrod.bsky.social · 26/04/2026
Exclu Le Parisien : des centaines de médecins, scientifiques et personnalités publient une tribune pro-#vaccination, contre "des idéologies qui manipulent les peurs" : "C'est un bien commun de l’humanité, nous ne laisserons personne la remettre en cause."
leparisien.fr
Vaccination : le cri d’alarme contre « des idéologies qui manipulent les peurs » - Le Parisien
EXCLUSIF. À l’occasion de la semaine de la vaccination, Le Parisien publie un texte offensif, initié par l’Institut Pasteur et rédigé par de
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Anna Alexandrova @annaalexandrova.bsky.social · 25/04/2026
If you are planning to attend, the registration is open. We @hpscambridge.bsky.social are pouring our hearts into this conference and it will be amazing. Even though my own submission was not accepted! #philsci #philsky #hps #metascience
spspcambridge2026.com
Society for the Philosophy of Science in Practice 2026 Conference | SPSP Cambridge 2026
The Society for the Philosophy of Science in Practice 2026 Conference at the Department of History and Philosophy of Science at the University of Cambridge
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Jenna Norton @jenna-m-norton.bsky.social · 25/04/2026
NAS President Marcia McNutt claims she is being bipartisan by avoiding “topics for which there is a partisan divide.” But this is blatantly partisan. She is doing exactly what one party wants. Worse, in direct opposition to the science in these fields. 🧵1/?
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Adam Rogers @jetjocko.bsky.social · 25/04/2026
Here’s the head of the National Academy of Science saying that the academies shouldn’t work on climate change or vaccines because of political partisanship, and instead focus on fields with “bipartisan” support like national defense and AI.
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Science Magazine @science.org · 25/04/2026
U.S. President Donald Trump has fired all 24 members of the National Science Board, the body that oversees the National Science Foundation. scim.ag/4cxQWhl
scim.ag
Trump fires NSF's oversight board
Dismissal of the National Science Board is widely seen as latest move to erase NSF’s independence
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Diana Fisher @dianafisher1080.bsky.social · 26/04/2026
Extinction of the human species: What could cause it and how likely is it to occur?' by Professor Seán Ó hÉigeartaigh (University of Cambridge), on Wednesday 6 May at 6pm UK time. cassyni.com/events/AKmfE...
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ae @aelkus.bsky.social · 26/04/2026
theconversation.com/a-few-weeks-...
theconversation.com
A few weeks of X’s algorithm can make you more right-wing – and it doesn’t wear off quickly
Elon Musk’s social media platform is boosting conservative content – and it’s having long-lasting effects on how users see the world.
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Alex Gao @algao.bsky.social · 16/04/2026
Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze! www.science.org/doi/10.1126/...
science.org
Science | AAAS
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David Bikard @dbikard.bsky.social · 17/04/2026
Very proud of this work and all the efforts from my team and collaborators on this! You can now use DGRs for in vivo targeted hypermutagenesis in E. coli. We also included some early proof of concept in Yeast thanks to @seth-shipman.bsky.social !
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Kotaro Chihara @kochihara.bsky.social · 20/04/2026
Happy to share our new work on how phages escape bacterial immunity. We show that a phage homing endonuclease drives segmental amplification of anti-defense genes, pointing to a versatile and rapid mode of adaptation. www.nature.com/articles/s41... #PhageSky #MicroSky
nature.com
Phage homing endonuclease amplifies anti-defense genes to evade bacterial immunity - Nature Communications
Phages employ diverse counter-defense strategies to overcome bacterial immune systems. Here, the authors reveal that the phage homing nuclease SegB facilitates immune evasion by promoting the segmenta...
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Kranzusch Lab @kranzuschlab.bsky.social · 21/04/2026
Structures of the QatBC complex from Angela Gao and Doug Wassarman in our group reveal an evolutionary link between QatABCD and Type IV CBASS and a role for protein deazguanylation in diverse anti-phage defense systems www.nature.com/articles/s41... www.science.org/doi/10.1126/...
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Sorek Lab @soreklab.bsky.social · 23/04/2026
We found that TIR domains in animal immune proteins, including the human TLR4, are enzymes that cleave NAD+ to produce the signaling molecule cADPR Read our new preprint by talented Bohdana Hurieva: “Conserved catalytic activity of immune TIR domains in animals” www.biorxiv.org/content/10.6...
biorxiv.org
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PhilInBioMed @philinbiomed.bsky.social · 20/04/2026
Join our upcoming PhilInBioMed‑Seminar: Apr 21 | 5 - 6:30 pm (CET) | virtual on Zoom Kenneth S. Kendler (Virginia Commonwealth University, USA): “A Conversation about Major Themes in the Philosophy of Psychiatry” Further information here: philinbiomed.cnrs.fr/event/philin...
philinbiomed.cnrs.fr
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 19/04/2026
#ESR #VeilleESR Tribune de la C3N du #CNRS signée par plus de 700 scientifiques (membres du comité national, directrices et directeurs d'unités) pour alerter une nouvelle fois sur les conséquences des coupes budgétaires c3n-cn.fr/2026/04/10/b...
c3n-cn.fr
Coordination des instances du Comité National
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Wolfgang Cramer @cramer-bondeau.fr · 17/04/2026
[Lettre ouverte du Conseil scientifique de la Fondation pour la recherche sur la biodiversité (FRB)] Présenter l’écologie scientifique comme une opinion est dangereux pour la démocratie www.fondationbiodiversite.fr/actualite/le...
fondationbiodiversite.fr
[Lettre ouverte du CS] Présenter l’écologie scientifique comme une opinion est dangereux pour la démocratie - Fondation pour la recherche sur la biodiversité
À plusieurs reprises, notamment le 26 mars, la commission a adopté une attitude outrageusement sceptique vis-à-vis de l’information scientifique et technique, en particulier dans le domaine de l’écolo...
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 19/04/2026
#ESR #VeilleESR #Unjoursansfin #Groundhogday (2004-2026)
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PLOS Biology @plosbiology.org · 14/04/2026
Some #bacteria polymerize excess carbon into polyhydroxybutyrate (PHB), a biodegradable storage polymer. This study shows that #PHB -producing bacteria kill #Celegans nematodes by disrupting pharyngeal & intestinal function @plosbiology.org 🧪 plos.io/4cFAwDz
Bacteria producing PHB harm C. elegans in multiple ways. Top: Model of how bacterially produced PHB affect C. elegans and which mechanisms can be alleviated by nuc-1 knock out. PHB, poly-β-hydroxybutyrate; Dar, deformed anal region. Bottom: Transmission electron micrograph of bioplastic polyhydroxybutyrate granules filling the intestine of C. elegans. Imaged by Gregor Hendricks, PHD at UMass Chan Medical School Electron Microscopy Core.
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Xavier Trepat @xaviertrepat.bsky.social · 17/04/2026
Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.
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Waggoner Lab @labwaggoner.bsky.social · 17/04/2026
Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge @labliston.bsky.social @sciimmunology.bsky.social @babrahaminst.bsky.social @drntombizodwa.bsky.social www.science.org/doi/10.1126/...
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Marc Veldhoen @marcveld.bsky.social · 17/04/2026
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset www.thelancet.com/jo... 1/9
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Prof Sheena Cruickshank @sheencr.bsky.social · 17/04/2026
Good RFKjr was challenged on his damaging actions cutting healthcare access, vaccine access and racist statements in congress but does anything happen because of this? www.theguardian.com/us-news/2026...
theguardian.com
RFK Jr accused of ‘dangerous conspiracy theories’ at heated budget hearing
Trump ally grilled by lawmakers over ‘terrible decisions’ on vaccines, public health and funding cuts to key programs
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Magdalena Skipper @magdalenaskipper.bsky.social · 17/04/2026
Scientists are going into politics in the US in increasing numbers. This is a brilliant and much needed trend 🧪 www.nature.com/articles/d41...
nature.com
‘Science needs defending’: record number of researchers run for office in US mid-terms
Many Democrats making the switch to politics are motivated by the Trump administration’s cuts to science — whereas energy and AI are a pull for some Republicans.
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Éditions du Collège de France @editionscdf.bsky.social · 16/04/2026
[#Parution] La #leçon de clôture de François Héran “Face à l'immigration, le savant et le politique”, @editionscdf.bsky.social, est disponible en librairie à partir d’aujourd’hui www.college-de-france.fr/fr/editions/... @lecomptoir-fmsh.bsky.social @college-de-france.fr #immigration #sociologie
Première de couverture du livre de François Héran. Illustration de couverture : Jean-Pierre Gack, Les Passeurs d'horizon 9, acrylique sur toile, 100 x 100 cm, 2026 (Nantes, galerie d'art contemporain Toulouse Lauwers).Quatrième de couverture du livre de François Héran. Texte complet disponible ici : https://www.college-de-france.fr/fr/editions/lecons-de-cloture/face-immigration-le-savant-et-le-politique-9782722608795-0.
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Stem Cells, Regeneration & Evolution @stemdevevo.bsky.social · 17/04/2026
Super cool papier from Félix and co ! Congrats !
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PLOS Biology @plosbiology.org · 17/04/2026
Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @plosbiology.org 🧪 plos.io/4vG0mz1
Overview of RB-TnSeq screens. Top left: Schematic for RB-TnSeq screen experimental set-up. Top middle: Pie chart depicting the number of RB-TnSeq screens completed for each category. Top right: Previously published TnSeq fitness with 27ng/mL isoniazid plotted against BarSeq fitness with 25 ng/mL isoniazid. Dotted line represents linear correlation between statistically significant hits from RB-TnSeq with TnSeq. Bottom left: BarSeq fitness (log2 fold change) for sugI (Rv3331) and sugA (Rv1236). Bottom right: Cofitness data for Rv3220c and Rv1626.
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Thomas Pradeu @pradeu.bsky.social · 17/04/2026
French time, UTC+2
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