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PlessLab

@plesslab.bsky.social
1.3K followers 288 following 66 posts

Ion channels, biophysics, chemical biology, protein engineering and molecular neuroscience; Professor at University of Copenhagen; www.theplesslab.com

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Biophysical Society @biophysicalsoc.bsky.social · 27/09/2026
Have you submitted your abstract yet for #bps2027? The deadline is fast-approaching, on October 1! Don't miss out on the opportunity to share your research at the largest gathering of biophysicists from around the world! buff.ly/VqqKII9
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Alexis Rohou @alexisrohou.bsky.social · 10/09/2026
Genentech Structural Biology is hiring a Principal Scientist - please share! We're looking for someone with expertise in solving structures and in computational techniques related to dynamics - MD, ensemble modeling, ensemble docking, and/or related methods.
careers.gene.com
Principal Scientist, Structural Biology in South San Francisco, California, United States of America | Research & Development at Genentech
Apply for Principal Scientist, Structural Biology job with Genentech in South San Francisco, California, United States of America. Research & Development at Genentech
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Journal of General Physiology @jgp.org · 03/09/2026
Tunable AMPA receptor function via recurrent #evolution of heterotetramers. New study from Yuhong Wang, Alexander Edwards, Jelena Baranovic, and Timothy Lynagh @msarscentre.bsky.social: rupress.org/jgp/article/... #MolecularPharmacology #MembraneTransport #Biochemistry #Biophysics #IonChannels
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PlessLab @plesslab.bsky.social · 28/08/2026
Voltage-clamp fluorometry turns 30 this year - thank you, Isacoff & Bezanilla! It has been a great tool to watch the outside of channels move, but of less use on the inside. That’s a shame because that is where a lot happens, incl. conformational changes related to sodium channel inactivation. 1/x
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Sergey Ovchinnikov @sokrypton.org · 15/08/2026
Try for your protein at py2dmol.solab.org (Style → Cartoon)
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PlessLab @plesslab.bsky.social · 17/07/2026
Big thanks to Isabelle Baconguis (Vollum Institute) and her group for including us in their epic foray into the structural plasticity of ASICs, now out in Nature Structural and Molecular Biology: www.nature.com/articles/s41... 1/4
nature.com
Conformational plasticity of human acid-sensing ion channel 1a - Nature Structural & Molecular Biology
Using cryo-electron microscopy, Cahill, Hartfield et al. identified six structural states of human acid-sensing ion channel 1a, revealing how acidic conditions and peptide toxins regulate channel acti...
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PlessLab @plesslab.bsky.social · 12/07/2026
En route to the 2026 ion channel GRC - looking forward to seeing everyone and catching up on everything related to those magic proteins! www.grc.org/ion-channels...
grc.org
2026 Ion Channels Conference GRC
The 2026 Gordon Research Conference on Ion Channels will be held in South Hadley, Massachusetts. Apply today to reserve your spot.
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PlessLab @plesslab.bsky.social · 08/04/2026
One week left to apply for the EMBO/FEBS lecture course on #ionchannels and #transporters in beautiful Erice in May 2026: meetings.embo.org/event/26-ion... Please share
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cryoEM papers @cryoempapers.bsky.social · 04/04/2026
Cryo-EM structures of human P2X2/3 heteromer channel reveal the structural basis of ligand selectivity pubmed.ncbi.nlm.nih.gov/41931608/ #cryoEM
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PlessLab @plesslab.bsky.social · 15/03/2026
Excited to be on my way to the Ligand Recognition and Molecular Gating GRC - many of our present projects started at this meeting 10 (!) years ago! @Nalcn @Split inteins
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Mohammed AlQuraishi @moalquraishi.bsky.social · 13/03/2026
New OpenFold3 preview out! (OF3p2) It closes the gap to AlphaFold3 for most modalities. Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9
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Betty C. Jung @bettycjung.bsky.social · 12/03/2026
Keep calm and be transparent: advice from scientists who retracted their papers www.nature.com/articles/d41... @elisabethbik.bsky.social
nature.com
Keep calm and be transparent: advice from scientists who retracted their papers
Retractions correct the scientific record, but they have stigma attached to them. Some in the research community want that to change.
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PlessLab @plesslab.bsky.social · 06/03/2026
3000th clone added to our clone library. Happy weekend
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Cordero-Vásquez Lab @cvlab.bsky.social · 27/01/2026
Sudha (@chakrapanilab.bsky.social) and Julio (@cvlab.bsky.social) are organizing the 2026 Ion Channel Gordon Research Conference: Ion Channels Across Scales — Bridging Molecular Events to Physiological Outcomes, to be held at Mount Holyoke College, July 12–17, 2026. 1/3
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Isabel del Pino Lab @idelpinolab.bsky.social · 23/01/2026
Kicking off 2026 on a positive note! Check out our latest work on developmental channelopathies. #IonChannels #NALCN #IHPRF1
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PlessLab @plesslab.bsky.social · 16/01/2026
Time to sign up! Registration for the joint FEBS/EMBO course on ion channels and transporters in Erice, Italy (May 13-19th 2026) is now open: meetings.embo.org/event/26-ion... Please share and repost.
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Lorne Proteins @lorneproteins.bsky.social · 14/01/2026
Lorne Proteins 2026 🏖️ Leach Lecturer Carol Robinson, Oxford, on establishing mass spec as a viable technique for structure/function studies; and John Kuriyan, Vanderbilt University, on the structural plasticity and evolutionary potential of DNA clamp loaders. 🔗 Register now: www.lorneproteins.org
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eLife @elife.bsky.social · 28/12/2025
A new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers. buff.ly/K7CGFLV
The commitments in the SAFE Labs Handbook.
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PlessLab @plesslab.bsky.social · 26/11/2025
To all trainees interested in channels and transporters: the joint FEBS/EMBO course will go ahead in Erice, Italy from May 13-19 2026: network.febs.org/posts/new-jo... Further details to come soon. Please share and repost.
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Itai Yanai @itaiyanai.bsky.social · 23/11/2025
PhD students and Postdocs: The Night Science Podcast (@nightsciencepod.bsky.social) is producing an episode highlighting young scientists talking about their creative process. DM me if you'd like us to consider you for this, & read below what PhD student Davis Garner will contribute! ⬇️
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Andrew Plested @andrewplested.bsky.social · 15/11/2025
Game changer, no doubt. Commercial systems will have expensive consumables I suppose, but huge savings to be made in cell culture, and many important but sparse native targets come into play. Crispr-tagged targets from iPSC neurons, for example. TRPC6 blind? 🤯
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PlessLab @plesslab.bsky.social · 13/10/2025
Very grateful to have been able to attend the second-ever NALCN conference. This provided a fantastic opportunity to catch up with collaborators and meet patients and families affected by NALCN-related diseases. Huge thanks to everyone at the Channeling Hope Foundation for making this event happen!
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Magnus Bauer @kinasekid.bsky.social · 30/09/2025
Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: www.biorxiv.org/content/10.1...
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PlessLab @plesslab.bsky.social · 29/09/2025
When I started working on ion channels 20+ yrs ago, I could have never imagined how many channels there are to explore! Now I’m delighted to be heading to thematic meetings on two of our favorite channels in the span of just weeks - can’t wait to catch up with the ASIC and NALCN communities!
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PlessLab @plesslab.bsky.social · 17/09/2025
After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN: www.biorxiv.org/content/10.1...
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Lorne Proteins @lorneproteins.bsky.social · 16/09/2025
Momentum is building! Join us for the 51st Lorne Proteins Conference Feb 8–12, 2026, Mantra Lorne on the Great Ocean Road, for fun networking activities 🏐 🎾 🥗 🪩 and breathtaking surf-coast accessibility 🏖️ 🏊 🏄 in the generous breaks between sessions! 🔗 Register here: www.lorneproteins.org/register
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Angelika Lampert @lampertlab.bsky.social · 06/09/2025
Come to the second edition of the world wide sodium channel conference! Submit an abstract by September 26.
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Journal of General Physiology @jgp.org · 05/09/2025
Adriano Senatore @utoronto.ca and colleagues explore the evolutionary origins of the sodium leak channel NALCN and its ancillary subunits FAM155/Mid1, UNC79, and UNC80. rupress.org/jgp/article/... #Evolution #IonChannels
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Oksana Iamshanova @iamshanovao.bsky.social · 01/09/2025
2nd #WSCC26 will take place in Grindelwald (Switzerland) 🚠 from 4th to 6th of February, 2026. 🌍 Join @lampertlab.bsky.social , @antoniospantazis.bsky.social, @khannalabuf.bsky.social, and others. 💡 Submit abstracts by the 26th of September, 2025: lnkd.in/eDhPUVKd 💻 More info: lnkd.in/eJw9pfMz
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PlessLab @plesslab.bsky.social · 22/08/2025
Wonderful visit to beautiful Bergen, Norway. Big thanks to @herculeria.bsky.social for hosting and to Tim Lynagh for guiding me up the local hills
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Lorne Proteins @lorneproteins.bsky.social · 21/08/2025
🥁🥁🥁 The 51st Lorne Conference on Protein Structure and Function is officially live! After the resounding success of the 50th Lorne Conference in 2025 celebrating five decades of pioneering science and community, the legacy continues... 🏄🏖️🌞 February 8–12, 2026 Register here: www.lorneproteins.org
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Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · 15/08/2025
Friends don’t use friend’s plasmids without sequencing them. For some types of plasmids from academic and industrial labs, up to 40% contained mutations academic.oup.com/nar/article/...
academic.oup.com
Prevalence of errors in lab-made plasmids across the globe
Abstract. Plasmids are indispensable in life sciences research and therapeutics development. Currently, most labs custom-build their plasmids. As yet, no s
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Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 06/08/2025
Villum Sabbatical grant: For US-based researchers wishing to visit a Danish university for up to 12 months Deadline Aug. 15th 2025 villumfonden.dk/en/group/cha...
Villum Foundation wishes to encourage the exchange of scientific ideas between the US and Denmark. Villum Sabbatical supports research stays of up to one year at a Danish university. Researchers at the associate professor or professor level based at a US university may receive up to 1 MDKK to cover their salary (in part or in full), salary of accompanying group members (postdocs and PhD students), travel and research costs associated with the stay. Applications are only accepted from the head of the department at the Danish host institution.

If a visiting researcher subsequently decides to relocate to Denmark, they are encouraged to apply for one of Villum Foundations’s investigator grants (Young Investigator, Ascending Investigator, Investigator)
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henrietteautzen.bsky.social @henrietteautzen.bsky.social · 03/08/2025
🚨 One week left to apply! I am hiring a fully funded PhD fellow and a postdoc to work on membrane protein structural biology and pharmacology at Univ Copenhagen Come work with a great team and exciting projects in a collaborative environment! 🔗 Links to the ads in comments #CryoEM #AcademicJobs
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Journal of General Physiology @jgp.org · 16/07/2025
@michaelclerx.com et al. @uniofnottingham.bsky.social present variability in reported midpoints of activation and inactivation for the cardiac fast sodium current, INa, show the correlation between these midpoints, and discuss possible experimental sources of variability. rupress.org/jgp/article/...
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Christian A. Olsen @christianaolsen.bsky.social · 08/07/2025
We are hiring at the Department of Drug Design and Pharmacology. Check out these opportunities and consider becoming our new colleague at University of Copenhagen. employment.ku.dk/faculty/?sho...
employment.ku.dk
164291 Associate Professor or Professor
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PlessLab @plesslab.bsky.social · 06/07/2025
“It’s the company that matters!” This is certainly true for acid-sensing ion channel 1a, whose function is modulated by the presence of monocarboxylate transporter 1 All was made possible by the drive & curiosity of the fantastic @mette-h-poulsen.bsky.social www.biorxiv.org/cgi/content/...
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Sten Linnarsson @sten.linnarsson.org · 25/06/2025
A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
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PlessLab @plesslab.bsky.social · 25/06/2025
Exciting news for protein design!
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Jason Rasgon @vectorgen.bsky.social · 01/08/2023
I guess I should re-post from the Bird Site "The Rules For Academic Success here": I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses... This list gets longer all the time
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Andrew Plested @andrewplested.bsky.social · 05/06/2025
The 3rd Berlin Single Molecule Biophysics Course will run from 8th to 12th September at the HU-Berlin, Institute of Biology. Learn about single channels, single molecule TIRF, theory and analysis. Apply by 7th July at bsmbc@icloud.com. Fee waivers and bursaries available. ! Please share widely !
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PlessLab @plesslab.bsky.social · 03/06/2025
Great meeting on acid-sensing ion channels coming up in the fall in Germany - make sure to sign up: www.asic-meeting.org
asic-meeting.org
ASIC 2025 Meeting - Wissenschaftliches Treffen über ASICs
Erleben Sie die neuesten Fortschritte in der ASIC-Forschung beim ASIC 2025 Meeting in Tutzing.
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Rafeeque Mavoor @rafeequemavoor.bsky.social · 13/05/2025
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
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CCeMMP Outreach @ccemmp-outreach.bsky.social · 07/05/2025
CCeMMP Seminar alert⏰ We welcome Professor Juan Du, Department of Molecular Biosciences, Northwestern University, Illinois, USA! “The importance of Physiological Temperature in Biomedical & Biophysical Research” More details and register: ccemmp.org/events/ccemm...
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PlessLab @plesslab.bsky.social · 03/05/2025
Very important to keep in mind: Asp/Glu aren’t necessarily always charged!
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Steve Wang @stevewang251.bsky.social · 26/04/2025
Heard from a former (undergrad) student who just defended her PhD. Students: tell your old profs about your successes and achievements. It's not bragging, and we love to hear about it. It's one of the best parts of being an educator. #academicsky
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Azadeh Shahsavar @azadeh-shahsavar.bsky.social · 24/04/2025
Beyond excited to present our study on the glycine transporter #GlyT2, a promising #non-opioid target for the treatment of neuropathic pain. @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Structural insights into allosteric mechanism of glycine transporter-mediated analgesia
Chronic neuropathic pain, caused by nerve damage or disease, affects 10% of the population with rising incidence. The burden is exacerbated by ineffective treatments and overreliance on opioids. Neuro...
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Boris Vauzeilles @borisvauzeilles.bsky.social · 31/03/2025
Save the date!!! For the first time since 2015, the annual conference of the International Chemical Biology Society comes back to Europe and joins forces with the biennal European Chemical Biology Symposium, to organize #ChemBioParis2025, in the heart of the City of Light. Oct 6-9, 2025.
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bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 29/03/2025
Structural basis for selective inhibition of human GABA transporter GAT3 www.biorxiv.org/content/10.1101/202…
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Joe Rogers @josephrogers.bsky.social · 20/03/2025
Stellar line up for our protein design conference. Copenhagen, Sept 1-4, 2025. 10 days to abstract deadline. Get applying! benzon-foundation.dk/benzon-sympo...
benzon-foundation.dk
Benzon Symposium no. 69 - Protein structure prediction and design in biology and pharmacology - Benzon Foundation
Radisson Collection Hotel, Copenhagen, September 1-4, 2025 Organizers: Kresten Lindorff-Larsen, Birthe B. Kragelund, Joseph M. Rogers, Amelie Stein,Anders Krogh, Wouter Boomsma and Hanne Mørck Nielsen...
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