The endosomal Na+ /H+ exchanger HsNHE6 regulates organellar pH and is implicated in neurological disease. Here the authors determine its cryo-EM structure and show a kinetic preference for K+ over Na+...

A drug strategy abandoned after causing tremors, seizures and death in animals has been revived with a redesign that makes the compound less “sticky” — allowing it to let go faster from its...

Atypical inhibitors of dopamine transporter lack the rewarding effects of psychostimulants and offer a promising strategy for the treatment of drug use disorders. In this study, we present the cryo-e...

Chronic neuropathic pain, caused by nerve damage or disease, affects 10% of the population with rising incidence. The burden is exacerbated by ineffective treatments and overreliance on opioids. Neuro...

The astrocytic γ-aminobutyric acid (GABA) transporter, GAT3, is essential for terminating GABAergic signalling in the central nervous system. Selective inhibition of GAT3 offers a potential strategy f...