Reposted by @chakrapanilab.bsky.social
Check out our latest paper on the glycine receptor with
@chakrapanilab.bsky.social
where we show the interplay between the orthosteric and allosteric binding sites.
www.science.org/doi/10.1126/...
science.org
Structural basis for domain coupling in heteromeric glycine receptors revealed by an atypical allosteric agonist
Counteracting ligands stabilize glycine receptor states revealing mechanisms of pentameric ligand-gated channel allostery.
