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Christian A. Olsen

@christianaolsen.bsky.social
511 followers 210 following 17 posts

Professor Drug Design and Pharmacology University of Copenhagen

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Christian A. Olsen @christianaolsen.bsky.social · 17/03/2026
Check out our new preprint, where we inhibit quorum sensing, using cysteine, as an anti-virulence strategy to target S. aureus. @bgless.bsky.social, @hingmer.bsky.social Thanks to the #LEO_Foundation and the @novo-nordisk.bsky.social for financial support. chemrxiv.org/doi/full/10....
Inhibition of quorum sensing in Staphylococcus aureus to treat MRSA skin infection by destruction of auto-inducing peptides. Olsen Laboratory, University of Copenhagen, 2026
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Christian A. Olsen @christianaolsen.bsky.social · 30/10/2025
We are looking for a PhD candidate for an exciting project in chemical biology and microbiology. Please apply through the below link if you want to pursue new anti-virulence strategies to target antibiotic-resistant bacteria. jobportal.ku.dk/phd/?show=15...
jobportal.ku.dk
PhD fellowship in Chemical Biology at Department of Drug Design and Pharmacology
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Christian A. Olsen @christianaolsen.bsky.social · 17/07/2025
Check out the write-up of our new publication in #mBio, where we profiled a large number auto-inducing peptide (AIP) signaling molecules from staphylococci. @ucph.bsky.social @bgless.bsky.social @benjaminsb.bsky.social news.ku.dk/all_news/202...
news.ku.dk
Bacteria from cows show promising results in treating MRSA infections
New research from the University of Copenhagen shows that signaling molecules from a specific Staphylococcus bacterium can treat MRSA infections as effectively as antibiotics.
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Christian A. Olsen @christianaolsen.bsky.social · 17/07/2025
The final version of this publication is now online: journals.asm.org/doi/epdf/10....
journals.asm.org
Mapping of quorum sensing interaction network of commensal and pathogenic staphylococci
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Christian A. Olsen @christianaolsen.bsky.social · 08/07/2025
We are hiring at the Department of Drug Design and Pharmacology. Check out these opportunities and consider becoming our new colleague at University of Copenhagen. employment.ku.dk/faculty/?sho...
employment.ku.dk
164291 Associate Professor or Professor
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Reposted by Christian A. Olsen
PlessLab @plesslab.bsky.social · 14/03/2025
Our latest paper on the sodium leak channel NALCN complex is now online. We found that the neuronal SNARE proteins syntaxin 1A and SNAP25 inhibit sodium leak currents both in heterologous systems and in neurons! www.science.org/doi/10.1126/...
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Reposted by Christian A. Olsen
Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 12/02/2025
Chemical Solutions to Structural Biology symposium. Registration and abstract submission now open: isbuc.ku.dk/chemical-sol...
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Christian A. Olsen @christianaolsen.bsky.social · 16/02/2025
Check out the final version of this paper. Now out in #JACS_Au @pubs.acs.org pubs.acs.org/doi/10.1021/...
pubs.acs.org
Discovery of De Novo Macrocycle Inhibitors of Histone Deacetylase 11
Histone deacetylase (HDAC) enzymes are epigenetic regulators that affect diverse protein function by removing acyl groups from lysine side chains throughout the proteome. The most recently discovered ...
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Christian A. Olsen @christianaolsen.bsky.social · 04/02/2025
Congratulations @carlosmyruela.bsky.social, @beatfierz.bsky.social and team on a great and important publication, providing new insights into SIRT7 activity
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Christian A. Olsen @christianaolsen.bsky.social · 31/01/2025
I am extremely happy to share this new @biorxivpreprint.bsky.social, which after a long wait updates our previous preprint. Thanks to main drivers @bgless.bsky.social and @benjaminsb.bsky.social as well as all involved colleagues and collaborators! www.biorxiv.org/content/10.1...
Staphylococcal QS mapping, Olsen Lab, UCPH, 2025
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Christian A. Olsen @christianaolsen.bsky.social · 30/01/2025
I am grateful to @tnhansen.bsky.social, #Annika-Mergel, and #Marcos-San-Segundo for co-authoring this piece! @ucph.bsky.social
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Christian A. Olsen @christianaolsen.bsky.social · 30/01/2025
We have a new review article on recent applications of SuFEx chemistry in chemical biology now on-line at #TrendsChem @cellpress.bsky.social Thanks to @novo-nordisk.bsky.social for funding our work. authors.elsevier.com/a/1kWpX9CpcY... Previously on ChemRxiv: chemrxiv.org/engage/chemr...
SuFEx chemistry, Trends in Chemistry, Olsen Lab, UCPH, 2025
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Christian A. Olsen @christianaolsen.bsky.social · 27/01/2025
Thank you #JACS-Au for the selection
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Christian A. Olsen @christianaolsen.bsky.social · 21/01/2025
We have an exciting PhD position available. In collaboration with researchers @scripps.edu, we will investigate bacterial communication within the gut microbiome for potential health benefits, using chemical tools. Deadline 9 February, see 👇 candidate.hr-manager.net/ApplicationI...
candidate.hr-manager.net
PhD fellowship in Chemical Microbiology at Department of Drug Design and Pharmacology
Faculty of Health and Medical Sciences, University of Copenhagen We are offering a three-year PhD fellowship in Chemical Microbiology commencing 1 May 2025
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Christian A. Olsen @christianaolsen.bsky.social · 11/01/2025
I am delighted to share that this paper is now published as an Editor's Choice article in JACS Au @pubs.acs.org pubs.acs.org/doi/10.1021/...
pubs.acs.org
Peptide Backbone Cleavage and Transamidation via Thioester-to-Imide Acyl Transfer
Cysteine thioesters are involved in a myriad of central biological transformations due to their unique reactivity. Despite their well-studied properties, we discovered an unexpected transamidation rea...
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Christian A. Olsen @christianaolsen.bsky.social · 19/12/2024
I am very happy to share that we have received support from #Sygeforsikringen_danmark to investigate bacterial crosstalk within the gut microbiota together with #IngmerLab @ucph.bsky.social and #GhadiriLab @scripps.edu sundhedsdonationer.dk/projekter/ba...
sundhedsdonationer.dk
Bakterielle signalmolekyler til brug for øget tarmsundhed - Sundhedsdonationer
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Christian A. Olsen @christianaolsen.bsky.social · 10/12/2024
New preprint @chemrxiv.bsky.social on discovery of macrocyclic inhibitors of HDAC11 with the Christian Heinis #EPFL Main contributors @danieladankova.bsky.social, @alexanderln.bsky.social, @carlosmyruela.bsky.social 🙏 @ERC_Research, @novonordiskfond, @DFF_raad for 💶 chemrxiv.org/engage/chemr...
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Christian A. Olsen @christianaolsen.bsky.social · 06/12/2024
In a new preprint @chemrxiv.bsky.social, work from @bgless.bsky.social and Sabrina Schmied investigate the mechanism of a rearrangement that can lead to peptide/protein backbone cleavage. Thanks to #LEOFondet for funding the project that led to this discovery. chemrxiv.org/engage/chemr...
chemrxiv.org
Peptide Backbone Cleavage and trans-Amidation via Thioester-to-Imide Acyl Transfer
Cysteine thioesters are involved in a myriad of cen-tral biological transformations because of their unique reactivity. Despite their well-studied proper-ties, we discovered an unexpected trans-amidat...
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