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Pereda Lab

@peredalab.bsky.social
113 followers 171 following 24 posts

Structural Molecular Biology | Cell Adhesion and Signaling Also @peredalab@mstdn.science

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Carl Zimmer @carlzimmer.com · 27/09/2026
Four days ago, a scientist was surprised by the news that Anthropic discovered new virus genes for making DNA. He says he’s been studying them for years—and feeding his data to Anthropic’s AI as part of his own research. Coincidence? Here’s my story. nyti.ms/3VSWayc
nyti.ms
Did Anthropic’s A.I. Really Make a Scientific Discovery on Its Own? (Gift Article)
An expert at the University of Copenhagen said his team had been sharing its research with the company’s A.I. model, Claude, and that its new finding matched their work.
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erzbergerlab.bsky.social @erzbergerlab.bsky.social · 25/09/2026
In-cell structures visualize human pre-ribosome assembly in the nucleolus | Science www.science.org/doi/10.1126/...
science.org
In-cell structures visualize human pre-ribosome assembly in the nucleolus
In eukaryotes, ribosome biogenesis initiates within the nucleolus, a hallmark multilayered compartment of the nucleus. Structures of pre-ribosomes have been characterized ex situ, but their assembly p...
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Instituto de Química Física Blas Cabrera (IQF-CSIC) @iqf-csic.bsky.social · 23/09/2026
“Decoding the Rules of Phase Separation through Minimalist Peptide Models and Atomistic Simulations" By David De Sancho - @dipcehu.bsky.social 📅 FRIDAY, September 25 at 12:00 p.m. 📌 IQF-CSIC Auditorium Everyone is welcome!
Poster with data from the post
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sbesp.bsky.social @sbesp.bsky.social · 22/09/2026
Check out the August 2026 #SBEpaperofthemonth López-Perrote A et al. "CONCR lncRNA organizes a 3'-end structural domain that engages DDX11 for DNA replication and sister chromatid cohesion" Mol Cell. 2026 doi.org/10.1016/j.mo... @maitehuartelab.bsky.social
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Martin Pacesa @martinpacesa.bsky.social · 21/09/2026
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
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paveltomancak.bsky.social @paveltomancak.bsky.social · 20/09/2026
21627 applications. Nothing to celebrate here. Impossible to evaluate fairly & safely. Neither the science (too diverse & possibly LLM generated) nor the soft criteria (likely LLM generated). Without an interview stage - a security risk! marie-sklodowska-curie-actions.ec.europa.eu/whats-new/ne...
marie-sklodowska-curie-actions.ec.europa.eu
MSCA Postdoctoral Fellowships 2026 receives record number of applications
The 2026 call has attracted considerable interest from the research community with 21,627 applications submitted.
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Pereda Lab @peredalab.bsky.social · 18/09/2026
Thanks a lot to @instruct-eric.bsky.social this Scientific Highlight portraying our recent work on the structural basis of the interaction of an anti-HPA-1a alloantibody with integrin αIIbβ3 instruct-eric.org/scientifichi...
instruct-eric.org
International cryo-electron microscopy collaboration helps to improve understanding of Fetal/neonatal alloimmune thrombocytopenia
Instruct-ERIC is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers.
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Milot Mirdita @milot.bsky.social · 16/09/2026
ColabFold 1.6.3 is out! 2.5x faster, pip-installable, ipSAE+pDockQ2 scores. Thanks Choonghwan Lee, Marielle Russo, Gyuri Kim 🐍pip install colabfold[alphafold] CF2 Sneak Peak with AF3/Boltz/Protenix/ESMFold2… 🐍pip install "colabfold[alphafold3]@git+https://github.com/sokrypton/ColabFold@af3-preview"
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Pablo Alcón @palconh.bsky.social · 16/09/2026
Deadline approaching! Please apply via this link. 👇 🧬🔬
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CSIC @csic.es · 13/09/2026
🦠Resuelta la estructura de NO16, un virus oceánico que infecta bacterias y amplía el conocimiento sobre los bacteriófagos marinos 🔬El hallazgo abre nuevas vías para explorar su uso frente a infecciones bacterianas en acuicultura ⬇️
bsky.app
Centro Nacional de Biotecnología (CNB) (@cnb-csic.bsky.social)
Un estudio CNB resuelve la estructura de NO16, un virus que infecta bacterias marinas patógenas de peces y moluscos y causa pérdidas en acuicultura. Esto ayuda a entender la evolución y potencial de los virus marinos como herramientas biotecnológicas. ℹ️https://f.mtr.cool/fjojjqu4um
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Janet Iwasa @jiwasa.bsky.social · 09/09/2026
Interested in molecular animation? Give ProteinBlender a try! It's free and open source. animation-lab.github.io/ProteinBlend... The latest tools include a DNA builder (shown in the tutorial video below). We'd love to hear what you think! We have short tutorials that cover all the features!
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University of Leicester @uniofleicester.bsky.social · 10/09/2026
42 years ago today, DNA fingerprinting was discovered at Leicester. 🧬 Prof Sir Alec Jeffreys’ discovery went on to transform forensic science and change lives around the world. Not bad for a morning in the lab. #CitizensOfChange #DNA42 #MadeAtUni
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Max Planck Institute of Molecular Cell Biology and Genetics @mpi-cbg.de · 07/09/2026
New tool to score AlphaFold-predicted molecular interactions: Mihaly Badonyi @mbadonyi.bsky.social & @tothpetroczylab.bsky.social have developed Pinc, an algorithm to convert AlphaFold's uncertainty into a single number. Publication in Protein Science. onlinelibrary.wiley.com/doi/10.1002/...
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sbesp.bsky.social @sbesp.bsky.social · 28/08/2026
Check out the July 2026 #SBEpaperofthemonth Sen-Martín et al, "Mavacamten shows broad benefit in human and mouse models of MYBPC3-related hypertrophic cardiomyopathy" @natcardiovascres.nature.com 2026 Jul;5(7):638-657. doi: 10.1038/s44161-026-00833-3
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Pablo Alcón @palconh.bsky.social · 21/08/2026
The summer is (almost) over and, as promised, a postdoc position to join our lab is now officially open! Please apply on our website via the link below, or share with your fellow biochemists / structural biologists / DNA repair aficionados! (deadline 30 September) mbg.au.dk/en/news-and-...
mbg.au.dk
Position as postdoc in biochemistry and structural biology of DNA repair - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - Protein Science, Aarhus University
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Jon Humphries @jdhl18.bsky.social · 15/08/2026
FERMT3 alternative splicing enhances kindlin-3 membrane recruitment for neutrophil adhesion during stress myelopoiesis ashpublications.org/blood/articl...
ashpublications.org
FERMT3 alternative splicing enhances kindlin-3 membrane recruitment for neutrophil adhesion during stress myelopoiesis
Key Points. A four–residue IPRR insertion enhances kindlin-3 membrane recruitment and promotes β2 integrin activationFERMT3 alternative splicing dynamicall
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Marie Ruiz-Vidal @ruizvidal7.bsky.social · 14/08/2026
Bruno Ganz et Peter Falk, Berlin, 1987. 'Les Ailes du désir' de Wim Wenders © Walter Yablonsky
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Arteviajero @arteviajero.com · 11/08/2026
Iglesia de San Salvador de Cantamuda (S. XII-XIII), auténtica maravilla del románico en el norte de la provincia de Palencia ⬇️⬇️⬇️ arteviajero.com/articulos/co...
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Instruct-ERIC @instruct-eric.bsky.social · 11/08/2026
On Tuesday 13 October Instruct-ERIC are hosting a webinar in collaboration with Refeyn, to discuss Mass Photometry and how it can benefit your research. Register and find out more here: instruct-eric.org/events/instr...
instruct-eric.org
Instruct-ERIC Industry Webinar - Mass Photometry to support Structural Biology Research - In Collaboration with Refeyn
<p> </p> <p>On Tuesday 13 October Instruct-ERIC are hosting a webinar in collaboration with Refeyn, to discuss Mass Photometry and how it can benefit your research.</p> <p> </p> <p style="text-align:…
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Ben Goult @bengoult.bsky.social · 10/08/2026
New paper out today in Blood In this work led by Serena Lee, we show that alternative splicing of FERMT3 creates a kindlin-3 isoform with enhanced membrane recruitment, leading to stronger β2 integrin activation and neutrophil adhesion during stress myelopoiesis. DOI: doi.org/10.1182/bloo...
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Carmen San Martín @carmensmp.bsky.social · 05/08/2026
How does an adenovirus transform from an immature particle into an infectious virus? See our new preprint for a closer look at how protease activity orchestrates structural changes that enable adenovirus maturation and infectivity. www.biorxiv.org/content/10.6...
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Jon Agirre @glycojones.bsky.social · 04/08/2026
Some questions for our structural biology community: What protocols do you think would be useful to have? Do you prefer to watch step-by-step videos, or follow written instructions? Of course, not everything has to be a video, but certain workflows are simply best documented on video #protocols
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Alana Cowell 🔬 @alanacowell.bsky.social · 03/08/2026
Please sign the form below if you value scientific research! Diamond Light Source is a lifeline for scientists across Europe. From instrument access, to the courses they run, I and many scientists wouldn't be where we are today without their support. tinyurl.com/2d9t2xyl #cryoem #beamline #science
openletter.earth
Open Letter in Response to Funding Pressures Affecting Diamond Light Source
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Shao-Liang Zheng @shaoliangzheng.bsky.social · 31/07/2026
📚💎 Introducing #crystallography at the #kindergarten level! 🔬✨ A center-based activity framework and a children's book to introduce crystallography to young learners 👧👦🌈 doi.org/10.1107/S205... @actacryste.iucr.org #IUCr #Crystallography #STEM #ScienceOutreach
doi.org
A model for crystallography engagement with children in early elementary school with activities and book development
Introducing crystallography at the kindergarten level is discussed through a center-based activity framework and the development of a children's book for crystallography.
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Monica Balsera @monicabalsera.bsky.social · 31/07/2026
Congratulations to German Rivas and Irene Otero-Muras on this great initiative. Our group is proud to be part of SYNMAC and looks forward to contributing to its success @cib-csic.bsky.social @i2sysbio.es @csic.es @irnasa.bsky.social #SYNMAC
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Centro de Investigaciones Biológicas Margarita Salas (CSIC) @cib-csic.bsky.social · 21/07/2026
SYNMAC (CSIC Hub in Engineering Synthetic Biological Matter) is a multidisciplinary strategic initiative in research, advanced training, and innovation funded by @csic.es under the 2025 CONEXIONES-CSIC. Our researcher, German Rivas, coordinates the project together with Irene Otero-Muras (I2sys2bio)
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Pereda Lab @peredalab.bsky.social · 29/07/2026
Thanks a lot. Again, the support from Instruct-ERIC was key in this project and beyond. Not only allowed us to access state-of-the-art methodologies and equipment, but also help us to establish fantastic collaborations and to learn a lot in the process. 😍
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Pereda Lab @peredalab.bsky.social · 28/07/2026
📢Grateful to institutions that made this work possible: ➡️Landsteiner Foundation for Blood Transfusion Research ➡️MICIUN AEI and ERDF @ageinves.bsky.social ➡️Instruct-ERIC @instruct-eric.bsky.social for access to cryo-EM & imaging analysis @cryoemcnbcsic.bsky.social @instructi2pc.bsky.social (9/9)
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Pereda Lab @peredalab.bsky.social · 28/07/2026
By revealing how HPA-1a antibody 26.4 engages and blocks αIIbβ3, we can better understand how functional alterations of β3 integrins contribute, together with other factors, to the severity of FNAIT. This opens the door to novel FNAIT diagnostics and targeted treatments (8/9)
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Pereda Lab @peredalab.bsky.social · 28/07/2026
In this manner, the Fab not only creates steric hindrance during extension, but it likely prevents the initial movements, acting as a lock!. Hence, we named it the “His-Tyr lock” 🔒 (7/9)
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Pereda Lab @peredalab.bsky.social · 28/07/2026
One key contact occurs between H117-Y118 of the antibody heavy chain contact the disulfide bridge C473-C503 of the I-EGF2. This disulfide is the pivoting point between the I-EGF1 and I-EGF2 during αIIbβ3 extension and activation… (6/9)
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Pereda Lab @peredalab.bsky.social · 28/07/2026
Integrin activation works like a knee straightening: the bent "legs" of αIIbβ3 extend outward. In the β3 subunit, this motion pivots at a hinge point between the I-EGF1 and I-EGF2 domains… (5/9)
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Pereda Lab @peredalab.bsky.social · 28/07/2026
Fab 26.4 contacts not only the PSI domain, but also the I-EGF1 and I-EGF2 domains. The interactions with the I-EGF1/2 domains are key to understand how Ab 26.4 prevents integrin activation … (4/9)
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Pereda Lab @peredalab.bsky.social · 28/07/2026
To answer this question, we solved the cryo-EM structure of the Fab fragment of 26.4 bound to αIIbβ3. We found integrin aIIbb3 in the complex is in a bent-closed (i.e. inactive) state. How does the antibody stabilized this inactive conformation? … (3/9)
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Pereda Lab @peredalab.bsky.social · 28/07/2026
Maternal anti-HPA1a antibodies recognize Leu33 in the PSI domain of β3, causing fetal/neonatal alloimmune thrombocytopenia (FNAIT) One such antibody, named 26.4, blocks αIIbβ3 from binding fibrinogen after thrombin stimulation; a key step in clot formation. How does 26.4 bind the integrin?… (2/9)
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Pereda Lab @peredalab.bsky.social · 28/07/2026
Happy to share our latest paper! www.science.org/doi/10.1126/... We visualized by cryo-EM how a disease-causing anti-HPA-1a antibody binds to integrin αIIbβ3 and locks it in an inactive state Great colab with Coert Margadant’s lab & groups at Osaka Univ, Sanquin, CNB-CSIC, ISBG Details below… 1/9
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Mario González-Jiménez @mariogonzalez.es · 26/07/2026
Although these two photos were not taken from exactly the same place, they reveal very the scale of what has been lost (Pantano del Burguillo, Ávila) #ElBurguillo #IFBurgohondo
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Mario González-Jiménez @mariogonzalez.es · 25/07/2026
As of this morning, the #IFBurgohondo wildfire has scorched 18,000 hectares of forests of pine, ash, holm oak, oak, and chestnut that, until yesterday, were full of life
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Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · 21/07/2026
La investigadora @saraotaegi.bsky.socialrecibe el segundo Premio a la Mejor Tesis en Biofísica de la Sociedad Española de Biofísica (@jisbe.bsky.social) El resultado de su trabajo, combina la criomicroscopía electrónica y la espectrometría de masas (MS) para estudiar virus marinos ¡Enhorabuena!
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cryoEM papers @cryoempapers.bsky.social · 18/07/2026
High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation pubmed.ncbi.nlm.nih.gov/42467762/ #cryoEM
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Rafael Pinilla-Redondo (Rafa) @rafomics.bsky.social · 16/07/2026
1/10 🚨Preprint! One RING to rule them all (phages)👑💍⚔️ Bacteria build giant DNA-scaffolded RNase rings (larger than the ribosome!) to shut down viral infection🧬🧵👇 biorxiv.org/content/10.6...
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Rafael Pinilla-Redondo (Rafa) @rafomics.bsky.social · 16/07/2026
++ For a deeper dive into the mechanism, @arturocdr.bsky.social has a fantastic thread, including a beautiful animation of the Retron IX ring! 👇💍🔥 bsky.app/profile/artu...
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Guillermo Montoya @guillermo-montoya.bsky.social · 16/07/2026
Tremendous bluesky tutorial by @arturocdr.bsky.social explaining our recent paper in colab with @rafomics.bsky.social enjoy it!!!
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Arturo Carabias @arturocdr.bsky.social · 16/07/2026
🧬 Thrilled to share our latest @biorxiv-microbiol.bsky.social preprint! Here we find that Retron-IX build crazy supramolecular rings scaffolded by DNA molecules that sense phage infection! www.biorxiv.org/content/10.6... Read more below🧵! (1/X)
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Sociedad Española de Bioquímica y Biología Molecular (SEBBM) @sebbm.bsky.social · 13/07/2026
🗓️Mañana a las 16:00h "Webinar Grupo biología sintética y biotecnología molecular" coordinado por Ylenia Jabalera Ruz 🗣️Reyes Nuñez Franco - CIC bioGUNE ✍️ f.mtr.cool/nzsevijhwy ▶️ Síguelo en directo: f.mtr.cool/ltziivmvtj
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SBBC @sbbc-salamanca.bsky.social · 13/07/2026
JAE Intro 2026 opportunities at SBBC. 🔬3 research projects in Structural Biology and Biophysics Contact us to learn more! @olgacalvog.bsky.social @peredalab.bsky.social @monicabalsera.bsky.social #jaeintro
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Ben Goult @bengoult.bsky.social · 10/07/2026
New preprint! 🎉 We discovered an unexpected way that the postsynaptic scaffold protein Densin-180 binds SHANK proteins. Instead of using a conventional C-terminal PDZ-binding motif, Densin-180 uses an internal PDZ-binding motif that engages the canonical SHANK3 PDZ domain. 🧵1/8
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Mario González-Jiménez @mariogonzalez.es · 07/07/2026
Thanks to the wonders of the modern world it is possible to read a good translation of my article following this link: www-jotdown-es.translate.goog/2025/10/pure...
www-jotdown-es.translate.goog
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Delegación del CSIC Castilla y León @csiccyl.bsky.social · 03/07/2026
En la temporada hemos hablado de las pinzas ópticas de Carlos Bustamante @ibfg.bsky.social, de atracción de talento con @tank-silvia.bsky.social @irnasa.bsky.social o de los avances frente a la leucemia con Isidro Sánchez @ciccancer.bsky.social entre otros muchos temas 🔝 go.ivoox.com/rf/176735505
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clairesnaylor.bsky.social @clairesnaylor.bsky.social · 29/06/2026
Look out for Thermo Fisher at #FEBS2026 in Maastricht and a great lunchtime symposium on 7 July from Deniz Urgurlar on lowering barriers to #cryoEM enabling faster, more reproducible structure determination across #structuralbiology, #biochemistry, and #cellbiology. 👉 Register now ter.li/7dky6tca
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