Lazarevic et al. reveal a shared loss of a TBX5-dependent atrial gene network in cardiomyocytes and a disease-specific network gain in activated fibroblasts across atrial fibrillation and heart failur...

Chen et al. developed a self-powered smart magnetoelastic stent for real-time hemodynamic monitoring and stenosis detection.

Da Pra, Boriati and colleagues show that physiological glucocorticoids suppress growth-factor-induced cardiomyocyte regeneration by inhibiting ERK signaling and propose glucocorticoid receptor antagon...

Kathiriya et al. identify a cardiac progenitor lineage with expression of Tbx5 and anterior heart field-specific expression of Mef2c that bisects the intraventricular septum during development and sho...

Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage–fibroblast interactions that control late-stage fibros...

Chen, Wang, Zhong and colleagues show that females derive greater cardiovascular benefits from guideline-recommended levels of physical activity and require less activity than males to see their benef...

Tan et al. identify PRDM16 as a key repressor of fibrotic switching in smooth muscle cells and show that its downregulation in atherosclerosis drives smooth muscle cells toward a synthetic fate, promo...

Lin, Geng and colleagues identify a non-canonical AHR pathway that is activated by canonical AHR inhibitors, promoting the proliferation of quiescent endothelial cells with potential applications in c...

Amiad Pavlov, Heffler, et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic t...

Yamazoe et al. show that B cell-derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic ap...

Mulholland et al. identify progenitor exhausted T cells, expressing intermediate levels of PD-1 (PD-1int), as a prominent source of pro-inflammatory cytokines in the murine atherosclerotic aorta and p...

Wünnemann et al. generate a subcellular resolution spatial map of the murine heart after myocardial infarction, revealing that immune cells can infiltrate the organ through the endocardium.

Boccella, Yu and colleagues reveal that the transmembrane protein ANTXR1 regulates post-infarction fibrotic remodeling, and its inhibition blocks collagen turnover and improves heart function.

Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.

Mellor et al. report that deficiency of GABARAPL1, an ATG8-specific linking protein, impairs diastolic function in diabetic mice. This effect can be reversed by gene delivery of the gene encoding GABARAPL1 in diabetic mice and a human organoid model of type 2 diabetes.

Watanabe et al. show that cytopathic hypoxia, through upregulation of COX2 and secretory PLA2, stabilizes HIF-1α, contributing to impaired mitochondrial respiration and reduced cardiac contraction in ...

Nature Cardiovascular Research - Zheng et al. generated a mouse model of phospho-ablation in all canonical ryanodine receptor 2 (RyR2) phosphorylation sites. They show that RyR2 phosphorylation at...

Nature Cardiovascular Research - By regulating the level of accessible cholesterol on endothelial cells via OSBP/ORP-mediated transport, tetraspanin tunes the balance of Cdc42 and RhoA activities...

Sangha, Dhingra et al. develop and validate a deep learning model to diagnose hypertrophic cardiomyopathy from electrocardiographic images, demonstrating its effectiveness across multiple 12-lead layo...

Chou et al. demonstrate that activation of the thrombin receptor protease-activated receptor 1 in the lung lymphatic vasculature mediates morphological changes in lymphatic endothelial cell junctions ...

Nature Cardiovascular Research - Yang et al. draw evidence from population-based and sibling cohort studies to reveal that women suffering from premenstrual disorders are at an increased risk of...

Nature Cardiovascular Research - Through RNA profiling of right ventricular tissue from patients with chronic thromboembolic pulmonary hypertension, Jafari et al. uncover mechanisms underlying...

Nature Cardiovascular Research - Li, Lu et al. demonstrate that O-GlcNAcylation enhances angiogenic transdifferentiation from fibroblasts to endothelial cells through a HIRA-dependent H3.3...

Lai et al. present the machine learning model MAARS to predict arrhythmic sudden cardiac death from multimodal imaging and clinical data in patients with hypertrophic cardiomyopathy.

Nature Cardiovascular Research - Pocock et al. reveal that transient activation of 5′ AMP-activated protein kinase and estrogen-related receptor drives robust maturation of multicellular...

Pampols-Perez et al. identify the mechanosensitive ion channel PIEZO2 as a novel marker for embryonic coronary artery endothelial cells and as a critical regulator of coronary vascular remodeling. The...

Das et al. show that the correct editing activity of the methionyl tRNA synthetase, regulated by AIMP3, is required to prevent the accumulation of homocysteine and the resulting cardiomyocyte cell dea...

Wang, Tang and colleagues develop the low-signal signed iterative random forest pipeline to investigate epistasis in the genetic control of cardiac hypertrophy, identifying epistatic variants near CCD...

By integrating single-cell transcriptomics and T cell receptor repertoire analyses of regulatory T (Treg) cells in a cohort of patients with acute coronary syndrome from the LILACS trial, Case et al. ...

Kraft et al. identify TIE2 activation as a key driver of PIK3CA-related venous malformations and demonstrate that inhibiting TIE2 signaling can suppress the growth of advanced lesions.

Lei et al. show that cold preservation of heart transplants triggers mineralocorticoid receptor clustering in cardiomyocyte nuclei, and blocking this improves heart transplant function.

Nature Cardiovascular Research - Qian et al. used cardiac magnetic resonance images and electrocardiograms from the UK Biobank and an ischemic heart disease cohort and developed more than 3,500...

Adamopoulos, Rovas et al. show that high regional wall shear stress correlates with fibrosis and electrical scarring in the left atrium of patients with atrial fibrillation, providing insight into the...

Nature Cardiovascular Research - Sadhu et al. identify and functionally validate ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.