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@hdbuzzfeed.bsky.social
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Huntington’s disease research news. In plain language. Written by scientists. hdbuzz.net Editors - @sjh508 @rjharding

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HDBuzz @hdbuzzfeed.bsky.social · 18h
uniQure reports that after 4 years, people given high-dose AMT-130 continue to show signs of slower HD progression, providing hope for their recent regulatory submission. But the new analyses are nuanced. We unpack the hopeful but complex results in this article → en.hdbuzz.net/amt-130-at-f...
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HDBuzz @hdbuzzfeed.bsky.social · 28/09/2026
September brought progress across the Huntington’s disease research landscape. From brain waves and visual thinking to DNA repeats, nutrition, inclusive care, new technologies, and encouraging SKY-0515 data, we round up a busy month in HD research. Full article here → en.hdbuzz.net/september-20...
Picture of a toolbox with title, “September 2026: This month in Huntington’s disease research
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HDBuzz @hdbuzzfeed.bsky.social · 24/09/2026
The CAG repeat that causes Huntington’s disease (HD) has a tendency to grow with age. New research on over 900,000 people uncovers parallel patterns and finds CAG growth can happen in many other parts of the genome. #hdresearch Read the full article → en.hdbuzz.net/studying-stu...
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HDBuzz @hdbuzzfeed.bsky.social · 21/09/2026
Unique research highlights an overlooked mental health disparity among Indigenous North American people with Huntington’s disease (HD) - and the need for care grounded in trust, community partnership, and cultural understanding. Read more here: en.hdbuzz.net/highlighting...
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HDBuzz @hdbuzzfeed.bsky.social · 16/09/2026
Skyhawk Therapeutics shared data for SKY-0515, an experimental once-daily pill that targets both huntingtin and somatic instability, making it a possible “two-for-one” drug to treat HD. Read more about this exciting news on HDBuzz → en.hdbuzz.net/encouraging-...
Graphic of a megaphone with the words, "Encouraging news from Skyhawk Therapeutics!" above.Picture of pills from a pill bottle with words on text boxes: "A potential 2-for-1 approach to treat HD is safe and shows potential! SKY-0515 is an experimental once-daily pill that aims to lower huntingtin AND target somatic instability."Close up photo of a doctor checking lab results. Words in text boxes read, "In the Phase 1/2 study, SKY0515 did just that, and showed positive changes in tests of movement & thinking." But will that add up to a treatment that slows HD?"Text box: "Skyhawk's Phase 2/3 study, FALCON-HD, will tell us whether the Phase 1/2 study's promising signs hold up in a larger, placebo-controlled trial."
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HDBuzz @hdbuzzfeed.bsky.social · 14/09/2026
What if nutrition is one of the warning lights we should be checking earlier in Huntington’s disease? New research suggests simple nutrition measures may help identify when people with HD need extra support. en.hdbuzz.net/food-for-tho...
Photo of puzzle pieces on a dinner plate. Title reads, "Food for Thought: The Importance of Nutrition in Huntington's Disease".Graphic of a wind cloud blowing at a woman holding onto an umbrella. Text reads, "Living with HD can be like walking into a strong headwind..."Text continues, "... you're still moving forward, but it takes more energy. So a new study on nutrition in people with HD set out to discover if..."Text continues, "1. malnutrition is more common in HD,
2. malnutrition is linked with symptoms such as movement and thinking changes, and
3. simple nutrition checks might help care teams spot when extra support is needed."
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HDBuzz @hdbuzzfeed.bsky.social · 10/09/2026
A review of 23 studies suggests that EEG could offer a non-invasive way to track brain changes across the course of Huntington’s disease (HD). #hdresearch Read all about it → en.hdbuzz.net/could-brain-...
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HDBuzz @hdbuzzfeed.bsky.social · 07/09/2026
Five Huntington’s disease (HD) researchers discuss the cutting-edge techniques driving their work, accelerating discovery and guiding development of treatments. #hdresearch Read all about it → en.hdbuzz.net/hot-techniqu...
Five research scientists compare notes. Title reads "Hot Techniques in HD Research: Five HD researches discuss the cutting-edge techniques driving their work."Scientist looks in a microscope. "From reading DNA molecule by molecule...""... to visualizing proteins and neurons in remarkable detail,"Man with a camera over the words, "these technologies are giving scientists an increasingly complete picture of how HD begins and progresses."
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HDBuzz @hdbuzzfeed.bsky.social · 03/09/2026
What if Huntington’s disease (HD) changes how we “see” the world before we even notice symptoms? New research suggests visual thinking skills may help track HD progression. en.hdbuzz.net/keeping-an-e...
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HDBuzz @hdbuzzfeed.bsky.social · 02/09/2026
NEWS! uniQure has submitted AMT-130 for regulatory approval in the US and UK. This drug is NOT yet approved; regulators must now review the evidence. Read more about this milestone here -> uniqure.gcs-web.com/node/12991/pdf and on HDBuzz here -> en.hdbuzz.net/the-other-sh...
Graphics of a megaphone and arrow pointing to words: "Press Release: uniQure has submitted AMT-130 for regulatory approval in the US & UK"
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HDBuzz @hdbuzzfeed.bsky.social · 31/08/2026
August was a busy month for Huntington’s disease (HD) research! Setbacks, new trials, a conference, and the HDBuzz Prize for Young Science Writers! Catch up on everything in our monthly roundup: en.hdbuzz.net/august-2026-...
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HDBuzz @hdbuzzfeed.bsky.social · 27/08/2026
A new Huntington's disease (HD) clinical trial has officially begun! It will test whether the drug pridopidine can slow the progression of HD. For more details, read our article: en.hdbuzz.net/first-partic...
An "OPEN" sign on a door handle. Over it is the title "PRECISE-HD trial of pridopidine begins!" and the logo HDBuzz.Over a photo of medication pills is the text: "Analysis of a previous trial’s data suggested that people who were not taking antidopaminergic medications (ADMs) appeared to have greater benefit from pridopidine than those who were."Over a photo of medication pills is the text "PRECISE-HD is a new confirmatory trial specifically designed to test that hypothesis."
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Reposted by HDBuzz
Huntington's Disease Foundation @hdfcures.bsky.social · 25/08/2026
Rachel Harding & Leora Fox from @hdbuzzfeed.bsky.social will join us on 9/9 to share the buzz from HDF’s recent HD2026 Symposium. They'll recap some of the exciting science from the meeting and hold a live Q&A. Register Now: us06web.zoom.us/.../501.../W... #curehd #HD2026 #researchspotlightwebinars
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Reposted by HDBuzz
Andy Gates @andygates.bsky.social · 20/08/2026
If you've got stage 2 HD and want to do a science, here's a new Phase 1 study for a potential injectable therapy. They've got a cunning plan for getting treatments across the blood-brain barrier.
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HDBuzz @hdbuzzfeed.bsky.social · 24/08/2026
New research points to HTT1a, a toxic shortened form of huntingtin (HTT), as a key driver of disease and a promising therapeutic target in Huntington’s disease (HD). Read the full article here: en.hdbuzz.net/taking-a-sho...
Aerial photo of a car driving along a windy, gravel road through the forest. Title above the photo reads "Taking a Short Cut: New Routes to Huntingtin-Lowering Therapies" and below is the logo for HDBuzz.
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HDBuzz @hdbuzzfeed.bsky.social · 20/08/2026
New Huntington’s disease (HD) trial begins! A Phase 1 study is testing SRP-1005, a huntingtin-lowering therapy given by injection under the skin. It’s early days, but this approach could add an important new arrow to the HD drug development quiver. More details here -> en.hdbuzz.net/a-shot-in-th...
HDBuzz logo plus the title "A shot in the arm for HTT lowering: INSIGHT trial begins!" Photo is of gloved hands administering a needle into a person's arm.
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Reposted by HDBuzz
Jose Lucas Lab @jjlucaslab.bsky.social · 20/08/2026
Thanks, Leora Fox & Rachel Harding @hdbuzzfeed.bsky.social, for the excellent summary of my presentation at @hdfcures.bsky.social Meeting on the #HUNTIAM clinical trial (Thiamine+Biotin) for HD, including the evidence that originated it. 👇👇👇 en.hdbuzz.net/hd2026-milto... @cbm-csic-uam.bsky.social
en.hdbuzz.net
Thank you – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 17/08/2026
Announcing the 2026 HDBuzz Prize for Young Science Writers – sponsored by the Hereditary Disease Foundation! Submission details here: en.hdbuzz.net/the-2026-hdb...
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HDBuzz @hdbuzzfeed.bsky.social · 14/08/2026
Day 3 of #HD2026 put the huntingtin protein (HTT) under the microscope. Researchers shared new insights into HTT1a, next-generation HTT-lowering approaches, somatic expansion, brain circuitry, and why boosting healthy HTT might help. Read our roundup here: en.hdbuzz.net/hd2026-milto...
The final day of HD2026 put the huntingtin protein (HTT) under the microscope.Researchers shared:

- new insights into HTT1a
- next-generation HTT-lowering approaches
- why boosting healthy HTT might help

 And lots more!
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HDBuzz @hdbuzzfeed.bsky.social · 13/08/2026
Day 2 #HD2026 - insights into the mechanics of somatic instability, new ways we can track Huntington’s disease (HD) in people over time, how AI can help us drive research forward, and new developments in our understanding of the HTT protein. Catch up on everything we learned on HDBuzz.net
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HDBuzz @hdbuzzfeed.bsky.social · 13/08/2026
Welcome to Day 3 of the #HD2026 Milton Wexler Biennial Symposium, where HDBuzz is reporting live for this final day of talks. Morning sessions will focus on huntingtin (HTT), including a fragment of the expanded HTT protein that seems to be extra harmful.
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HDBuzz @hdbuzzfeed.bsky.social · 12/08/2026
Day 1 of #HD2026 - From what human brains can teach us about HD, to HTT1a, somatic CAG expansion and the normal biology of HTT, today’s talks spanned the spectrum from fundamental biology to potential treatments. Catch up on everything we learned right here. en.hdbuzz.net/hd-2026-milt...
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HDBuzz @hdbuzzfeed.bsky.social · 12/08/2026
We are back for Day 2 at #HD2026! This morning kicks off with talks focussed on HD genetics and how DNA repair machines might influence how symptoms start and then progress in people with HD.
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HDBuzz @hdbuzzfeed.bsky.social · 11/08/2026
Good morning from Boston! We’re looking forward to bringing you live updates from Day 1 of #HD2026, a biannual conference hosted by the Huntington’s Disease Foundation (HDF) that brings together HD scientists and clinicians from around the world.
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HDBuzz @hdbuzzfeed.bsky.social · 10/08/2026
Welcome to #HD2026! Held every other year in Boston, MA and organized by the Huntington’s Disease Foundation (HDF), this conference brings together almost 300 of the world-leading experts in Huntington’s disease (HD) and other CAG repeat diseases.
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HDBuzz @hdbuzzfeed.bsky.social · 06/08/2026
Prilenia Therapeutics has donated data from two of its Huntington’s Disease (HD) clinical trials to CHDI Foundation, creating a valuable resource that researchers can use to better understand placebo effects, disease progression and future trial design. en.hdbuzz.net/prilenia-sha...
Hands holding a box of files (presumably) to be shared. Title reads: "Prilenia shares HD trial data with CHDI to help future research." Underneath is the HDBuzz logo.Text reads: Although data sharing has become increasingly common across biomedical research, it has not always been routine, so this is an important step forward for the field.Text reads: Researchers will use the data to better understand placebo effects, disease progression and how to improve the design and interpretation of future clinical trials.Text reads: In a disease where every participant and every dataset is precious, this an important investment in the future of HD research.
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HDBuzz @hdbuzzfeed.bsky.social · 03/08/2026
Roche's decision to stop development of two huntingtin-lowering programmes is disappointing, but the story doesn't end there. Years of research have answered some key questions, raised many new ones, and will inform the next generation of HD trials. Read about it here: en.hdbuzz.net/looking-back...
A road with arrows, one pointing forward and one back. Title words on screen: "Looking Back & Moving Forward - Four weeks after Roche announced two Huntington's disease programs were closing, questions remain..."
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HDBuzz @hdbuzzfeed.bsky.social · 30/07/2026
July was a hard month for Huntington’s disease research, with Roche ending two HD programs. But the month also brought promising new tools to visualize and track huntingtin, and important studies on eating and self-awareness in HD. Read the full recap: en.hdbuzz.net/july-2026-th...
July 2026 was a month of hard news and continuing progress. Image - arrows pointing up and down. Logo - HDBuzzSketch of someone reading a newspaper that's on fire. On the firey side is "HARD NEWS" and the fire's out smoking side is "CONTINUING PROGRESS".
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HDBuzz @hdbuzzfeed.bsky.social · 27/07/2026
Published ANX005 trial results show the drug is safe, works as designed and may help people with Huntington’s disease - so what’s the holdup? en.hdbuzz.net/putting-it-i...
Trial drug to rein in runaway pruning is safe, so what’s next? HD can affect how well the immune system works within brain cells. Immune support cells called microglia “prune” unnecessary or damaged brain cell connections. But in people with HD, microglia can become overactive and “prune” (eliminate) useful connections. ANX005 (tanruprubart) aims to correct that immune system imbalance. The study showed the drug works as designed, has potential for benefit, and is safe. So what now?
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HDBuzz @hdbuzzfeed.bsky.social · 20/07/2026
Scientists screened over a trillion tiny ring-shaped protein fragments to find ones that can grab onto the huntingtin. They captured huntingtin straight out of cells and discovered it’s almost always paired with a partner called HAP40. en.hdbuzz.net/catching-a-g...
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Catching a Giant Protein: Five New Ways to Grab Huntingtin – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 17/07/2026
A new study suggests that reduced awareness of symptoms, known as anosognosia, may appear even in the earliest stages of HD. The findings highlight that understanding symptom progression requires more than one perspective. en.hdbuzz.net/mirror-mirro...
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HDBuzz @hdbuzzfeed.bsky.social · 14/07/2026
Skyhawk Therapeutics have received the regulatory approval needed to broaden its FALCON-HD trial to include the United States, Canada, and the UK. The expanded trial will enroll up to 400 more people with Stage 2 and early Stage 3 HD across more than 40 sites worldwide.
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HDBuzz @hdbuzzfeed.bsky.social · 09/07/2026
Roche announced it is stopping development of two of its huntingtin-lowering ASO drugs, tominersen and RG6496. This marks a disappointing end to an important chapter in HD clinical research. en.hdbuzz.net/roche-ends-t...
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HDBuzz @hdbuzzfeed.bsky.social · 07/07/2026
For the past 20 years, PET tracers have been a game-changer for Alzheimer’s disease, making it possible to see amyloid plaques in the brain without invasive procedures. So what about Huntington’s? en.hdbuzz.net/are-we-final...
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Are we finally getting that PET we’ve always wanted? – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 30/06/2026
New 12-month data from Skyhawk’s SKY-0515 is in and all four measures that make up the cUHDRS are at or above baseline, beating expected natural decline. Plus, a first look at expanding US trial sites. en.hdbuzz.net/skyhawk-shar...
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Skyhawk Shares A Closer Look at SKY-0515 Data, Plus A Peek At Expanding US Trial Access – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 30/06/2026
From the clinic, we heard from uniQure about their recent FDA meeting, a stem cell trial dosed its first participant, and Skyhawk shared data on SKY-0515. In the lab, the science of slowing HD at the DNA level keeps building. en.hdbuzz.net/june-2026-th...
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June 2026: This Month in Huntington’s Disease Research – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 26/06/2026
PROTACs act like a precision pruning tool, trimming away toxic huntingtin protein while leaving the healthy form intact. In cells and HD mice, this targeted clean-up improved health and slowed disease features. en.hdbuzz.net/precision-pr...
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Precision Pruning with PROTACs: Selective Targeting of Toxic Huntingtin – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 22/06/2026
Australia just made history by banning life insurers from using genetic testing against you. But for HD families in other countries, the laws meant to protect haven’t kept pace with the science. en.hdbuzz.net/your-dna-sho...
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Your DNA Shouldn’t Cost You Your Insurance: What HD Families Need to Know – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 15/06/2026
REGEN4HD, a new study testing whether transplanting neural stem cells is safe as a potential treatment for HD, has dosed their first participant. Read the full article on our website for more information. en.hdbuzz.net/first-partic...
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First participant dosed in pioneering neural stem cell trial for Huntington’s disease – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 13/06/2026
Huntington’s disease affects more than movement: it also has a major impact on mental health. Researchers explore why psychological care matters and how it needs to be adapted across each stage of HD. en.hdbuzz.net/evolving-nee...
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Evolving Needs, Evolving Care: Adapting Psychological Support Across Different Stages of Huntington’s Disease – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 09/06/2026
Your body assembles DNA like a team of workers who set and bond a pattern of tiles. A recent study shows that one special assistant might slow somatic CAG expansion and delaying HD onset. en.hdbuzz.net/sealing-the-...
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Sealing the gap: a case for slower, smarter DNA repair – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 06/06/2026
In 2025, you helped us reach 329,000 people with independent, unbiased HD research news. Our 2025 Annual Report is here. Take a look at what we built together, and consider helping us keep going. en.hdbuzz.net/hdbuzz-2025-...
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HDBuzz 2025 Annual Report: Here’s what you made possible – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 01/06/2026
One year into treatment, SKY-0515 continues to lower huntingtin levels and shows encouraging trends in HD signs and symptoms. A larger clinical trial is now enrolling and will help determine whether SKY-0515 can truly slow disease progression in Huntington's disease. en.hdbuzz.net/skyhawk-repo...
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Skyhawk reports encouraging 12-month results for oral Huntington’s disease drug SKY-0515 – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 31/05/2026
May 2026: 2 year data from the votoplam trial suggests disease progression may slow; AMT-130 heads to the UK for regulatory review; pigs reveal immune cells invading the HD brain; and new science zooms in on toxic huntingtin fragments. en.hdbuzz.net/may-2026-thi...
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May 2026: This Month in Huntington’s Disease Research – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 26/05/2026
Recently a paper was published where scientists targeted a small, harmful piece of the huntingtin message (HTT1a) in HD mice. This reduced toxic protein clumps and delayed genetic changes, more than targeting full length HTT. Full article: en.hdbuzz.net/fixing-the-r...
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Fixing the Recipe: Lowering a Slice of Huntingtin – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 22/05/2026
A recent study suggests that strengthening the brain’s own clean-up system could slow Huntington’s disease. en.hdbuzz.net/tagging-the-...
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Tagging the Trash: Turnover of Toxic Huntingtin  – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 18/05/2026
After the EMA recommended refusing approval for pridopidine, Prilenia quietly withdrew its European application in November 2025. Here’s what happened, and why you’re only hearing about it now. Full article: en.hdbuzz.net/prilenias-ap...
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Prilenia’s Application for European Approval of Pridopidine Withdrawn – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 14/05/2026
A recent study in pigs suggests the HD brain could be under attack from the body’s own immune system. The results reveal that invading cytotoxic T cells might contribute to neurodegeneration in HD, suggesting a new therapeutic pathway. en.hdbuzz.net/intruders-in...
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Intruders in the Brain: What a Pig Model Reveals about Immune Cells in HD – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 11/05/2026
What does “good care” look like in Huntington’s Disease? A new Dutch study asked familial and professional caregivers, and uncovered how differently it’s experienced in practice. en.hdbuzz.net/the-great-ca...
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The Great Care Conundrum: What “Good” Care Looks Like in Huntington’s Disease – HDBuzz
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HDBuzz @hdbuzzfeed.bsky.social · 08/05/2026
The U.S. regulatory path for AMT-130 remains complex, but uniQure has announced plans to seek approval for its Huntington’s disease gene therapy in the UK. Full Article: en.hdbuzz.net/a-second-pat...
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A Second Path: uniQure Plans Regulatory Filing for AMT-130 in the UK – HDBuzz
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