HDBuzz @hdbuzzfeed.bsky.social · 18huniQure reports that after 4 years, people given high-dose AMT-130 continue to show signs of slower HD progression, providing hope for their recent regulatory submission. But the new analyses are nuanced. We unpack the hopeful but complex results in this article → en.hdbuzz.net/amt-130-at-f... 022
HDBuzz @hdbuzzfeed.bsky.social · 28/09/2026September brought progress across the Huntington’s disease research landscape. From brain waves and visual thinking to DNA repeats, nutrition, inclusive care, new technologies, and encouraging SKY-0515 data, we round up a busy month in HD research. Full article here → en.hdbuzz.net/september-20... 010
HDBuzz @hdbuzzfeed.bsky.social · 24/09/2026The CAG repeat that causes Huntington’s disease (HD) has a tendency to grow with age. New research on over 900,000 people uncovers parallel patterns and finds CAG growth can happen in many other parts of the genome. #hdresearch Read the full article → en.hdbuzz.net/studying-stu... 022
HDBuzz @hdbuzzfeed.bsky.social · 21/09/2026Unique research highlights an overlooked mental health disparity among Indigenous North American people with Huntington’s disease (HD) - and the need for care grounded in trust, community partnership, and cultural understanding. Read more here: en.hdbuzz.net/highlighting... 020
HDBuzz @hdbuzzfeed.bsky.social · 16/09/2026Skyhawk Therapeutics shared data for SKY-0515, an experimental once-daily pill that targets both huntingtin and somatic instability, making it a possible “two-for-one” drug to treat HD. Read more about this exciting news on HDBuzz → en.hdbuzz.net/encouraging-... 012
HDBuzz @hdbuzzfeed.bsky.social · 14/09/2026What if nutrition is one of the warning lights we should be checking earlier in Huntington’s disease? New research suggests simple nutrition measures may help identify when people with HD need extra support. en.hdbuzz.net/food-for-tho... 011
HDBuzz @hdbuzzfeed.bsky.social · 10/09/2026A review of 23 studies suggests that EEG could offer a non-invasive way to track brain changes across the course of Huntington’s disease (HD). #hdresearch Read all about it → en.hdbuzz.net/could-brain-... 040
HDBuzz @hdbuzzfeed.bsky.social · 07/09/2026Five Huntington’s disease (HD) researchers discuss the cutting-edge techniques driving their work, accelerating discovery and guiding development of treatments. #hdresearch Read all about it → en.hdbuzz.net/hot-techniqu... 030
HDBuzz @hdbuzzfeed.bsky.social · 03/09/2026What if Huntington’s disease (HD) changes how we “see” the world before we even notice symptoms? New research suggests visual thinking skills may help track HD progression. en.hdbuzz.net/keeping-an-e... 030
HDBuzz @hdbuzzfeed.bsky.social · 02/09/2026NEWS! uniQure has submitted AMT-130 for regulatory approval in the US and UK. This drug is NOT yet approved; regulators must now review the evidence. Read more about this milestone here -> uniqure.gcs-web.com/node/12991/pdf and on HDBuzz here -> en.hdbuzz.net/the-other-sh... 020
HDBuzz @hdbuzzfeed.bsky.social · 31/08/2026August was a busy month for Huntington’s disease (HD) research! Setbacks, new trials, a conference, and the HDBuzz Prize for Young Science Writers! Catch up on everything in our monthly roundup: en.hdbuzz.net/august-2026-... 030
HDBuzz @hdbuzzfeed.bsky.social · 27/08/2026A new Huntington's disease (HD) clinical trial has officially begun! It will test whether the drug pridopidine can slow the progression of HD. For more details, read our article: en.hdbuzz.net/first-partic... 031
Reposted by HDBuzzHuntington's Disease Foundation @hdfcures.bsky.social · 25/08/2026Rachel Harding & Leora Fox from @hdbuzzfeed.bsky.social will join us on 9/9 to share the buzz from HDF’s recent HD2026 Symposium. They'll recap some of the exciting science from the meeting and hold a live Q&A. Register Now: us06web.zoom.us/.../501.../W... #curehd #HD2026 #researchspotlightwebinars 021
Reposted by HDBuzzAndy Gates @andygates.bsky.social · 20/08/2026If you've got stage 2 HD and want to do a science, here's a new Phase 1 study for a potential injectable therapy. They've got a cunning plan for getting treatments across the blood-brain barrier. 041
HDBuzz @hdbuzzfeed.bsky.social · 24/08/2026New research points to HTT1a, a toxic shortened form of huntingtin (HTT), as a key driver of disease and a promising therapeutic target in Huntington’s disease (HD). Read the full article here: en.hdbuzz.net/taking-a-sho... 031
HDBuzz @hdbuzzfeed.bsky.social · 20/08/2026New Huntington’s disease (HD) trial begins! A Phase 1 study is testing SRP-1005, a huntingtin-lowering therapy given by injection under the skin. It’s early days, but this approach could add an important new arrow to the HD drug development quiver. More details here -> en.hdbuzz.net/a-shot-in-th... 022
Reposted by HDBuzzJose Lucas Lab @jjlucaslab.bsky.social · 20/08/2026Thanks, Leora Fox & Rachel Harding @hdbuzzfeed.bsky.social, for the excellent summary of my presentation at @hdfcures.bsky.social Meeting on the #HUNTIAM clinical trial (Thiamine+Biotin) for HD, including the evidence that originated it. 👇👇👇 en.hdbuzz.net/hd2026-milto... @cbm-csic-uam.bsky.socialen.hdbuzz.netThank you – HDBuzz 132
HDBuzz @hdbuzzfeed.bsky.social · 17/08/2026Announcing the 2026 HDBuzz Prize for Young Science Writers – sponsored by the Hereditary Disease Foundation! Submission details here: en.hdbuzz.net/the-2026-hdb... 012
HDBuzz @hdbuzzfeed.bsky.social · 14/08/2026Day 3 of #HD2026 put the huntingtin protein (HTT) under the microscope. Researchers shared new insights into HTT1a, next-generation HTT-lowering approaches, somatic expansion, brain circuitry, and why boosting healthy HTT might help. Read our roundup here: en.hdbuzz.net/hd2026-milto... 023
HDBuzz @hdbuzzfeed.bsky.social · 13/08/2026Day 2 #HD2026 - insights into the mechanics of somatic instability, new ways we can track Huntington’s disease (HD) in people over time, how AI can help us drive research forward, and new developments in our understanding of the HTT protein. Catch up on everything we learned on HDBuzz.net 020
HDBuzz @hdbuzzfeed.bsky.social · 13/08/2026Welcome to Day 3 of the #HD2026 Milton Wexler Biennial Symposium, where HDBuzz is reporting live for this final day of talks. Morning sessions will focus on huntingtin (HTT), including a fragment of the expanded HTT protein that seems to be extra harmful. 143
HDBuzz @hdbuzzfeed.bsky.social · 12/08/2026Day 1 of #HD2026 - From what human brains can teach us about HD, to HTT1a, somatic CAG expansion and the normal biology of HTT, today’s talks spanned the spectrum from fundamental biology to potential treatments. Catch up on everything we learned right here. en.hdbuzz.net/hd-2026-milt... 034
HDBuzz @hdbuzzfeed.bsky.social · 12/08/2026We are back for Day 2 at #HD2026! This morning kicks off with talks focussed on HD genetics and how DNA repair machines might influence how symptoms start and then progress in people with HD. 101
HDBuzz @hdbuzzfeed.bsky.social · 11/08/2026Good morning from Boston! We’re looking forward to bringing you live updates from Day 1 of #HD2026, a biannual conference hosted by the Huntington’s Disease Foundation (HDF) that brings together HD scientists and clinicians from around the world. 172
HDBuzz @hdbuzzfeed.bsky.social · 10/08/2026Welcome to #HD2026! Held every other year in Boston, MA and organized by the Huntington’s Disease Foundation (HDF), this conference brings together almost 300 of the world-leading experts in Huntington’s disease (HD) and other CAG repeat diseases. 151
HDBuzz @hdbuzzfeed.bsky.social · 06/08/2026Prilenia Therapeutics has donated data from two of its Huntington’s Disease (HD) clinical trials to CHDI Foundation, creating a valuable resource that researchers can use to better understand placebo effects, disease progression and future trial design. en.hdbuzz.net/prilenia-sha... 032
HDBuzz @hdbuzzfeed.bsky.social · 03/08/2026Roche's decision to stop development of two huntingtin-lowering programmes is disappointing, but the story doesn't end there. Years of research have answered some key questions, raised many new ones, and will inform the next generation of HD trials. Read about it here: en.hdbuzz.net/looking-back... 001
HDBuzz @hdbuzzfeed.bsky.social · 30/07/2026July was a hard month for Huntington’s disease research, with Roche ending two HD programs. But the month also brought promising new tools to visualize and track huntingtin, and important studies on eating and self-awareness in HD. Read the full recap: en.hdbuzz.net/july-2026-th... 031
HDBuzz @hdbuzzfeed.bsky.social · 27/07/2026Published ANX005 trial results show the drug is safe, works as designed and may help people with Huntington’s disease - so what’s the holdup? en.hdbuzz.net/putting-it-i... 021
HDBuzz @hdbuzzfeed.bsky.social · 20/07/2026Scientists screened over a trillion tiny ring-shaped protein fragments to find ones that can grab onto the huntingtin. They captured huntingtin straight out of cells and discovered it’s almost always paired with a partner called HAP40. en.hdbuzz.net/catching-a-g...en.hdbuzz.netCatching a Giant Protein: Five New Ways to Grab Huntingtin – HDBuzz 021
HDBuzz @hdbuzzfeed.bsky.social · 17/07/2026A new study suggests that reduced awareness of symptoms, known as anosognosia, may appear even in the earliest stages of HD. The findings highlight that understanding symptom progression requires more than one perspective. en.hdbuzz.net/mirror-mirro... 011
HDBuzz @hdbuzzfeed.bsky.social · 14/07/2026Skyhawk Therapeutics have received the regulatory approval needed to broaden its FALCON-HD trial to include the United States, Canada, and the UK. The expanded trial will enroll up to 400 more people with Stage 2 and early Stage 3 HD across more than 40 sites worldwide. 022
HDBuzz @hdbuzzfeed.bsky.social · 09/07/2026Roche announced it is stopping development of two of its huntingtin-lowering ASO drugs, tominersen and RG6496. This marks a disappointing end to an important chapter in HD clinical research. en.hdbuzz.net/roche-ends-t... 001
HDBuzz @hdbuzzfeed.bsky.social · 07/07/2026 For the past 20 years, PET tracers have been a game-changer for Alzheimer’s disease, making it possible to see amyloid plaques in the brain without invasive procedures. So what about Huntington’s? en.hdbuzz.net/are-we-final...en.hdbuzz.netAre we finally getting that PET we’ve always wanted? – HDBuzz 022
HDBuzz @hdbuzzfeed.bsky.social · 30/06/2026New 12-month data from Skyhawk’s SKY-0515 is in and all four measures that make up the cUHDRS are at or above baseline, beating expected natural decline. Plus, a first look at expanding US trial sites. en.hdbuzz.net/skyhawk-shar...en.hdbuzz.netSkyhawk Shares A Closer Look at SKY-0515 Data, Plus A Peek At Expanding US Trial Access – HDBuzz 000
HDBuzz @hdbuzzfeed.bsky.social · 30/06/2026From the clinic, we heard from uniQure about their recent FDA meeting, a stem cell trial dosed its first participant, and Skyhawk shared data on SKY-0515. In the lab, the science of slowing HD at the DNA level keeps building. en.hdbuzz.net/june-2026-th...en.hdbuzz.netJune 2026: This Month in Huntington’s Disease Research – HDBuzz 010
HDBuzz @hdbuzzfeed.bsky.social · 26/06/2026PROTACs act like a precision pruning tool, trimming away toxic huntingtin protein while leaving the healthy form intact. In cells and HD mice, this targeted clean-up improved health and slowed disease features. en.hdbuzz.net/precision-pr...en.hdbuzz.netPrecision Pruning with PROTACs: Selective Targeting of Toxic Huntingtin – HDBuzz 000
HDBuzz @hdbuzzfeed.bsky.social · 22/06/2026Australia just made history by banning life insurers from using genetic testing against you. But for HD families in other countries, the laws meant to protect haven’t kept pace with the science. en.hdbuzz.net/your-dna-sho...en.hdbuzz.netYour DNA Shouldn’t Cost You Your Insurance: What HD Families Need to Know – HDBuzz 000
HDBuzz @hdbuzzfeed.bsky.social · 15/06/2026REGEN4HD, a new study testing whether transplanting neural stem cells is safe as a potential treatment for HD, has dosed their first participant. Read the full article on our website for more information. en.hdbuzz.net/first-partic...en.hdbuzz.netFirst participant dosed in pioneering neural stem cell trial for Huntington’s disease – HDBuzz 031
HDBuzz @hdbuzzfeed.bsky.social · 13/06/2026Huntington’s disease affects more than movement: it also has a major impact on mental health. Researchers explore why psychological care matters and how it needs to be adapted across each stage of HD. en.hdbuzz.net/evolving-nee...en.hdbuzz.netEvolving Needs, Evolving Care: Adapting Psychological Support Across Different Stages of Huntington’s Disease – HDBuzz 000
HDBuzz @hdbuzzfeed.bsky.social · 09/06/2026Your body assembles DNA like a team of workers who set and bond a pattern of tiles. A recent study shows that one special assistant might slow somatic CAG expansion and delaying HD onset. en.hdbuzz.net/sealing-the-...en.hdbuzz.netSealing the gap: a case for slower, smarter DNA repair – HDBuzz 010
HDBuzz @hdbuzzfeed.bsky.social · 06/06/2026In 2025, you helped us reach 329,000 people with independent, unbiased HD research news. Our 2025 Annual Report is here. Take a look at what we built together, and consider helping us keep going. en.hdbuzz.net/hdbuzz-2025-...en.hdbuzz.netHDBuzz 2025 Annual Report: Here’s what you made possible – HDBuzz 003
HDBuzz @hdbuzzfeed.bsky.social · 01/06/2026One year into treatment, SKY-0515 continues to lower huntingtin levels and shows encouraging trends in HD signs and symptoms. A larger clinical trial is now enrolling and will help determine whether SKY-0515 can truly slow disease progression in Huntington's disease. en.hdbuzz.net/skyhawk-repo...en.hdbuzz.netSkyhawk reports encouraging 12-month results for oral Huntington’s disease drug SKY-0515 – HDBuzz 000
HDBuzz @hdbuzzfeed.bsky.social · 31/05/2026May 2026: 2 year data from the votoplam trial suggests disease progression may slow; AMT-130 heads to the UK for regulatory review; pigs reveal immune cells invading the HD brain; and new science zooms in on toxic huntingtin fragments. en.hdbuzz.net/may-2026-thi...en.hdbuzz.netMay 2026: This Month in Huntington’s Disease Research – HDBuzz 000
HDBuzz @hdbuzzfeed.bsky.social · 26/05/2026Recently a paper was published where scientists targeted a small, harmful piece of the huntingtin message (HTT1a) in HD mice. This reduced toxic protein clumps and delayed genetic changes, more than targeting full length HTT. Full article: en.hdbuzz.net/fixing-the-r...en.hdbuzz.netFixing the Recipe: Lowering a Slice of Huntingtin – HDBuzz 011
HDBuzz @hdbuzzfeed.bsky.social · 22/05/2026A recent study suggests that strengthening the brain’s own clean-up system could slow Huntington’s disease. en.hdbuzz.net/tagging-the-...en.hdbuzz.netTagging the Trash: Turnover of Toxic Huntingtin – HDBuzz 000
HDBuzz @hdbuzzfeed.bsky.social · 18/05/2026After the EMA recommended refusing approval for pridopidine, Prilenia quietly withdrew its European application in November 2025. Here’s what happened, and why you’re only hearing about it now. Full article: en.hdbuzz.net/prilenias-ap...en.hdbuzz.netPrilenia’s Application for European Approval of Pridopidine Withdrawn – HDBuzz 010
HDBuzz @hdbuzzfeed.bsky.social · 14/05/2026A recent study in pigs suggests the HD brain could be under attack from the body’s own immune system. The results reveal that invading cytotoxic T cells might contribute to neurodegeneration in HD, suggesting a new therapeutic pathway. en.hdbuzz.net/intruders-in...en.hdbuzz.netIntruders in the Brain: What a Pig Model Reveals about Immune Cells in HD – HDBuzz 000
HDBuzz @hdbuzzfeed.bsky.social · 11/05/2026What does “good care” look like in Huntington’s Disease? A new Dutch study asked familial and professional caregivers, and uncovered how differently it’s experienced in practice. en.hdbuzz.net/the-great-ca...en.hdbuzz.netThe Great Care Conundrum: What “Good” Care Looks Like in Huntington’s Disease – HDBuzz 010
HDBuzz @hdbuzzfeed.bsky.social · 08/05/2026The U.S. regulatory path for AMT-130 remains complex, but uniQure has announced plans to seek approval for its Huntington’s disease gene therapy in the UK. Full Article: en.hdbuzz.net/a-second-pat...en.hdbuzz.netA Second Path: uniQure Plans Regulatory Filing for AMT-130 in the UK – HDBuzz 001