Sex differences have traditionally been attributed to gonadal hormones, but accumulating evidence shows that sex chromosomes exert distinct, cell-autonomous effects on health, aging, and disease. XX a...

Establishment of cell lineages during development is regulated by transcription factors binding at cis-regulatory elements to activate gene regulatory programs. Many transcription factors require chro...

Summary: The placenta is the only mammalian organ that harbors a cancer-like genome while remaining functional and healthy. This Review highlights its high mutational load, structural variants, aneupl...

A genome-rewriting approach known as adenine base editing offers a precise way to investigate gene function in early human embryos.

Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

This book covers diverse aspects of stem cell research and exemplifies some of the developments and improvements in the field.

High-resolution spatial transcriptome analysis of a human embryo at Carnegie stage 6 reveals three distinct developmental trajectories from the epiblast towards amnion, primitive streak and axial meso...

Ethical discussions are urgently needed as genome-editing science advances, some researchers say.

Summary: This Editorial offers an honest look at impact factor trends in developmental biology, explains how Development serves its community, and makes the case that sustaining developmental biology ...

A primate embryoid system is established from cynomolgus totipotent blastomere-like cells. This fertilization-independent system recapitulates development from a totipotent-like state through an inter...

Since the discovery of induced pluripotent stem cells (iPSCs) 20 years ago, iPSC technology has transformed stem cell research and regenerative medicine. This perspective reviews key advances in reprogramming mechanisms and highlights the growing clinical, translational, and societal applications of iPSCs.

Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon

A stem-cell-based monkey embryo model that self-organizes into a comprehensive body plan could lead the way to more-sophisticated models of early human development.

Gene regulatory networks establish cell identity during development by regulating transcription factor binding at cis-regulatory elements, many of which require chromatin remodelers for accessibility....

Dosage compensation of sex chromosomes through X-chromosome inactivation (XCI) is required for mice extra-embryonic tissue growth and embryo development. The species specificity in mechanisms and timi...