Spatial regulation of cell adhesion molecules in tissue dynamics underpins morphogenesis. Uechi et al. found that condensate dynamics of Sidekick, tuned by its conserved motif, contributes to its confined accumulation to tricellular junctions and molecular recruitment during epithelial dynamics, which eventually helps epithelial remodeling.

Spatial regulation of cell adhesion molecules in tissue dynamics underpins morphogenesis. Uechi et al. found that condensate dynamics of Sidekick, tuned by its conserved motif, contributes to its conf...

A new study observed the key signalling role that metabolism plays in controlling the tempo of development.

Biomolecular condensates are made of multiple components but current techniques cannot capture their complex composition quantitatively. Now it has been shown that the dense-phase binodal point defini...

Epithelial morphogenesis relies on coordinated multicellular movements regulated by adhesion and force-generating molecules. It remains elusive how cells ensure organization of these molecules in spac...

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...