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Struan Grant

@struangrant.bsky.social
4.4K followers 3.6K following 116 posts

Professor of Genetics and Pediatrics, UPenn/CHOP🧬. orcid.org/0000-0003-2025-5302. Views my own. 🏴󠁧󠁢󠁳󠁣󠁴󠁿🇺🇸

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Struan Grant @struangrant.bsky.social · 15/12/2024
Re-posting given recent adds go.bsky.app/9asWtuD
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Struan Grant @struangrant.bsky.social · 21/09/2026
New preprint from team member Anthony Gacita (@agacita.bsky.social) reports the 'Genomic Analysis of Variants in Unresolved Rare Disease' (GAVURD) system, which uses trio WGS alignment data to short list putative pathogenic non-coding variants for a given proband. www.biorxiv.org/content/10.6...
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Reposted by Struan Grant
Struan Grant @struangrant.bsky.social · 11/09/2026
Fantastic night last night hosting, along with Tara Wenger, the first ever Scottish Cèilidh at @chopresearch.bsky.social to celebrate 20 years for myself, Hakon Hakonarson and Marni Falk in the Division of Genetic & Genomic Medicine. Slàinte!
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Reposted by Struan Grant
Struan Grant @struangrant.bsky.social · 31/08/2026
Please see current opening: careers.chop.edu/us/en/job/10...
careers.chop.edu
Research Associate Scientist I - Grant Laboratory in Philadelphia, Pennsylvania, United States of America | Research at Children’s Hospital of Philadelphia
Apply for Research Associate Scientist I - Grant Laboratory job with Children’s Hospital of Philadelphia in Philadelphia, Pennsylvania, United States of America. Research at Children’s Hospital of Phi...
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Struan Grant @struangrant.bsky.social · 11/09/2026
Fantastic night last night hosting, along with Tara Wenger, the first ever Scottish Cèilidh at @chopresearch.bsky.social to celebrate 20 years for myself, Hakon Hakonarson and Marni Falk in the Division of Genetic & Genomic Medicine. Slàinte!
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Struan Grant @struangrant.bsky.social · 31/08/2026
Please see current opening: careers.chop.edu/us/en/job/10...
careers.chop.edu
Research Associate Scientist I - Grant Laboratory in Philadelphia, Pennsylvania, United States of America | Research at Children’s Hospital of Philadelphia
Apply for Research Associate Scientist I - Grant Laboratory job with Children’s Hospital of Philadelphia in Philadelphia, Pennsylvania, United States of America. Research at Children’s Hospital of Phi...
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Struan Grant @struangrant.bsky.social · 31/07/2026
In @genomeresearch.bsky.social: @atothezphd.bsky.social "Cross-species variant-to-function analyses implicate MEIS1 in conferring sleep abnormalities and impaired cerebellar development". Co-led with Allan Pack @chopresearch.bsky.social @penngenetics.bsky.social genome.cshlp.org/content/earl...
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Struan Grant @struangrant.bsky.social · 05/07/2026
Had a fantastic 4th of July watching France beat Paraguay in Philadelphia!
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Struan Grant @struangrant.bsky.social · 30/06/2026
Congratulations to Dr. Max Dudek @maxdudek.bsky.social for being awarded his PhD yesterday!
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Struan Grant @struangrant.bsky.social · 20/06/2026
Great game today. Obviously not the result we wanted. Roll on Brazil! 🏴󠁧󠁢󠁳󠁣󠁴󠁿⚽️
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Struan Grant @struangrant.bsky.social · 26/04/2026
Great debate at the ECTS annual meeting @ectssociety.bsky.social . With Hanna Taipaleenmaki for the motion and Maria Ines Almeida against. Interestingly, lncRNAs won!
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Struan Grant @struangrant.bsky.social · 24/03/2026
Delighted to contribute to this review of the genetics of obesity, just out in @natmetabolism.nature.com, led by Amélie Bonnefond and Philippe Froguel. @chopresearch.bsky.social @penngenetics.bsky.social www.nature.com/articles/s42...
nature.com
The genetics of obesity: aetiology, prevention and therapy - Nature Metabolism
This Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesi...
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Struan Grant @struangrant.bsky.social · 24/03/2026
Delighted to contribute to this review of the genetics of obesity, just out in @natmetabolism.nature.com, led by Amélie Bonnefond and Philippe Froguel. @chopresearch.bsky.social @penngenetics.bsky.social www.nature.com/articles/s42...
nature.com
The genetics of obesity: aetiology, prevention and therapy - Nature Metabolism
This Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesi...
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Reposted by Struan Grant
Max Dudek @maxdudek.bsky.social · 20/03/2026
Excited to finally share my recent preprint with @struangrant.bsky.social! www.biorxiv.org/content/10.6... We collected chromatin accessibility QTLs (caQTLs) from 10 different studies and observed that they are less depleted at selectively constrained genes compared to eQTLs. 👇👇👇
biorxiv.org
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Struan Grant @struangrant.bsky.social · 13/03/2026
www.research.chop.edu/cornerstone-...
research.chop.edu
Research Studies Show Genetics 'Powerful Component' of Bone Density Across Lifespan
Two CHOP studies highlight the importance of understanding genetic and genomic influences on pediatric bone development.
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Struan Grant @struangrant.bsky.social · 25/02/2026
My lab is seeking to co-hire another postdoctoral fellow with the @shaonsengupta.bsky.social team. See details below! careers.chop.edu/us/en/job/10...
careers.chop.edu
Research Postdoctoral Fellow - Grant & Sengupta Labs in Philadelphia, Pennsylvania, United States of America | Fellows, Students & Interns at Children’s Hospital of Philadelphia
Apply for Research Postdoctoral Fellow - Grant & Sengupta Labs job with Children’s Hospital of Philadelphia in Philadelphia, Pennsylvania, United States of America. Fellows, Students & Interns at Chil...
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Struan Grant @struangrant.bsky.social · 29/01/2026
A true honor speaking at the 'Festschrift' for my PhD supervisor from many years back. Best wishes to Stuart Ralston!
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Struan Grant @struangrant.bsky.social · 15/01/2026
20 years ago today we first reported the TCF7L2 association with type 2 diabetes @natgenet.nature.com. Much to still figure out for this locus.... www.nature.com/articles/ng1...
nature.com
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes - Nature Genetics
Nature Genetics - Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
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Struan Grant @struangrant.bsky.social · 13/01/2026
Delighted to contribute to this work led by Kyla Mace and @kayserlab.bsky.social: "Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2". @penngenetics.bsky.social @chopresearch.bsky.social www.nature.com/articles/s41...
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Struan Grant @struangrant.bsky.social · 06/01/2026
Delighted to contribute. "Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk". @alessandrachesi.bsky.social @lisanwang.bsky.social rdcu.be/eXOb5
rdcu.be
Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk
npj Dementia - Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer’s disease risk
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Reposted by Struan Grant
Struan Grant @struangrant.bsky.social · 02/01/2026
www.youtube.com/watch?v=XGvE...
youtube.com
Annual Report: CHOP Scientists' 2025 Highlights with Struan Grant, PhD
YouTube video by CHOP Research Institute
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Struan Grant @struangrant.bsky.social · 02/01/2026
www.youtube.com/watch?v=XGvE...
youtube.com
Annual Report: CHOP Scientists' 2025 Highlights with Struan Grant, PhD
YouTube video by CHOP Research Institute
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Struan Grant @struangrant.bsky.social · 08/12/2025
Congratulations to @khanhtrang.bsky.social. Delighted to contribute to this V2G across ~60 cell types & 15 autoimmune GWAS reports. @chopresearch.bsky.social @penngenetics.bsky.social
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ASBMR @asbmr.bsky.social · 25/11/2025
Thank you for sharing! It's members like you that demonstrate the quality of the programs that ASBMR offers. We hope people will take advantage of the opportunity to work with the best and brightest in bone and mineral research! 🦴
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Struan Grant @struangrant.bsky.social · 20/11/2025
An outline of our recent bone 🦴 papers - with @j-a-mitchell.bsky.social and Babette Zemel. @chopresearch.bsky.social @penngenetics.bsky.social www.chop.edu/preview-link...
chop.edu
Children’s Hospital of Philadelphia Researchers Identify Genetic Factors Influencing Bone Density in Pediatric Patients
Understanding the causal gene was related to the dynamic between osteoblasts, which form new bone tissue, and osteoclasts, which break down old bone tissue. When children are growing, osteoblasts are far more active to help achieve proper bone growth.
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Struan Grant @struangrant.bsky.social · 19/11/2025
As an ASBMR Ambassador, I invite you to check out the ASBMR @asbmr.bsky.social 2026 Student Cohort Program www.asbmr.org/student-cohort. The application deadline has been extended to November 28, 2025.
asbmr.org
ASBMR Student Cohort Program
A new cohort program designed for undergraduate, graduate, and medical professional students involved in the bone, mineral, and musculoskeletal field. This cohort program provides accepted applicants
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Struan Grant @struangrant.bsky.social · 19/11/2025
As an ASBMR Ambassador, I invite you to check out the ASBMR @asbmr.bsky.social 2026 Student Cohort Program www.asbmr.org/student-cohort. The application deadline has been extended to November 28, 2025.
asbmr.org
ASBMR Student Cohort Program
A new cohort program designed for undergraduate, graduate, and medical professional students involved in the bone, mineral, and musculoskeletal field. This cohort program provides accepted applicants
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Struan Grant @struangrant.bsky.social · 04/11/2025
@shaonsengupta.bsky.social and I are still hiring! Please DM us if interested www.nature.com/naturecareer...
nature.com
Post Doctoral Research Fellow – Circadian Biology and Genomics - Philadelphia, Pennsylvania (US) job with Children's Hospital of Philadelphia | 12846607
A postdoctoral fellow is needed to join a strong team involved in spanning both dry and wet lab approaches.
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Struan Grant @struangrant.bsky.social · 17/10/2025
Penn Genetics @penngenetics.bsky.social and CHOP Genetics @chopresearch.bsky.social are at #ASHG25 Booth #1319 - come on by!
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Struan Grant @struangrant.bsky.social · 17/10/2025
I'll again be at the #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 1.30-2.30pm today - come on by!
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Struan Grant @struangrant.bsky.social · 17/10/2025
Come see Matt Pahl (@pahlmc.bsky.social) present at the #ASHG25 Session on Predicted Effector Genes. Here are the details for the session: Learn about the current predicted effector gene landscape 11:45AM-1:15PM ET Room 259A
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Struan Grant @struangrant.bsky.social · 16/10/2025
I'll again be at the #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 3.30-4.30pm today - come on by!
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Struan Grant @struangrant.bsky.social · 16/10/2025
Come see Winter Bruner, PhD today: "A comprehensive MPRA of both trans-ancestral genome-wide and suggestively-associated childhood obesity loci implicates a role for CBLN4 in microglia". Room 205ABC Thurs 11.00-11.15 Key contribution from Molly Ridler
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Struan Grant @struangrant.bsky.social · 15/10/2025
I'll be at the #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 3.30-4.30pm today - come on by!
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Struan Grant @struangrant.bsky.social · 14/10/2025
Check out #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 Exhibit Level Halls A-B, Nonprofit and Advocacy Pavilion Tuesday, October 15 - Thursday, October 17
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Struan Grant @struangrant.bsky.social · 15/10/2025
Great collaboration with the Joan O'Brien team - come see Vrathasha Vrathasha today: "3D genomic approaches mapping accessible chromatin and architecture implicate causal risk variants in primary open-angle glaucoma pathogenesis". Key contribution from @pahlmc.bsky.social. 10.45-11.00am Room 206AB
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Anthony M. Gacita MD PhD @agacita.bsky.social · 15/10/2025
Come say hi at the #ASHG25 poster session today! I’ll be discussing my work on identifying pathogenic non coding variants in undiagnosed children. Poster 4083W. See you there! #ASHG2025 #Genetics #CHOP
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Jacqueline S. Dron, PhD @jsdron.bsky.social · 14/10/2025
Can’t believe #ASHG25 is finally here! Excited to share what I’ve been working on as lead analyst for the Global Lipids Genetics Consortium 🧬👩‍💻 Join me at the Plenary Session on Friday, Oct 17 (5–6:30 PM) — I’ll be presenting some unpublished results from our genome-wide interaction study 👀
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Matt Sampson @kidneyomicsamps.bsky.social · 14/10/2025
Our team is excited to meet folks at #ASHG25 #kidneyomics
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Max Dudek @maxdudek.bsky.social · 14/10/2025
I'll be at #ASHG25 this week! Check out my poster Wed 2:30-4:30, at 5071W. "Bridging the GWAS-eQTL colocalization gap with insights from caQTL analyses" with @struangrant.bsky.social and Laura Almasy
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Struan Grant @struangrant.bsky.social · 14/10/2025
Our #ASHG25 poster activities each day: 1097W Khanh Trang: Bone* 5071W Max Dudek: caQTLs 8042W Amber Zimmerman: Sleep 4083W Anthony Gacita: Pathogenic noncoding variants 9252T Mary Ann Weidekamp: Neuro & metab LDSC 5047T Ekta Singh: Ciliopathies 9206F Matthew Pahl: Glaucoma V2G* *Reviewers’ Choice
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John Morris @johnomix.bsky.social · 14/10/2025
Finalizing my slides for #ASHG25 while on my flight to Boston in true PI fashion. Come check out the finished product tomorrow morning at 10:45am in the excitingly named "Seq-ing Function with Single Cells and CRISPR Perturbations" session! 🙂
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Struan Grant @struangrant.bsky.social · 14/10/2025
Check out #ASHG25 Penn Genetics @penngenetics.bsky.social Booth #1319 Exhibit Level Halls A-B, Nonprofit and Advocacy Pavilion Tuesday, October 15 - Thursday, October 17
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Struan Grant @struangrant.bsky.social · 14/10/2025
Just out: Led by @j-a-mitchell.bsky.social and Babette Zemel "gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood" @asbmr.bsky.social. Funded by our #NICHD award R01 HD100406. @chopresearch.bsky.social @penngenetics.bsky.social academic.oup.com/jbmr/article...
academic.oup.com
The gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood
Abstract. The polygenic risk score genetic quantitative ultrasound speed of sound (gSOS) was developed using machine learning algorithms in adults of Europ
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Amelia Eisch 🧪🧠👩‍🔬 🐁 @eisch.bsky.social · 14/10/2025
#ScienceJobs #PostdocOpening 🧬🧪
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Struan Grant @struangrant.bsky.social · 14/10/2025
Open to connecting with potential candidates at #ASHG25 !
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Struan Grant @struangrant.bsky.social · 14/10/2025
Our #ASHG25 platform activities: Vrathasha Vrathasha: 3D genomics & glaucoma. 206AB, W 10.45-11 Winter Bruner: MPRA & childhood obesity. 205ABC, T 11-11.15 Matt Pahl: Ancillary Session, Predicted Effector Genes. 259A, F 1.45-1.15 Struan Grant chairs Metabolic Matrix session. 253ABC, S 10-11
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Struan Grant @struangrant.bsky.social · 11/10/2025
A fun day hanging with Tom Romer @chopshopstore.bsky.social, designer extraordinaire!
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Katelyn Connelly, Ph.D. @kconnelly92.bsky.social · 10/10/2025
Congratulations to my labmates @junzhong.bsky.social and Aidan for their new publication on non-coding somatic mutations in PDAC! I’m honored to have been a part of the work & @amundadottir.bsky.social team.
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Laufey Amundadottir @amundadottir.bsky.social · 10/10/2025
So excited that our manuscript is now online! Led by the super talented @junzhong.bsky.social & Aidan O'Brien in my lab with lots of help from Minal Patel @kconnelly92.bsky.social Jason Hoskins @efsunarda.bsky.social @struangrant.bsky.social and others. Very grateful to our team and collaborators!!
gut.bmj.com
Large-scale multiomic analysis identifies non-coding somatic driver mutations and nominates ZFP36L2 as a driver gene for pancreatic ductal adenocarcinoma
Background The identification and characterisation of somatic cancer driver mutations in the non-coding genome remains challenging. Objective To broadly characterise non-coding driver mutations for p...
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