Expression of human NRXN1 isoforms in C. elegans neurons revealed gain-of-function of schizophrenia-associated 3′ deletions! Work by Dustin Haskell (now @lawrenceuni.bsky.social), and with immense thanks to @kristenbrennand.bsky.social! academic.oup.com/hmg/article/...
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In vivo dissection of human NRXN1 isoforms reveals gain-of-function pathogenicity of schizophrenia-associated 3′ deletions
Abstract. Heterozygous deletions in NRXN1, encoding the presynaptic adhesion molecule Neurexin 1, are among the most frequently identified rare variants in