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Michael P Hart 🏳️‍🌈 (he/him)

@michaelphart1.bsky.social
571 followers 519 following 32 posts

Neuroscientist and geneticist @PennGenetics and @PennMedicine. Our lab studies plasticity of neuronal circuits and behavior in C. elegans. www.mphartlab.com

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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 10/09/2026
Expression of human NRXN1 isoforms in C. elegans neurons revealed gain-of-function of schizophrenia-associated 3′ deletions! Work by Dustin Haskell (now @lawrenceuni.bsky.social), and with immense thanks to @kristenbrennand.bsky.social! academic.oup.com/hmg/article/...
academic.oup.com
In vivo dissection of human NRXN1 isoforms reveals gain-of-function pathogenicity of schizophrenia-associated 3′ deletions
Abstract. Heterozygous deletions in NRXN1, encoding the presynaptic adhesion molecule Neurexin 1, are among the most frequently identified rare variants in
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Reposted by Michael P Hart 🏳️‍🌈 (he/him)
Genetics Society of America @genetics-gsa.bsky.social · 07/09/2026
🪱 In #GENETICS, Sophia Villiere and @michaelphart1.bsky.social identify rig-6/contactin as a temporally restricted regulator of GABAergic neuron remodeling in #Celegans, acting cell-autonomously to promote neurite outgrowth during the L4-to-adult transition. 🔗 buff.ly/8430n1J
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Javier Apfeld @javierapfeld.bsky.social · 05/08/2026
We need your help spreading the word about the C. elegans Community Mentor Match Program! Please talk about the program in your next lab meeting and share this slide with your lab: docs.google.com/presentation...
docs.google.com
Mentor match QR codes 2026
Join the C. elegans Community Mentor Match Program! sign up for mentors sign up for mentees and to join peer-mentoring groups https://forms.gle/nfNWQRnpymu6tCYC9 https://forms.gle/pZdwor7wERmQ4oMG8
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 18/06/2026
Lovely gift from my former PhD student @maracowen.bsky.social !! Who’s to say the worm friend isn’t a pink pseudo-colored C. elegans!?!?
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Reposted by Michael P Hart 🏳️‍🌈 (he/him)
Javier Apfeld @javierapfeld.bsky.social · 27/05/2026
Worm friends, we need your help! For the next C. elegans Mentor Match cycle, we’re gathering testimonials from past mentors and mentees. One of our biggest challenges is recruiting new mentees, and hearing directly from past participants could really help. Please record a short video, and share!
padlet.com
C. elegans Mentor Match Testimonials
Made with Padlet
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 02/04/2026
Please join us in celebrating the life and legacy of Assoc. Prof. Laura Grafe, and the dedication of the Dr. Laura Grafe Endowed Student Research Fund. Sunday April 19th, 2026 2:00 - 4:00 pm Bryn Mawr College lnkd.in/ehM3jxDD] To contribute to the Dr. Laura Grafe Endowed Fund for Student Research
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 01/01/2026
2025 was… something. But time closing it out on the slopes with family has me smiling and optimistic for 2026!
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 19/11/2025
A fun evolution and behavior project initiated by a summer undergrad Reina Eugene (PGSIP intern!) with Dustin Haskell - Variation in Social Feeding Behaviors and Interactions Among Caenorhabditis Nematodes @penngenetics.bsky.social @ecol-evol.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Variation in Social Feeding Behaviors and Interactions Among Caenorhabditis Nematodes
Different species of roundworms (nematodes) are frequently found together in the wild and can aggregate in groups while feeding. We find that different species of worms display a range of feeding beh...
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Reposted by Michael P Hart 🏳️‍🌈 (he/him)
Genetics Society of America @genetics-gsa.bsky.social · 22/10/2025
In the October issue of #GENETICS, @michaelphart1.bsky.social and colleagues report #Celegans mutant analysis that identified conserved #autism genes with functions in experience-dependent neuron remodeling and circuit plasticity. buff.ly/ZrxH4rM
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Reposted by Michael P Hart 🏳️‍🌈 (he/him)
Genetics Society of America @genetics-gsa.bsky.social · 09/10/2025
In #GENETICS, @michaelphart1.bsky.social and colleagues performed a mutant screen in #Celegans to identify conserved #autism genes with functions in experience-dependent neuron remodeling and circuit plasticity. buff.ly/f5UYogl
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 13/08/2025
Do you like neuronal #plasticity? #genetics? #Celegans? Check out 1st installment of work by Kristi Zoga in the lab. Kristi screened 20 conserved #autism genes for roles in experience-dependent #neuron remodeling and a related behavior. doi.org/10.1093/genetics/iyaf156
doi.org
Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories
Abstract. Variation in over 100 genes are now associated with increased risk for autism and related neurodevelopmental conditions, but how this variation r
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 06/08/2025
This all checks out. As a donor, the endless fundraising texts and emails I receive after donating make me donate LESS!!! Figure out a better way to not piss off unit supporters @housedemocrats.bsky.social
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 14/07/2025
Feature article on latest work from @tdrivas.bsky.social Genetic testing of critically ill adults yields surprises—and reveals disparities in treatment of Black patients | Science www.science.org/content/arti...
science.org
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Vote Save America @votesaveamerica.crooked.com · 08/07/2025
We're asking YOU to run for office and we're partnering with the best of the best to make it happen: Pipeline Fund, LEAD NC, Annie's List, Texas Leadership Pipeline, Instituto, Run for Something, and National Democratic Training Committee. Learn more at votesaveamerica.com/run
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Mallory Harris, PhD @malar0ne.bsky.social · 23/06/2025
The White House's proposed FY26 budget would cut NIH funding by >40%. Our new #SCIMaP report projects the budget would lead to economic losses throughout the US with $10M+ lost in almost every House district. scienceimpacts.org/fy26 @joshuasweitz.bsky.social @asinclair.bsky.social @cl10.bsky.social
scienceimpacts.org
SCIMaP - Impacts of Federal Cuts to Science and Medical Research
Developed by an interdisciplinary research team, this website shows how funding cuts reduce economic activity and employment nationwide
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Stand Up for Science! @standupforscience.net · 09/06/2025
(5/5) 🚨 It’s time to flood the zone. NIH scientists just took a huge risk speaking out. Now it’s our turn. 📜 Read the Bethesda Declaration ✍️ Sign the Public Letter of Support 👯‍♀️Follow NIHers doing the work: @nihvigils.bsky.social Read and sign here 👉 www.standupforscience.net/bethesda-dec...
standupforscience.net
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Reposted by Michael P Hart 🏳️‍🌈 (he/him)
Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 13/05/2025
"Women are PIs on 58% of the canceled grants, although they are PIs on only 34% of all active NSF grants. Similarly, Blacks are PIs on 17% of the terminated grants, although they make only 4% of the total pool. Hispanic PIs and those with disabilities were twice as likely to lose a grant."
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 13/05/2025
Devastated by the loss of my amazing friend and colleague Laura Grafe (@grafelab.bsky.social, Bryn Mawr). She was beautiful, brilliant, and bursting with life! Her love and light burned so bright, it will forever be with everyone who was lucky enough to know her. Rest In Peace @pennngg.bsky.social
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 12/05/2025
Beyond excited to host @dacolon.bsky.social today for the Distinguished Seminar Series at @pennmedicine.bsky.social @penngenetics.bsky.social!! Come see a terrific talk at noon!
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NPR @npr.org · 16/04/2025
Researchers and advocates have pushed back at what they consider inaccurate and stigmatizing comments made by the health secretary, and note the causes of autism are complex.
npr.org
RFK pushes to find 'environmental' cause of autism, calls rising rates an 'epidemic'
Researchers and advocates have pushed back at what they consider inaccurate and stigmatizing comments made by the health secretary, and note the causes of autism are complex.
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 16/04/2025
Ire isn't the right word... he is wrong and is stigmatizing 1 in ~40 children. 'Kennedy called research into the genetic factors in whether a child will develop autism “a dead end.” “Genes don’t cause epidemics,” he said. “You need an environmental toxin.”" www.nytimes.com/2025/04/16/u...
nytimes.com
RFK Jr. Calls Autism ‘Preventable,’ Drawing Ire From Researchers
The health secretary said he would prioritize studies into environmental causes while harshly discounting other factors scientists say are likely contributing to rising rates of the condition.
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Rachel Maddow @maddow.bsky.social · 15/04/2025
"After nearly five hours, he and his wife were released. They are now pursuing legal action. "It's not about the immigrants," his sister, told NBC10 Boston. "It's coming to us Americans, and it's going to go after all of us." www.nbcboston.com/news/politic...
nbcboston.com
‘Treated like a criminal': US citizen says he was detained returning from Canada
Bachir Atallah, a real estate attorney from New Hampshire, says he and his wife, Jessica Fakhri, were stopped crossing from Canada into Vermont
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 08/04/2025
So excited to host @singhvilabglia.bsky.social (One of my favorite scientists to spend time with!!) tomorrow for the @pennngg.bsky.social and MINS seminar!! Come learn about glia!!
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Teddy Drivas 🏳️‍🌈 (he/him) @tdrivas.bsky.social · 02/04/2025
Patience, collaboration, and perseverance pay off! Our investigation of the population prevalence of NF1 pathogenic variants is out today in @naturecomms.bsky.social! We find these variants are much more common than anticipated and confer increased risk for cancer. www.nature.com/articles/s41...
nature.com
A genotype-first approach identifies high incidence of NF1 pathogenic variants with distinct disease associations - Nature Communications
Our current understanding of neurofibromatosis type 1 (NF1) is based on patients ascertained through phenotype-first approaches, which estimate a low prevalence at 1 in 3,000. Here, the authors levera...
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Reposted by Michael P Hart 🏳️‍🌈 (he/him)
callista yee @csybio.bsky.social · 25/03/2025
attention worm peeps! we need YOU to help recruit more mentees for the C. elegans Community Mentor Match program! 🪱🧪 mentees of all stages are welcome to join! Please help us sign up more mentees by sharing this this slide with your lab in your next lab meeting! docs.google.com/presentation...
docs.google.com
Join the C. elegans Community Mentor Match Program!
Join the C. elegans Community Mentor Match Program! sign up for mentors sign up for mentees and to join peer-mentoring groups https://forms.gle/DpGTWRMrNGL96wHy8 https://forms.gle/pVBD5DYGXyLT4waLA
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 07/03/2025
Amazing support for SCIENCE with so many familiar faces! (Dog, sign, and picture courtesy of @glennislogsdon.bsky.social) @tdrivas.bsky.social @korblab.bsky.social @standupforscience.bsky.social #standupforscience2025
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Genetics Society of America @genetics-gsa.bsky.social · 04/03/2025
Wonder what it would be like to present your research at a conference attended by #NobelPrize recipients? See them in the hallway & have a chance to chat? Hear about their illustrious work that earned them this year's Nobel Prize in Physiology and Medicine? This is your chance! 1/3🧵
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 26/02/2025
Not great… not great whyy.org/articles/pen...
whyy.org
Philly-area lawmakers walk out of meeting with Penn president over DEI cuts
A Pennsylvania state senator and state representative left the meeting after they say a university administrator referred to diversity as a “lightning rod.”
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 26/02/2025
Philadelphia Stand Up For Science! #standupforscience2025 Friday, March 7 · 11am - 1pm Philadelphia City Hall standupforscience2025.org
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Genetics Society of America @genetics-gsa.bsky.social · 25/02/2025
Join the @standupforscience.bsky.social rally on March 7 to help protect the American scientific enterprise & defend science as a public good that drives social, political, & economic progress. Learn more & find your local site: buff.ly/3EWhSZM #standupforscience2025 #scienceforall
buff.ly
STAND UP FOR SCIENCE
March 7, 2025. Washington DC and nationwide. Because science is for everyone.
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American Society for Cell Biology @ascbiology.bsky.social · 05/02/2025
Your Action Is Needed! Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy www.ascb.org/science-poli...
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 04/02/2025
Awesome, albeit freezing, ski weekend with my siblings and nephew in Vermont! Definitely worth taking an extra 2 days off despite an impending grant deadline!
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Ardem Patapoutian @ardemp.bskyverified.social · 09/12/2024
I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏 www.nytimes.com/2024/12/09/h...
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Janet Kinneberg @jkinneberg.bsky.social · 23/01/2025
Everyone can use this UMR tool (UnitedforMedicalResearch.org ) to see the impact of #NIH funding on jobs and economic activity state-by-state. Please contact your elected representatives with this information and share it with your friends and neighbors. #NIHinYourState bsky.app/profile/nano...
neighbors.as
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 22/01/2025
www.nature.com/articles/d41...
nature.com
How to be a brilliant ally to your neurodivergent lab mate
Two researchers, one with bipolar disorder and ADHD, the other with autism, discuss supportive workplaces, building networks, and how and when to disclose diagnoses.
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Reposted by Michael P Hart 🏳️‍🌈 (he/him)
Genetics Society of America @genetics-gsa.bsky.social · 17/01/2025
With how busy the start of the semester is, the #Worm25 organizers have announced an extension of the deadline to apply to organize a workshop at the conference!📣 You now have until January 31. Read guidelines, examples of topics, & apply: buff.ly/3DTfvq3 🪱
buff.ly
Workshop Applications - 25th International Worm Meeting
Visit our website to learn more.
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Reposted by Michael P Hart 🏳️‍🌈 (he/him)
Genetics Society of America @genetics-gsa.bsky.social · 15/01/2025
Abstract submission and registration for #Worm25 are OPEN! 🪱📣 Don't miss the premier event for Worm researchers this Summer! Submit an abstract on a variety of topics including cell biology, development, gene regulation & genomics, and more: buff.ly/40arx5W 1/2🧵
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 18/12/2024
PhD training can make you a great scientist, but can also make you lifelong friends!! Loved celebrating Toni Moi Prince's wedding with friends from @pennngg.bsky.social (class of 2008)!! @grafelab.bsky.social , Sam White, and @tdrivas.bsky.social (honorary)!! 🧪🧠
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 05/12/2024
Sharing our recent manuscript on this new and better platform 🦋 - Brandon Bastien PhD used sophisticated tools to dissect neuron type specific roles for the synaptic adhesion gene CNTNAP in regulating behavior in C. elegans! 🧪 🧠 🪱 rdcu.be/d2zF2
rdcu.be
nlr-1/CNTNAP regulates dopamine circuit structure and foraging behaviors in C. elegans
Communications Biology - Removal of nlr-1/CNTNAP from monoamine neurons in C. elegans reveals neuron-specific roles in foraging behaviors, including a critical role for nlr-1 in dopamine neuron...
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 20/11/2024
Last week I joined here 💙! This week @tdrivas.bsky.social and I welcomed Odys to the family (short for Odysseus)! Some things are looking up! Ajax is mostly happy about it! 🧠🧪🐶
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Michael P Hart 🏳️‍🌈 (he/him) @michaelphart1.bsky.social · 11/11/2024
New paper ALERT!! Mara Cowen, PhD discovered and defined how conserved autism-associated genes modify a 'social' behavior in C. elegans!! So proud of her work in the lab! www.nature.com/articles/s41...
nature.com
Conserved autism-associated genes tune social feeding behavior in C. elegans - Nature Communications
C. elegans aggregate in large clumps during feeding. Here, the authors find conserved autism-associated genes mediate distinct molecular and circuit signaling components that tune C. elegans feed...
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