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Nick Chavkin

@nickchavkin.bsky.social
173 followers 171 following 5 posts

Assistant Professor of Pediatric Cardiology - Seattle Children’s Research Institute - University of Washington. Cardiovascular Biology, Endothelial Cells, Age-Related Somatic Mutations, Cell Cycle, Heart Failure.

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Nick Chavkin @nickchavkin.bsky.social · 13/06/2026
Excited to share my new lab's first publication! "Coronary endothelial cells undergo venous-enriched disrupted maturation following myocardial infarction" in Basic Research in Cardiology. link.springer.com/article/10.1...
link.springer.com
Coronary endothelial cells undergo venous-enriched disrupted maturation following myocardial infarction - Basic Research in Cardiology
The coronary microvascular plexus responds to cardiac ischemia through angiogenic neovascularization in the ischemic and border zones to sustain the demand for oxygen and nutrients. Although new blood...
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Miriam B. Goodman, PhD @wormsense.bsky.social · 27/10/2025
Molecular & Cellular Physiology (MCP) Monday We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n facultypositions.stanford.edu/en-us/job/49...
facultypositions.stanford.edu
Stanford | Faculty Positions: Details - Assistant Professor of Molecular and Cellular Physiology
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Hao Yin @haoyin.bsky.social · 20/09/2025
#Senescence #Mechanobiology Senescent #EndothelialCell HUVEC (+H2O2 or Doxorubicin) have ⬆️ #Viscoelasticity (Microfluidic cytometric measurement of suspended whole-cell deformation) ⏫F-actin, Calnexin ER, Lamin A Nuclear envelope #CellRepPhysSci 2025 www.sciencedirect.com/science/arti...
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NEJM.org @nejm.org · 16/09/2025
In patients with nonobstructive HCM, mavacamten did not significantly improve peak oxygen uptake or decrease symptoms as compared with placebo, and more patients had a reduction in LVEF with mavacamten. Full ODYSSEY-HCM phase 3 trial results and Research Summary: nej.md/4oSZx2m #MedSky
The New England Journal of Medicine                  
Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy 
A Research Summary based on Desai MY et al. | 10.1056/NEJMoa2505927 | Published on August 30, 2025 

Visual representations of the patients in the trial and the treatments they were assigned.                      

Read the full Research Summary at NEJM.org.
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Nature Reviews Cardiology @natrevcardiol.nature.com · 12/09/2025
New online! The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative #CardioSky
bit.ly
The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative
Nature Reviews Cardiology, Published online: 12 September 2025; doi:10.1038/s41569-025-01209-zIn this Review, Khoury and colleagues examine the growing body of evidence demonstrating the benefits of screening for cardiovascular risk factors, including dyslipidaemia and high blood pressure, starting in childhood to reduce the lifetime burden of cardiovascular disease.
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Science News @scinews.bsky.social · 06/09/2025
Natural medicines target tumor vascular microenvironment to inhibit cancer growth www.sciencedirect.com/science/arti...
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@NicoliLab @nicolilab.bsky.social · 29/07/2025
Check out how mRNA can influence cell motility! See how here: www.cell.com/cell-reports.... Thanks for the shout-out Yale News and @cp-trendscellbio.bsky.social! news.yale.edu/2025/02/13/f... www.cell.com/trends/cell-...
cell.com
G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration
Boraas et al. identify that mRNAs and the stress granule RNA-binding protein G3BP1 form ribonucleoprotein (RNP) complexes at FAs. These RNPs regulate FA protein mobility and cell migration under norma...
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Fernando Santana @lfsantana68.bsky.social · 23/07/2025
Manning & Rivera et al. (www.jacc.org/doi/10.1016/...) show that pruning just a few capillaries in the SA node plunges the heart’s pacemaker into metabolic overdraft—slowing the rate and jacking up beat-to-beat variability. The physiological equivalent of running on fumes. @jaccjournals.bsky.social
jacc.org
Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF
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Nature Cardiovascular Research @natcardiovascres.nature.com · 15/07/2025
❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more! www.nature.com/natcardiovas...
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Nick Chavkin @nickchavkin.bsky.social · 09/07/2025
Excited to share a recent review article that I published on Cardiovascular Aging and Hematopoietic Mosaic Loss of Y Chromosome. Main take-home: there are strong similarities between loss of Y and aging in clinical correlations and disease progression. www.oaepublish.com/articles/jca...
oaepublish.com
Age-related cardiovascular disease and mosaic hematopoietic loss of the Y chromosome
Age is the strongest risk factor for cardiovascular morbidity and mortality, driven in part by aging leukocytes negatively impact cardiovascular health. This effect is particularly pronounced in men, ...
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Seattle Children’s @seattlechildrens.org · 08/07/2025
Bluesky, we're here! 👋 We’re excited to connect with the growing biomedical research community here. Follow us for groundbreaking discoveries, new insights, and research updates from Seattle Children's Research Institute. 🧬 #MedSky
Researchers in a lab. Text reads Seattle Children's Research Institute. Turning discoveries into lifesaving therapies. Follow Us!
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EVBO @evborg.bsky.social · 13/06/2025
#EVBOSeminarSeries Moderated by Joanna Kalucka. Speakers: Ralf Adams and Mariona Graupera. ⏰When: Wednesday, 18th June 2025, 3PM EU time (2PM UK). Place: online. See you there! For registration evbo.org
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Nature Reviews Cardiology @natrevcardiol.nature.com · 19/05/2025
New online! Dual mechanotherapy for the treatment of cardiac fibrosis #CardioSky
bit.ly
Dual mechanotherapy for the treatment of cardiac fibrosis
Nature Reviews Cardiology, Published online: 19 May 2025; doi:10.1038/s41569-025-01172-9Inhibition of mechanotransduction selectively in cardiac fibrolasts, especially when combined with inhibition of transforming growth factor-β signalling, triggers a reversal of fibroblast activation and suppresses fibrosis in diseased hearts.
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NAVBO @navbo.bsky.social · 23/04/2025
Please join us next Tuesday April 29th at 1 pm EST for our next Symposium on Precision Genomics: CRISPR and Single-Cell Technologies in Vascular Biology, featuring #AaronJames @bgcoonlab.bsky.social @chadweldy.bsky.social and moderated by @vsleekim.bsky.social ! Register here: tinyurl.com/yhcdr68a
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Sara Nunes Vasconcelos, PhD she/her/hers🇨🇦🇧🇷 @saravasconcelos.bsky.social · 23/04/2025
Big thanks to Karen Hirschi for the great presentation and for visiting us in Toronto! We really appreciated the insights and the chance to connect in person. @medicinebydesign.bsky.social @uhnresearch.bsky.social
Seminar presentation 4 ppl having dinner
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UVA CVRC @uvacvrc.bsky.social · 20/03/2025
@lukedunaway.bsky.social, PhD, recently received an @americanheart.bsky.social Career Development Award to study iron's role in chronic kidney disease. Luke is a postdoc in @brantisakson.bsky.social's Lab and member of our Cardiovascular Training Program. Congratulations! #CardioSky #MedSky
cvrc.virginia.edu
Luke Dunaway, PhD, Wins AHA Award for Chronic Kidney Disease Research – Robert M. Berne Cardiovascular Research Center
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Makinen lab - Lymphatic Biology and Pathology @taijamakinenlab.bsky.social · 20/03/2025
If you’re curious about why lymphatic endothelial cells have their jigsaw puzzle-like shape, check out our paper @Nature rdcu.be/eejhZ
rdcu.be
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium
Nature - Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result...
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Henry Han @hancardiomd.bsky.social · 20/03/2025
Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives A scientific statement of the #HFA of @escardio.bsky.social onlinelibrary.wiley.com/doi/full/10.... @shelleyzieroth.bsky.social @cardioobdoc.bsky.social @drrajivsankar.bsky.social #CardioSky
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Immunity @cp-immunity.bsky.social · 18/03/2025
Online now: Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors
dlvr.it
Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors
Central nervous system malignancies include primary tumors and brain metastases (BrMs) originating from extracranial cancers. Bejarano et al. examine primary and metastatic brain tumors and find distinct vascular alterations in IDH mutant gliomas, IDH WT…
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Denis Wirtz @deniswirtz.bsky.social · 12/02/2025
"NIH admit freezing is illegal, will resume issuing grants" popular.info/p/breaking-n...
popular.info
BREAKING: NIH admits funding freeze is illegal, will resume issuing grants
An internal memo issued February 12 was obtained by Popular Information.
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Yale Cardiovascular Research Center @yalecvrc.bsky.social · 30/01/2025
Hello from the Yale Cardiovascular Research Center! We look forward to interacting with the science community on blue sky!
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Baptiste Lacoste @blacoste.bsky.social · 09/01/2025
New study shows that genomic instability promotes brain endothelial cell aging and impairs brain homeostasis doi.org/10.1038/s414... #cerebrovascular
doi.org
Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction - Cell Death & Disease
Cell Death & Disease - Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction
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Eric Topol @erictopol.bsky.social · 05/01/2025
Mosaic pattern loss of Y chromosome, which occurs in ~40% of men by age 70, is causally linked to heightened risk of many diseases, including cardiovascular, bladder cancer, and Alzheimer's. But it's almost never assessed clinically. A new review nature.com/articles/s41...
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ISACB @appliedcvb.bsky.social · 29/12/2024
Member publication alert: Monocyte adhesion to and transmigration through endothelium following cardiopulmonary bypass shearing is mediated by IL-8 signaling www.frontiersin.org/journals/car...
frontiersin.org
Frontiers | Monocyte adhesion to and transmigration through endothelium following cardiopulmonary bypass shearing is mediated by IL-8 signaling
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Bluesky @bsky.app · 03/12/2024
Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪
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Sébastien Gauvrit @sebgauvrit.bsky.social · 18/11/2024
Here's a starter pack focusing on cardiovascular research. I'm sure the pack is incomplete. If you'd like to be added to the list, please let me know! go.bsky.app/SgaGkv5
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Rosa Ma @rosaxma.bsky.social · 25/11/2024
What cell types drive congenital heart defects (CHD)? Some new answers in our latest preprint, where we explored: 1). Key cell types contributing to CHD genetics 2). Impact of noncoding variants on CHD risk www.medrxiv.org/content/10.1101/202…
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Oliver lab @lymphaticsprox1.bsky.social · 25/11/2024
Terrific first paper from the Liu's lab on the role of CXCL12/CXCR4 signaling in the lymphatic vasculature (and also they got the cover)! Congratulations Xiaolei and many more papers to come journals.biologists.com/dev/article-...
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Taben Hale @tmhalephd.bsky.social · 20/11/2024
I am excited to share this call for papers for AJP Heart & Circulatory Physiology on Technologies in Omics of the Cardiovascular System. Please share with your networks. journals.physiology.org/ajpheart/cfp...
Call for papers on "Special Technologies in Omics of the Cardiovascular System" for AJP Heart Circ
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Vishal Mohanakrishnan @vishalmkrishnan.bsky.social · 19/11/2024
Bone remodeling is traditionally driven by osteoblasts and osteoclasts, but our study reveals a third essential player: "Type R capillaries". 🦴🔬😍 Excited to share my PhD work from Ralf H. Adams lab, now published in @natureportfolio.bsky.social Nature Cell Biology. www.nature.com/articles/s41...
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Timothy Hla @hlatim.bsky.social · 18/11/2024
Exciting Gordon conference on vascular cell biology - Jan 2025 in Ventura, CA org by Karen Hirschi, @UVA www.grc.org/vascular-cel...
grc.org
2025 Vascular Cell Biology Conference GRC
The 2025 Gordon Research Conference on Vascular Cell Biology will be held in Ventura, California. Apply today to reserve your spot.
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