I will be honest, I am somewhat amazed we are getting any funding data for FY2025 out of NIH. The databook has not yet been updated, so we’re not out of the woods yet. Still, there’s a …

Euan Ashley’s lab uncovers the workings of epistasis, a type of interaction between gene variants, that could possibly transform our understanding of inherited heart diseases and much more.

Nature Cardiovascular Research - Weldy et al. show that smooth muscle expression of the RNA editing enzyme ADAR1 regulates activation of the double-stranded RNA sensor MDA5 in a novel mechanism of...

imageimageVascular sites have distinct susceptibility to disease. Here, through single cell epigenomic profiling and predictive machine learning modeling, this study revealed that regulatory enhancers are vascular site specific, providing insight ...

Scientists conducting medical research are facing an existential crisis: Layoffs and budget cuts pushed by President Trump that, they say, jeopardize finding a cure for cancer. They tell "Sunday Morni...

Senators from both parties endorsed a $400 million increase to the budget of the National Institutes of Health on Thursday

Staff at the National Science Foundation (NSF) were notified on 25 June that the agency’s office space, located in Alexandria, Va., will be taken over by Department of Housing and Urban Development (H...

The administration's cuts at the National Institutes of Health will obliterate billions in economic gains, America's scientific predominance and untold human lives.

Transcription factors (TFs) establish cell identity during development by binding regulatory DNA in a sequence-specific manner, often promoting local chromatin accessibility, and regulating gene expre...

4/20/2025

NAVBO Symposium: Precision Genomics: CRISPR and Single-Cell Technologies in Vascular Biology  Speakers:  “Integrated transcriptomics of human blood vessels”Aaron James, Johns Hopkins University School...

BACKGROUND: Genome-wide association studies have identified common genetic variants at ≈300 human genomic loci linked to coronary artery disease susceptibility. Among these genomic regions, the most i...

U.S. national-security leaders included me in a group chat about upcoming military strikes in Yemen. I didn’t think it could be real. Then the bombs started falling.

ALT: a cartoon of homer simpson holding a card

As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.

The Trump administration is exploiting a loophole to keep a funding freeze in place, leaving researchers in limbo.

BACKGROUND: Immune checkpoint inhibitors (ICIs) are successful in treating many cancers but may cause immune-related adverse events. ICI-mediated myocarditis has a high fatality rate with severe cardi...

Researchers say it would hurt facilities that work on medical issues such as cancer research and heart disease. Elon Musk contends the old policy was ‘a ripoff.’

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

It's been well known for many decades that exercise provides many benefits to our health. But a new scientific consortium is revealing new insights into just how profound exercise can be for the human...

Nature Reviews Cardiology - Vascular cells are finely regulated by complex microenvironments, including biomechanical signals from the extracellular matrix. In this Review, Kong and colleagues...

This cross-sectional study evaluates the association of BAG3 genetic variation with penetrance and longitudinal outcomes of dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM).

Despite extensive mapping of cis-regulatory elements (cREs) across cellular contexts with chromatin accessibility assays, the sequence syntax and genetic variants that regulate transcription factor (T...