Nature Communications - Pyridoxal 5’-phosphate (PLP, vitamin B6) is crucial for various metabolic processes. Here, the authors identified SLC25A38 as a key regulator of mitochondrial PLP...

Immune cells lose their cancer-fighting prowess after taking tumours’ organelles on board.

Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae lethal phenotype of a fruit f...

See why MIC60, a part of the MICOS complex in mitochondria, is fatal when removed, as St. Jude researchers design mouse model to study mitochondrial disruption

Increased activity of heat shock factor 1 (HSF1) promotes longevity; however, the mechanisms underlying this are unclear. Here, the authors show that in the nematode worm Caenorhabditis elegans, HSF1 ...

S-adenosylmethionine (SAM) is crucial for cellular processes, primarily serving as the principal methyl group donor of the cell and playing a key role in gene regulation and translation on the ribosom...

Mitochondrial disease encompasses untreatable conditions affecting tissues with high energy demands. A severe manifestation of mitochondrial disease is Leigh syndrome (Leigh), which causes defects in ...

Autophagic dysfunction is a hallmark of neurodegenerative disease, leaving neurons vulnerable to the accumulation of damaged organelles and proteins. However, the late onset of diseases suggests that ...

Aligning Science Across Parkinson’s (ASAP) aims to foster collaboration and discovery by supporting virtual and in-person events that facilitate connections and provide an avenue for sharing ideas. Se...

MITOtalks: Online Seminar Series Focusing on Mitochondria