The Institute of Biomedicine is involved in both research and education. In both of these

The neonatal heart experiences rapid metabolic growth after birth to meet increasing energetic and biosynthetic demands. How mitochondrial cofactor availability limits this transition remains unclear....

Polyadenylation is a conserved post-transcriptional RNA modification with fundamentally different consequences for RNA fate across biological systems.…

Do you want to contribute to top quality medical research? The Wredenberg group at Karolinska Institutet is seeking a highly motivated postdoctoral researcher to investigate how mitochondrial function

Do you want to contribute to improving human health? The Division of Molecular Metabolism at Karolinska Institutet is located in the newly built Biomedicum at the Solna campus. The division offers a h

Nature Communications - Here, using long-read RNA sequencing, SILAC proteomics, and cryo-EM, the authors show that loss of mitochondrial methylation impairs rRNA processing and ribosome maturation,...

Mitochondrial ribosome biogenesis requires the assistance of multiple assembly factors. Here, the authors provide insights into the essential role of the GTPase MTG3 during small subunit biogenesis an...

An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving POLG mutations.

Vill du bidra till medicinsk forskning av toppkvalitet? Att vara doktorand innebär att vara antagen till en utbildning på forskarnivå (forskarutbildning) där man följer en individuell studieplan.

Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae lethal phenotype of a fruit f...

Do you want to contribute to improving human health? Research at the Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunct