Sign in

Saroj Khadka

@microbiosaroj.bsky.social
222 followers 382 following 32 posts

Graduate Student at the University of Pittsburgh #h2p || Studying #Klebsiella Surface Polysaccharides in Mike Lab (themikelab.com) 🔗 sarojkhadka.com

PostsRepliesMedia
Reposted by Saroj Khadka
Pitt Program in Microbiology & Immunology @pitt-pmi.bsky.social · 03/09/2026
Congratulations to @microbiosaroj.bsky.social from the @lauraamike.bsky.social lab on his upcoming PhD thesis defense! 🎈 🎉
Saroj Khadka will defend his dissertation entitled “Control of capsular polysaccharide chain length and attachment in Klebsiella pneumoniae” on September 28th in Scaife Hall.
132
Saroj Khadka @microbiosaroj.bsky.social · 28/08/2026
Heartbroken to hear the tragic news from home. A devastating flash-flood has taken severe toll on central Nepal. 450+ confirmed casualties & an est. hundreds remain missing. 🙏 Pls consider donating to the GoN's centralized Disaster Relief Fund supporting rescue & relief efforts: pmdrf.nchl.com.np
110
Reposted by Saroj Khadka
Laura Mike @lauraamike.bsky.social · 26/08/2026
Last year, we reported that arginine stimulates mucoidy in hypervirulent Klebsiella pneumoniae. Now we show an opposing cue, sugars! Here, we report that sugar import suppresses mucoidy. Full story in @natcomms.nature.com: www.nature.com/articles/s41... #microsky #klebclub See 🧵 for a summary:
nature.com
2216
Reposted by Saroj Khadka
Klebsiella Club @klebclub.bsky.social · 03/04/2026
‼️ Excited to announce 1st session of #KlebClub2026! We kick things off with a session on pathogenesis, with *Jay Vornhagen* as keynote speaker, alongside 2 short talks selected from submitted abstracts - Sylvie MIQUEL & @microbiosaroj.bsky.social 🗓 Thursday 9 🕘 9:00 -10:30 AM (EDT) (1/2)
1128
Reposted by Saroj Khadka
Klebsiella Club @klebclub.bsky.social · 27/03/2026
🚨 Big news! 🚨 Here the FINAL 2026 Speaker list for our seminar series!! ✨ Get ready for: • Pathogenesis session • Pediatrics #Klebsiella • Translational Microbiology • #KlebClub Community Flash talks! Starting April 9th - 9 AM EST! #KlebClub2026 #microsky #UTIsky #phagesky Registration is FREE
KlebClub program
155
Reposted by Saroj Khadka
Laura Mike @lauraamike.bsky.social · 11/02/2026
📢 Our latest paper is now in @infectionimmunity.bsky.social We asked: How different are classical (cKp) vs hypervirulent (hvKp) Klebsiella pneumoniae bloodstream isolates if they are all the same K type (K2)? 📄 doi.org/10.1128/iai.... #KlebClub #MicroTwitter
174
Reposted by Saroj Khadka
Katy Patras @katypatras.bsky.social · 10/01/2026
Type 2 diabetes mellitus exacerbates vaginal group B Streptococcus colonization via impaired mucosal cytokine response | bioRxiv share.google/FOlGfq0GNfsM...
share.google
Type 2 diabetes mellitus exacerbates vaginal group B Streptococcus colonization via impaired mucosal cytokine response
Type 2 diabetes mellitus (T2D) is a metabolic disorder that confers increased risk of microbial infections, including those caused by the opportunistic pathogen group B Streptococcus (GBS). Asymptomat...
093
Reposted by Saroj Khadka
Dave DiCello @davedicello.bsky.social · 03/12/2025
This composition had eluded me for nearly a decade, but yesterday I was finally able to capture it. A train rolled through just as the Duquesne Incline was crossing over the tracks in #Pittsburgh, creating a picture perfect winter scene. It was worth the hours and hours I've waited over the years.
12080071831
Reposted by Saroj Khadka
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 27/11/2025
Emergence of hypervirulent Klebsiella pneumoniae ST111 with a novel virulence plasmid causing pyogenic liver abscess www.biorxiv.org/content/10.1101/202…
001
Reposted by Saroj Khadka
Kevin Blake PhD @kevinsblake.bsky.social · 24/11/2025
Every biologist knows the story of Fleming's chance discovery of penicillin. But is it true? Here, with @asimovpress.bsky.social, I write about inconsistencies in the canonical story, and explore a few alternative theories about what really happened in that St. Mary's lab in the summer of 1928.
press.asimov.com
The Penicillin Myth
Competing theories seek to explain inconsistencies surrounding Alexander Fleming’s famed discovery.
24323
Reposted by Saroj Khadka
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 12/11/2025
Phenotypic Heterogeneity Shapes Phage Resistance and Cocktail Efficacy in Klebsiella pneumoniae www.biorxiv.org/content/10.1101/202…
011
Reposted by Saroj Khadka
Dr. Stephanie @punkrockscience.bsky.social · 07/11/2025
Watson’s death is a fantastic reminder that you can be intelligent without being a good person.
3624117
Reposted by Saroj Khadka
FEMS Journals @femsjournals.bsky.social · 06/11/2025
🦠 Small changes, big defense! Jordan Vacheron & coll. show specific SNPs in #Pseudomonas protegens CHA0 (algC & ykcC) remodel LPS to block #phage ΦGP100—while growth, competitiveness & root colonization stay intact, in lab conditions. 🧬 @unil.bsky.social 👉 buff.ly/MFOH2er
143
Reposted by Saroj Khadka
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 05/11/2025
Sugar Import Suppresses Klebsiella pneumoniae Mucoidy in cAMP-CRP-dependent Manner www.biorxiv.org/content/10.1101/202…
001
Reposted by Saroj Khadka
Science Magazine @science.org · 03/11/2025
Volunteers who swallowed disease-causing bacteria were less likely to get sick after an oral vaccine. scim.ag/4qBtYe2
scim.ag
Vaccine protects people from paratyphoid fever in a ‘human challenge’ study
Volunteers who swallowed disease-causing bacteria were less likely to get sick after an oral vaccine
3325
Reposted by Saroj Khadka
Madhu Pai, MD, PhD @madhupai.bsky.social · 26/10/2025
The shrinking future of Ph.D.s in America Attacks on science and universities Anti-immigration wave Visa challenges It all adds up www.axios.com/2025/10/26/p...
axios.com
The pipeline for Ph.D.s out of U.S. universities is shrinking
America graduates more Ph.D.s than any other country. They go on to invent things, cure diseases and win Nobel Prizes. But admission slots are disappearing.
13016
Reposted by Saroj Khadka
Midwest Microbial Pathogenesis Conference @mmpconference.bsky.social · 23/10/2025
Mark your calendars! #mmpc2026 The 2026 Midwest Microbial Pathogenesis Conference will be take place September 25-27, 2026 at the University of Minnesota! We are excited to welcome keynote speaker Dr. Andy Camilli. Give us a follow and watch for important information here ➡️ mmpc2026.umn.edu
mmpc2026.umn.edu
Midwest Microbial Pathogenesis Conference | Midwest Microbial Pathogenesis Conference 2026
01113
Reposted by Saroj Khadka
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 11/10/2025
A novel post-translational modification of fimbriae drives pathogenicity in Klebsiella pneumoniae www.biorxiv.org/content/10.1101/202…
012
Reposted by Saroj Khadka
Shabaana Khader @khadershabaana.bsky.social · 05/10/2025
UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu Apply here apply.interfolio.com/174404
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
26371
Reposted by Saroj Khadka
Nature Microbiology @natmicrobiol.nature.com · 01/10/2025
#Perspective Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps. #MicroSky #MicrobiomeSky 🦠 www.nature.com/articles/s41...
nature.com
How nutrient starvation impacts the gut microbiome - Nature Microbiology
In this Perspective, Estrela and Huang discuss nutrient starvation in the context of the gut microbiome, outlining what is known and highlighting key questions for future research to address knowledge gaps.
03815
Reposted by Saroj Khadka
Greta Zaborskyte @gretazabo.bsky.social · 02/10/2025
Our story on within-host #evolution of #Klebsiella is now out in @natcomms.nature.com 🌟 www.nature.com/articles/s41...
nature.com
Parallel within-host evolution alters virulence factors in an opportunistic Klebsiella pneumoniae during a hospital outbreak - Nature Communications
Multidrug-resistant Klebsiella pneumoniae is a critical priority pathogen. Here, the authors explore its evolution in 110 patients during a hospital outbreak, highlighting selected mutation-driven adaptations that alter its key virulence traits.
032
Reposted by Saroj Khadka
Vaughn Cooper @vscooper.micropopbio.org · 23/09/2025
🚨 Microbiologists! We are recruiting Assistant / Associate Professors in 3 collaborative areas of our U. Pittsburgh School of Medicine. 1) MMG (my dept): fundamental research in med micro 2) Peds ID / I4Kids institute 3) Center for Vaccine Research 🔗 to all 3 w/info: www.linkedin.com/posts/vaughn...
linkedin.com
Faculty Professor Associate - Full-Time | Vaughn Cooper
We are recruiting Faculty microbiologists in three (3) different, complementary, and collaborative areas at the University of Pittsburgh associated with the School of Medicine. 1) Fundamental researc...
190125
Reposted by Saroj Khadka
Julie Le Bris @julielebris.bsky.social · 10/09/2025
How complex functions, with important physiological and evolutionary impacts get repeatedly and efficiently transferred across genomes? That’s what we explored using one of the fastest-evolving loci in Bacteria: the capsule locus. The paper: www.biorxiv.org/content/10.1... Thread👇
biorxiv.org
Serotype swapping in Klebsiella spp. by plug-and-play
Understanding how complex, multi-gene systems evolve and function across genetic backgrounds is a central question in molecular evolution. While such systems often impose costs through epistatic inter...
22922
Reposted by Saroj Khadka
Waggoner Lab @labwaggoner.bsky.social · 04/09/2025
C. albicans colonization is a susceptibility factor for disseminated Salmonella infection and arginine as a central metabolite in the cross-kingdom interaction between fungi, bacteria and host @nature.com www.nature.com/articles/s41...
0134
Reposted by Saroj Khadka
ASM @asm.org · 02/09/2025
Zinc is a critical nutrient for many bacterial pathogens. New research in #JBacteriology expands our understanding of a novel zinc transport system & provides evidence for an alternative mechanism of cell wall protein localization in C. diphtheriae. asm.social/2zf
The znu gene cluster and conserved motif.
1138
Reposted by Saroj Khadka
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 31/08/2025
Gut mucin fucosylation dictates the entry of botulinum toxin complexes www.biorxiv.org/content/10.1101/202…
052
Reposted by Saroj Khadka
Christina Faherty @christinafaher1.bsky.social · 25/08/2025
"Focused efforts and sustained investment in novel antibacterials are needed to address #AMR priority pathogens, which include #high-burden antibiotic-resistant bacteria such as Salmonella and #Shigella spp..." @shigellameeting.bsky.social‬ #MicroSky #IDSky 🦠🧫🔬 www.thelancet.com/journals/lan...
thelancet.com
The WHO Bacterial Priority Pathogens List 2024: a prioritisation study to guide research, development, and public health strategies against antimicrobial resistance
The 2024 WHO BPPL is a key tool for prioritising research and development investments and informing global public health policies to combat AMR. Gram-negative bacteria and rifampicin-resistant M tuber...
054
Reposted by Saroj Khadka
Joanne Flynn @joanneflynn19.bsky.social · 20/08/2025
We are hiring! The Dept of Microbiology and Molecular Genetics is looking for faculty at the Assistant or Associate professor level (tenure track). Please consider joining our vibrant microbiology and immunology community at the University of Pittsburgh School of medicine
1106106
Reposted by Saroj Khadka
Midwest Microbial Pathogenesis Conference @mmpconference.bsky.social · 19/08/2025
Did you miss the opportunity to submit an abstract to MMPC? We have extended the deadline to August 25! Please consider sharing your latest and greatest research! www.mmpconference2025.com/submit-an-ab...
mmpconference2025.com
MMPC 2025 - Submit an Abstract
Submission Dates Abstract submission will open on May 1, 2025 Oral abstract submission deadline: July 15, 2025 Poster abstract submission deadline: Extended to August 25! Instructions for abstract s...
0612
Reposted by Saroj Khadka
Madhu Pai, MD, PhD @madhupai.bsky.social · 18/08/2025
The return of the Swiss cheese model, now for anti microbial resistance! www.thelancet.com/journals/lan...
thelancet.com
A layered strategy for tackling antimicrobial resistance: the Swiss cheese model for policy, prevention, and engagement
Murphy’s Law, “anything that can go wrong will go wrong”,1 finds no more fitting application in public health than in the case of antimicrobial resistance (AMR). AMR will emerge whenever conditions pe...
34615
Reposted by Saroj Khadka
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 16/08/2025
LPS O-antigen polysaccharide length impacts outer membrane permeability of enteric gram-negative bacteria www.biorxiv.org/content/10.1101/202…
031
Reposted by Saroj Khadka
Eric Topol @erictopol.bsky.social · 15/08/2025
First real-time human embryo implantation recorded (in 2D and 3D). Time lapse video of 2 embryos (200 μm apart) implanting in the 3D platform science.org/doi/10.1126/...
722045
Reposted by Saroj Khadka
Antimicrobial resistance #AMR @antimicrobial.bsky.social · 15/08/2025
#AMR infections are surging in Gaza as health care collapses. 60% of lower-limb wounds come from explosive weapons, driving infections amid medicine shortages and destroyed labs. MSF & WHO warn: zero fully functional hospitals. #Gaza #infectiousdisease www.thelancet.com/journals/lan...
thelancet.com
Multidrug-resistant bacteria amid health-system collapse in Gaza
Gaza's health-care system has faced widespread destruction during the ongoing Israeli military invasion that began in October, 2023, leading to a proliferation of disease outbreaks.1,2 During this tim...
02918
Reposted by Saroj Khadka
Dave Levitan @davelevitan.bsky.social · 12/08/2025
This op-ed from NIH director Jay Bhattacharya is *infuriating*. He says we have to stop funding mRNA vaccine research because it hasn't "earned public trust." Motherfucker, WHO DID THAT.
washingtonpost.com
Opinion | Jay Bhattacharya: Why the NIH is pivoting away from mRNA vaccines
As a vaccine for broad public use, mRNA technology has failed to earn the public’s trust.
1334009886
Reposted by Saroj Khadka
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 08/08/2025
Sequestration of the phagocyte metabolite itaconate by P. aeruginosa RpoN promotes successful pulmonary infection www.biorxiv.org/content/10.1101/202…
041
Reposted by Saroj Khadka
Juan David Valencia Bacca @juanvalenciabacca.bsky.social · 05/08/2025
currentprotocols.onlinelibrary.wiley.com/doi/10.1002/... Our new article in Current Protocols is out: Microbiologists, immunologists, host-pathogen folks: this one’s for you 🧬🦠 #Klebsiella #HostPathogen #Microbiology Huge thanks to my mentor @azmicro.bsky.social for the guidance and support!
currentprotocols.onlinelibrary.wiley.com
Murine Models of Klebsiella pneumoniae Gastrointestinal Infection
Klebsiella pneumoniae (Kpn) is a Gram-negative opportunistic pathogen and a leading cause of hospital-acquired infections. The gastrointestinal (GI) tract serves as a critical site for Kpn colonizati....
194
Reposted by Saroj Khadka
Staph papers @staph-papers.bsky.social · 05/08/2025
Overexpression of Agr quorum sensing system in uropathogenic Staphylococcus aureus in response to simulated urinary metabolic conditions enhancing growth and virulence
t.co
Overexpression of Agr quorum sensing system in uropathogenic Staphylococcus aureus in response to simulated urinary metabolic conditions enhancing growth and virulence - PubMed
Staphylococcus aureus (S. aureus) is a major opportunistic pathogen, causing acute and chronic infections including urinary tract infection (UTI). S. aureus relies on the Accessory gene regulator (Agr),...
011
Reposted by Saroj Khadka
Lauren Palmer @laurenpalmer.bsky.social · 04/08/2025
Super excited to share our paper online 🚨today🚨 in Cell Host & Microbe‬! Xiaomei Ren @xiaomeiren.bsky.social and Mason Clark @rmasonclark.bsky.social‬ co-led discovery of ecological factors for Acinetobacter baumannii carriage in the gut, a reservoir for pathogen spread. 🎉 tinyurl.com/443kfefk
1310442
Reposted by Saroj Khadka
Nandita Garud @nanditagarud.bsky.social · 22/07/2025
I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!
garud.eeb.ucla.edu
Garud Lab
18598
Reposted by Saroj Khadka
Andreas Bäumler @abaumler.bsky.social · 22/07/2025
Infection and Immunity is now welcoming nominations for highly promising scientists at the assistant professor level (or equivalent) to submit research to the next New Voices in Microbiology Collection! Please nominate by the August 18 deadline using the below link: app.asm.org/account/logi...
16437
Reposted by Saroj Khadka
Tami Lieberman @contaminatedsci.bsky.social · 22/07/2025
We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome. See thread for more information and reach out!
2105115
Reposted by Saroj Khadka
Keith Jolley @kjolley.bsky.social · 18/07/2025
BIGSdb v1.51.4 has been released. This adds a new #Kaptive plugin for surface polysaccharide typing of Acinetobacter baumannii and Klebsiella. github.com/kjolley/BIGS... for details. Kaptive is developed by @tomstantonmicro.bsky.social, @kelwyres.bsky.social , @katholt.bsky.social and colleagues.
Output from Kaptive analysis shown in a BIGSdb isolate record. Tabular results are shown followed by a graphical representation of the genes within the locus analysed.
1104
Reposted by Saroj Khadka
Brooke Fitzwater, PhD (she/her) 🐟🪱🏳️‍🌈♾️ @oceanfilly.bsky.social · 18/07/2025
As Requested - A Starter Pack of PIs in Biology (or adjacent) fields who are recruiting POSTDOCS! Please don't hesitate to reach out if you wish to be added! go.bsky.app/4gbXXR3
1512379
Reposted by Saroj Khadka
Dr. Rabbithole @drrabbithole.bsky.social · 17/07/2025
🚨🚨NIH will only accept six new, renewal, resubmission, or revision applications from an individual Principal Investigator/Program Director or Multiple Principal Investigator for all council rounds in a calendar year grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-132: Supporting Fairness and Originality in NIH Research Applications
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supporting Fairness and Originality in NIH Research Applications NOT-OD-25-132. NIH
275
Reposted by Saroj Khadka
Vaughn Cooper @vscooper.micropopbio.org · 15/07/2025
According to Pitt colleague and mensch @jeremymberg.bsky.social, NIH funding remains horrifically behind. New NOA's are at 54% of FY24 Non-competitive renewals are at 66% of FY24. (My lab is in the bad fraction of both) Tell your rep to reclaim the purse! jeremymberg.github.io/jeremyberg.g...
jeremymberg.github.io
NIH_since_1_20_25
0179
Reposted by Saroj Khadka
Maryse Berkhout @maryseberkhout.bsky.social · 15/07/2025
Just published in @femsjournals.bsky.social🦠: Akkermansia muciniphila, Ruminococcus torques and Bacteroides thetaiotaomicron differ in their preferences for degradation of porcine gastric mucin O- and N-glycans. #microsky #microbiomesky #glycotime @mib-wur.bsky.social doi.org/10.1093/fems...
doi.org
Distinct in vitro utilization and degradation of porcine gastric mucin glycans by human intestinal bacteria
The degradation and utilization of mucin glycans depend on microbial composition and the interactions between the present bacteria.
2115
Reposted by Saroj Khadka
WHO @who.int · 12/07/2025
The United Nations warns that the fuel shortage in Gaza has reached critical levels. Fuel is the backbone of survival in #Gaza. It powers hospitals, water systems, sanitation networks, ambulances, and every aspect of humanitarian operations. 🧵
Joint statement by OCHA, UNDP, UNFPA, UNOPS, UNRWA, WFP, and WHO on fuel shortage in Gaza.
617285
Reposted by Saroj Khadka
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 11/07/2025
Acinetobacter phages use distinct strategies to breach the capsule barrier www.biorxiv.org/content/10.1101/202…
032
Reposted by Saroj Khadka
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 09/07/2025
Staphylococcus aureus exhibits spatiotemporal heterogeneity in Sae activity during kidney abscess development www.biorxiv.org/content/10.1101/202…
023
Reposted by Saroj Khadka
Claus Wilke @clauswilke.com · 07/07/2025
This is the best explanation I've seen yet for _why_ language models prefer em-dashes (—). In brief: The tokenization scheme mean em-dashes result in a smaller loss than other, equivalent punctuation options. msukhareva.substack.com/p/the-myster...
msukhareva.substack.com
The mystery of em‑dashes: part two with quantitative evidence
A couple of weeks ago I made an assumption: the rise of em‑dashes in AI‑generated text happened because model providers started scanning older, pre‑Kindle books.
37128