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Kelly Wyres

@kelwyres.bsky.social
1.6K followers 515 following 35 posts

Computational microbiologist; genomics, metabolic modelling, Klebsiella, capsules, population biology. Toddler mum and wannabe pilates enthusiast.

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Reposted by Kelly Wyres
sylvain Brisse @sylvainbrisse.bsky.social · 04/06/2026
It's out! The LIN code approach for genomic taxonomy of microbial strains and its applications in genomic epidemiology journals.plos.org/plosbiology/...
journals.plos.org
Life Identification Numbers: A strain nomenclature approach to aid epidemiological surveillance of bacterial pathogens
Unified bacterial strain taxonomies are needed for coherent communication of findings in microbiological research. This Essay provides an overview of a novel bacterial strain taxonomy and describes ho...
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Kelly Wyres @kelwyres.bsky.social · 18/04/2026
Do you work on Klebsiella oxytoca genomes? Want to know which K and O loci they have? Check out the new Klebs oxy species complex databases here: github.com/klebgenomics... Poster today #ESCMIDGlobal2026 by Naoise McGarry! Papers to follow soon. @klebnet.bsky.social @klebclub.bsky.social
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Andrew Rambaut (🐏🎀) @arambaut.bsky.social · 28/02/2026
The first version of FigTree was released nearly 20 years ago and it is still widely used (including by me). But there are currently 85 issues on the GitHub repo (github.com/rambaut/figt...) and some of them I don’t really like the look of.
github.com
rambaut/figtree
Automatically exported from code.google.com/p/figtree - rambaut/figtree
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Kelly Wyres @kelwyres.bsky.social · 23/02/2026
Looking forward to sharing our recent work on population metabolism of #klebsiella pneumoniae this week. Join me to learn about metabolic diversity within species, featuring work by @bananabenana.bsky.social @helena-bethany.bsky.social and a sneak peak at our latest from @kalanip.bsky.social
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Kelly Wyres @kelwyres.bsky.social · 19/02/2026
Thanks @theviin.bsky.social for the invite to join this great meeting, and share our work on Kaptive for capsule typing, and how we can apply it to inform #klebsiella vaccines: tinyurl.com/npaj4vzr With @tomstantonmicro.bsky.social @shaunkeegan.bsky.social @katholt.bsky.social and many others
tinyurl.com
Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine cover...
Thomas Stanton and colleagues use whole genome sequencing to evaluate the prevalence of Klebsiella pneumoniae K and O antigen types in 13 countries in Africa and South Asia to help inform vaccine desi...
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Reposted by Kelly Wyres
Chiara Crestani @chcrestani.bsky.social · 28/01/2026
🧫 Our publication,“Global perspectives on Klebsiella epidemiology and biology: conference report on the KLEBS 2024 symposium,” is now out! 📄 Link to paper: www.nature.com/articles/s44... @kelwyres.bsky.social @katholt.bsky.social @sylvainbrisse.bsky.social @pasteur.fr
nature.com
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PLOS Biology @plosbiology.org · 16/12/2025
Why so many co-circulating #Klebsiella pneumoniae clones? By studying >7000 isolates, @bananabenana.bsky.social @kelwyres.bsky.social &co identify structured, clone-specific #metabolic specialisation across the population that enables reciprocal cross-feeding @plosbiology.org 🧪 plos.io/4qdC2B2
Collapsed phylogenetic tree of the Klebsiella pneumoniae Species Complex (top) and the presence of metabolic capabilities (bottom), leading to lineage-specific metabolic networks and traits
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Kelly Wyres @kelwyres.bsky.social · 15/12/2025
Ditto, ditto, ditto! We are thrilled this is now available in @plosbiology.org 🎉🎉🎉 Our analysis of metabolic diversity in #klebsiella pneumoniae, showing clone specific metabolism. 🦠 Fantastic work by @bananabenana.bsky.social, summarised beautifully below. 🤩
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Microbiology Society @microbiologysociety.org · 02/12/2025
📣🦠Check out our new Editor’s Spotlight! Senior MGEN editor Jesse Shapiro tells us about a recently published paper on the bystander effect on the evolution of Bordetella parapertussis, a non-target species of the pertussis vaccine #MGEN Read the full blog here: microb.io/48zfOlJ
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Reposted by Kelly Wyres
Kat Holt @katholt.bsky.social · 19/11/2025
#AMR #Klebsiella cause >100,000 neonatal deaths globally each year. Our new preprint shows more than half of #Klebsiella pneumoniae neonatal sepsis cases in African and South Asian are nosocomial, acquired through transmission in neonatal units. #WAAW doi.org/10.1101/2025...
figure showing estimated proportion of cases in clusters, for each site. range from 0.04 to 0.93, mean estimate in random effects model is 0.57 [0.46,0.68]
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sylvain Brisse @sylvainbrisse.bsky.social · 30/11/2025
Huge preprint if you are interested in bacterial strain taxonomy! The why and how of cgMLST LIN codes: An extensively revised and expanded version doi.org/10.1101/2024... I will summarize it for you in this thread 👇
doi.org
Life Identification Numbers: A bacterial strain nomenclature approach
Unified strain taxonomies are needed for the epidemiological surveillance of bacterial pathogens and international communication in microbiological research. Core genome multilocus sequence typing (cg...
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Kelly Wyres @kelwyres.bsky.social · 28/11/2025
Want to learn about #klebsiella genomics? Check out our free online resource, developed as part of the @klebnet.bsky.social project and in collaboration with ECDC Gen-Epi Bio train. #genomics #amr #sero-epi #hypervirulence #LINcodes
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Microbiology Society @microbiologysociety.org · 20/06/2025
Registration is open for the Microbial Genomics of Eukaryotes meeting in Glasgow! This event will showcase diverse scientific achievements in eukaryotic genome research. Register now and submit your abstract by 12 August: microb.io/MicroGenomic...
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Hugh Cottingham @hughcottingham.bsky.social · 30/07/2025
Pleased to say that our preprint benchmarking Nanopore data for MLST, cgMLST, cgSNP & AMR typing from bacterial isolates is out! TL;DR you can get almost perfect results from 50x depth using live SUP basecalling with a GPU in under 20 hours #microsky#IDsky 🦠🧬🖥️ /1 www.medrxiv.org/content/10.1...
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Susie Grigson @susiegriggo.bsky.social · 30/07/2025
🚨 New preprint 🚨 My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky www.biorxiv.org/content/10.1...
biorxiv.org
Synteny-aware functional annotation of bacteriophage genomes with Phynteny
Accurate genome annotation is fundamental to decoding viral diversity and understanding bacteriophage biology; yet, the majority of bacteriophage genes remain functionally uncharacterised. Bacteriopha...
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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 24/07/2025
AlphaGEM Enables Precise Genome-Scale Metabolic Modelling by Integrating Protein Structure Alignment with deep-learning-based Dark Metabolism Mining www.biorxiv.org/content/10.1101/202…
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Kelly Wyres @kelwyres.bsky.social · 22/07/2025
Our new #klebsiella O type nomenclature, codesigned with Chris Whitfield, is now live in @pathogenwatch.bsky.social! Need a quick explainer on the new names? Check out my blog post: tinyurl.com/y8yb3rbb (+link to full review article) #MicroSky @klebnet.bsky.social @tomstantonmicro.bsky.social
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Kelly Wyres @kelwyres.bsky.social · 22/07/2025
Woohoo Kaptive is now integrated within BIGSdb for #Klebsiella and #Acinetobacter. Thanks @kjolley.bsky.social! Also like to acknowledge that the Acineto dbs were developed and maintained by Johanna Kenyon and team at Griffith Uni.
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MicroSeq2026 @microseqasm.bsky.social · 03/07/2025
🦋Hello BlueSky!🦋 Let's get right into it. MicroSeq is back September 3-4, 2025! Stay tuned for more details on registration and abstract submission coming soon here and at www.microseqconference.com. 🌟Save the date!🌟 #MicroSeq2025
A call to save the date for MicroSeq2025, returning September 3-4. MicroSeq is an online meeting where microbiology meets sequencing, including bacteria, viruses, and fungi.
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Eva Heinz @evaheinz7.bsky.social · 04/07/2025
First paper on our projects on #Klebsiella transmission in the hospital environment; I'm so lucky to get to work with the wonderful teams@ Malawi Liverpool Wellcome Program, Kamuzu University, Queen Elizabeth Central Hospital🇲🇼 #MicroSky #IDSky #GlobalHealth 🧬💻🧪 (1/3) www.medrxiv.org/content/10.1...
medrxiv.org
High ward-level and within-sample diversity of Klebsiella pneumoniae on a Malawian neonatal unit revealed by single colony whole genome sequencing and post-enrichment metagenomics
Klebsiella pneumoniae is a frequent cause of antimicrobial resistant healthcare associated infections in neonates across sub-Saharan Africa, with multiple lineages associated with neonatal sepsis. How...
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Kelly Wyres @kelwyres.bsky.social · 02/07/2025
So excited that this is now online. It's been a huge collaborative effort to estimate the prevalence of capsule and O antigens associated with #klebsiella neonatal sepsis in Africa and South Asia. The first step to prioritising antigens for a vaccine to protect 1000s of newborns. #MicroSky #AMR
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Kelly Wyres @kelwyres.bsky.social · 22/05/2025
Working on #klebsiella genomes? ✅ Want to collaborate globally to advance Klebs genomic epi? ✅ Please join us via the KlebNET-GSP Epidemiology consortium ⬇️ #microsky #AMR
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Kelly Wyres @kelwyres.bsky.social · 27/03/2025
Great night at the ASM VIC branch student and ECR awards. Such a high standard of scientific talks, and broad range of science. Congrats to all of the speakers and winners! 🎉🎉🎉 @aussocmic.bsky.social
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Sam Manna @sammanna.bsky.social · 12/03/2025
Interested in a PhD focusing on Streptococcus pneumoniae or pyogenes? Our group is looking for new PhD students to join our lab! Apply here: career10.successfactors.com/sfcareer/job...
career10.successfactors.com
Career Opportunities: PhD Student - Microbiology (42694)
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Kelly Wyres @kelwyres.bsky.social · 10/02/2025
Check out our latest Kaptive update for highly sensitive and accurate identification of surface polysaccharide loci from WGS of #AMR pathogens, #Klebsiella and #Acinetobacter baumanii. Led by the awesome @tomstantonmicro.bsky.social 🦠🧫
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Germán Bonilla-Rosso @germusthermophilus.bsky.social · 19/01/2025
🧬🖥️ 🦠🧫 🧪🔬 Hey BSky Bioinformatics and Genomics! Some years ago many people were compiling 𝐥𝐢𝐬𝐭𝐬 𝐨𝐟 𝐰𝐨𝐦𝐞𝐧 𝐢𝐧 𝐬𝐜𝐢𝐞𝐧𝐜𝐞 as an effort to break biases when looking for reviewers and collaborators... Is there anything like that for Bioinformatics and Genomics? #WomenInSTEM
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Sandra Reuter @sandrareuter.bsky.social · 14/01/2025
📣Our latest paper is out now in mSystems: Not quite as it may seem - investigating #plasmid diversity and evolution in #Klebsiella pneumoniae at a single institution over time. A short thread 🧵 @zaminiqbal.bsky.social
Composite of the paper header showing all authors and an equation showing phylogenetic trees plus plasmids give a complex plasmid picture.
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Zamin Iqbal @zaminiqbal.bsky.social · 15/01/2025
Great thread
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Alan McNally @alanmcn1.bsky.social · 15/01/2025
This scheme was how Zong and I first established our collaboration. Led to two MRC grants and 33 papers. Can’t encourage people enough to go for this.
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Tim Dallman @tdallman.bsky.social · 17/01/2025
What do you think are the critical features pathogen genomic data-sharing platforms require to meet the public health need? Please participate in this public consultation!
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Lars Barquist @lbarquist.bsky.social · 17/01/2025
Interested in predicting AMR in bacteria? We show ignoring phylogenetic structure in genome collections leads to overly optimistic evaluations of machine learning methods for AMR prediction. With @nwheeler443.bsky.social and former PhD student Yanying Yu. 🦠🧫🧬🖥️🧪 www.biorxiv.org/content/10.1...
biorxiv.org
Biased sampling confounds machine learning prediction of antimicrobial resistance
Antimicrobial resistance (AMR) poses a growing threat to human health. Increasingly, genome sequencing is being applied for the surveillance of bacterial pathogens, producing a wealth of data to train...
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Kelly Wyres @kelwyres.bsky.social · 23/11/2024
Time to say 'Au revoir Paris' after a fantastic #KLEBS2024. Great science and great people. So proud to have @tomstantonmicro.bsky.social @kalanip.bsky.social @bananabenana.bsky.social representing the lab, and congrats to Tom and Kalani for their poster prizes! 👏
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 20/11/2024
Ziyaad Dangor talking on Klebsiella pneumoniae as an important infectious cause of death in infants in LMIC settings. K. pneumoniae contributes to "pathway to death" in almost a quarter of infants between months 1 and 59 months of life. #KLEBS2024
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Ben Vezina @bananabenana.bsky.social · 21/11/2024
(1/6) Our new short paper on incidental bacterial domestication between patient isolation and creation of frozen stock. Geno/phenotype changes are obscured by rich media and more prevalent than we previously thought. #MicroSky
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Kelly Wyres @kelwyres.bsky.social · 20/11/2024
Here we go! #KLEBS2024 400 in person and 400 online participants from 71 countries...... Wow!
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Kelly Wyres @kelwyres.bsky.social · 20/11/2024
Finally time for #KLEBS2024! Starting with the genomics workshop before we kick off the main event: 2 whole days of #klebsiella 🦠 Looking forward to catching up with great collaborators and friends, and making new connections with Klebs aficionados. 🎉🎉🎉
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Klebsiella Club @klebclub.bsky.social · 16/11/2024
Let's increase #klebclub chatter on 🔵🦋! Klebsiella aficionados add your handle below and we will build a starter pack. 🔁 to spread the word
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Kelly Wyres @kelwyres.bsky.social · 26/07/2024
Ever wondered why there are so many co-circulating #klebsiella pneumo clones? ... me too! So I'm thrilled to present this new preprint from my lab, where we explore this very question. The culmination of 3+ yrs hard work by @bananabenana.bsky.social! doi.org/10.1101/2024...
doi.org
A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism that supports persistent co-existence of diverse lineages
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Kelly Wyres @kelwyres.bsky.social · 13/05/2024
Are you a fan of #klebsiella genomics? Looking for a post-doc role? ...🥁 ... I'm recruiting! Join my team in Melbourne (Australia) to help us build the first Klebsiella clone risk framework. See details here tinyurl.com/yrka232h Applications close June 9th. #klebNET @klebclub.bsky.social
tinyurl.com
Job Search
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One Health Microbiome Center @psumbiome.bsky.social · 18/03/2024
📢 The One Health Microbiome Symposium is extending the deadline for registration and abstract submission to March 22nd! If you would like to attend and potentially give a talk or poster presentation, now's your last chance! Tickets are going quickly‼️ www.eventbrite.com/e/one-health...
eventbrite.com
One Health Microbiome Symposium
The second biennial symposium hosted by the One Health Microbiome Center at Penn State University will be held on May 30-31st, 2024.
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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · 18/02/2024
AlphaFind: Discover structure similarity across the entire known proteome www.biorxiv.org/content/10.1101/202…
biorxiv.org
AlphaFind: Discover structure similarity across the entire known proteome https://www.biorxiv.org/content/10.1101/2024.02.15.580465v1
AlphaFind is a web-based search engine that provides fast structure-based retrieval in the entire se
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Vaughn Cooper @vscooper.micropopbio.org · 13/01/2024
Are you an early-stage researcher seeking support to attend ASM Microbe? 🧪🧬 The ASM Peggy Cotter Travel Award Program provides funds for outstanding early career Branch members to attend ASM Microbe. asm.org/Travel-Award...
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Kelly Wyres @kelwyres.bsky.social · 09/01/2024
Back to the socials after the holidays and first post is an absolute joy--> 📣📣📣 Congratulations to twitter.com/helena_betha... for preprinting the first chapter of her PhD thesis 🎉🎉🎉 doi.org/10.1101/2023...
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Lewis C. E. Mason @lewiscemason.bsky.social · 24/11/2023
The evolution and international spread of extensively drug resistant Shigella sonnei. The international outbreak (England, France, Belgium, USA, Australia) was ciprofloxacin, azithromycin, and ceftriaxone resistant - three of four WHO recommended antibiotic treatment options for shigellosis. 🖥️🧪🧬🦠🧫
nature.com
The evolution and international spread of extensively drug resistant Shigella sonnei - Nature Commun...
An increase in shigellosis cases among men who have sex with men in the United Kingdom has been linked to an extensively drug-resistant strain of Shigella sonnei. In this genomic epidemiology study, t...
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Patrick R. Secor @prsecor.bsky.social · 20/11/2023
New 🧫🦠🧪 paper from the lab: Targeted deletion of Pf prophages from diverse Pseudomonas aeruginosa isolates impacts quorum sensing and virulence traits doi.org/10.1101/2023... #phagesky #microsky
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Eva Heinz @evaheinz7.bsky.social · 28/09/2023
Hot off the press - Longitudinal analysis within one hospital in sub-Saharan Africa over 20 years reveals repeated replacements of dominant clones of Klebsiella pneumoniae and stresses the importance to include temporal patterns for vaccine design considerations 🖥️ 🧬 www.medrxiv.org/content/10.1...
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Marco Galardini @mgalactus.bsky.social · 09/11/2023
We have published a manuscript describing a software tool to reduce ambiguity and improve interpretability in microbial GWAS, called panfeed. Here's a quick explainer: www.microbial-pangenomes-lab.org/2023/11/09/M... And here's the link to the paper: www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
Reduced ambiguity and improved interpretability of bacterial genome-wide associations using gene-clu...
The wide adoption of bacterial genome sequencing and encoding both core and accessory genome variation using k-mers has allowed bacterial genome-wide association studies (GWAS) to identify genetic var...
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